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Punicalagin alleviates hypercholesterolemia in mice through modulating farnesoid X receptor signaling and modulating gut microbiota

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Food Science and Human Wellness 2025年第1期14卷 175-189页

作者： Huanhuan Liu Hongli Liu Chunhong Yan Jiaxiu Liu Yu Cao Guopeng Li Xiaodong Xia State Key Laboratory of marine Food Processing and Safety Control National Engineering Research Center of SeafoodSchool of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Beijing Advanced Innovation center for Food Nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Punicalagin has been demonstrated to exhibit anti-oxidant and anti-inflammatory properties,but whether and how it could impact hypercholesterolemia remains not fully *** aim of this study was to investigate the influence of punicalagin on hypercholesterolemia in mice and its related *** 6 weeks'intervention,punicalagin significantly reduced serum total cholesterol and low-density lipoprotein cholesterol(LDL-C)levels in mice fed a high-fat high-cholesterol(HFHC)***,punicalagin supplementation lowered hepatic cholesterol level,which corresponded to the down-regulation of cholesterol synthesis genes(Fdps,Cyp51)and up-regulated bile acid synthesis genes(Cyp7a1,Cyp27a1).In addition,bile acid reabsorption was retarded in punicalagin-fed mice through down-regulating ileal apical sodium-dependent BA transporter(ASBT).Furthermore,intestinal farnesoid X receptor(FXR)-fibroblast growth factor 15(Fgf15)pathway was inhibited while hepatic FXR-small heterodimeric partner(SHP)pathway was activated in punicalagin *** analysis and targeted metabolomics showed that punicalagin decreased the abundance of bile-salt hydrolase(BSH)-producing bacteria(Clostridiaceae and Bifidobacteriaceae)and the ratio of primary BAs to secondary *** conclusion,the cholesterol-lowering effect of punicalagin partly through down-regulating cholesterol synthesis and increasing cholesterol catabolism,which could be achieved by regulating gut microbiota,altering bile acid composition and modulating FXR signaling *** findings indicate the potential application of punicalagin-related products as an alternative strategy for hypercholesterolemia prevention and mitigation.

关键词： Punicalagin Hypercholesterolemia Farnesoid X receptor Bile acid metabolism Gut microbiota

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DHA and EPA protect against cognitive impairment induced by chronic sleep deprivation through regulating iron-mitophagy homeostasis

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Food Science and Human Wellness 2025年

作者： Lu Chen Yueqi Yang Ning Zhang Bin Sun Hongxia Che Zhengping Wang Jun Han Min Wen Institute of Biopharmaceutical research， Liaocheng University College of marine Science and Biological engineering， Qingdao University of Science and Technology Pet Nutrition R research and Development center Gambol Pet Group Co.，Ltd.

The cognitive impairments resulting from insufficient sleep have emerged as a significant public health concern in contemporary society， lacking effective treatments due to the absence of elucidation regarding its molecular mechanism. This study aimed to investigate the efficacy of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against cognitive deficits in a mouse model of chronic sleep deprivation (CSD)， and to elucidate the underlying mechanisms. CSD mice display significant cognitive deficits in the Morris water maze task with obviously neuronal damage. We observed that dysregulation of iron transport proteins (IRP1， TfR1， DMT1， and FPN1) in CSD mice resulted in iron deposition in the cortex. Subsequent assessment revealed upregulation of mitophagy and neuronal lipid peroxidation and downregulation of proteins in the mitochondrial respiratory chain complexes (I-V). Further molecular analysis revealed inhibition of the Sirt3-Nrf2 pathway and its downstream antioxidant molecules (e.g. GPX4， HO-1， SOD2， and NQO1). In contrast， dietary supplementation with DHA or EPA alleviated CSD-induced cognitive impairment by inhibiting neuronal ferroptosis through regulating iron-mitophagy homeostasis. Notably， EPA showed superior efficiency in ameliorating cognitive impairment， potentially due to its stronger interaction with Sirt3 compared to DHA.

