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Strain-specific effects of Akkermansia muciniphila on the regulation of intestinal barrier

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food Science and Human Wellness 2023年第5期12卷 1526-1537页

作者： Yang Liu Qing Liu Chengcheng Zhang Jianxin Zhao Hao Zhang Wei Chen Qixiao Zhai State Key Laboratory of food Science and Technology School of Food Science and TechnologyJiangnan UniversityWuxi 214122China national engineering research Center for functional food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine research Center and Jiangsu Translational Medicine research Institute Wuxi Branch Wuxi 214122China

Akkermansia muciniphila, one of the most promising next-generation probiotics, was reported to exhibit beneficial modulatory effects on the gut barrier. However, the strain-specific and underlying regulatory mechanisms of this species on gut barrier function were not well studied. Therefore, this study evaluated the protective effect of A. muciniphila strains on the intestinal barrier and investigated the mode of action and material basis of this modulatory effect. We first confirmed the strain-specific effects of A. muciniphila on intestinal barrier regulation and found that this phenomenon may be explained by the different abilities of strains to affect tight junction protein expression in enterocytes. Comparative genomic analysis proved that the ability of A. muciniphila to regulate the intestinal barrier was exerted in part by the functional genes(such as COG0438, COG0463, and COG2244)related to the synthesis of cellular surface proteins. The role of these surface proteins in intestinal barrier regulation was further verified by strain-comparative experiments in animal and cell models and surface protein removal trials. This study confirmed the different effects of A. muciniphila strains on gut barrier modulation and provided molecular and genetic targets for the screening of A. muciniphila strains with superior protection against gut barrier dysfunction.

关键词： Akkermansia muciniphila Intestinal barrier Strain specificity Comparative genomics Bacterial surface components

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Study on the preparation process of large particle cerium oxide

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Journal of Rare Earths 2010年第S1期28卷 136-138页

作者：马莹王宝荣李莉娜乔军苏允兰王笃金王晶晶 national engineering research Center of Rare Earth Metallurgy and functional Materials Baotou research Institute of Rare Earths Institute of Chemistry Chinese Academy of Sciences

The large particle cerium oxide was prepared using oxalic acid as precipitation agent. The effects of preparation conditions on the particle size of cerium oxide were discussed. The results showed that the particle size of cerium oxide could be controlled effectively by the temperature,acidity of the solution,aging time,etc. The optimized preparation process of large particle cerium oxide was obtained. The cerium oxide with size between 50 μm to 150 μm was prepared by the process. Moreover,the cerium oxide particles were dispersed uniformly.

关键词： large particle cerium oxide rare earths

Supplementation with yak (Bos grunniens) bone collagen hydrolysate altered the structure of gut microbiota and elevated short-chain fatty acid production in mice

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food Science and Human Wellness 2023年第5期12卷 1637-1645页

作者： Zitao Guo Dalong Yi Bo Hu Lingyu Zhu Ji Zhang Yuliang Yang Chunyu Liu Yi Shi Zhenghua Gu Yu Xin Huaigao Liu Liang Zhang national engineering research Center of Cereal Fermentation and food Biomanufacturing Jiangnan UniversityWuxi 214122China Jiangsu Provincial research Center for Bioactive Product Processing Technology Jiangnan UniversityWuxi 214122China Anhui Guotai Biotechnology Co. LtdXuancheng 242100China national engineering research Center for functional food Jiangnan UniversityWuxi 214122China

In this study, yak bone collagen hydrolysate(YBCH)was produced by mixed proteases and provided to standard-diet mice at a different dose(low dose(LD), medium dose(MD), and high dose(HD))to investigate its effects on the composition of gut microbiota and short-chain fatty acids(SCFA)production. It was found that YBCH was mainly composed of small molecular peptides whose molecular weight below 2 000 Da. Notably, supplementation with different doses of YBCH could significantly downregulate the ratio of Firmicutes to Bacteroidetes in the fecal microbiota. At the family level, the Lachnospiraceae abundance was significantly reduced in the YBCH gavage groups(mean reduction ratio 41.7 %, 35.2%, and 36.4% for LD, MD, and HD group, respectively). The predicted functions of gut microbes in the MD group were significantly increased at “lipid metabolism” and “glycan biosynthesis and metabolism”. Moreover, the SCFA production in the YBCH groups was elevated. Especially, the concentration of acetic acid, propionic acid, and butyric acid in the MD group was separately increased 79.7%, 89.2%, and 78.8% than that in the NC group. These results indicated that YBCH might be applied in the development of functional food for intestinal microecological regulation.

