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Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets

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Journal of animal Science and Biotechnology 2024年第2期15卷 878-897页

作者： Chang Cui Yulong Wei Yibo Wang Wen Ma Xiaoyu Zheng Jun Wang Ziwei Ma Caichi Wu Licui Chu Shihai Zhang Wutai Guan Fang Chen Guangdong Provincial Key Laboratory of animal nutrition control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of animal Science and national engineering research center for breeding swine industry South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China

Background The benefits of combining benzoic acid and essential oils(BAO)to mitigate intestinal impairment during the weaning process have been well established,while the detailed underlying mechanism has not been fully *** research has primarily focused on the reparative effects of BAO on intestinal injury,while neglecting its potential in enhancing intestinal stress *** In this study,we investigated the pre-protective effect of BAO against LPS-induced stress using a modified experimental *** were pre-supplemented with BAO for 14 d,followed by a challenge with LPS or saline to collect blood and intestinal *** Our findings demonstrated that BAO supplementation led to significant improvements in piglets’final weight,average daily gain,and feed intake/body gain ***,BAO supplementation positively influenced the composition of intestinal microbiota,increasing beneficial Actinobacteriota and Alloprevotella while reducing harmful Desulfobacterota,Prevotella and ***,BAO supplementation effectively mitigated oxidative disturbances and inflammatory responses induced by acute LPS *** was evidenced by elevated levels of T-AOC,SOD,and GSH,as well as decreased levels of MDA,TNF-α,and IL-6 in the ***,piglets subjected to LPS challenge and pre-supplemented with BAO exhibited significant improvements in intestinal morphological structure and enhanced integrity,as indicated by restored expression levels of Occludin and Claudin-1 compared to the non-supplemented *** analysis revealed that BAO supplementation enhanced the jejunal antioxidative capacity by increasing GSH-Px levels and decreasing MDA levels under the LPS challenge and stimulated the activation of the Nrf2 signaling ***,the reduction of TLR4/NF-κB/MAPK signaling pathways activation and proinflammatory factor were also observed in the jejunal of those piglets fed with ***

关键词： Anti-stress Benzoic acid Essential oils Intestine LPS Weaned piglets

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Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy

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Science China(Life Sciences) 2024年第8期67卷 1676-1696页

作者： Xupeng Zang Shengchen Gu Wenjing Wang Junsong Shi Jianyu Gan Qun Hu Chen Zhou Yue Ding Yanjuan He Lei Jiang Ting Gu Zheng Xu Sixiu Huang Huaqiang Yang Fanming Meng Zicong Li Gengyuan Cai Linjun Hong Zhenfang Wu State Key Laboratory of swine and Poultry breeding industry National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular breeding South China Agricultural UniversityGuangzhou 510642China Yunfu Subcenter of Guangdong Laboratory for Lingnan Modern Agriculture Yunfu 527300China Guangdong Key Laboratory of animal breeding and nutrition Institute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640China Key Laboratory of South China Modern Biological Seed industry Ministry of Agriculture and Rural AffairsGuangzhou 510520China

Dynamic crosstalk between the embryo and mother is crucial during ***,we comprehensively profile the single-cell transcriptome of pig peri-implantation embryos and corresponding maternal endometrium,identifying 4 different lineages in embryos and 13 cell types in the ***-specific gene expression characterizes 4 distinct trophectoderm subpopulations,showing development from undifferentiated trophectoderm to polar and mural *** expression of genes in different types of endometrial cells illustrates their molecular response to embryos during ***,we developed a novel tool,ExtraCellTalk,generating an overall dynamic map of maternal-foetal crosstalk using uterine luminal proteins as *** cross-species comparisons,we identified a conserved RBP4/STRA6 pathway in which embryonic-derived RBP4 could target the STRA6 receptor on stromal cells to regulate the interaction with other endometrial *** results provide insight into the maternal-foetal crosstalk during embryo implantation and represent a valuable resource for further studies to improve embryo implantation.