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A comprehensive review on rectification and power management strategies for triboelectric nanogenerators

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Science China Technological Sciences 2025年第03期68卷 5-33页

作者： Zhongjie LI Bingyan CUI Biao WANG Fan SHEN Hao WU Ying GONG Yan PENG Hengyu GUO Dan ZHANG Institute of Artificial Intelligence School of Future Technology Shanghai University School of Mechatronic engineering and Automation Shanghai University engineering research center of Unmanned Intelligent marine Equipment Shanghai University Department of Applied Physics Chongqing University

Nanogenerators utilize nanomaterials to harvest mechanical or thermal energy at the micro-nano scale, thereby providing power for small self-sustaining devices. Compared to traditional generators, nanogenerators offer advantages such as compact size, high flexibility, and broad versatility. Triboelectric nanogenerators(TENGs), based on triboelectric theory, can collect energy from mechanical sources such as vibrations or sliding movements. TENGs hold promise for powering small electronics. However, the high pulse characteristics of their output voltage prevent them from directly charging electronic devices. To address the requirements of the internet of things(IoTs), this paper comprehensively reviews state-of-the-art power management systems used to enhance the current stability and output power of TENGs. First, the working principle and resistive load output characteristics of TENGs are elaborated. Power management circuits(PMCs) based on full-wave rectifiers,half-wave rectifiers, and Bennet's doublers are subsequently analyzed and compared. Mechanical and electronic switches proposed to further improve rectifier performance are also detailed. Mechanical switches are categorized as travel and voltagetriggered switches, while electronic switches include silicon-controlled rectifiers(SCRs), metal-oxide-semiconductor fieldeffect transistors(MOSFETs), and integrated circuits. In conclusion, the characteristics and applications of PMCs are summarized, along with the identification of existing limitations in their application. Subsequently, appropriate solutions and prospects for further development are explored.

关键词： triboelectric nanogenerators power management circuit rectifier switch

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Modeling the potential distribution of Argentine shortfin squid in the southwest Atlantic Ocean

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Journal of Oceanology and Limnology 2025年第1期43卷 326-340页

作者： Hewei LIU Wei YU College of marine Living Resource Sciences and Management Shanghai Ocean UniversityShanghai 201306China national engineering research center for Oceanic Fisheries Shanghai Ocean UniversityShanghai 201306China Key Laboratory of Sustainable Exploitation of Oceanic Fisheries Resources Ministry of EducationShanghai Ocean UniversityShanghai 201306China Key Laboratory of Oceanic Fisheries Exploration Ministry of Agriculture and Rural AffairsShanghai Ocean UniversityShanghai 201306China

The Argentine shortfin squid Illex argentinus is an economically important short-lived species widely distributed in the southwest Atlantic *** abundance and distribution of *** are associated with climate change and environmental *** potential distribution of *** was modeled with various environmental variables including sea surface temperature(SST),sea surface height(SSH),chlorophyll a,sea surface salinity(SSS),net primary productivity(NPP),mixed layer depth(MLD),eddy kinetic energy(EKE),and photosynthetically active radiation(PAR)using the maximum entropy(MaxEnt)approach during the peak fishing seasons(January–April).The habitat suitability index(HSI)was defined as the probability of species emergence from the MaxEnt model and the area of HSI≥0.6 was regarded as *** indicate that the predicted habitat correlated with the actual fishing position,with similar trends in the percentages of suitable habitats and catch per unit effort(CPUE)of *** from January to ***,SST,SSH,PAR,and MLD were identified critical environmental variables for the distribution of *** addition,the median of preferred ranges of the critical environmental variables were concentrated within the suitable habitats of *** Area under the Receiver Operating Characteristic Curve(AUC)was greater than 0.96 for all four *** in latitudinal and longitudinal gravity centers(LATG and LONG)of fishing effort were consistent with latitudinal and longitudinal gravity centers(LATG_H and LONG_H)of the *** findings suggest that the MaxEnt model is an effective tool to predict the potential distribution of ***,SST,SSH,PAR,and MLD should be given with more extensive attention in predicting the potential distribution of ***,as they are important environmental indicators that can help decision-makers search for the fishing ground of *** in the Southwest Atlantic.

