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CTL Responses to Regulatory Proteins Tat and Rev in HIV-1 B’/C Virus-Infected Individuals

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Biomedical and Environmental Sciences 2008年第4期21卷 314-318页

作者： MING-MING JIA KUN-XUE HONG JIAN-PING CHEN HONG-WEI LIU SHA LIU XIAO-QING ZHANG HONG-JING ZHAO YI-MING SHAO Branch of aids State Key Laboratory for Infectious Diseases Prevention and Control national Center for aids/std control and prevention Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To characterize HIV-1 specific CTL responses to regulatory proteins Tat and Rev in HIV-B＇/C virus-infected ART-naive individuals. Methods HIV-1-specific CTL responses were analyzed by IFN-7 ELISPOT assay using overlapping peptides spanning the consensus sequences of HIV-1 clade C Tat and Rev proteins. Statistical analysis and graphical presentation were performed using SIGMAPLOT 10.0 and SIGMASTAT 3.5. For samples with a positive response, the magnitude of CTL responses was compared between HIV-1 C proteins by Wilcoxon rank sum test, and the significance threshold was P〈0.05. Results Tat and Rev were frequently recognized, with 23% and 52% of the tested individuals having detectable responses to these proteins, respectively. Several immunodominant regions were detected in Rev. No significant correlation was observed between the magnitude and breadth of CTL responses to regulatory proteins and the control of virus replication in this study. Conclusion Tat and Rev can serve as targets for HIV-l-specific CTL, and several immunodominant regions are detectable in Rev. Further characterization of epitopes and their role in virus control may shed light on pathogenesis of HIV- 1 natural infection and also be useful for the design and testing of candidate vaccines.

关键词： HIV-1 Immune responses ELISPOT Cytotoxic T-lymphocytes

Interpretation of the national Action Plan for Eliminating Hepatitis C as a Public Health Threat(2021–2030)

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China CDC weekly 2022年第29期4卷 627-630页

作者： Jian Li Lin Pang Zhongfu Liu national Center for aids/std control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary Hepatitis C virus(HCV)infection is a major public health problem in *** 2016,the World Health Organization(WHO)proposed a goal to eliminate viral hepatitis as a public health threat by 2030,and in 2018,the national Health Commission of China launched Hepatitis C Elimination Action by *** C control and prevention has made significant progress in China in recent *** implement the“Healthy China 2030”plan and the Healthy China Initiative(2019–2030),and to contribute to the global target of eliminating viral hepatitis as a public health threat by 2030,the national Health Commission of China and eight other government departments jointly issued the national Action Plan for Eliminating Hepatitis C as a Public Health Threat(2021–2030)(hereinafter referred to as the“national Plan”)in *** national Plan has an overarching goal and 15 specific targets that cover health education,comprehensive prevention interventions,testing and treatment,and capacity *** national Plan introduces key tasks and strategies of“five strengthenings,one expanding,and one implementation,”i.e.,strengthening health education,comprehensive prevention,referral and treatment,drug supply,and information management;expanding testing;and implementing relevant medical insurance *** national Plan also proposes key guaranteeing measures of“four intensifications and one mobilization,”i.e.,intensification of organizational leadership,capacity building,scientific research and international cooperation,and supervision and fulfillment;mobilization of social *** national Plan is an important component of the Healthy China initiative,adhering to the integration of treatment and prevention and deepening the“integration of medical treatment,medical insurance,and medicine supplies.”In this review,we describe the national Plan and discuss its challenges and prospects.

关键词： jointly prevention Action

Spatial Analysis of HIV/aids Cases Among Out-of-School Youth Aged 15-24 Years-China,2010-2020

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China CDC weekly 2021年第48期3卷 1015-1017页

作者： Shaorong Wang Junjie Wang Peng Xu Wanting Lyu Mengjie Han national Center for aids/std control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?There are 4,000 new HIV infections every day worldwide,and 31%of which are in adolescents aged 15–24 years ***,previous study is not aware of the distribution of out-of-... 详细信息

关键词： HIV/aids Spatial Cases

Epidemiological Characteristics of Newly Diagnosed Cases of HIV through Injection Drug Use-China, 2012–2019

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China CDC weekly 2020年第48期2卷 920-923页

作者： Houlin Tang Chang Cai Yan Cui Qianqian Qin Fan Lyu national Center for aids/std control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?The annual rates of newly diagnosed cases of human immunodeficiency virus(HIV)are increasing in China,yet the annual number of newly diagnosed cases of HIV infected throu... 详细信息

关键词： injection immunodeficiency HIV

Epidemiological Characteristics of Newly-Reported HIV Cases Among Youth Aged 15−24 Years-China, 2010−2019

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China CDC weekly 2020年第48期2卷 913-916页

作者： Hao Zhao Hui Liu Lu Wang Xuan Yang Shaorong Wang Mengjie Han Jian Li national Center for aids/std control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?An estimated 1,400 new cases of human immunodeficiency virus(HIV)occur every day among youths ***,HIV distribution among youth aged 15–24 years in China has not been res... 详细信息

关键词： globally Cases cases

A Pilot Program of Pre-Exposure and Post-Exposure Prophylaxis Promotion among Men Who Have Sex with Men-7 Study Sites, China, 2018–2019

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维普期刊数据库

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China CDC weekly 2020年第48期2卷 917-919页

作者： Xiaofang Wang Jie Xu Zunyou Wu national Center for aids/std control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known on this topic?Pre-exposure prophylaxis(PrEP)and post-exposure prophylaxis(PEP)had been proved to be effective in HIV prevention among men who have sex with men(MSM)*** of either PrEP or P... 详细信息

