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Time Series and Spatial Epidemiological Analysis of the Prevalence of Iodine Deficiency Disorders in China

Biomedical and Environmental Sciences 2022年第8期35卷 735-745页

作者： FAN Li Jun GAO Yun Yan MENG Fan Gang LIU Chang LIU Lan Chun DU Yang LIU Li Xiang LI Ming SU Xiao Hui LIU Shou Jun LIU Peng Institute of lodine DeficiencyDisorders Center for Endemic Disease ControlChinese Center forDisease Control and PreventionHarbin Medical UniversityHarbin 150081HeilongjiangChina national health commission&education bureau of heilongjiang province Key laboratory of Etiology and EpidemiologyHarbin Medical UniversityHarbin 150081HeilongjiangChina

Objective To recognize the spatial and temporal characteristics of iodine deficiency disorders(IDD),China national IDD surveillance data for the years of 1995–2018 were *** Time series analysis was used to describe and predict the IDD related indicators,and spatial analysis was used to analyze the spatial distribution of salt iodine *** In China,the median urinary iodine concentration increased in 1995–1997,then decreased to adequate levels,and are expected to remain appropriate in 2019–*** goiter rate continually decreased and is expected to be maintained at a low *** 2002,the coverage rates of iodized salt and the consumption rates of qualified iodized salt(the percentage of qualified iodized salt in all tested salt) increased and began to decline in 2012;they are expected to continue to *** epidemiological analysis indicated a positive spatial correlation in 2016–2018 and revealed feature regarding the spatial distribution of salt related indicators in coastal areas and areas near iodine-excess *** Iodine nutrition in China showed gradual ***,a recent decline has been observed in some areas following changes in the iodized salt supply in *** the future,more regulations regarding salt management should be issued to strengthen IDD control and prevention measures,and avoid the recurrence of IDD.

关键词： Salt iodine lodine deficiency disorders Time series analysis Space epidemiology Reform for the salt industry system

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Spatial-Temporal Analysis of Drinking Water Type of Endemic Fluorosis—China,2009–2022

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China CDC weekly 2024年第2期6卷 25-29页

作者： Lijun Zhao Zhe Li Mang Li Hongna Sun Wei Wei Lin Gao Qiaoshi Zhao Yang Liu Xiaohong Ji Cheng Li Jian Wang Yanhui Gao Junrui Pei Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina Key Lab of Etiology and Epidemiology Education Bureau of Heilongjiang Province(23618504)Ministry of Health of PRHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Endemic fluorosis,caused by high fluoride levels in drinking water,has been a significant health issue in rural areas of China for many *** is added by this report?There has been a notable decline in the detection rate of dental fluorosis in children aged 8–12 years in drinking water fluorosis areas across the country from 2009 to *** 14 provincial-level administrative divisions are classified as low-probability clusters,Tianjin remains classified as a high-probability *** are the implications for public health practice?The current policy for preventing and controlling endemic fluorosis in China needs *** than focusing solely on regions with high incidence,there should be a shift towards monitoring and early warning of fluoride ***,local containment measures should be intensified.

关键词： intensified Spatial fluoride

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DNA Methylation of KLRC1 and KLRC3 in Autoimmune Thyroiditis:Perspective of Different Water Iodine Exposure

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Biomedical and Environmental Sciences 2024年第9期37卷 1044-1055页

作者： Yao Chen Jinjin Liu Mengying Qu Bingxuan Ren Huaiyong Wu Li Zhang Zheng Zhou Lixiang Liu Hongmei Shen Disorders Control Centre for Endemic Disease ControlChinese Centre for Disease Control and PreventionHarbin Medical UniversityHarbin 150081HeilongjiangChina national health commission&education bureau of heilongjiang province Key Laboratory of Etiology and EpidemiologyHarbin Medical UniversityHarbin 150081HeilongjiangChina heilongjiang Provincial Key Laboratory of Trace Elements and Human health Harbin Medical UniversityHarbin 150081HeilongjiangChina Division of health Risk Factor Monitoring and Control Shanghai Municipal Center for Disease Control and PreventionShanghai 200336China Department of Public health Administration Affiliated Hospital of Jining Medical UniversityJining 272060ShandongChina Heze Municipal Hospital Shandong Provincial Hospital Heze HospitalHeze 274700ShandongChina