关键词： Illex argentinus maximum entropy model potential distribution oceanographic environmental condition

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Intermetallic compounds for nitrogen electrochemistry

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Green Energy & Environment 2025年第2期10卷 268-291页

作者： Haohong Wei Cheng Tang Yanyun Wang Yongcheng Feng Huancong Shi Mingjin Cui Huakun Liu Shixue Dou Laiquan Li Institute of Energy Materials Science School of Energy and Power EngineeringUniversity of Shanghai Science and TechnologyShanghai200093China Tsinghua center for Green Chemical engineering Electrification(CCEE) Department of Chemical EngineeringTsinghua UniversityBeijing100084China State Grid New Energy Cloud Carbon Neutralization Innovation center State Grid Zhejiang Electric Power Co.LtdHuzhou Power Supply CompanyZhejiang313000China Shanghai marine Diesel Engine research Institute.Shanghai 201108China

Electrochemical nitrogen transformation techniques represent a burgeoning avenue for nitrogen pollutant remediation and synthesizing valuable nitrogenous products from atmospheric *** compounds(IMCs)nanocrystals,featured with unique geometric,electronic and functional properties,have emerged as promising *** review discusses various synthesis approaches for IMCs,including thermal annealing,wet chemical synthesis,electrochemical synthesis,and other emerging methods,analyzing their advantages and *** we summarized the recent advances of IMCs in electrocatalytic nitrogen transformation reactions,such as nitrate reduction reaction,nitric oxide reduction reaction,nitrogen reduction reaction,and hydrazine oxidation *** significant progress,challenges remain in the field,particularly in adopting more refined strategies to improve catalyst performance and *** review aims to comprehensively understand the structural properties of IMCs and their structure-performance relationship,guiding the development of more efficient and stable catalysts for future nitrogen electrochemistry.

关键词： Intermetallic compounds Electrocatalysis Nitrogen transformation reactions Synthesis methods Catalyst design

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Interaction of Ca^(2+)and Fe^(3+)in co-precipitation process induced by Virgibacillus dokdonensis and its application

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Journal of Environmental Sciences 2025年第1期147卷 131-152页

作者： Huaxiao Yan Yuping Liu Haojuan Zhang Shengping Jin Zuozhen Han Jusun Woo Maurice E.Tucker Long Meng Xiangqun Chi Chao Han Yanyang Zhao Yueming Zhao Hui Zhao College of Chemical and Biological engineering College of Earth Science and EngineeringShandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary MineralsShandong University of Science and TechnologyQingdao 266590China Laboratory for marine Mineral Resources Center for Isotope Geochemistry and GeochronologyQingdao National Laboratory for Marine Science and TechnologyQingdao 266237China School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Korea School of Earth Sciences University of BristolBristol BS81RJUK Cabot Institute University of BristolCantock’s CloseBristol BS81UJUK Qingdao West Coast New District First High School Qingdao 266555China

Biomineralization has garnered significant attention in the field of wastewater treatment due to its notable cost reduction compared to conventional *** reinjection water from oilfields containing an exceedingly high concentration of calcium and ferric ions will pose amajor hazard in ***,the utilization of biomineralization for precipitating these ions has been scarcely investigated due to limited tolerance among halophiles towards such extreme *** this study,free and immobilized halophiles Virgibacillus dokdonensis were used to precipitate these ions and the effects were compared,at the same time,biomineralizationmechanisms and mineral characteristicswere further *** results showthat bacterial concentration and carbonic anhydrase activitywere higher when additionally adding ferric ion based on calcium ion;the content of protein,polysaccharides,deoxyribonucleic acid and humic substances in the extracellular polymers also increased compared to *** ions were biomineralized into calcite and vaterite with mul-tiple *** to iron doping,the crystallinity and thermal stability of calcium carbonate decreased,the content of O-C=O,N-C=OandC-O-PO_(3) increased,the stable carbon isotope values became much more negative,andβ-sheet in minerals *** calcium concentrations facilitated ferric ion precipitation,while ferric ions hindered calcium *** immobilized bacteria performed better in ferric ion removal,with a precipitation ratio exceeding 90%.Free bacteria performed better in calcium removal,and the precipitation ratio reached a maximum of 56%.This research maybe provides some reference for the co-removal of calcium and ferric ions from the oilfield wastewater.

