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Synthesis,Crystal Structure and Antimicrobial Activity of a New Ternary Copper(Ⅱ) Complex with p-Chlorophenoxyacetic Acid and 2-Amino Benzothiazole

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Chinese Journal of Structural Chemistry 2010年第5期29卷 676-681页

作者：辜海彬龙麟李萍萍王利陈武勇 national engineering laboratory for clean technology of leather manufacture Sichuan University

A novel ternary complex of Cu（pcpa）2（aben）2 （pcpa=p-chlorophenoxyacetic acid anion,aben=2-amino benzothiazole） was synthesized by the reaction of copper acetate,2-amino benzothiazole and p-chlorophenoxyacetic *** analysis,IR,UV and X-ray single-crystal diffraction were carried out to determine the composition and crystal *** crystal crystalli-zes in the monoclinic system,space group C2/c with a=25.795（4）,b=7.384（3）,c =17.741（6）,β=107.47（2）°,C30H24Cl2CuN4O6S2,Mr=735.09,V=3223.2（18） 3,Z=4,Dc=1.515 Mg/m3,λ（MoKα）=0.71073 ,μ=1.022 mm-1,F（000）=1500,the final R=0.0464 and wR=0.1244.A total of 3218 unique reflections were collected,of which 2228 with I 〉 2σ（I） were *** Cu（II） atom is four-coordinated with two carboxylate oxygen atoms of the two pcpa ligands and two nitrogen atoms in thiazole rings of two aben *** analysis of crystal structure shows intermolecular and intramolecular hydrogen bonds between amino-nitrogen atoms of the two aben ligands and carboxylate oxygen atoms of the two pcpa *** antimicrobial properties of the title complex and its two free ligands were tested against representative bacterial and fungal *** show that the antibacterial activity of the complex is less than or equal to that of 2-amino benzothiazole,but for yeasts and moulds,it exhibits excellent inhibitory effect better than that of its two free ligands.

关键词： benzothiazole p-chlorophenoxyacetic acid ternary copper complex crystalstructure antimicrobial activity

Biodegradability of leather:a crucial indicator to evaluate sustainability of leather

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Collagen and leather 2024年第04期6卷 39-47页

作者： Ya-nan Wang Yuxin Zhang Zhen Wang national engineering laboratory for clean technology of leather manufacture Sichuan University Key laboratory of leather Chemistry and engineering Sichuan University Ministry of Education College of Biomass Science and engineering Sichuan University

Biodegradability is a crucial indicator to evaluate the sustainability of ***,a rapid method for biodegradation test in an aqueous medium by measuring biochemical oxygen demand was used to determine the biodegradability of leather from different tanning methods,tanning conditions and process *** addition,the difference in biodegradability between leather and leather-like synthetic materials were investigated-Chrome-free tanned leather showed higher degree of biodegradation and faster biodegradation rate than chrome tanned *** them,leathers tanned with biomass-based tanning agents were much easier to biodegrade because the crosslinking network of tanned leather constructed with biomass was more susceptible to microbial *** enhancement of tanning effects through changing tanning methods and conditions(such as tanning agent dosage,pH and temperature) resulted in the decline of leather *** development of novel chrome-free tanning technologies should balance between these two *** biodegradability of leather from tanning to post-tanning to finishing showed a stepwise decrease because various chemicals were applied and bound to leather during *** so,finished leather still possessed significantly higher biodegradability compared to leather-like PU and microfiber synthetic materials,demonstrating superior environmental sustainability of natural *** results are expected to provide support for the evaluation of the ecological properties of leather and green upgrade of the leather industry.

