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A non-probabilistic reliability topology optimization method based on aggregation function and matrix multiplication considering buckling response constraints

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 321-336页

作者： Lei WANG Yingge LIU Juxi HU Weimin CHEN Bing HAN Institute of Solid Mechanics School of Aeronautic Science and EngineeringBeihang UniversityBeijing 100191China Aircraft and Propulsion Laboratory Ningbo Institute of TechnologyBeihang UniversityNingbo 315100Zhejiang ProvinceChina State Key Laboratory of Navigation and Safety Technology Shanghai Ship and Shipping Research InstituteShanghai 200135China national engineering research center of ship&shipping control system Shanghai Ship and Shipping Research InstituteShanghai 200135China

A non-probabilistic reliability topology optimization method is proposed based on the aggregation function and matrix *** expression of the geometric stiffness matrix is derived,the finite element linear buckling analysis is conducted,and the sensitivity solution of the linear buckling factor is *** a specific problem in linear buckling topology optimization,a Heaviside projection function based on the exponential smooth growth is developed to eliminate the gray *** aggregation function method is used to consider the high-order eigenvalues,so as to obtain continuous sensitivity information and refined structural *** cyclic matrix programming,a fast topology optimization method that can be used to efficiently obtain the unit assembly and sensitivity solution is *** maximize the buckling load,under the constraint of the given buckling load,two types of topological optimization columns are *** variable density method is used to achieve the topology optimization solution along with the moving asymptote optimization *** vertex method and the matching point method are used to carry out an uncertainty propagation analysis,and the non-probability reliability topology optimization method considering buckling responses is developed based on the transformation of non-probability reliability indices based on the characteristic ***,the differences in the structural topology optimization under different reliability degrees are illustrated by examples.

关键词： buckling topology optimization aggregation function uncertainty propagation analysis non-probabilistic reliability

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina national Medical Products Administration(NMPA)Key Laboratory for Quality research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial center for Quality control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial center for engineering and Technology research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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CPS Modeling of CNC Machine Tool Work Processes Using an Instruction-Domain Based Approach

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engineering 2015年第2期1卷 247-260页

作者： Jihong Chen Jianzhong Yang Huicheng Zhou Hua Xiang Zhihong Zhu Yesong Li Chen-Han Lee Guangda Xu national Numerical control system engineering research center Huazhong University of Science and Technology

Building cyber-physical system(CPS) models of machine tools is a key technology for intelligent manufacturing. The massive electronic data from a computer numerical control(CNC) system during the work processes of a CNC machine tool is the main source of the big data on which a CPS model is established. In this work-process model, a method based on instruction domain is applied to analyze the electronic big data, and a quantitative description of the numerical control(NC) processes is built according to the G code of the processes. Utilizing the instruction domain, a work-process CPS model is established on the basis of the accurate, real-time mapping of the manufacturing tasks, resources, and status of the CNC machine tool. Using such models, case studies are conducted on intelligent-machining applications, such as the optimization of NC processing parameters and the health assurance of CNC machine tools.

关键词： cyber-physical system (CPS) big data computer numerical control (CNC) machine tool electronic data of work processes instruction domain intelligent machining

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A sub-circuit MOSFET model with a wide temperature range including cryogenic temperature

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Journal of Semiconductors 2011年第6期32卷 27-32页

作者：贾侃孙伟锋时龙兴 national ASIC system engineering research center Southeast University

A sub-circuit SPICE model of a MOSFET for low temperature operation is *** resistors are introduced for the freeze-out effect,and the explicit behavioral models are developed for *** model can be used in a wide temper... 详细信息

关键词： SPICE model low temperature sub-circuit freeze-out effect voltage control resistor

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Safety Mechanism Design and Verification of Safety Computer Parallel Program

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Chinese Journal of Electronics 2018年第6期27卷 1163-1169页

作者： ZHANG Yuzhuo HONG Chunhua CAO Yuan MA Lianchuan WEN Yinghong School of Electronic and Information engineering Beijing Jiaotong University national engineering research center of Rail Traffic control system Beijing Jiaotong University

The extensive application of Commercial off-the-shelf(COTS) components into safety computers in train control systems has caused safety problems. Aiming at the parallel programs, a concurrent program safety management mechanism based on transactional memory is proposed. The proposed mechanism implements concurrent behaviors of the application in the safe policy. A verification framework based on invariant proof and parallel separation logic theory is designed and operating system operation semantics are given for mathematical reasoning and proving. An example of code execution process is demonstrated to explain the safety control process of concurrent safety mechanism. The results indicate that the program can meet the safety and reliability requirements of concurrent safety computer platforms.

