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Functionalize d 3D-printe d porous titanium scaffold induces in situ vascularized bone regeneration by orchestrating bone microenvironment

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Journal of Materials Science & Technology 2023年第22期153卷 92-105页

作者： Bo Yuan Pin Liu Rui Zhao Xiao Yang Zhanwen Xiao Kai Zhang Xiangdong Zhu Xingdong Zhang national engineering research Center for biomaterials Sichuan UniversityChengdu 610064China College of Biomedical engineering Sichuan UniversityChengdu 610064China

Titanium(Ti)and its alloys have been extensively explored for treating load-bearing bone ***-ever,high-stress shielding,weak osteogenic activity,and insufficient vascularization remain key chal-lenges for the long-term clinical outcomes of Ti-based ***,inspired by structural and func-tional cues of bone regeneration,a silicon-doped nano-hydroxyapatite(nSiHA)/titanium dioxide(TiO_(2))composite coating with a hierarchical micro/nano-network structure is constructed on the surface of a 3D-printed porous Ti scaffold via a combined strategy of acid-alkali(AA)treatment and electrochemi-cal deposition technique,which not only endows the scaffold with excellent osteoinduction ability but can also effectively immobilize and release vascular endothelial growth factor(VEGF).The results of the in vitro cell experiments show that the functionalized Ti scaffold significantly promotes osteogenesis in bone marrow mesenchymal stem cells(BMSCs)and angiogenesis in human umbilical vein endothelial cells(HUVECs)by activating the extracellular signal-regulated protein kinase(ERK)and HIF-1αsignaling *** being implanted into a rat femoral condyle defect model,the functionalized Ti scaffold can induce in situ vascularized bone regeneration by orchestrating the two coupled processes of angio-genesis and *** findings indicate that the functionalized Ti scaffold has great potential in bone tissue regeneration and is a promising candidate for load-bearing bone defect repair.

关键词： Porous titanium 3D-printing Hierarchical micro/nano-structure Bone microenvironment Vascularization Bone regeneration

Peptide dendrimer-crosslinked inorganic-organic hybrid supramolecular hydrogel for efficient anti-biofouling

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Chinese Chemical Letters 2018年第3期29卷 501-504页

作者： Xiaoqi Lian Dongxu Shi Jin Ma Xiaojun Cai Zhongwei Gu national engineering research Center for biomaterials Sichuan University College of Materials Science and engineering Nanjing Tech University

We reported a kind of inorganic-organic hybrid supramolecular hydrogel with excellent anti-biofouling capability. The hydrogel was formed via ionic interaction between the negative-charged sodium polyacrylate （SPA） entwined clay nanosheets （CNS） and positive-charged polyhedral oligomeric silsesquioxane （POSS） core-based generation one （L-Arginine） dendrimer （POSS-R）. Due to their strong ionic interaction, this kind of hydrogel exhibited a rapid gelation behavior which accomplished even at a low POSS-R concentration about 1% w/v. With the increase of POSS-R concentration, these hydrogels appeared more compact structure, accompanied by remarkable enhanced mechanical strength. In addition, these hydrogels demonstrated rapid thixotropic response and shape-memory capability, as well as good hiocompatibility. More importantly, these hydrogels exhibited outstanding anti-biofouling property due to the inherent anti-biofouling capability of SPA. Overall, these findings demonstrated a novel sort of inorganic-organic hybrid supramolecular hydrogel with tunable mechanical strength and excellent anti-biofouling capability, which may have a broad application potential in tissue engineering.

关键词： Peptide dendrimer Supramolecular hydrogel Anti-biofouling

Effect of zinc substitution in hydroxyapatite coating on osteoblast and osteoclast differentiation under osteoblast/osteoclast co-culture

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Regenerative biomaterials 2019年第6期6卷 349-359页

作者： Guolong Meng Xiaoli Wu Ruijuan Yao Jing He Wu Yao Fang Wu national engineering research Center for biomaterials Sichuan UniversityChengdu 610064P.R.China