关键词： Calcium carbonate Calcium ion Ferric ion Biomineralization Co-removal Immobilization

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A robust statistical prediction model for late-summer heavy precipitation days in North China

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Science China Earth Sciences 2025年第1期68卷 158-171页

作者： Shunli JIANG Tingting HAN Xin ZHOU Huijun WANG Zhicong YIN Xiaolei SONG Collaborative Innovation center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of EducationNanjing University for Information Science and TechnologyNanjing210044China Nansen-Zhu International research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China Southern marine Science and engineering Guangdong Laboratory(Zhuhai) Zhuhai519080China

Recently,heavy precipitation(HP)events have occurred frequently in North China(NC),causing devastating economic losses and human ***,the short-term climate prediction of HP is quite *** year-to-year increment(DY)method and sliding correlations,we developed a robust seasonal prediction model for late-summer HP days(HPDs)in NC during 1982–2022,utilizing three independent predictors—February sea surface temperature(SST)in the Indian Ocean(SST_IO),February snow depth over North Asia(SDE_NA),and May melted snow depth in NC(MSDE_NC).The SST_IO anomalies affect NC's precipitation through the Pacific-Japan *** SDE_NA anomalies are associated with East Asian anomalous anticyclone by southeastern propagation of Rossby wave at *** MSDE_NC anomalies are followed by vertical motion and moisture anomalies in situ and thereby cause precipitation *** prediction model can well simulate the variations of the HPDs,with a correlation coefficient(CC)of 0.81(0.65)between the observed and predicted HPDs_DY(HPDs_anomaly).The percentage with the same sign for 15 extreme HPDs_anomaly years(PSSE)is 100%.Moreover,in the cross-validation test during 1982–2022,the PSSE for HPDs_anomaly is as high as 100%,along with a low rootmean-square error of *** independent hindcasts during 2013–2022,the CC between the observed and predicted HPDs_DY(HPDs_anomaly)is 0.93(0.83),together with high Nash-Sutcliffe efficiency(0.82)and agreement index(0.89).Specifically,the predictions are broadly consistent with the observations for 2015,2016,2017,2021,and 2022,reflecting excellent performance of this prediction model of HPDs in NC.

关键词： Heavy precipitation at North China Year-to-year increment approach Robust seasonal prediction Sea surface temperature Snow depth

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Efficient photodegradation of perfluoroalkyl substances under visible light by hexagonal ZnIn_(2)S_(4) nanosheets

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Journal of Environmental Sciences 2025年第2期148卷 116-125页

作者： Fuyu Liu Hui Xue Tingshuo Kang Qiupei Lei Jiazhe Chen Zhihong Zuo Bin Han Xize Lu Xiao Yang Xiangcheng Shan Xiaoyang Song Qingzhe Zhang Yongguang Yin Yong Cai Shandong Key Laboratory of Environmental Processes and Health Qingdao Key Laboratory of Marine Pollutant PreventionSchool of Environmental Science and EngineeringShandong UniversityQingdao 266237China research center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Shenzhen research Institute of Shandong University A301 Virtual University Park in South DistrictShenzhen 518057China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 10085China Department of Chemistry and Biochemistry Florida International UniversityMiamiFlorida 33199USA

Perfluoroalkyl substances(PFASs)are typical persistent organic pollutants,and their removal is urgently required but *** has shown potential in PFASs degradation due to the redox capabilities of photoinduced charge carriers in ***,hexagonal ZnIn_(2)S_(4)(ZIS)nanosheets were synthesized by a one-pot oil bath method and were well characterized by a series of *** the degradation of sodium p-perfluorous nonenoxybenzenesulfonate(OBS),one kind of representative PFASs,the assynthesized ZIS showed activity superior to P25 TiO_(2) under both simulated sunlight and visible-light *** good photocatalytic performance was attributed to the enhanced light absorption and facilitated charge *** pH conditions were found crucial in the photocatalytic process by influencing the OBS adsorption on the ZIS *** e−and h+were the main active species involved in OBS degradation in the ZIS *** work confirmed the feasibility and could provide mechanistic insights into the degradation and defluorination of PFASs by visible-light photocatalysis.

