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Wireless electrical stimulation generated by piezoelectric nanomaterial promotes the dental pulp regeneration via regulating mitochondrial Ca^(2+)/PKA signaling pathway

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Journal of Materials Science & Technology 2024年第1期168卷 24-34页

作者： Jianmao Zheng Jiyuan Zuo Cairong Xiao Qining Guo Xiaobin Fu Chengyun Ning Peng Yu Guangdong Provincial Key Laboratory of Stomatology Hospital of StomatologySun Yat-Sen UniversityGuangzhou 510080China School of Materials Science and engineering National Engineering Research Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510641China

The induction of dental pulp stem cells(DPSCs)into odontogenic differentiation is a cutting-edge method of dental pulp regeneration treatment.However,it remains a challenge to develop biomaterials and ther-apies that can induce odontogenic differentiation.Here,we propose a wireless electrical stimulation strat-egy to induce DPSCs odontogenic differentiation via K_(0.5)Na_(0.5)NbO_(3)piezoelectric nanoparticles(KNN)and polarized KNN(PKNN),which can be endocytosed by DPSCs.In vitro,several odontogenic differentiation indexes were also increased in DPSCs treated with KNN and PKNN,and the increase was more obvious in the PKNN group.Intracellular wireless electrical field promoted mitochondrial calcium concentration via mitochondrial calcium unidirectional transporter(MCU),increased the production of adenosine triphos-phate(ATP),and induced odontogenic differentiation through the activation of the cAMP-PKA signaling pathway.In vivo,dental pulp-like tissue was induced by electrical stimulation wirelessly with KNN and PKNN,which was more clinically friendly compared with the wired device,and the induction was more obvious in the PKNN group consistent with in vitro experiments.In conclusion,this work demonstrates the potential of PKNN as an effective stimulus that can induce odontogenic differentiation of DPSCs and be applied to dental pulp regeneration treatment.

关键词： Piezoelectric nanoparticles Dental pulp stem cells Odontogenic differentiation

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Efficient and stable organic solar cells enabled by a poly(carbazole phosphonic acid)hole transporter

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Science China Chemistry 2024年第6期67卷 1941-1945页

作者： Zhijun Ren Siwei Luo Xiaoyu Shi Yunjie Dou Tianxiao Liu Lingyuan Wang Kwok Kiu Tsang Feifei Wang Yu Zhao Yangyang Liu Xiaodong Hu Xiaoxiao Peng Wei Liu He Yan Shangshang Chen State Key Laboratory of Coordination Chemistry MOE Key Laboratory of High Performance Polymer Materials&TechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China Department of Chemistry Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsEnergy Institute and Hong Kong Branch of Chinese NationalEngineering Research Center for Tissue Restoration and ReconstructionHong Kong University of Science and TechnologyHong Kong999077China

Conventional self-assembled monolayer(SAM)hole transporters in organic solar cells(OSCs)generally suffer from poor uniformity and limited thickness tolerance,hindering their large-scale production.To overcome these limitations,we introduce a novel polymeric hole transporter synthesized by polymerizing carbazole phosphonic acid(PACz).The resultant Poly-2PACz material exhibits exceptional conductivity,high tolerance for variations in layer thickness,and improved film uniformity compared with conventional SAMs.Consequently,the OSCs utilizing Poly-2PACz achieve a remarkable power conversion efficiency of 19.1%and a high fill factor of 81.2%,surpassing the devices based on 2PACz.Moreover,Poly-2PACz-based OSCs demonstrate excellent operational stability,retaining over 80%of their initial efficiency after 1,400 h of continuous light exposure in ambient conditions.This work presents a novel strategy for designing hole transporters,paving the way for more efficient and stable OSCs.

关键词： organic solar cells hole transporters poly(carbazole phosphonic acid) stability

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Preparing lipid nanoparticles with tunable drug loading capacity and morphology via improved sequential nanoprecipitation

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Science China Chemistry 2024年第5期67卷 1373-1374页

作者： Haoran Wang Ben Zhong Tang Hong Kong Branch of Chinese national engineering research center for tissue restoration and reconstruction Department of Chemistry.Institute of Molecular Functional MaterialsState Key Laboratory of NeuroscienceDivision of Biomedical Engineering and Division of Life ScienceThe Hong Kong University of Science and TechnologyHong Kong 999077China School of Science and engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Nanotechnology hailed as a revolutionary new technology of the 21st century, has ignited a wave of innovation across diverse fields spanning chemistry, physics, materials science,medicine, engineering, and electronics. In 2016, Nature published an article titled “The nanolight revolution is coming”, underscoring that “virus-sized particles that emit light in every color could transform applications ranging from television displays to cancer treatment”.