关键词： endometrial remodeling ExtraCellTalk implantation maternal-foetal crosstalk trophoblast

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Dietary adenosine supplementation improves placental angiogenesis in IUGR piglets by up-regulating adenosine A2a receptor

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animal nutrition 2023年第2期13卷 282-288页

作者： Zifang Wu Jiawei Nie Deyuan Wu Shuangbo Huang Jianzhao Chen Huajin Liang Xiangyu Hao Li Feng Hefeng Luo Chengquan Tan Guangdong Provincial Key Laboratory of animal nutrition control National Engineering Research Center for Breeding Swine IndustryInstitute of Subtropical Animal Nutrition and FeedCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouGuangdong 510642China Dekon Food and Agriculture Group ChengduChina

Abnormal placental angiogenesis is associated with the occurrence of intrauterine growth restriction(IUGR)in piglets,and effective treatment strategies against this occurrence remain to be *** has been reported to play an important role in angiogenesis,but its role in placental angio-genesis is still ***,we investigated the effect of dietary adenosine supplementation on IUGR occurrence in piglets by analyzing the role of adenosine in placental angiogenesis for Normal and IUGR ***,88 sows were allotted to 2 treatments(n=44)and fed a basal diet supplemented with 0%or 0.1%of adenosine from day 65 of gestation until farrowing,followed by collecting the placental samples of Normal and IUGR piglets,and recording their *** results showed that adenosine supplementation increased the mean birth weight of piglets(P<0.05)and placental efficiency(P<0.05),while decreasing the IUGR piglet rate(P<0.05).Expectedly,the placenta for IUGR neonates showed a down-regulated vascular density(P<0.05)and angiogenesis as evidenced by the expression level of vascular cell adhesion molecule-1(VCAM1)(P<0.05).Notably,dietary adenosine supplementation promoted angiogenesis(P<0.05)both in the Normal and IUGR *** importantly,the expression level of adenosine A2a receptor(ADORA2A)was lower(P<0.05)in the IUGR placenta than in Normal placenta,whereas adenosine treatment could significantly increase ADORA2A expression,and also had an interaction effect between factors IUGR and ***,placentae for IUGR piglets showed impaired angiogenesis and down-regulated expression level of ADORA2A,while dietary adenosine supplementation could activate ADORA2A expression,improve the placental angio-genesis,and ultimately decrease the occurrence of IUGR in piglets.

关键词： Angiogenesis IUGR Placenta Adenosine ADORA2A

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Tauroursodeoxycholic acid(TUDCA)improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets

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Journal of animal Science and Biotechnology 2022年第6期13卷 1917-1931页

作者： Min Song Fenglin Zhang Yiming Fu Xin Yi Shengchun Feng Zhichang Liu Dun Deng Qiang Yang Miao Yu Canjun Zhu Xiaotong Zhu Lina Wang Ping Gao Gang Shu Xianyong Ma Qingyan Jiang Songbo Wang Guangdong Provincial Key Laboratory of animal nutrition control ALLT ECH-SCAU Animal Nutrition Control Research Allianceand National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642P.R.China Institute of animal Science Guangdong Academy of Agricultural SciencesState Key Laboratory of Livestock and Poultry BreedingKey Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Key Laboratory of Animal Breeding and NutritionGuangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and EvaluationGuangzhou 510640P.R.China Maoming Branch Guangdong Laboratory for Lingnan Modern Agricultural Science and TechnologyMaoming 525000P.R.China