关键词： PFASs Defluorination Photocatalysis Visible light ZnIn_(2)S_(4)

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Vibration safety assessment and parameter analysis of buried oil pipelines based on vibration isolation holes under strong surface impact

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Earthquake engineering and engineering Vibration 2025年第1期24卷 69-82页

作者： Wang Guobo Mei Hua Wang Jianning He Wei Yin Yao Zhai Yuxin Zuo Pengfei College of Civil engineering and Architecture Wenzhou UniversityWenzhou 325035China Zhejiang engineering research center of Disaster Prevention and Mitigation for Coastal Soft Soil Foundation WenZhou 325035China China national Machinery Industry Co. Ltd.Beijing 100080China Faculty of engineering China University of GeosciencesWuhan 430074China China Railway Construction Group Co. Ltd.Beijing 100072China School of Civil engineering and Architecture Wuhan University of TechnologyWuhan 430070China

Strong surface impact will produce strong vibration,which will pose a threat to the safety of nearby buried pipelines and other important lifeline *** on the verified numerical method,a comprehensive numerical parameter analysis is conducted on the key influencing factors of the vibration isolation hole(VIH),which include hole diameter,hole net spacing,hole depth,hole number,hole arrangement,and soil *** results indicate that a smaller ratio of net spacing to hole diameter,the deeper the hole,the multi-row hole,the hole adoption of staggered arrangements,and better site soil conditions can enhance the efficiency of the VIH *** average maximum vibration reduction efficiency within the vibration isolation area can reach 42.2%.The vibration safety of adjacent oil pipelines during a dynamic compaction projection was evaluated according to existing standards,and the measurement of the VIH was recommended to reduce excessive *** single-row vibration isolation scheme and three-row staggered arrangement with the same hole parameters are suggested according to different *** research findings can serve as a reference for the vibration safety analysis,assessment,and control of adjacent underground facilities under the influence of strong surface impact loads.

关键词： vibration isolation hole buried oil pipeline strong surface impact vibration velocity vibration safety assessment

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Checklist of marine fishes in the Beibu Gulf:fish classification,resource protection,and biodiversity challenge

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Journal of Oceanology and Limnology 2025年第1期43卷 232-247页

作者： Zhisen LUO Murong YI Xiaodong YANG Xiao CHEN Jinxi WANG Changping JIANG Fengming LIU Konglan LUO Xiongbo HE Hung-Du LIN Bin KANG Yunrong YAN College of Fisheries Guangdong Ocean UniversityZhanjiang 524088China College of marine Sciences South China Agricultural UniversityGuangzhou 510642China Fisheries College Ocean University of ChinaQingdao 266003China Guangdong Provincial engineering and Technology research center of Far Sea Fisheries Management and Fishing of South China Sea Guangdong Ocean UniversityZhanjiang 524088China

marine fish diversity in the Beibu Gulf from 2014 to 2022 was analyzed,using various methods including at-sea fisheries resource surveys,fishing port surveys,underwater survey techniques,and data from literature,books,and databases,from which 1059 fish species across 40 orders,166 families,and 503 genera were *** them,Acanthuriformes displayed the highest diversity,followed by Carangiformes and ***,eight alien species were found in the Beibu *** International Union for Conservation of Nature(IUCN)Red List assessment revealed 51threatened species,primarily cartilaginous *** changes affected 88.70%of species due to classification adjustments,misidentifications,and junior *** study contributed new data of the gulf,including one additional order,six new families,34 new genera,and 81 new species,emphasizing the dynamic nature of marine *** diversity in the gulf was relatively lower than the broader South China Sea,attributed to limited habitats and survey *** survey methods,such as gill nets,trap nets,and underwater cameras,yielded varying *** currents may have transported deep-sea species into the Beibu Gulf,leading to accidental *** gaps exist in unexplored areas,warranting further ***,the Beibu Gulf hosts significant marine biodiversity,but taxonomic challenges and undiscovered species require new research and conservation efforts.

关键词： northwestern South China Sea new record taxonomic change fish diversity survey method

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