关键词： sized loading treatment

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仿病毒膜融合型纳米囊泡在体制备CAR-T细胞

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Science Bulletin 2024年第3期69卷 354-366页

作者：赵贵张玥许从飞王均 School of Biomedical Sciences and engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China national engineering research center for tissue restoration and reconstruction South China University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Biomedical engineering South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Materials and engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China

Engineered T cells expressing chimeric antigen receptor(CAR)exhibit high response rates in B-cell malignancy treatments and possess therapeutic potentials against various diseases.However,the complicated ex vivo production process of CAR-T cells limits their application.Herein,we use virus-mimetic fusogenic nanovesicles(FuNVs)to produce CAR-T cells in vivo via membrane fusion-mediated CAR protein delivery.Briefly,the FuNVs are modified using T-cell fusogen,adapted from measles virus or reovirus fusogens via displaying anti-CD3 single-chain variable fragment.The FuNVs can efficiently fuse with the T-cell membrane in vivo,thereby delivering the loaded anti-CD19(aCD19)CAR protein onto T-cells to produce aCD19 CAR-T cells.These aCD19 CAR-T cells alone or in combination with anti-OX40 antibodies can treat B-cell lymphoma without inducing cytokine release syndrome.Thus,our strategy provides a novel method for engineering T cells into CAR-T cells in vivo and can further be employed to deliver other therapeutic membrane proteins.

关键词： CAR-T Nanovesicle Fusogen Cancer immunotherapy

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Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nhigh astrocytes in the hippocampus

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The innovation 2024年第1期5卷 98-108页

作者： Zongshan Shen Shuhong Kuang Yong Zhang Jiayao Chen Shuting Wang Congfei Xu Yunjia Huang Min Zhang Shuheng Huang Jun Wang ChuanJiang Zhao Zhengmei Lin Xuetao Shi Bin Cheng Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510060China national engineering research Centre for tissue restoration and reconstruction South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical engineering of Guangdong Province South China University of TechnologyGuangzhou 510006China School of Biomedical Science and engineering South China University of TechnologyGuangzhou 510650China The First Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510080China

Cognitive decline has been linked to periodontitis through an undetermined pathophysiological mechanism.This study aimed to explore the mechanism underlying periodontitis-related cognitive decline and identify therapeutic strategies for this condition.Using single-nucleus RNA sequencing we found that changes in astrocyte number,gene expression,and cell‒cell communication were associated with cognitive decline in mice with periodontitis.In addition,activation of the NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome was observed to decrease the phagocytic capability of macrophages and reprogram macrophages to a more proinflammatory state in the gingiva,thus aggravating periodontitis.To further investigate this finding,lipid-based nanoparticles carrying NLRP3 siRNA(NPsiNLRP3)were used to inhibit overactivation of the NLRP3 inflammasome in gingival macrophages,restoring the oral microbiome and reducing periodontal inflammation.Furthermore,gingival injection of NPsiNLRP3 reduced the number of Serpina3nhigh astrocytes in the hippocampus and prevented cognitive decline.This study provides a functional basis for the mechanism by which the destruction of periodontal tissues can worsen cognitive decline and identifies nanoparticle-mediated restoration of gingival macrophage function as a novel treatment for periodontitis-related cognitive decline.

关键词： NLRP3 periodontal number

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Scalable production of mesoporous titanium nanoparticles through sequential flash nanocomplexation

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Chinese Chemical Letters 2024年第4期35卷 303-309页

作者： Feng Cui Fangman Chen Xiaochun Xie Chenyang Guo Kai Xiao Ziping Wu Yinglu Chen Junna Lu Feixia Ruanb Chuanxu Cheng Chao Yang Dan Shao School of Biomedical Sciences and engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China Institutes for Life Sciences School of MedicineSouth China University of TechnologyGuangzhou 510006China School of Biology and Biological engineering South China University of TechnologyGuangzhou 510006China Department of Orthopedics Academy of Orthopedics-Guangdong ProvinceOrthopedic Hospital of Guangdong ProvinceGuangdong Provincial Key Laboratory of Bone and Joint Degenerative DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510665China national engineering research center for tissue restoration and reconstruction South China University of TechnologyGuangzhou 510006China

