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Epidemiological Analysis on Reported Hepatitis C Cases in China from 2012 to 2016

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Biomedical and Environmental Sciences 2018年第10期31卷 773-776页

作者： HEI Fa Xin YE Shao Dong DING Guo Wei PANG Lin WANG Xiao Chun LIU Zhong Fu national Center for aids/std control and prevention Chinese Center for Disease Control and Prevention

Viral hepatitis is an important challenge to public health *** hepatitis B is well controlled due to vaccination,the disease burden caused by the spread of hepatitis C has become increasingly *** C is an infectious disease that is mainly *** rate of chronicity ranges from 55% to 85% after people are infected with the hepatitis C virus （HCV）.

关键词： HCV Figure Epidemiological Analysis on Reported Hepatitis C Cases in China from 2012 to 2016

HIV prevalence and influencing factors analysis of sentinel surveillance among men who have sex with men in China, 2003-2011

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Chinese Medical Journal 2012年第11期125卷 1857-1861页

作者： WANG Lan WANG Lu Jessie L.Norris LI Dong-min GUO Wei DING Zheng-wei WANG Ning national Center for aids/std control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Background Men who have sex with men （MSM） have been impacted by HIV and now as an important driver of the HIV/aids epidemic in China. This study collected HIV sentinel surveillance system data on the MSM population to describe the characteristics and trends of the HIV epidemic among MSM in China from 2003 to 2011. Methods Data on HIV prevalence and risk behaviors from 2003 to 2011 were obtained from the national HIV sentinel surveillance database. Results MSM sentinel surveillance data for 2011 showed that proportions of MSM who consistently used condoms during anal sex in the last six months and at last anal sex encounter were 43.3% and 74.1%, respectively. Between 2005 and 2011 there were no significant changes in the proportion of consistent condom use. The proportion of MSM who had multiple male sex partners in the last six months increased. Overall HIV prevalence over the years showed a rising trend from 0.9% in 2003 to 6.3% in 2011. The syphilis antibody positive rate was 7.8% in 2011. In addition, the proportion of MSM in heterosexual marriages was rising, aids awareness was also increasing, and the proportion of MSM who had taken an HIV test in the last year and was aware of the results rose. The proportion who had received intervention services in the last year stabilized. Conclusions HIV prevalence in MSM populations is rapidly and widely distributed. MSM who are in heterosexual marriages may be a bridge group transmitting HIV to their heterosexual partners. The risky sexual behavior among MSM will remain a serious and important driver of China＇s aids epidemic over the next period of time. Intervention need to be strengthened, as does the effective implementation of measures to control aids and prevent it from spreading further.

关键词： MSM HIV prevalence epidemic, risk sexual behaviors

Improving China＇s antiretroviral treatment program： assessing current and future performance using the principals of ethics

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Chinese Medical Journal 2009年第11期122卷 1346-1351页

作者： YIN Wen-yuan ZHANG Fu-jiet Naomi Juniper WU Zun-you Division of Health Education and Behavioral Intervention National Centre for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Division of Treatment and Care National Centre for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China

The global commitment to providing antiretroviral therapy （ART） to people living with human immunodeficiency virus/acquired immunodeficiency syndrome （HIV/aids） in low-income countries has raised hope that the increasing momentum in the fight against the worldwide HIV/aids pandemic will be sufficient to control it. However, improved availability of subsidized antiretroviral （ARV） treatments in low-income .countries raises complex ethical issues. In many resource-constrained countries the number of individuals infected with HIV in need of treatment far exceeds the supply of ARV medication. Resource allocation decisions can be made on the basis of many epidemiological, ethical, or preferential treatment priority criteria. Healthcare systems and funding in low-income countries are limited, requiring a step-by-step approach to scaling- up programs to reach their stated aims.

关键词： acquired immunodeficiency syndrome antiretroviral treatment program ethics

Advances in research of HIV transmission networks

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Chinese Medical Journal 2020年第23期133卷 2850-2858页

作者： Zhi-Long Dong George Fu Gao Fan Lyu national institute for Viral Disease control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China national Center for aids/std control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Transmission network analysis is a crucial evaluation tool aiming to explore the characteristics of the human immunodeficiency virus epidemic,develop evidence-based prevention strategies,and contribute to various areas of human immunodeficiency virus/acquired immunodeficiency syndrome prevention and *** recent decades,transmission networks have made tremendous strides in terms of modes,methods,applications,and various other *** network methods,including social,sexual,and molecular transmission networks,have played a pivotal *** transmission network research method has its advantages,as well as its *** this study,we established a systematic review of these aforementioned transmission networks with respect to their definitions,applications,limitations,recent progress,and synthetic applications.