关键词： Yak bone collagen hydrolysate Peptides Gut microbiota Short-chain fatty acid Lachnospiraceae

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In vitro digestibility of Aucklandia costus-loaded nanophytosomes and their use in yoghurt as a food model

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food Bioscience 2022年第6期50卷 1016-1024页

作者： Fadwa W.Abdulqahar Tamer M.El-Messery Ahmed A.Zaky Marwa M.El-Said food Science Department College of AgricultureUniversity of AnbarRamadyIraq Dairy Department Food Industries and Nutrition Research InstituteNational Research CentreDokkiCairo12622Egypt Department of food Technology Food Industries and Nutrition Research InstituteNational Research CentreDokkiCairo12622Egypt

This work achieved the encapsulation of valuable bioactive substances from Aucklandia costus(AC)in nanophytosomes as a new phytoconstituent delivery *** fluid extraction(SFE)and solvent-maceration methods were used to extract oil and phenolics from AC,*** physicochemical characterization of SFE-oil and phenolic extract(PE)-High-performance liquid chromatography(HPLC)and Gas chromatography–mass spectrometry(GC-MS)were used to identify and quantify all compounds extracted from AC using both extraction *** nanophytosomes was studied using dynamic light scattering(DLS),encapsulation efficiency(EE),and transmission electron microscopy(TEM).The in vitro digestibility of SFE-oil and PE-loaded nanophytosomes after in vitro digestion was *** was selected as a food model for fortification with AC-loaded nanophytosomes at different concentrations(5%,10%,and 15%).pH,acidity,water holding capacity(WHC),and viscosity were evaluated in all yoghurt samples during storage,while color analysis and sensory evaluation were evaluated at 0 *** SFE-oil-and PE-loaded nanophytosomes showed promising results,and the bioavailability suggested that nanoencapsulation provided a controlled release of the phenolic and flavonoid ***,the addition of AC-loaded nanophytosomes into yoghurt resulted in increases in the viscosity(16.53 Pa s-1)and decreases in WHC(59.50%).Yoghurts with AC-loaded nanophytosomes were more stable than the control(yoghurt without nanophytosomes).Overall,the current findings indicated that AC-loaded nanophytosomes would be a preferable candidate for incorporation into yoghurt to improve its *** research might provide scientific evidence supporting AC-loaded nanophytosomes as possible fortifying elements in manufacturing functional yoghurt and a new vision for designing unique dairy products with functional qualities.

关键词： Aucklandia costus Supercritical fluid extraction Maceration Nanophytosomes Yoghurt

Pretreating near infrared spectra with fractional order Savitzky–Golay differentiation(FOSGD)

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Chinese Chemical Letters 2015年第3期26卷 293-296页

作者： Kai-Yi Zheng Xuan Zhang Pei-Jin Tong Yuan Yao Yi-Ping Du Shanghai Key Laboratory of functional Materials Chemistry and Research Centre of Analysis and TestEast China University of Science and Technology Department of Chemical engineering National Tsing Hua University

With the aid of Riemann–Liouville fractional calculus theory,fractional order Savitzky–Golay differentiation（FOSGD） is calculated and applied to pretreat near infrared（NIR） spectra in order to improve the performance of multivariate *** to integral order Savitzky–Golay differentiation（IOSGD）,FOSGD is obtained by fitting a spectral curve in a moving window with a polynomial function to estimate its coefficients and then carrying out the weighted average of the spectral curve in the window with the *** NIR datasets including diesel,wheat and corn datasets were utilized to test this *** results showed that FOSGD,which is easy to compute,is a general method to obtain Savitzky–Golay smoothing,fractional order and integral order *** order differentiation computation to the NIR spectra often improves the performance of the PLS model with smaller RMSECV and RMSEP than integral order ones,especially for physical properties of interest,such as density,cetane number and hardness.

关键词： Golay FOSGD fractional fitting smoothing utilized compute polynomial Liouville calibration

Establishment of an in vitro micropropagation protocol for Boscia senegalensis (Pers.) *** Poir.

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第4期12卷 303-312页

作者： Mutasim M.KHALAFALLA Hussien M.DAFFALLA Eltayb ABDELLATEF Elsadig AGABNA Hany A.EL-SHEMY Commission for Biotechnology and Genetic engineering National Centre for Research Desertification research Institute National Centre for Research Faculty of Agriculture research Park (FARP) and Biochemistry Department Faculty of AgricultureCairo University

This report describes in vitro micropropagation of Boscia senegalensis,so-called famine foods,that helped the people in Darfur and Kordofan,Sudan survive during the 1984-1985 *** types of explants prepared from green mature zygotic embryos were cultured on Murashige and Skoog (MS) medium augmented with 1-5 mg/L 6-benzyladenine (BA).The highest number of shoots per explant (14.3±0.9) was achieved on MS medium supplemented with 3 mg/L BA,while the highest shoot length [(3.5±0.4) cm] was obtained with 1 mg/L *** shoot cluster,when subcultured to its same medium,significantly increased the rate of shoot multiplication by the end of the third *** maximum mean number of shoots per explant (86.5±3.6) was produced after three multiplication cycles on 3 mg/L BA-supplemented *** vitro induced shoots were excised and rooted on half strength MS medium fortified with 0.25 mg/L indole-3-butyric acid (IBA) to obtain complete ***-regenerated plantlets obtained in vitro for the first time,were hardened and 95% survived under greenhouse conditions.