Background:Tauroursodeoxycholic acid(TUDCA),a hydrophilic bile acid,is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary ***,TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced colitis in ***,the effect of TUDCA on the intestinal barrier of weaned piglets remains largely ***:The weaned piglets and porcine IPEC-J2 intestinal epithelial cells were used to investigate the effects of TUDCA on intestinal barrier function in weaned piglets and explore the possible underlying *** vivo,72 healthy weaned piglets were randomly allocated into 2 groups according to their gender and body weight,and piglets were fed the basal diet with 0(control,CON)and 200 mg/kg TUDCA for 30 d,*** female and three male piglets reflecting the average bodyweight were slaughtered in each group and samples were *** vitro,IPEC-J2 cells were subjected to 100μmol/L TUDCA to explore the possible underlying ***:Our results demonstrated that dietary TUDCA supplementation significantly reduced the diarrhea incidence of weaned piglets,possibly attributing to the TUDCA-enhanced intestinal barrier function and *** addition,TUDCA supplementation altered serum metabolites and the relative abundance of certain gut bacteria,which might contribute to the improved intestinal barrier ***,the in-vitro results showed that TUDCA improved the ***-induced epithelial barrier impairment of IPEC-J2 cells and increased Takeda G-coupled protein receptor 5(TGR5)protein ***,knockdown of TGR5 and inhibition of myosin light chain kinase(MLCK)pathway abolished the TUDCA-improved epithelial barrier impairment in ***-treated IPEC-J2 cells,indicating the involvement of TGR5-MLCK in this ***:These findings showed that TUDCA improved intestinal barrier function associated with TGR5-MLCK pathway and the al

关键词： Gut bacteria Intestinal barrier function Serum metabolites Tauroursodeoxycholic acid(TUDCA) TGR5-MLCK pathway Weaned piglets

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A review of the amino acid metabolism in placental function response to fetal loss and low birth weight in pigs

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Journal of animal Science and Biotechnology 2022年第4期13卷 987-998页

作者： Chengquan Tan Zihao Huang Wenyu Xiong Hongxuan Ye Jinping Deng Yulong Yin Guangdong Provincial Key Laboratory of animal nutrition control National Engineering Research Center for Breeding Swine IndustryInstitute of Subtropical Animal Nutrition and FeedCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642GuangdongChina national engineering Laboratory for Pollution control and Waste Utilization in Livestock and Poultry Production Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina

The fertility of sows mainly depends on the embryo losses during gestation and the survival rate of the postfarrowing *** selection of highly-prolific sows has been mainly focused on the selection of genotypes with high ovulatory ***,in the early-and post-implantation stages,the rate of embryo losses was increased with the increase of *** the various factors,placental growth and development is the vital determinant for fetal survival,growth,and *** the potential survival of fetuses with deficient placental development,their life-conditions and growth can be damaged by a process termed intrauterine growth retardation(IUGR).The newborn piglets affected by IUGR are prone to increased morbidity and mortality rates;meanwhile,the growth,health and welfare of the surviving piglets will remain hampered by these conditions,with a tendency to exacerbate with *** amino acids such as glycine,proline,and arginine continue to increase with the development of placenta,which are not only essential to placental growth(including vascular growth)and development,but can also be used as substrates for the production of glutathione,polyamines and nitric oxide to benefit placental function in many ***,the exact regulation mechanism of these amino acids in placental function has not yet been *** this review,we provide evidence from literature and our own work for the role and mechanism of dietary functional amino acids during pregnancy in regulating the placental functional response to fetal loss and birth weight of *** review will provide novel insights into the response of nutritionally nonessential amino acids(glycine and proline)to placental development as well as feasible strategies to enhance the fertility of sows.

关键词： Amino acids Birth weight Fetal loss Pigs Placenta

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Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs

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animal nutrition 2022年第4期11卷 190-200页

作者： Bingnan Liu Dongming Yu Jing Sun Xiaoyan Wu Zhongquan Xin Baichuan Deng Lijuan Fan Jian Fu Liangpeng Ge Wenkai Ren State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory of Lingnan Modern AgricultureNational Engineering Research Center for Breeding Swine IndustryGuangdong Provincial Key Laboratory of Animal Nutrition ControlCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouChina Chongqing Academy of animal Sciences ChongqingChina

Intestinal microbes are closely associated with host health,depending on metabolic crosstalk between the microbiota and *** metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host;however,our understanding about the influence of intestinal microbiota on host tryptophan metabolism is ***,we established germ-free(GF)pig models to systemically explore the influence of intestinal microbiota on tryptophan *** GF pigs were kept in GF conditions throughout the experiment(GF group).Six GF pigs were transplanted with fecal microbiota from donor sows to act as control *** with control pigs,the GF pigs had remarkable alterations in tryptophan *** differential metabolites(P<0.05)were mainly found in the liver,circulation system and large ***,the alteration of metabolites in tryptophan metabolism varied among organs,especially for the serotonin *** GF pigs,tryptophan and kynurenine in the large intestine and 5-hydroxytryptophan in most organs were increased(P<0.05),while metabolites in the indole pathway in most organs were decreased(P<0.05).Collectively,our study reveals changes in tryptophan metabolism in GF pigs,highlighting the critical role of gut microbes in shaping host tryptophan metabolism.