关键词： Biodegradability BOD Chrome-free tanning leather Sustainability

Biomimetic Design of Oxidized Bacterial Cellulose-gelatin-hydroxyapatite Nanocomposites

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Journal of Bionic engineering 2016年第4期13卷 631-640页

作者： Mao Yang Wenjuan Zhen Hui Chen Zhihua Shan national engineering laboratory for clean technology leather manufacture Sichuan University Chengdu 610065 China Department of sports medicine Chengdu Sport University Chengdu 610041 China

Oxidized Bacterial Cellulose （OBC）-hydroxyapatite （HAp）-gelatin （Gel） nanocomposites were prepared by a biomimetic process. HAp nanocrystals were precipitated in a mixed solution ofNa2HPO4 （pH 9.2） and Gel solution at 37 ℃, and OBC was used to generate a three-dimensional （3D） network stent. The tensile strength of OBC-HAp-G was higher than 0.3 MPa, and the complete degradation time was approximately 90 d in Simulated Body Fluid （SBF）. Fourier transform infrared spectroscopy demonstrated that a coordinate bond had formed possibly between HAp and the cellulose hydroxyl. X-ray diffraction showed that both the oxidation of bacterial cellulose and an increase in Gel content induced the formation of tiny HAp crystallites during composite fabrication. Specific surface area and porosity measurements indicated that a low Gel concentration contributed to retention of porous structure. The Ca and P contents on the surface of materials increased initially and then decreased with an increase in Gel content, as measured by energy dispersive spectroscopy. From the thermogravimetric data, the increase in decomposition temperature suggested the formation of chemical bonds among OBC, HAp, and Gel. The above results suggest that the OBC-HAp-G0.3 composite is a potential bone scaffold material.

关键词： bacterial cellulose hydroxyapatite nanocomposite gelatin scaffold material

Amphiphilic block and random copolymers: aggregation and hydrophobic modification on metal-free tanned collagen fibers

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Collagen and leather 2024年第03期6卷 54-65页

作者： Yudan Yi Xinxin Fan Qijun Li Ya-nan Wang national engineering laboratory for clean technology of leather manufacture Sichuan University College of Biomass Science and engineering Sichuan University Key laboratory of leather Chemistry and engineering Ministry of EducationSichuan University

Hydrophobicity enhancement of metal-free leather, which is crucial for improving its comprehensive performance, can be achieved by using amphiphilic copolymer retanning agents. However, the relationship between the sequential structure and the hydrophobic modification effect of amphiphilic copolymers remains unclear. Herein, an amphiphilic block copolymer was synthesized using stearyl methacrylate and 2-(dimethylamino)ethyl methacrylate via atom transfer radical polymerization, and the corresponding random copolymer with similar monomer compositions and molecular weights was prepared for comparison. The aggregation behavior of block and random copolymers was investigated. DLS and TEM results indicate that the block copolymer exhibits a larger aggregate size than the corresponding random copolymer. Molecular dynamics simulations suggest that the block copolymer aggregate exhibit a thicker hydrophilic shell and more concentrated distribution of cationic DMA block than the random copolymer aggregate. Subsequently, the block and random copolymers were used for the hydrophobic modification of metal-free tanned collagen fibers(CFs). The block copolymer shows superior binding capacity to CFs than the random one because of its larger size and more concentrated charge distribution. Hence, the block copolymer can form a dense and uniform hydrophobic film on the surface of collagen fibrils and endow CFs with higher hydrophobicity than the random one. This work provides theoretical guidance for modulating the hydrophobicity of CFs by tailoring the sequential structure of amphiphilic copolymers, which is expected to inspire the manufacturing of high-perfor-mance metal-free leather.

关键词： Block copolymer Collagen fiber Hydrophobic modification Metal-free leather Random copolymer

A biomimetic and pH-sensitive polymeric micelle as carrier for paclitaxel delivery

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Regenerative Biomaterials 2018年第1期5卷 15-24页

作者： Boxuan Ma Weihua Zhuang Gongyan Liu Yunbing Wang national engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China national engineering laboratory of clean technology of leather manufacture Department of Biomass ChemistrySichuan UniversityChengdu 610064China