关键词： Safety computer Parallel program Transactional memory Invariant proof Concurrent separation logic

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Toward Intelligent Machine Tool

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engineering 2019年第4期5卷 679-690页

作者： Jihong Chen Pengcheng Hu Huicheng Zhou Jianzhong Yang Jiejun Xie Yakun Jiang Zhiqiang Gao Chenglei Zhang national Numerical control system engineering research center Huazhong University of Science and TechnologyWuhan 430074China

With the development of modern information technology-and particularly of the new generation of artificial intelligence(AI)technology-new opportunities are available for the development of the intelligent machine tool(IMT).Based on the three classical paradigms of intelligent manufacturing as defined by the Chinese Academy of engineering,the concept,characteristics,and systemic structure of the IMT are presented in this *** stages of machine tool evolution-from the manually operated machine tool(MOMT)to the IMT-are discussed,including the numerical control machine tool(NCMT),the smart machine tool(SMT),and the ***,the four intelligent control principles of the IMT-namely,autonomous sensing and connection,autonomous learning and modeling,autonomous optimization and decision-making,and autonomous control and execution-are presented in *** paper then points out that the essential characteristic of the IMT is to acquire and accumulate knowledge through learning,and presents original key enabling technologies,including the instruction-domain-based analytical approach,theoretical and big-data-based hybrid modeling technology,and the double-code control *** on this research,an intelligent numerical control(INC)system and industrial prototypes of IMTs are *** intelligent practices are conducted,demonstrating that the integration of the new generation of AI technology with advanced manufacturing technology is a feasible and convenient way to advance machine tools toward the IMT.

关键词： Intelligent manufacturing Intelligent machine tool Intelligent numerical controller New-generation artificial intelligence

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research on High Precision Tracking Method of Guided Transport Vehicle Based on Autonomous Combination Positioning

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Chinese Journal of Electronics 2020年第4期29卷 779-785页

作者： CAO Yuan ZHANG Shuangshuang YANG Guizhi WEN Tao national engineering research center of Rail Transportation Operation and control system Beijing Jiaotong University School of Electronic and Information engineering Beijing Jiaotong University

Guided transport vehicle(GTV) uses satellite positioning technology, lidar, and highperformance video sensors to achieve real-time positioning and tracing, these devices cost a *** addition, GTV shifts left and right during operation due to there is no fixed orbits *** is very important to detect the lateral offset in real time to ensure the accurate tracing of the vehicle along the dotted *** at the above issues, this paper proposes a low-cost high precision tracing method for GTV based on integrated positioning,high resolution estimation of the vehicles positioning information is implemented by Cubature Kalman filters(CKF) with a loosely coupled mode based on GPS/SINS in this method; Considering that GTV has a fixed driving route, a two-stage map matching algorithm based on Hidden Markov model(HMM) is proposed, which further improves the accuracy; The lateral offset distance is detected based on the positioning information, which provides theoretical support for the subsequent control of the precise operation of the *** algorithm’s feasibility has been verified by real vehicle experiments,the results show that the proposed algorithm achieves a centimeter-level positioning accuracy, and when the lateral offset distance is not less than 65 cm, the detection accuracy of the lateral offset distance is more than 92%.

关键词： Positioning and tracing CKF Map matching Lateral offset detection

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Design and Analysis of Double One Out of Two with a Hot Standby Safety Redundant Structure

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Chinese Journal of Electronics 2020年第3期29卷 586-594页

作者： WEN Jiakun CAO Yuan MA Lianchuan DU Siqi School of Electronic and Information engineering Beijing Jiaotong University national engineering research center of Rail Transportation Operation and control system Beijing Jiaotong University

In the rail transit system, the running foundation of the computer control system is required to be highly reliable, available and safe. A redundant system structure of double one out of two with a hot standby applied to the safety computer platform of the train control system is proposed in this paper. Considering the common cause failure, fault diagnosis rate, repair rate and switching success rate, the Markovian approach is adopted for modeling four safety redundant structures,including two out of three, double one out of two, one out of two with a hot standby and double one out of two with a hot standby. The calculation of the failure rate and PFH values is carried out with MATLAB to evaluate the reliability, safety and influencing factors of each structure. The final conclusion is that double one out of two with a hot standby structure can be best in the aspect of both reliability and safety with appropriate DC and β parameters.

关键词： Markov model Safety redundant structure Reliability Safety Double one out of two with a hot standby

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A Self-Adaptive Programming Mechanism for Reconfigurable Parsing and Processing

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China Communications 2016年第S1期13卷 87-97页

作者： DUAN Tong SHEN Juan WANG Peng LIU Shiran national Digital Switching system engineering & Technological research center

In this paper, we present a self-adaptive programming mechanism(SAP) that targets programming hardware devices of reconfigurable parsing and processing. The SAP programming system locates in software of network data plane and has three features:(1) programmable packet parsing: the packet header format can be customized and new header type can be added;(2) reconfigurable packet processing: the match fields to be handled in each match table can be specified;(3) function-adaptive control: any function control systems can determine the packet processing flow independently without the need of knowing the specifics of the underlying hardware. Finally, we implement a prototype on NetF PGA-10 G together with two representative function control systems(router and Open Flow switch) to demonstrate how SAP works. We believe the data plane of reconfigurable parsing and processing will lead to future switches that provide greater flexibility, and unlock the potential of network function innovation.

关键词： programming mechanism selfadaptive reconfigurable network data plane Net FPGA

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Time-Varying Formation Tracking control of Heterogeneous Multi-Agent systems With Intermittent Communications and Directed Switching Networks

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 294-296页

作者： Yuhan Wang Zhuping Wang Hao Zhang Huaicheng Yan the Shanghai research Institute for Intelligent Autonomous systems Tongji University the national Key Laboratory of Autonomous Intelligent Unmanned systems the Frontiers Science center for Intelligent Autonomous system of Ministry of Education the College of Electronic and Information engineering the Department of Control Science and Engineering Tongji University the Key Laboratory of Advanced control and Optimization for Chemical Processes of Ministry of Education the School of Information Science and engineering East China University of Science and Technology

Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems.

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