关键词： Human immunodeficiency virus HIV Transmission networks Social network Sexual network Molecular transmission network Molecular epidemiology

Exploration of an Efficient Simultaneous Molecular Detection Method of HIV,HCV,and Syphilis from a Single Dried Blood Spot

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Biomedical and Environmental Sciences 2021年第4期34卷 257-264页

作者： MA Jie Qiong XU Qing Qing HE Lin HE Xiao Xia CHEN Kai WANG Yue Hua XING Wen Ge JIANG Yan national HIV Reference Laboratory National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective The aim of the present study was to evaluate the performance of the simultaneous detection of HIV-1 RNA,HIV-1 DNA,and HCV RNA using one dried blood spot(DBS)as an alternative sample to *** A total of 571 paired DBS/plasma samples were collected from men who have sex with men(MSM)and injection drug users(IDUs),and serological and molecular assays were *** plasma results as the reference standard,the performance of DBS tests for HIV-1 RNA,HIV-1 DNA,and HCV RNA was ***’s correlation coefficients and Bland-Altman analysis were performed to assess the correlation and concordance between DBS and *** Among paired plasma/DBS samples with detectable HIV-1 RNA and HCV RNA,five samples(5/32)were not detectable in DBS,while measurable HIV-1 RNA levels were present in plasma(1.44 to3.99 log10 copies/m L).There were two samples(2/94)with undetectable HCV RNA in DBS,while measurable HCV RNA levels were present in plasma(-5 to 5.99 log10 copies/m L).The correlation between HIV-1 RNA light chain variable region(VL)values obtained from plasma and DBS showed that r=0.683(P<0.01),n=27 and r=0.612(P<0.01),n=89 in HCV ***-Altman analysis revealed that in HIV-1 RNA,the mean(±SD)difference between HIV-1 RNA in plasma and DBS was 1.00±1.01 log10 copies/m L,and all samples were within±1.96 SD(-0.97 to 2.97 log10 copies/m L)for *** mean difference(±SD)in HCV RNA was 0.15±1.08 log10 copies/m L,and 94.38%(84/89)were within±1.96 SD(-1.96 to 2.67 log10 copies/m L).Overall,HIV-1 RNA and HCV RNA levels obtained from a DBS were lower than those obtained from ***-1 DNA in a DBS showed concordant results with HIV-1 RNA in ***-1 DNA RT-PCR using a DBS showed acceptable *** The performance of the simultaneous detection of HIV-1 RNA,HIV-1 DNA,and HCV RNA using one DBS was ***,as an alternative sample to plasma,may be a viable option for the simultaneous detection of HIV-1 RNA,HIV-1 DNA,and HCV R

关键词： Dried blood spot(DBS) Correlation Bland-Altman HIV-1 RNA HIV-1 DNA HCV RNA

HIV-specific T cell immunity across the entire HIV genome in Chinese men who have sex with men

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Chinese Medical Journal 2006年第23期119卷 1958-1965页

作者： ZHANG Xiao-yan HUANG Xiang-gang XU Jian-qing LI Shen-wei JIANG Shu-lin ZHANG Xiao-xi LI Dong-liang RUAN Yu-hua XING Hui SHAO Yi-ming State Key Laboratory for Infectious Disease prevention andcontrol National Centre for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention Beijing100050 China Chaoyang District Centre for aids/std control and prevention Beijing 100021 China

Background Man who has sex with man （MSM） is one of the high risk groups for spreading HIV/aids. It was reported that the most prevalent human irnmunodeficiency virus type 1 （HIV-1） strain among MSM is subtype B; however, T cell immunity remains unknown across the HIV-1 B genome in this population. Methods Using Elispot assay with synthetic peptides spanning the sequence of HIV-1 consensus B, HIV-l-specific cytotoxic T-cell lymphocyte responses were quantified among 3 treated and 19 untreated HIV-1 infected MSM from Beijing, China. Cross-sectional association between viral loads and cellular immune responses were analyzed. Results Peptide pools corresponding to each HIV-1 protein were used for Env, Gag, Pol, Nef, Tat/Rev, Vpr/Vpu and Vif. The results showed that the magnitude of T cell responses in the 3 treated HIV^＋ MSM group [median, 770 spot forming cells （SFCs） per 106 peripheral blood mononuclear cells （PBMCs）] might be significantly lower than that in the 19 untreated HIV^＋ MSM group （median, 6175 SFCs per 106 PBMCs）. Nef, Gag and Pol are the most frequently targeted HIV-1 antigens; and 16 subjects （73%） were identified with vigorous T cell immunity against each of these three proteins. The overall magnitude of T cell immunity closely related to its breadth （r=-0.72, P〈0.05） and was inversely but weakly associated with viral loads （r=-0.15）. Further analysis showed that both Gag （r=-0.24） and Pol specific T cells （r=-0.12） contributed to this inverse association whereas Nef specific T cells showed no association with viral loads. Conclusions The magnitude of HIV-1 specific T cells is inversely but weakly associated with viral loads among MSM; HIV-specific T cell responses against conservative sequences （Gag and Pol） are the main contributors to this association among Chinese HIV^＋ MSM. These findings have important implications for vaccine design.