Objective This study aimed to identify differentially methylated genes(DMGs) associated with natural killer cells in patients with autoimmune thyroiditis(AIT), focusing on the influence of varying water iodine exposure *** Participants were divided into categories based on median water iodine(MWI)concentrations: iodine-fortified areas(IFA, MWI 300 μg/L). A total of 176 matched AIT cases and controls were recruited and divided into 89, 40, and 47 pairs for IFA, IAA, and IEA, respectively. DMGs were identified using 850K Bead Chip analysis for 10/10 paired samples. Validation of DNA methylation and m RNA expression levels of the DMGs was conducted using Methyl Target^(TM) and QRT-PCR for 176/176paired *** KLRC1, KLRC3, and SH2D1B were identified as significant DMGs. Validation revealed that KLRC1 was hypomethylated and highly expressed, whereas KLRC3 was hypermethylated and highly expressed in individuals with AIT. Furthermore, KLRC1 was hypomethylated and highly expressed in both IFA and *** The DNA methylation status of KLRC1 and KLRC3 may play crucial roles in AIT pathogenesis. Additionally, DNA methylation of KLRC1 seems to be influenced by different iodine concentrations in water.

关键词： Autoimmune thyroiditis DNA methylation KLRC1 KLRC3 SH2D1B Iodine

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Disease and Economic Burden of Kashin-Beck Disease—China,2021

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China CDC weekly 2024年第2期6卷 40-44页

作者： Silu Cui Wenjun Que Zhe Jiao Qing Deng Xufeng Zhang Yanhong Cao Ning Liu Ailin Li Alphonse Sowanou Zhe Li Tuo Wang Yang Li Jun Yu Junrui Pei NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Kashin-Beck Disease ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Endemic Fluorosis ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage *** is an endemic disease that is highly prevalent among the Chinese population and poses a significant health *** is added by this report?This is the first national report on the economic burden of KBD in *** to the data from 2021,KBD has caused significant disease and economic *** most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese Yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the *** strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas.

关键词： prevention degeneration burden

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Serum Thyroglobulin——A Sensitive Biomarker of Iodine Nutrition Status and Affected by Thyroid Abnormalities and Disease in Adult Populations

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Biomedical and Environmental Sciences 2017年第7期30卷 508-516页

作者： DU Yang GAO Yan Hui FENG Zhuo Ying MENG Fan Gang FAN Li Jun SUN Dian Jun Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityKey Lab of Etiology and EpidemiologyNational Health and Family Planning Commission(23618504) heilongjiang Land Reclamation bureau General Hospital

Objective To evaluate the usefulness of the thyroglobulin （Tg） level in adults as a nutritiona biomarker of iodine status and to identify the factors related to the serum Tg level. Methods A cross-sectional study was conducted in adult populations of areas differing in iodine nutrition from three provinces （Autonomous Region） in China. Serum levels of thyroid hormones and Tg as well as thyroid autoantibodies were measured. The thyroid volume and nodule were measured by ultrasound. A multivariate linear regression analysis was used to assess iodine intake and other indeterminate factors associated with the serum Tg level. Results A total of 573 adults were recruited for this study. The serum Tg levels differed significantly among the three groups （22.27 ~g/L, 9.73 pg/L and 15.77 pg/L in the excess, more-than-adequate, and deficient groups, respectively）. The results of multivariate linear regression analysis indicate that excess and deficient iodine intake, goiter, thyroid nodule, hypothyroidism are significantly related with higher Tg level, and TgAb positivity is significantly related with lower serum Tg. Conclusion The serum Tg level reflects abnormal thyroid function and is a sensitive functiona biomarker of iodine nutrition status.