关键词： prevention China. Sites

Supervised Analysis of Hepatitis C Virus RNA-Positive Case Reporting in County-Level Hospitals--China,2013−2018

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China CDC weekly 2020年第31期2卷 587-590页

作者： Faxin Hei Guowei Ding Shaodong Ye Hailiang Yu Lin Pang Zhongfu Liu national Center for std/aids prevention and control Chinese Center for Disease Control and PreventionBeijingChina

What is already known on this topic?To understand the status of the diagnosis and reporting of hepatitis C and standardize the reporting of hepatitis C cases in county-level hospitals,we conducted the first supervised analysis of hepatitis C cases in county-level hospitals in China from 2013 to 2018,covering all provincial-level administrative divisions(PLADs)except *** is added by this report?Through 6 years of supervision,we have obtained key data such as the nucleic acid detection rate and positive rate of hepatitis C virus(HCV)antibody positive cases in our county-level hospitals,the report rate and accuracy of HCV RNA positive cases,and standardized and improved the hepatitis C case reporting in countylevel hospitals to improve data quality and provide data support for the judgment and estimation of hepatitis C in *** are the implications for public health practice?By strengthening the management and supervision of hepatitis C case reporting,the reporting rate and accuracy of HCV RNA positive cases in county-level hospitals in China had been greatly *** combining the number of HCV antibody tests and the number of viral nucleic acid tests in medical institutions around the country,it was possible to effectively assess the current status of hepatitis C in China and to provide a scientific basis for the development of hepatitis C prevention and treatment measures.

关键词： prevention diagnosis strengthening

Characteristics of Long-term Nonprogressors and Viremia controllers Infected with HIV-1 via Contaminated Blood Donations or Transfusions Conducted 20 Years Earlier

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维普期刊数据库

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Biomedical and Environmental Sciences 2017年第12期30卷 907-912页

作者： LIU Jia FAN Pan Ying XUE Xiu Juan YAN Jiang Zhou SUN Guo Qing LIU Chun Hua TIAN Sui An LI Ning SUN Ding Yong ZHU Qian WANG Zhe institute for prevention and control of aids and std Henan Center for Disease Control and PreventionZhengzhou 450016HenanChina

To characterize long-term nonprogressors （LTNPs） and viremia controllers （VCs）, infected with HIV-1 through contaminated blood donation or transfusion between 1992 and 1996 in Henan, China. LTNPs and VCs were defined by CD4＋T lymphocyte （CD4） count and viral load （VL）. Of 29,294 patients infected with HIV-1 via contaminated blood donation or transfusion that had conducted for more than 20 years, 92 were LTNPs/VCs. There were 70 LTNPs （0.24%）, 43 VCs （0.15%）, and 48 LTNPs＋VCs- （0.16%）.

关键词： Characteristics of Long-term Nonprogressors HIV-1 v/a Contaminated Blood Donations

A community-based comprehensive intervention to reduce syphilis infection—among low-fee female sex workers in China:a matched-pair,community-based randomized study

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Infectious Diseases of Poverty 2019年第6期8卷 51-60页

作者： Wei Dong Chu Zhou Ke-Ming Rou Zun-You Wu Jun Chen Sarah Robbins Scott Man-Hong Jia Yue-Jiao Zhou Xi Chen Division of HIV prevention National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention155 Changbai RoadBeijing 102206China Department of Epidemiology UCLA Fielding School of Public HealthLos AngelesUSA institute of aids/std control and prevention Yunnan Provincial Center for Disease Control and PreventionKunmingChina institute of aids control and prevention Guangxi Zhuang Autonom ous Region for Disease Control and PreventionNanningChina Division of aids/std control and prevention Hunan Provincial Center for Disease Control and PreventionChangshaChina

Background:Low-fee female sex workers(FSWs)are at high risk of acquiring and spreading human immunodeficiency virus(HIV)/sexually transmitted diseases(stds)in *** is an urgent need to develop comprehensive intervention measures targeted towards low-fee FSWs to reduce HIV/std ***,this study aimed to reduce HIV/std infections among low-fee FSW through a matched-pair,comiDunity-based randomized intervention trial carried out in 12 cities in three provinces in ***:Four cities from Guangxi Zhuang Autonomous Region,four from Yunnan Province,and four from Hunan Province were paired and participants received either the intervention package(including condom promotion,HIV and syphilis testing,reimbursement for syphilis treatment costs,and free anti-retroviral therapy or the current standard of ***-based,convenience sampling was used to recruit FSWs.A face-to-face interview and HIV and syphilis blood testing was conducted at baseline and follow-up intervals of 24 *** linear mixed models(GLMM)were used to evaluate the effect of the intervention package on reducing HIV/std infection in the ***:A total of 1024 eligible FSWs were enrolled in the baseline survey and 843 in the *** results showed that syphilis infeaion was reduced by 49%in the intervention group compared to the current standard of care group(P=0.0378,OR=0.51;95%CI:0.27-0.96).FSWs aged 35 years or older were 2.38 times more likely to get syphilis infection compared to those younger than 35 years old(P<0.0001,OR=2.38,95%CI:1.55-3.65).The risk of syphilis infection among more educated FSWs was 0.43 times less than those with lower levels of education(P<0.05,OR=0.43,95%CI:0.63-0.93).Conclusions:This study demonstrates that comprehensive interventions can lead to significant declines in syphilis infection amongst low-tier *** both behavioral and biomedical intervention measures should be considered when developing programs for low-fee FS

关键词： China Female sex workers Human immunodeficiency virus Syphilis