关键词： human immunodeficiency virus homosexuafity immunity, cellular viral load

Analysis of Knowledge Level and Use of Antiretroviral Pre-Exposure and Post-Exposure Prophylaxis Among MSM—China,2019–2022

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China CDC weekly 2023年第13期5卷 292-296页

作者： Jiahuan Guo Wenting Kang Tongtong Liu Jie Xu Houlin Tang Fan Lyu Guang Zhang national Center for aids/std control and prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Association of std&aids prevention and control BeijingChina Chinese Center for Health Education BeijingChina

Summary What is already known on this topic?Men who have sex with men(MSM)in China have a high rate of human immunodeficiency virus(HIV)***-exposure prophylaxis(PrEP)and postexposure prophylaxis(PEP)have been shown to be effective in preventing HIV,which may help to contain the HIV epidemic among *** is added by this report?This study found that knowledge and usage of PrEP were low among MSM,indicating that this population is at high risk for HIV *** of PrEP and PEP among MSM is necessary to reduce the risk of HIV infection in this *** are the implications for public health practice?PrEP and PEP are novel HIV prevention strategies that have been demonstrated to be effective and *** further reduce HIV transmission among MSM in China,it is necessary to promote the use of PrEP and PEP.

关键词： prevention MSM immunodeficiency

Detection of recent HIV-1 infections among men who have sex with men in Beijing during 2005-2006

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Chinese Medical Journal 2008年第12期121卷 1105-1108页

作者： LI Shen-wei ZHANG Xiao-yan LI Xin-xu WANG Min-jie LI Dong-liang RUAN Yu-hua ZHANG Xiao-xi SHAO Yi-ming State Key Laboratory for Infectious Disease prevention and control National Center for AIDS/STD Control and Prevention China CDC Beijing 100050 China Chaoyang District Center for aids/std control and prevention Beijing 100021 China

Background Men who have sex with men （MSM） have become one of the most risky populations for HIV infection in China. Though several cross-sectional sero-prevalence studies have been conducted, the annual HIV incidence remains unknown in this population.Methods We applied IgG-capture BED-enzyme immunoassay （BED-CEIA） to define the recent HIV-1 infections among MSM in Beijing in the years 2005 and 2006 and the annual HIV incidence was estimated.Results Overall, 1067 MSM samples were collected, including 526 samples in the year 2005 and 541 in 2006. In 2005, of 17 HIV seropositive samples, 7 were identified as recent HIV-1 infections and the estimated HIV infection incidence was 2.9% per year （95% CI, 0.8%-5.0%）. In 2006, of 26 HIV seropositive samples, 9 were identified as recent HIV-1 infections and the estimated annual incidence was 3.6% （95% CI, 1.3%-5.9%）, which was 0.7% higher than that in 2005. Individuals engaging in male group sexual intercourse （5.17% vs 0.87%, P=0.019） and having receptive anal sexual intercourse more than five times （2.79% vs 0.33%, P=0.047） in the past 6 months significantly increase the risk of being infected by HIV-1.Conclusions A high level of annual HIV-1 infection incidence was observed among MSM in Beijing for the consecutive years 2005 and 2006 with a continuous increasing trend. The rising incidence and related high risk behavior among MSM alarmed the health authorities and calls for more effective intervention strategies among this population.

关键词： HIV-1 men who have sex with men HIV incidence IgG-capture BED-enzyme immunoassay

Overview of HIV drug resistance and its implications for China

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Chinese Medical Journal 2006年第23期119卷 1999-2004页

作者： Maria Au Jessica Haberer Division of Treatment and Care National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China

Since the initiation of China＇s nationwide free antiretroviral therapy （ART） in 2002, the availability of highly active antiretroviral therapy （HAART） in China has increased dramatically. HAART has been proven to prolong survival and control HIV disease progression. At the same time, experience in developed countries indicates that the high mutation rate of the virus in the presence of HAART is associated with drug resistance and diminished efficacy. The increase in HAART availability and use in China therefore also comes with the potential for increased resistance. Transmission of drug-resistant strains to individuals who have never been exposed to ART is on the rise. Moreover, studies have shown that new infections by drug-resistant virus result in suboptimal response to ART. With the rapid scale up of ART in China in recent years, the prevalence of HIV drug resistance will likely increase, posing a major public health concern in China. This review article provides an overview of ART resistance, the current worldwide trends in HIV drug resistance, the effect of HIV drug resistance in clinical management, and the implications for China＇s HIV treatment and care.

关键词： human immunodeficiency virus drug resistance antiretroviral therapy mutation