关键词： Germ-free pig Gut microbiota Tryptophan Indole Kynurenine

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Dietary fibers with low hydration properties exacerbate diarrhea and impair intestinal health and nutrient digestibility in weaned piglets

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Journal of animal Science and Biotechnology 2023年第2期14卷 771-791页

作者： Shuangbo Huang Zhijuan Cui Xiangyu Hao Chuanhui Cheng Jianzhao Chen Deyuan Wu Hefeng Luo Jinping Deng Chengquan Tan Guangdong Provincial Key Laboratory of animal nutrition control National Engineering Research Center for Breeding Swine IndustryInstitute of Subtropical Animal Nutrition and FeedCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642GuangdongChina Dekon Food and Agriculture Group Chengdu 610031China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642GuangdongChina.

Background:This study aimed to investigate the hydration properties of different-source fibrous materials by com-paring their water-binding capacity(WBC),water swelling capacity(WSC),viscosity,and in vivo effects of selected samples on growth performance,nutrient digestibility,diarrhea,and intestinal health in weaned ***:A total of 13 commercially available fibrous materials were first compared in chemical composition and in vitro hydration ***,40 weaned piglets were randomized to five experimental dietary groups(8 piglets per group):control diet(a basal diet without dietary fiber,CON),basal diet supplemented with 5%microcrys-talline cellulose(MCC),5%wheat bran(WB),5%Moringa oleifera leaf powder(MOLP),or 5%sugar beet pulp(SBP),fol-lowed by analyzing their growth performance and diarrhea rate in a 28-d *** the feeding experiment,anaesthetized piglets were killed,and their intestinal and colon content or plasma samples were analyzed in nutrient digestibility,intestinal morphology,intestinal barrier,short-chain fatty acids(SCFAs),and bacterial ***:In vitro studies showed low hydration properties for WB and MCC,while medium hydration properties for MOLP and *** vivo studies indicated that compared with medium hydration property groups,low hydration prop-erty groups showed(1)exacerbated diarrhea,impaired intestinal health,and reduced apparent fecal digestibility of dry matter,gross energy,acid detergent fiber,and neutral detergent fiber;(2)decreased SCFAs concentration and rela-tive levels of Lactobacillus and Bifidobacterium,but increased levels of Escherichia coli and Brachyspira hyodysenteriae in colon ***,SBP showed optimal performance in reducing diarrhea and increasing SCFAs *** analysis revealed a positive correlation of fiber hydration properties with in vitro SCFAs production,and diarrhea index and nutrient digestibility were negatively and positively correlated wi

关键词： Diarrhea Dietary fiber Hydration property Intestinal health Nutrient digestibility Weaned piglet

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nutritional strategies to alleviate oxidative stress in sows

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animal nutrition 2022年第2期9卷 60-73页

作者： Qihui Li Siwang Yang Fang Chen Wutai Guan Shihai Zhang Guangdong Province Key Laboratory of animal nutrition control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of animal Science and national engineering research center for breeding swine industry South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China

The performance of high-yielding sows is directly related to the productivity of pig farming. Fetaldevelopment mainly occurs during the last month of pregnancy, and the aggressive metabolic burden ofsows during this stage eventually leads to systemic oxidative stress. When affected by oxidative stress,sows exhibit adverse symptoms such as reduced feed intake, hindered fetal development, and evenabortion. In addition, milk synthesis during the lactation period causes a severe metabolic burden. Thebiological response to oxidative stress during this period is associated with a decrease in milk production,which further affects the growth of piglets. Understanding the nutritional strategies to alleviateoxidative stress in sows is crucial to maintain their reproduction and lactation performance. Recently,advances have been made in the field of nutrition to relieve oxidative stress in sows during late pregnancyand lactation. This review highlights the nutritional strategies to relieve oxidative stress in sowsreported within the last 20 years.