As nano-scale drug delivery systems,smart micelles that are sensitive to specific biological environment and allowed for target site-triggered drug release by reversible stabilization of micelle structure are *** this work,a biocompatible and pH-sensitive copolymer is synthesized through bridging poly(2-methacryloyloxyethyl phosphorylcholine)(PMPC)block and poly(D,L-lactide)(PLA)block by a benzoyl imine linkage(Blink).Biomimetic micelles with excellent biocompatibility based on such PLA-Blink-PMPC copolymer are prepared as carriers for paclitaxel(PTX)*** to the rapid breakage of the benzoyl imine linkage under acidic condition,the micelle structure is disrupted with accelerated PTX *** pH-sensitive triggered drug release behavior in synchronization with acidic conditions at tumor site is helpful for improving the utilization of drug and facilitating antitumor *** micelles can be used as promising drug delivery systems due to their biocompatible and smart properties.

关键词： pH sensitive polymeric micelles drug delivery biomimetic

A fully absorbable biomimetic polymeric micelle loaded with cisplatin as drug carrier for cancer therapy

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Regenerative Biomaterials 2018年第1期5卷 1-8页

作者： Weihua Zhuang Boxuan Ma Gongyan Liu Xiaobing Chen Yunbing Wang national engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Biomass Chemistry National Engineering Laboratory of Clean Technology of Leather ManufactureSichuan UniversityChengdu 610064China

cis-dichlorodiammineplatinum(II)(CDDP)-loaded polymeric micelles for cancer therapy have been developed to reduce the serious side effects of cisplatin ***,polymeric micelles incorporated with cisplatin are prepared based on the complexation between CDDP and hydrophilic poly(L-glutamic acid)-b-poly(2-methacryloyloxyethyl phosphorylcholine)(PLG-b-PMPC)diblock *** CDDP-loaded micelles possess an average size of 91nm with narrow distribution,providing remarkable stability in media containing *** release of CDDP from the micelles is faster at pH 5.0 and pH 6.0 than that at pH 7.4 and in a sustained manner without initial burst *** addition,there is almost no difference in cellular uptake between these CDDP-loaded micelles and free ***,in vitro cytotoxicity test shows they possess high efficacy to kill 4T1 cells as compared with free ***,PLG-b-PMPC copolymer might be a promising carrier for CDDP incorporating in cancer therapy.

关键词： drug delivery cisplatin polymeric micelles cancer therapy

Effects of bactericide-protease interactions on the protease-assisted soaking performance

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Collagen and leather 2023年第3期5卷 48-59页

作者： Hao Liu Yahang Pan Bi Shi Yunhang Zeng national engineering laboratory for clean technology of leather manufacture Sichuan UniversityChengdu 610065China College of Biomass Science and engineering Sichuan UniversityChengdu 610065China

Protease-assisted soaking has received increasing attention in recent ***,few reports have elaborated on the effect of bactericides,which are used to protect raw hides from microbial damage in the soaking process,on the performance of protease-assisted *** we investigate the effects of three bactericides,namely,2-methyl-4-isothiazolin-3-one(MIT),sodium propyl 4-hydroxybenzoate(SPHB)and cetyl trimethyl ammonium bromide(CTAB),on the catalytic activity of *** and SPHB have little effect on the proteolytic activity,whilst CTAB has a negative *** spectroscopy,synchronous fluorescence spectroscopy,molecular docking and molecular dynamics simulation were used to analyse the bactericide-protease *** data reveal that MIT and SPHB are bound to the non-catalytic sites of protease,whilst CTAB affects the catalytic triad of ***,the protease and bactericides were used alone,simultaneously and sequentially in the soaking process,and their soaking performances were *** evaluation shows that the use of protease increases the microorganisms in the soaking float,and MIT exhibits the best bactericidal *** simultaneous use of protease and MIT effectively inhibits bacteria and scarcely affects the removal of unstructured proteins from hides and the attack on epidermis by *** findings contribute to a better understanding of the scientific use of protease with other auxiliaries in soaking.

