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Iron metabolism and arthritis: Exploring connections and therapeutic avenues

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中华医学杂志(英文版) 2024年第14期137卷 1651-1662页

作者： Zhuo Dachun Xiao Wenze Tang Yulong Jiang Shuai Geng Chengchun Xie Jiangnan Ma Xiaobei Zhang Qing Tang Kunhai Yu Yuexin Bai Lu Zou Hejian Liu Jing Wang Jiucun Department of Rheumatology Shanghai Pudong Hospital Human Phenome Institute Zhangjiang Fudan International Innovation Center Fudan University Shanghai China State Key Laboratory of Genetic engineering School of Life Science Fudan University Shanghai China Department of Vascular Surgery Shanghai Pudong Hospital Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling Fudan University Pudong Medical Center Shanghai China Department of Anthropology and Human Genetics School of Life Sciences Ministry of Education Key Laboratory of Contemporary Anthropology Fudan University Shanghai China Division of Rheumatology Huashan Hospital State Key Laboratory of Genetic Engineering School of Life Science Fudan University Shanghai China Institute of Rheumatology Immunology and Allergy Allergy and Disease Research Center Fudan University Shanghai China research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences Beijing China

Iron is indispensable for the viablility of nearly all living organisms, and it is imperative for cells, tissues, and organisms to acquire this essential metal sufficiently and maintain its metabolic stability for survival. Disruption of iron homeostasis can lead to the development of various diseases. There is a robust connection between iron metabolism and infection, immunity, inflammation, and aging, suggesting that disorders in iron metabolism may contribute to the pathogenesis of arthritis. Numerous studies have focused on the significant role of iron metabolism in the development of arthritis and its potential for targeted drug therapy. Targeting iron metabolism offers a promising approach for individualized treatment of arthritis. Therefore, this review aimed to investigate the mechanisms by which the body maintains iron metabolism and the impacts of iron and iron metabolism disorders on arthritis. Furthermore, this review aimed to identify potential therapeutic targets and active substances related to iron metabolism, which could provide promising research directions in this field.

关键词： Iron metabolism Arthritis Inflammation Immunity Rheumatoid arthritis Psoriatic arthritis Gouty arthritis

Anisotropy of wrought magnesium alloys: A focused overview

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Journal of Magnesium and Alloys 2022年第6期10卷 1476-1510页

作者： Baodong Shi Chong Yang Yan Peng Fucheng Zhang Fusheng Pan national engineering research center for Equipment and Technology of Cold Rolled Strip School of Mechanical EngineeringYanshan UniversityHebei-West-Str.438Qinhuangdao 066004PR China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004PR China national engineering research center for Magnesium Alloys(CCMg) Chongqing UniversityChongqing 400044PR China

In this paper, the relationship between anisotropic mechanical properties and the corresponding microstructure evolution of wrought magnesium alloys is critically reviewed. Experimental observations of the strong anisotropy(including the strength differential effect) induced by texture and twinning are discussed under different loading conditions(i.e., monotonic, cyclic and multiaxial loading). An accurate constitutive model is essential to describe the mechanical responses and to predict the forming performance considering engineering applications. Therefore, macroscale constitutive modeling of the anisotropy of magnesium alloys with directional distortional hardening are comprehensively reviewed with different approaches. To clarify the origin of the anisotropic behavior, physics-based mesoscale modeling of the anisotropy is also compared in detail.

关键词： Wrought Mg alloys Mechanical anisotropy Deformation mechanism Constitutive modeling

Luminescent Properties of Samarium Ion in Calcium Molybdate

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Journal of Rare Earths 2004年第6期22卷 821-824页

作者：胡运生庄卫东叶红齐 national engineering research center for Rare Earth Materials General Research Institute for Nonferrous Metals Grirem Advanced Materials Corpration Limited College of Chemistry and Chemical engineering Central South University Changsha 410083 China

Trivalent samarium ion (Sm^(3+)) activated calcium molybdate (CaMoO_4) phosphor was prepared by solid-state reaction in air. The XRD pattern of the powder CaMoO_4∶Sm shows that the CaMoO_4∶Sm single phase is developed fully through our preparation procedure. The excitation spectrum of CaMoO_4∶Sm is composed of a broad absorption of host and some sharp lines of the f-f transition absorption of Sm^(3+). Illustrated in photoluminescence spectrum, CaMoO_4 doped with Sm^(3+) displays orange red emission that is ascribed to the inner 4f^5 electron transitions ~6H_(7/2)(orange)and ~6H_(9/2)(red)of Sm^(3+). Different from the sites of Sm^(3+) in CdWO_4, the Sm^(3+) ions substitute for the Ca^(2+) and form only one type emission center in the CaMoO_4 crystal lattice.