Mesoporous titanium nanoparticles(MTNs) have emerged as an important porous semiconductor owning to their large surface area and unique electronic/optical properties. However, the fundamental research for rational manufacturing MTNs in a highly scalable manner remains a challenge. In this study, we report a two-step flash nanocomplexation(FNC) approach to large-scalable generate MTNs through the sequential combination of two multi-inlet vortex mixers. By optimizing the concentrated titanium precursor,polyethylene glycol(PEG)-functionalized silane amount and p H, we have been able to produce MTNs with small particle size(31.5 nm), larger surface area(416.9 m^(2)/g) and pore volume(0.59 cm^(3)/g). Different from the traditional MTNs bulk, FNC-produced MTNs exhibited well-controlled manner and exceptional photocatalytic and antibacterial properties. Importantly, the optimized MTNs outperformed commercial P25 not only in protecting ultraviolet A(UVA)-exposed skin, but also in treating P. aeruginosa-infected wound. We believe that the high controllability and scalability of sequential flash nanocomplexation method offers great opportunities in enhancing the performance of mesoporous titanium nanoparticles.

关键词： Mesoporous titanium nanoparticles Flash nanocomplexation Photocatalytic Antibacterial Sequential

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The superiority of nonconjugated structures in fluorescence:through-space vs. through-bond charge transfer

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Science China Chemistry 2024年

作者： Weihao Tu Zuping Xiong Lei Wang Jianyu Zhang Jing Zhi Sun Haoke Zhang Benzhong Tang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang University Centre of Healthcare Materials Shaoxing Institute Zhejiang University Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and Technology School of Science and engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong

Constructing charge transfer（CT） state by introducing donor（D） and acceptor（A） is an efficient strategy to regulate the photophysical properties of luminescent materials. Traditional CT-type luminophores are built on π-conjugated fused-ring structures, which always show hybrid CT/locally excited（LE） states and luminescence quenching effect in the aggregate state. In this work, eight conjugated biphenyl（BP） and nonconjugated diphenylmethane（DPM） derivatives with different donors and acceptors are synthesized to investigate the CT properties. Systematic photophysical characterization and theoretical calculation demonstrate that the through-space CT（TSCT） in nonconjugated DA-DPM exhibit superior photophysical performance than the conjugated DA-BP with through-bond CT（TBCT）, the main manifestations are as follows:（1） TSCT luminophores produce longer maximum emission wavelength(λem) than the corresponding TBCT ones. For example, the longest λemof DMA-CN-DPM（DMA, dimethylamino） is 621 nm but the corresponding λemof DMA-CN-BP is only 480 nm.（2） TSCT-based DA-DPM demonstrates more sensitive responsiveness to environmental stimuli such as temperature and polarity.（3） Complete separation of the the highest occupied molecular orbital（HOMO） and the lowest unoccupied molecular orbital（LUMO） distribution exists in all kinds of conformation of DA-DPM, which was hard to realize in conjugated DA-BP.

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Step‑by‑Step Modulation of Crystalline Features and Exciton Kinetics for 19.2%Efficiency Ortho‑Xylene Processed Organic Solar Cells

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Nano-Micro Letters 2024年第2期16卷 258-272页

作者： Bosen Zou Weiwei Wu Top Archie Dela Pena Ruijie Ma Yongmin Luo Yulong Hai Xiyun Xie Mingjie Li Zhenghui Luo Jiaying Wu Chuluo Yang Gang Li He Yan Department of Chemistry Department of Chemistry and Hong Kong Branch of Chinese national engineering research center for tissue restoration and reconstruction The Hong Kong University of Science and TechnologyClear Water BayHong KongPeople’s Republic of China Department of Electronic and Information engineering Research Institute for Smart Energy(RISE)Guangdong‑Hong Kong‑Macao(GHM)Joint Laboratory for Photonic‑Thermal‑Electrical Energy Materials and DevicesThe Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China The Hong Kong University of Science and Technology Function HubAdvanced Materials ThrustNanshaGuangzhou 511400People’s Republic of China Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongPeople’s Republic of China Shenzhen Key Laboratory of New Information Display and Storage Materials College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China