关键词： Protease Bactericide leather Soaking

Skin collagen fiber-based radar absorbing materials

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Chinese Science Bulletin 2011年第2期56卷 202-208页

作者： LIU YiShan HUANG Xin GUO PeiPei LIAO XuePin SHI Bi Department of Biomass Chemistry and engineering Sichuan University Chengdu 610065 China' national engineering laboratory for clean technology of leather manufacture Sichuan University Chengdu 610065 China

By using skin collagen fiber (CF) as raw material,Schiff base structure containing CF (Sa-CF) was synthesized through CF-salicylaldehyde *** a novel radar absorbing material (Fe-Sa-CF) was prepared by chelating reaction between Sa-CF and Fe 3+.The coaxial transmission and reflection method was used to analyze the complex permittivity and complex magnetic permeability of these CF-based materials,and the radar cross section (RCS) method was used to investigate their radar absorbing properties in the frequency range of 1.0-18.0 *** results indicated that the conductivity of CF increased from initial 1.08×10-11 to 2.86×10-6 S/cm after being transferred into Fe-Sa-CF,and its dielectric loss tangent (tanδ) in the frequency range of 1.0-17.0 GHz also *** facts suggest that the Fe-Sa-CF is electric-loss type radar absorbing *** the frequency range of 3.0-18.0 GHz,Sa-CF (1.0 mm in thickness) exhibited somewhat radar absorbing property with maximum radar reflection loss (RL) of-4.73 *** for Fe-Sa-CF,the absorbing bandwidth was broadened,and the absorbing intensity significantly increased in the frequency range of 1.0-18.0 GHz where a maximum radar RL of-9.23 dB was *** addition,the radar absorbing intensity of Fe-Sa-CF can be further improved by increasing membrane *** the thickness reached to 2.0 mm,the RL values of Fe-Sa-CF were-15.0-18.0 dB in the frequency range of 7.0-18.0 ***,a kind of novel radar absorbing material can be prepared by chemical modification of collagen fiber,which is characterized by thin thickness,low density,broad absorption bandwidth and high absorption intensity.

关键词：雷达吸波材料胶原纤维皮肤介电损耗角正切吸收强度频率范围 CF卡千兆赫

A collagen-based electrolyte-locked separator enables capacitor to have high safety and ionic conductivity

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Journal of Energy Chemistry 2020年第8期29卷 324-332,I0011页

作者： Heng Xu Yaping Wang Xuepin Liao Bi Shi Biomass Chemistry and engineering Department Sichuan UniversityChengdu 610065SichuanChina national engineering laboratory for clean technology of leather manufacture Sichuan UniversityChengdu 610065.SichuanChina Key laboratory of leather Chemistry and engineering of Ministry of Education Sichuan UniversityChengdu 610065Sichuan.China

The conventional liquid electrolytes(LEs) have a high level of ionic conductivity;however, they often suffer from the poor processability and safety risks of potential leakage. Although solid-state electrolytes(SSEs) can solve these inherent problems of LEs, the ionic conductivity of most SSEs is several magnitudes lower than these of LEs. Herein, we report a novel strategy by building liquid ion-transport channels in a solid framework and prepared an electrolyte-locked separator(ELS) using a collagen fiber membrane(CFm). The liquid electrolyte was primarily infiltrated in the smaller voids of CFm, and its ionic conductivity could attain to 9.0×10-3 S cm-1 when the electrolyte absorption(EA) reached up to 112.0%. After centrifuging treatment, the electrolyte retentions(ER) and ionic conductivities of ELS were 108.93% and 8.37×10-3 S cm-1, respectively, which were much higher than those of commercial cellulose separator(CS), exerting excellent liquid-locking performances. In particular, the electrical double-layer capacitors(EDLC) assembled by ELS or CS were characterized and exhibited similar electrochemical performance,demonstrating the satisfactory ability and applicability of ELS for commercial use. In addition, the ELSbased EDLC exhibited favorable flexibility with relative lower loss of capacitance under different angles of bending.

关键词： Collagen fiber Ionic conductivity Capillary force Electrolyte retention EDLC