关键词： High iodine Iodine deficiency Thyroglobulin

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Serum Metabolomic Indicates Potential Biomarkers and Metabolic Pathways of Pediatric Kashin-Beck Disease

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Biomedical and Environmental Sciences 2020年第10期33卷 750-759页

作者： WANG Yu Meng WANG Wei Yi SUN Li Yan LI Qiang ZHAO Zhi Jun HU Jian ZHANG Rong Yu WANG Li Hua Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical University/Key Lab of Etiology and EpidemiologyEducation Bureau of Heilongjiang Province&Ministry of HealthHarbin 150081Heilongjiang China Qinghai Institute for Endemic Disease prevention and Control Xining 811602QinghaiChina

Objective To explore potential serum biomarkers of children with Kashin-Beck Disease(KBD)and the metabolic pathways to which the biomarkers *** A two-stage metabolomic study was *** discovery cohort included 56 patients,51 internal controls,and 50 external *** metabolites were determined by HPLC-(Q-TOF)-MS and confirmed by Human Metabolome Databases(HMDB)and Metlin *** 3.0 and the Kyoto Encyclopedia of Genes and Genomes(KEGG)database were used to analyze the metabolic pathways of the candidate *** use of HPLC-(Q-TRAP)-MS enabled quantitative detection of the target metabolites which were chosen using the discovery study and verified in another independent verification cohort of 31 patients,41 internal controls,and 50 external *** Eight candidate metabolites were identified out in the discovery study,namely kynurenic acid,N-α-acetylarginine,6-hydroxymelatonin,sphinganine,ceramide,sphingosine-1 P,spermidine,and *** metabolites exist in sphingolipid,glutathione,and tryptophan metabolic *** the second-stage study,five candidate metabolites were validated,including kynurenic acid,N-α-acetylarginine,sphinganine,spermidine,and sphingosine-1 *** for spermidine,all substances exhibited low expression in the case group compared with the external control group,and the difference in levels of sphinganine,spermidine,and sphingosine-1 P was statistically *** The direction of change of levels of sphinganine,spermidine,and sphingosine-1 P in the two-stage study cohorts was completely consistent,and the differences were statistically ***,these substances can be used as potential biomarkers of ***,these results raise the possibility that sphingolipid metabolic pathways may be closely related to KBD.

关键词： Kashin-Beck disease Potential biomarkers Metabolism pathways Serum

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Prevalence and Trends of Birth Defects—Five Counties,Shanxi province,China,2003–2022

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China CDC weekly 2023年第36期5卷 797-803页

作者： Duoduo Wang Zhijiao Song Yali Zhang Le Zhang Lei Jin Aiguo Ren Zhiwen Li Jufen Liu Institute of Reproductive and Child health/national health commission Key Laboratory of Reproductive health Peking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of health education Shanxi Women and Children Health HospitalTaiyuan CityShanxi ProvinceChina

Summary What is already known about this topic?The Shanxi province,located in northern China,holds the highest prevalence of birth defects(BDs)across the *** the implementation of a nationwide folic acid supplementation program in 2009,a significant reduction of 53.89%in the prevalence of neural tube defects(NTDs)was observed in Shanxi from 2012 to 2017.

关键词： nationwide holds Shanxi

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Acetyl-11-keto-beta-boswellic acid promotes sciatic nerve repair after injury: molecular mechanism

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Neural Regeneration Research 2022年第12期17卷 2778-2784页

作者： Yao Wang Zong-Liang Xiong Xiang-Lin Ma Chong Zhou Mo-Han Huo Xiao-Wen Jiang Wen-Hui Yu Department of Veterinary Medicine Northeast Agricultural UniversityHarbinHeilongjiang ProvinceChina College of Life Sciences Northeast Agricultural UniversityHarbinHeilongjiang ProvinceChina Key Laboratory of heilongjiang education Department for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbinHeilongjiang ProvinceChina Institute of Chinese Veterinary Medicine Northeast Agricultural UniversityHarbinHeilongjiang ProvinceChina

Previous studies showed that acetyl-11-keto-beta-boswellic acid(AKBA),the active ingredient in the natural Chinese medicine Boswellia,can stimulate sciatic nerve injury repair via promoting Schwann cell ***,the underlying molecular mechanism remains poorly *** this study,we performed genomic sequencing in a rat model of sciatic nerve crush injury after gastric AKBA administration for 30 *** found that the phagosome pathway was related to AKBA treatment,and brain-derived neurotrophic factor expression in the neurotrophic factor signaling pathway was also highly *** further investigated gene and protein expression changes in the phagosome pathway and neurotrophic factor signaling *** expression in the phagosome pathway was markedly decreased,and brain-derived neurotrophic factor,nerve growth factor,and nerve growth factor receptor expression levels in the neurotrophic factor signaling pathway were greatly ***,expression levels of the inflammatory factors CD68,interleukin-1β,pro-interleukin-1β,and tumor necrosis factor-αwere also *** basic protein-andβ3-tubulin-positive expression as well as the axon diameter-to-total nerve diameter ratio in the injured sciatic nerve were also *** findings suggest that,at the molecular level,AKBA can increase neurotrophic factor expression through inhibiting myeloperoxidase expression and reducing inflammatory reactions,which could promote myelin sheath and axon regeneration in the injured sciatic nerve.