关键词： photoluminescence calcium molybdate samarium, rare earths

The Synthesis of Cyclodextrin Derivatives with Ethilenic Bond and Their Application on Silk

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Journal of Donghua University(English Edition) 2011年第3期28卷 312-316页

作者：方熙黄良晨赵曙辉黄芳 College of Chemistry Chemical Engineering and Biotechnology Donghua University national engineering research center for Dyeing and Finishing of Textiles Donghua University

The cyclodextrin (CD) derivatives with ethilenic bonds mono-(2-O-tosyl)-6-acryloyl-β-cyclodextrin (β-CD-2-OTs-6-A) and 6-acryloyl-β-cyclodextrin (β-CD-6-A) were respectively synthesized. β-CD-2-OTs-6-A was prepared by the reaction propylene chloride with β-CD-2-OTs. β-CD-6-A was synthesized by the reaction propylene chloride with β-CD. The most suitable pH value for β-CD-6-A grafted onto silk fabric was proved to be 5. The optimal condition for grafting β-CD-2-OTs-6-A onto silk was proved: monomer concentration of 20% on weight of fabric(o.w.f), potassium persulfate of 1.85% o.w.f, liquor ratio of 1∶50, pH=5, and treated 30 min at 80 ℃. Compared with β-CD-6-A, the grafting reaction has a higher graft yield while β-CD-2-OTs-6-A acts as the monomer.

关键词： propylene chloride cyclodextrin graft silk

Influence of La^(3+) and Dy^(3+) on the properties of the long afterglow phosphor CaAl_2O_4: Eu^(2+), Nd^(3+)

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Rare Metals 2008年第4期27卷 335-339页

作者： TENG Xiaoming ZHUANG Weidong HE Huaqiang national engineering research center for Rare Earth Materials General Research Institute for Nonferrous Metals and Grirem Advanced Materials Co. Ltd. Beijing 100088 China

The long afterglow phosphor CaAl2O4： Eu^2＋, Nd^3＋ was prepared by the high temperature solid-state reaction method, and the influence of La^3＋ and Dy^3＋ on the properties of the long afterglow phosphor was studied by X-ray diffiaction （XRD）, photoluminescence （PL）, and thermoluminescence （TL）. The XRD pattem shows the host phase of CaAl2O4 is produced and no impurity phase appears. The peak wavelength of the phosphor does not vary with La^3＋ and Dy^3＋ doping. It implies that the crystal field, which affects the 5d electron states of Eu^2＋, is not changed dramatically after doping of La^3＋ and Dy^3＋. The TL spectra indicate that the phosphor doped with La^3＋ or Dy^3＋ produces different depths of trap energy level. In the mechanism of long afterglow luminescence, it is considered that La^3＋ or Dy^3＋ works as trap energy level. The decay time lies on the number of electrons in the trap energy level and the rate of the electrons returning to the excitation level.

关键词： rare earth aluminate long afterglow phosphor electron traps

Corrosion properties in a simulated body fluid of Mg/β-TCP composites prepared by powder metallurgy

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International Journal of Minerals,Metallurgy and Materials 2012年第11期19卷 1040-1044页

作者： Yong Wang Ze-hong Wu Hong Zhou Zhi-dong Liao Heng-fei Zhang College of Materials Science&engineering National Engineering Research Center for Magnesium AlloysChongqing UniversityChongqing 400045China

Magnesium matrix composites （MMC） reinforced with 5wt% tricalcium phosphate （TCP） particles were prepared by powder metallurgy. Pure magnesium （CP-Mg） was fabricated by the same procedure for comparison. Scanning electron microscopy and en- ergy-dispersive X-ray spectroscopy analyses revealed that TCP particles were distributed homogeneously in the MMC. In order to investi- gate the corrosion properties, MMC samples were immersed in a simulated body fluid （SBF） at 310~0.5 K for 72 h. The mass loss of the samples in SBF and the pH values of the SBF were evaluated. Moreover, electrochemical measurements were conducted in the SBF. It was shown that the corrosion rate of the MMC decreased with the addition of TCP compared with CP-Mg. Hydroxyapatite was formed on the surface of MMC samples after immersion in the SBF for 72 h but not on the surface of CP-Mg.