Zinc is an essential trace element required for bone remodelling process,but its role in such process remains to be *** particular,inconsistent results have been reported on the effect of Zn on osteoclastic responses,and supplement of receptor activator of nuclear factor kappa-B ligand(RANKL)factors has been commonly ***-culture is a suitable approach to elucidating the role of Zn in bone remodelling process,by better imitating the cellular environment as the presence of osteoblasts plays critical role in modulating osteoclastic *** this study,zincsubstituted HA coatings have been deposited using a liquid precursor plasma spraying process at two different concentrations(1,2 wt.%).The effect of zinc substitution on osteoblastic and osteoclastic differentiation has been studied in *** particular,a cultivation regime was designed to first induce osteoblastic differentiation of rat bone marrow stromal cells(BMSCs)for 14 days,and then induce osteoclastic differentiation of osteoclast-like precursor RAW 264.7 cells through the aid of the osteoblasts formed for additional 14 days,in the absence of the external addition of *** results showed that Zn substitution moderately promoted the BMSC differentiation into the osteoblasts and reduced the osteoclastic activity in early time(1 day co-culture).However,promotion of the osteoclastic activity were observed at later stages,as indicated by the significantly enhanced expressions of trap5b and IL-1(8-and 15-day co-culture)and moderate stimulation of the nucleus integration and formation of the multinucleated cells(14-day co-culture).Such stimulating effect of the osteoclastic activity was absent under mono-culture of RAW 264.7 cell,with simple RANKL *** results suggest that both the zinc and the presence of MSC/osteoblast play profound and highly interacted roles on osteoclast differentiation and activity,which is critical in modulating the bone remodelling process.

关键词： zinc bone marrow stromal cell osteoclast precursor osteoclast co-cultivation bone remodelling process

Comparison of the osteogenic capability of rat bone mesenchymal stem cells on collagen,collagen/hydroxyapatite,hydroxyapatite and biphasic calcium phosphate

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Regenerative biomaterials 2018年第2期5卷 93-103页

作者： Xiaoyu Sun Wen Su Xiaomin Ma Huaiying Zhang Zhe Sun Xudong Li national engineering research Center for biomaterials Sichuan UniversityChengdu 610064P.R.China

Collagen(COL),collagen/hydroxyapatite(COL/HA),HA and biphasic calcium phosphate were prepared as representative bone grafting materials with composition analogous to bone,and their structural characteristics were *** rat bone mesenchymal stem cells(BMSCs)were further seeded onto four groups of materials,and BMSCs grown in basic medium and standard osteogenic medium were set as controls of a reference model to show the basic and osteogenic behavior of cells without the intervention of *** behaviors were characterized,including proliferation,spreading morphology and expression of osteogenesis *** rat BMSCs proliferated properly with time on four groups of materials as well on two groups of controls,and typical cuboidal,polygonal and extremely-elongated morphologies of cells were *** to the real-time polymerase chain reaction data,a higher osteogenic gene expression level was dependent upon the growing morphology but not the proliferation rate of cells,and the osteogenic differentiation capacity of cells onto four groups of materials varied in specific *** general,BMSCs exhibited the highest osteogenic capacity onto COL/HA,but the poorest onto *** growing behaviors of cells on materials were further discussed in comparison with the cases of OC and BC of the reference *** present attempt to comparatively analyze cell experimental data with a reference model is expected to be useful for revealing the difference in the osteogenic capability of MSCs onto materials or even the bioactivity of materials.

关键词： osteogenic differentiation spreading morphology mineralization of collagen bioceramics

Graphene oxide and mineralized collagen-functionalized dental implant abutment with effective soft tissue seal and romotely repeatable photodisinfection

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Regenerative biomaterials 2022年第1期9卷 219-233页

作者： Yichun Gao Ke Kang Bin Luo Xiaoqing Sun Fang Lan Jing He Yao Wu national engineering research Center for biomaterials Sichuan UniversityChengdu 610064P.R.China

Grasping the boundary of antibacterial function may be better for the sealing of soft tissue around dental implant *** by‘overdone is worse than undone’,we prepared a sandwich-structured dental implant coating on the percutaneous part using graphene oxide(GO)wrapped under mineralized *** unique coating structure ensured the high photothermal conversion capability and good photothermal stability of *** prepared coating not only achieved suitable inhibition on colonizing bacteria growth of Streptococcus sanguinis,Fusobacterium nucleatum and Porphyromonas gingivalis but also disrupted the wall/membrane permeability of free *** enhancements on the antibacterial property were generally observed through the additional incorporation of dimethylaminododecyl ***,the coating with sandwich structure significantly enhanced the adhesion,cytoskeleton organization and proliferation of human gingival fibroblasts,which was effective to improve soft tissue ***,cell viability was preserved when cells and bacteria were cultivated in the same environment by a coculture *** was attributed to the sandwich structure and mineralized collagen as the outmost layer,which would protect tissue cells from photothermal therapy and GO,as well as accelerate the recovery of cell ***,the coating design would provide a useful alternative method for dental implant abutment surface modification and functionalization.