关键词： AKBA axon genomics inflammatory injury and repair myelin sheath myeloperoxidase neurotrophic factor peripheral nerve phagosome pathway regeneration Sprague-Dawley rat

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Exploration of transmission chain and prevention of the recurrence of coronavirus disease 2019 in heilongjiang province due to inhospital transmission

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World Journal of Clinical Cases 2021年第20期9卷 5420-5426页

作者： Qi Chen Yang Gao Chang-Song Wang Kai Kang Hong Yu Ming-Yan Zhao Kai-Jiang Yu Department of Critical Care Medicine Harbin Medical University Cancer HospitalHarbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina Department of Critical Care Medicine The sixth Affiliated Hospital of Harbin Medical UniversityHarbin Medical UniversityHarbin 150028Heilongjiang ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Critical Care Medicine The Second Hospital of HarbinHarbin 150056Heilongjiang ProvinceChina Institute of Critical Care Medicine The Sino Russian Medical Research Center of Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina Key Laboratory of Hepatosplenic Surgery Ministry of EducationHarbin 150001Heilongjiang ProvinceChina The Cell Transplantation Key Laboratory of national health commission Harbin 150001Heilongjiang ProvinceChina

The coronavirus disease 2019(COVID-19)epidemic is a major public health emergency characterized by fast spread,a wide range of infections,and enormous control *** the end of December 2019,Wuhan has become the first core infection area of China's COVID-19 *** March 2020,the domestic worst-hit areas have moved to the heilongjiang province due to the increased number of imported COVID-19 ***,we reported the major COVID-19 outbreak,which caused a rebound of the epidemic in Harbin,*** the rebound,different levels of causes for the recurrence of COVID-19,including citylevel,hospital-level,and medical staff-level cause,were ***,corresponding countermeasures to prevent the recurrence of the epidemic were also carried out on the city level,hospital level,and medical staff level,which eventually showed the effect of infection control function in a *** this study,we described the complete transmission chain,analyzed the causes of the outbreak,and proposed corresponding countermeasures from our practical clinical experience,which can be used as a valuable reference for COVID-19 control.

关键词： Transmission chain Prevention of the recurrence COVID-19 heilongjiang province In-hospital transmission

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Effects from changes in pulp nature after ultrasonic conditioning on high-sulfur coal flotation

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Mining Science and Technology 2009年第4期19卷 498-502,507页

作者： KANG Wen-ze XUN Hai-xin KONG Xiao-hong LI Ming-ming Resource and Environment Department Heilongjiang Institute of Science and Technology Harbin Heilongjiang 150027 China Mineral Processing Major Laboratory for education Department of heilongjiang province Harbin Heilongjiang 150027 China

A study of the effects of the pulp nature on desulphurization and de-ashing during high-sulfur coal flotation is described in this paper. Highlighted are the use of a solution oxygen gauge, a pH value gauge and a surface tension gauge to investigate changes in the pulp nature related to changes in the oxygen content, the pH value and the interfacial tension. The temperature be- fore and after ultrasonic conditioning was also investigated. The results showed that ultrasonic conditioning resulted in a decrease in the oxygen content and the interracial tension and an increase in the pH value and the temperature of the pulp. The perfect index of flotation and the perfect index of desulphurization of fine coal increased by 25.19% and 18.03%, respectively, after the pulp was ultrasonically conditioned. This study shows that ultrasonic conditioning can change the pulp nature and enhance the degree of desulphurization during high-sulfur coal flotation.

关键词： ultrasonic treatment pulp perfect index of flotation perfect index of desulphurization

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