关键词： Sow Oxidative stress nutritional strategy Plant extract Selenium Vitamin E

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Maternal supply of cysteamine alleviates oxidative stress and enhances angiogenesis in porcine placenta

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Journal of animal Science and Biotechnology 2022年第1期13卷 181-196页

作者： Shuangbo Huang Zifang Wu Zihao Huang Xiangyu Hao Longmiao Zhang Chengjun Hu Jianfu Wei Jinping Deng Chengquan Tan Guangdong Provincial Key Laboratory of animal nutrition control National Engineering Research Center for Breeding Swine IndustryInstitute of Subtropical Animal Nutrition and FeedCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642GuangdongChina Guangzhou DaBeiNong Agri-animal Huabandry Science and Technology Co. Ltd.Guangzhou 510642GuangdongChina Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642GuangdongChina

Background:Oxidative stress in placenta is associated with the occurrence of adverse pregnancy outcomes in sow,but there are few satisfactory treatment strategies for these *** study investigated the potential of cysteamine(CS)as an antioxidant protectant for regulating the reproductive performance,redox status,and placental angiogenesis of ***:The placental oxidative stress status and vascular density of piglets with different birth weights:control group,dietary 100 mg/kg CS could(1)decrease the stillbirth and invalid rates,and increase both the piglet birth weight in the low yield sows and the placental efficiency;(2)increase glutathione and reduce malondialdehyde in both the serum and the colostrum of sows;(3)increase the levels of total antioxidant capacity and glutathione in LBW placentae;(4)increase the vascular density,the mRNA level of VEGF-A,and the immune-staining intensity of platelet endothelial cell adhesion molecule-1 in the LB

关键词： Angiogenesis Cysteamine Oxidative stress Placenta Sow

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Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance

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animal nutrition 2023年第3期14卷 213-224页

作者： Yingao Qi Tenghui Zheng Siwang Yang Qianzi Zhang Baofeng Li Xiangfang Zeng Yongxing Zhong Fang Chen Wutai Guan Shihai Zhang Guangdong Province Key Laboratory of animal nutrition control College of Animal ScienceSouth China Agricultural UniversityGuangzhou510642China College of animal Science and national engineering research center for breeding swine industry South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina State Key Laboratory of animal nutrition Ministry of Agriculture and Rural Affairs Feed Industry CenterChina Agricultural UniversityBeijingChina Chia Tai Conti Agri-Husbandry Group Co. LtdShenzhenChina

Milk yield and composition are critical determining factors for the early growth and development of *** objective of this experiment was to comprehensively evaluate the effects of dietary sodium acetate(SA)supplementation on the milk yield and composition of sows and the growth performance of their offspring.A total of 80 sows(Landrace×Yorkshire,3 to 6 parity)were randomly assigned to 2groups(with or without 0.1%SA)from d 85 of gestation to d 21 of *** result shows that maternal 0.1%SA supplementation significantly increased sows milk yield,milk fat,immunoglobulin A(IgA)and IgG content in milk(P<0.05),with the up-regulation of short-chain fatty acids receptors(GPR41 and GPR43)expression and the activation of mammalian target of rapamycin complex C1(mTORC1)signaling ***,in our in vitro experiment,SA also activated m TORC1signaling in porcine mammary epithelial cells(P<0.05).Furthermore,the improvement of milk quality and quantity caused by maternal SA supplementation led to the increase in body weight(BW)and average daily weight gain(ADG)of weaning piglets,with the improvement of gut health and colonization of the beneficial bacteria(P<0.05).In conclusion,maternal supplementation of 0.1%SA improved the lactation performance(milk yield and milk fat)of sows,possibly with the activation of GPR41/GPR43-mTORC1 ***,enhanced milk quality improved growth performance,gut health and the colonization of beneficial microbial flora of their piglets.

关键词： Sow Sodium acetate Lactation performance Milk fat Gut health

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