关键词： dental implant abutment soft tissue sealing antibacterial graphene oxide mineralized collagen

research and Progress of Implantable Cardiovascular Materials and Devices

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engineering 2021年第12期7卷 1707-1709页

作者： Yunbing Wang national engineering research Center for biomaterials Sichuan UniversityChengdu 610064China

Cardiovascular diseases(CVDs)are the global leading cause of mortality,being responsible for over 17.7 million deaths annually[1].In China,the number of patients with cardiovascular diseases has reached 330 million and accounts for more than 43%of deaths caused by diseases-a much higher proportion than that of cancer,respiratory diseases,or other diseases[2].Among such diseases.

关键词： diseases Cardiovascular mortality

Regulation of the Macrophage Phenotype on Titanium Metal by Surface Modification

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Journal of Bionic engineering 2022年第6期19卷 1625-1636页

作者： Shibing Xiong Xugang Lu Rui Zuo Ping Huang Bangcheng Yang engineering research Center in biomaterials Sichuan UniversityChengdu610064China national engineering research Center for biomaterials Chengdu610064China Sichuan Guojia biomaterials Co. LtdChengdu610064China Panzhihua University Panzhihua Int Res Inst Vanadium and TitaniumPanzhihua617000SichuanChina

The regulation of macrophage phenotype(M1/M2)is very important for tissue *** macrophage phenotypes could be affected by the physical and chemical parameters of implant *** aim of this study was to investigate the effects of surface modifications of titanium metals on macrophage *** medical pure titanium metals(PT-Ti)subjected to Anodic Oxidation(AO-Ti),Sand Blasting/acid etching(SLA-Ti)and Plasma-sprayed HA coating(HA coating-Ti)were used for regulating the phenotype of *** results showed that the Raw264.7 cells of AO-Ti groups had no obvious pseudopodia and could spread evenly in all *** levels of IL-1βand TNF-α,which belong to pro-inflammatory genes,expressed by the cells on AO-Ti groups were the lowest among all of the modified titanium ***,the levels of IL-10 and TGF-β,which belong to anti-inflammatory genes,expressed on AO-Ti groups were much higher than those on the other ***,the AO-Ti could regulate the expression of SOCS-1 and SOCS-3 to affect the active of NF-κB *** gene expression results of macrophages showed that the AO-Ti was more conductive to inhibit the expression of M1-related genes and promote the expression of M2-related genes in an inflammatory *** AO-Ti was more beneficial to tissue repair than other modified titanium *** results showed that the anodic oxidation is an effective method to regulate the phenotype of macrophages.

关键词： Titanium Dental implant Bionic surface modification Anti-inflammatory Macrophage phenotype

Preface to the Special Issue:Bioadaption of biomaterials

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Journal of Materials Science & Technology 2016年第9期32卷 799-800页

作者： Yingjun Wang biomaterials and biomedical engineering at south china university of technology chinese academy of engineering chinese society for biomaterials national engineering research center for tissue restoration and reconstruction

Tissue repair is always a complex process and artificial biomaterials have never been perfect. For example, the mismatch of mechanical property between biomaterials and the host can result in stress shielding; the asy... 详细信息

关键词： Preface to the Special Issue Bioadaption of biomaterials

The optimized preparation of HA/L-TiO2/D-TiO2 composite coating on porous titanium and its effect on the behavior osteoblasts

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Regenerative biomaterials 2020年第5期7卷 505-514页

作者： Xi Fu Xingyu Zhou Pin Liu Hewei Chen Zhanwen Xiao Bo Yuan Xiao Yang Xiangdong Zhu Kai Zhang Xingdong Zhang national engineering research Center for biomaterials Sichuan UniversityNo.29Wangjiang RoadChengdu 610064China

Various surface bioactivation technology has been confirmed to improve the osteogenic ability of porous titanium(pTi)implants *** this study,a three-layered composite coating,*** layer of hydroxyapatite(HA),middle layer of loose titanium dioxide(L-TiO2)and inner layer of dense TiO2(D-TiO2),was fabricated on pTi by a combined processing procedure of pickling,alkali heat(AH),anodic oxidation(AO),electrochemical deposition(ED)and hydrothermal treatment(HT).After soaking in simulated body fluid for 48 h,the surface of the AHAOEDHT-treated pTi was completely covered by a homogeneous apatite *** MC3T3-E1 pro-osteoblasts as cell model,the cell culture revealed that both the pTi without surface treatment and the AHAOEDHT sample could support the attachment,growth and proliferation of the *** to the pTi sample,the AHAOEDHT one induced higher expressions of osteogenesis-related genes in the cells,including alkaline phosphatase,Type I collagen,osteopontin,osteoclast inhibitor,osteocalcin and zinc finger structure transcription *** thus,besides the good corrosion resistance,the HA/L-TiO2/D-TiO2-coated pTi had good osteogenic activity,showing good potential in practical application for bone defect repair.

关键词： porous titanium hydroxyapatite titanium dioxide composite coating osteoblasts