With plenty of popular and effective ternary organic solar cells(OSCs)construction strategies proposed and applied,its power conversion efficiencies(PCEs)have come to a new level of over 19%in single-junction devices.However,previous studies are heavily based in chloroform(CF)leaving behind substantial knowledge deficiencies in understanding the influence of solvent choice when introducing a third component.Herein,we present a case where a newly designed asymmetric small molecular acceptor using fluoro-methoxylated end-group modification strategy,named BTP-BO-3FO with enlarged bandgap,brings different morphological evolution and performance improvement effect on host system PM6:BTP-eC9,processed by CF and ortho-xylene(o-XY).With detailed analyses supported by a series of experiments,the best PCE of 19.24%for green solvent-processed OSCs is found to be a fruit of finely tuned crystalline ordering and general aggregation motif,which furthermore nourishes a favorable charge generation and recombination behavior.Likewise,over 19%PCE can be achieved by replacing spin-coating with blade coating for active layer deposition.This work focuses on understanding the commonly met yet frequently ignored issues when building ternary blends to demonstrate cutting-edge device performance,hence,will be instructive to other ternary OSC works in the future.

关键词： Organic solar cells Ternary design Solvent selection Flouro-methoxylated end group Morphological ordering

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Bright, photostable and long-circulating NIR-Ⅱ nanoparticles for whole-process monitoring and evaluation of renal transplantation

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national Science Review 2024年第2期11卷 207-220页

作者： Rongyuan Zhang Ping Shen Yu Xiong Tianjing Wu Gang Wang Yucheng Wang Liping Zhang Han Yang Wei He Jian Du Xuedong Wei Siwei Zhang Zijie Qiu Weijie Zhang Zheng Zhao Ben Zhong Tang Clinical Translational research center of Aggregation-Induced Emission The Second Affiliated HospitalSchool of MedicineSchool of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen) center for AIE research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and Engineering Shenzhen University School of Chemistry Xiangtan University HKUST-Shenzhen research Institute Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology Department of Urology The First Affiliated Hospital of Soochow University AIE Institute

Kidney transplantation is the gold standard for the treatment of end-stage renal diseases(ESRDs). However,the scarcity of donor kidneys has caused more and more ESRD patients to be stuck on the waiting list for transplant surgery. Improving the survival rate for renal grafts is an alternative solution to the shortage of donor kidneys. Therefore, real-time monitoring of the surgical process is crucial to the success of kidney transplantation, but efficient methods and techniques are lacking. Herein, a fluorescence technology based on bright, photostable and long-circulating aggregation-induced emission(AIE) active NIR-II nano-contrast agent DIPT-ICF nanoparticles for the whole-process monitoring and evaluation of renal transplantation has been reported. In the aggregated state, DIPT-ICF exhibits superior photophysical properties compared with the commercial dyes IR-26 and IR-1061. Besides, the long-circulating characteristic of the AIE nano-contrast agent helps to achieve renal angiography in kidney retrieval surgery,donor kidney quality evaluation, diagnosing vascular and ureteral complications, and assessment of renal graft reperfusion beyond renovascular reconstruction, which considerably outperforms the clinically approved indocyanine green(ICG).

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On-off-on fluorescence detection for biomolecules by a fluorescent cage through host-guest complexation in water

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Chinese Chemical Letters 2022年第5期33卷 2459-2463页

作者： Honghong Duan Fan Cao Minjie Zhang Meng Gao Liping Cao College of Chemistry and Materials Science Northwest UniversityXi’an 710069China national engineering research center for tissue restoration and reconstruction Key Laboratory of Biomedical Engineering of Guangdong ProvinceKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationInnovation Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510006China

Detection of nucleoside derivatives has paramount importance because they are the essential biomolec-ular units for all life.Herein,we report a host-guest approach by using a fluorescent tetraphenylethene-based octacationic cage as host and 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt(HPTS)as guest and fluorescent indicator to form non-fluorescent 1:1:1 host-(endo-exo)guest complex in water.This new host-(endo-exo)guest complex can be successfully used for detecting nucleosides(e.g.,ATP and GTP),DNA(e.g.,sm-DNA),and antibiotics(e.g.,Penicillin G)with off-on fluorescence response via a competitive host-guest exchange with HPTS as exo-guest in water.Furthermore,this on-off-on fluorescent host-guest com-plex is also used for cell imaging based on ATP concentration in HeLa cells.Therefore,this study not only provides insight into the construction of a supramolecular probe with on-off-on fluorescence via host-guest complexation and exchange in solution,but also realizes a universal method for detecting and monitoring biomolecules.

关键词： Host-guest complexation Tetraphenylethene-based octacationic cage Nucleoside derivatives Fluorescence Cell imaging

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