关键词： Boscia senegalensis Famine food Mature embryo Organogenesis

Adoption of precision agriculture technologies in India and in some developing countries:Scope,present status and strategies

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Progress in Natural Science:Materials International 2009年第6期19卷 659-666页

作者： Pinaki Mondal Manisha Basu Department of Agricultural and food engineering Indian Institute of Technology International centre for Automotive Technology 3. national research Development Corporation

Rapid socio-economic changes in some developing countries, including India, are creating new scopes for application of precision agriculture (PA). The implications of dramatic shifts for economic development, urbanization and energy consumption in some developing countries are immense. High-tech nature of traditional PA technologies developed in advanced countries created a real challenge for engineers to search suitable PA technologies for developing countries. It is expected that application of balanced soft and hard PA technologies based on the need of specific socio-economic condition of a country will make PA suitable for developing countries also. ‘Soft’ PA depends mainly on visual observation of crop and soil and management decision based on experience and intuition, rather than on statistical and scientific analysis. ‘Hard’ PA utilizes all modern technologies such as GPS, RS, and VRT. Three components, namely, ‘single PA technology’, ‘PA technology package’ (for the user to select one or combination) and ‘integrated PA technology’, have been identified as a part of adoption strategies of PA in the developing countries. Therefore, the objective of this paper is to find out the scope, the present status and the strategies for adoption of PA in India and in some developing countries. Application of PA in cash crop, plantation crop, etc. has been discussed. Application of some medium and low-tech PA tools such as chlorophyll meter and leaf colour chart. in small farms has been included. This exhaustive review of the present status of PA in India and in some developing countries is expected to help to find out the adoption trend and direction of future research. Detailed strategy for the adoption of PA in India has also been proposed.

关键词： Precision agriculture Indian agriculture Developing countries Adoption

Modulation of oxidative damage and genotoxicity of biosynthesized zinc oxide nanoparticles via supplementation with modified cinnamaldehyde-loaded chitosan nanoparticles in mice

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food Science and Human Wellness 2024年

作者： Mosaad A.Abdel-Wahhab Aziza A.El-Nekeety Asmaa S.Salman Zeinab K.Hamza Engy M.Akl Soher E.Aly Wenyi Kang Department of food Toxicology & Contaminants， national research centre Dokki， Cairo， Egypt Genetic and Cytology Department， national research centre Dokki， Cairo， Egypt Department of Fats and Oils， national research centre Dokki， Cairo， Egypt national R & D Center for Edible Fungus Processing Technology， Henan University Joint International research Laboratory of food & Medicine Resource Function functional food engineering Technology research Center Henan

Synthesis of zinc oxide nanoparticles (Zn-NPs) via green method is an outstanding alternative to conventional/regular methods; however， the safety or toxicity of the biosynthesized ZnO-NPs in vivo is not fully explored. This study was conducted to evaluate the protective efficiency of cinnamaldehyde-loaded chitosan nanoparticles (Cin@CSNPs) against oxidative damage and genotoxicity of zinc oxide nanoparticles (ZnO-NPs) in mice. ZnO-NPs were biosynthesized using the extract of fresh leaves of Mentha pulegium L. Cin was extracted from cinnamon essential oil， and was loaded into chitosan nanoparticle (Cin@CSNPs). Both ZnO-NPs， Cin@CSNPs and CSNPs were characterized. The in vitro release of Cin@CSNPs was determined. In the biological study， 6 groups of male Balb/c mice were treated by gavage for 3 weeks as follows， control group， the group received ZnO-NPs (25 mg/kg b.w)， the groups received Cin@CSNPs at low dose (50 mg/kg b.w) or high dose (100 mg/kg b.w)， and the groups received ZnO-NPs plus Cin@CSNPs at the two tested doses. Blood and tissue samples were collected for different biochemical， genetical and histological studies. The particle size of ZnO-NPs， CSNPs， and Cin@CSNPs were (20.78 ± 2.6)， (170.0 ± 3.7)， and (218.23 ± 2.9) nm， and ξ-potential were (32.7 ± 4.6)， (8.32 ± 0.27) and (4.8 ± 0.21)， respectively. ZnO-NPs disturbed the biochemical and oxidative stress indices， AFP， CEA， TNF-α， chromosomal aberrations in somatic and germ cells， and sperm abnormality along with severe pathological changes in the hepatic， renal， and testicular tissues. Cin@CSNPs improved significantly all the parameters tested and the histological picture in a dose-dependent. Therefore， the biosynthesized ZnO-NPs exhibit oxidative damage and genotoxicity， and Cin@CSNPs have potential protective effects against the risks of ZnO-NPs and may be a promising tool to overcome the challenges of using Cin in food and pharmaceuticals applications.

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Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin Jun Xu Delong Jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong Mei State Key Laboratory for Manufacturing Systems engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical engineering and Automation Luoyang Institute of Science and Technology School of Mechanical engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Lithium-ion battery State-of-health estimation Data-driven Machine learning Ensemble learning Ensemble diversity