关键词： metallic matrix composites powder technology corrosion hydroxyapatite magnesium

Thoughts on the development of novel network technology

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Science China(Information Sciences) 2018年第10期61卷 144-154页

作者： Jiangxing WU national Digital Switching System engineering and Technological R&D center

In this paper, we explore potential innovations that could lead to breakthrough developments in Internet technologies. The deep integration of the Internet and economic society brings professionalized service capacity demand, while existing Internet infrastructure with its current technological systems still face a number of challenges, such as intelligence, diversification, personalization, robustness, and ***, we analyze the actual foundation of innovation and specify the basic technical features of a novel network. Then, we propose a fully dimensionally definable open architecture as the primary direction, and consider reshaping baseline technologies as a starting point and discuss the core operational mechanisms of the novel network based on such reshaped baseline technologies.

关键词： novel Internet technology open architecture full-dimensional definability diversified addressing and routing intelligence general robust control

Targeting metabolism to improve CAR-T cells therapeutic efficacy

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Chinese Medical Journal 2024年第8期137卷 909-920页

作者： Shasha Liu Yuyu Zhao Yaoxin Gao Feng Li Yi Zhang Biotherapy center and Cancer center the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China School of Life Sciences Zhengzhou UniversityZhengzhouHenan 450052China engineering Key Laboratory for Cell Therapy of Henan Province ZhengzhouHenan 450052China School of Public Health Zhengzhou UniversityZhengzhouHenan 450000China

Chimeric antigen receptor T(CAR-T)cell therapy achieved advanced progress in the treatment of hematological ***,the application of CAR-T cell therapy for solid tumors still faces many *** with tumor cells for metabolic resources in an already nutrient-poor tumor microenvironment is a major contributing cause to CAR-T cell therapy’s low *** metabolic processes are now acknowledged to shape the tumor microenvironment,which is characterized by increased interstitial fluid pressure,low pH level,hypoxia,accumulation of immunosuppressive metabolites,and mitochondrial *** factors are important contributors to restriction of T cell proliferation,cytokine release,and suppression of tumor cell-killing *** review provides an overview of how different metabolites regulate T cell activity,analyzes the current dilemmas,and proposes key strategies to reestablish the CAR-T cell therapy’s effectiveness through targeting metabolism,with the aim of providing new strategies to surmount the obstacle in the way of solid tumor CAR-T cell treatment.

关键词： CAR-T cell therapy Metabolism Tumor microenvironment Immunotherapy Mitochondrial fitness

Design and implementation of a novel enterprise network defense system by maneuvering multi-dimensional network properties

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Frontiers of Information Technology & Electronic engineering 2019年第2期20卷 238-252页

作者： Yang CHEN Hong-chao HU Guo-zhen CHENG national Digital Switching System engineering & Technological R&D center

Although the perimeter security model works well enough when all internal hosts are credible, it is becoming increasingly difficult to enforce as companies adopt mobile and cloud technologies, i.e., the rise of bring your own device(BYOD). It is observed that advanced targeted cyber-attacks usually follow a cyber kill chain;for instance, advanced targeted attacks often rely on network scanning techniques to gather information about potential targets. In response to this attack method, we propose a novel approach, i.e., an "isolating and dynamic"cyber defense, which cuts these potential chains to reduce the cumulative availability of the gathered ***, we build a zero-trust network environment through network isolation, and then multiple network properties are maneuvered so that the host characteristics and locations needed to identify vulnerabilities cannot be ***, we propose a software-defined proactive cyber defense solution(SPD) for enterprise networks and design a general framework to strategically maneuver the IP address, network port, domain name, and path, while limiting the performance impact on the benign network user. Third, we implement our SPD proof-of-concept system over a software-defined network controller(OpenDaylight). Finally, we build an experimental platform to verify the system's ability to prevent scanning, eavesdropping, and denial-of-service attacks. The results suggest that our system can significantly reduce the availability of network reconnaissance scan information, block network eavesdropping, and sharply increase the cost of cyber-attacks.

关键词： Intranet defense Software-defined network Multi-dimensional maneuvering