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Safety assessment of a novel marine multi-stress-tolerant yeast Meyerozyma guilliermondii GXdK6 according to phenotype and whole genome-sequencing analysis

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food Science and Human Wellness 2024年第4期13卷 2048-2059页

作者： Xueyan Mo Mengcheng Zhou Yanmei Li Lili Yu Huashang Bai Peihong Shen Xing Zhou Haojun Zhu Huijie Sun ru Bu Chengjian Jiang State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi Research Center for Microbial and Enzyme Engineering TechnologyCollege of Life Science and TechnologyGuangxi UniversityNanning 530004China national Engineering research center for non-food Biorefinery State Key Laboratory of Non-Food Biomass and Enzyme TechnologyGuangxi Research Center for Biological Science and TechnologyGuangxi Academy of SciencesNanning 530007China Guangxi Key Laboratory for Green Processing of Sugar resources College of Biological and Chemical EngineeringGuangxi University of Science and TechnologyLiuzhou 545006China

The application of microorganisms as probiotics is limited due to lack of safety ***,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXdK6 with aroma-producing properties was identified from marine mangrove *** safety and probiotic properties were assessed in accordance with phenotype and whole-genome sequencing *** showed that the genes and phenotypic expression of related virulence,antibiotic resistance and retroelement were rarely *** morphogenesis genes(SIT4,HOG1,SPA2,ErK1,ICL1,CST20,HSP104,TPS1,and rHO1)and phospholipase secretion gene(VPS4)were *** hyphae and phospholipase were *** one retroelement(Tad1-65_BG)was *** biogenic amines(BAs)encoding genes were absent,except for spermidine synthase(JA9_002594),spermine synthase(JA9_004690),and tyrosine decarboxylase(inx).The production of single BAs and total BAs was far below the food-defined ***6 had no resistance to common antifungal *** enzymes,such as gelatinase,dNase,hemolytic,lecithinase,and thrombin were *** toxicity test with mice demonstrated that GXdK6 is ***6 has a good reproduction ability in the simulation gastrointestinal ***6 also has a strong antioxidant ability,β-glucosidase,and inulinase *** sum up,GXdK6 is considered as a safe probiotic for human consumption and food fermentation.

关键词： Meyerozyma guilliermondii Safety assessment Probiotics Marine mangrove microorganisms Whole-genome sequencing analysis

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Effect of ellagitannin metabolites ellagic acid and urolithins A-d on the non-enzymatic glycation of human serum albumin and inhibiting mechanisms

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food Science and Human Wellness 2024年

作者： Lu Zhang Chun-yan Peng Wen-na Zhou Fei-yan Lu Lin-ju Xu Qing-hui Wen Xing Xie Zong-cai Tu national r&d center of Freshwater Fish Processing， College of Life Science， Jiangxi Normal University State Key Laboratory of food Science and resources， Nanchang University

Effect of ellagitannins gut microbiota metabolites ellagic acid (EA) and urolithin A-urolithin d (UroA-Urod) on human serum albumin (HSA) glycation were firstly evaluated in this research. The inhibition mechanisms were investigated by methylglyoxal (MGO) trapping and radical scavenging ability assays， docking studies and Nano LC-Orbitrap-MS/MS technology. results indicated that the inhibition of urolithins on HSA glycation was highly positive correlated with the number of phenolic hydroxy groups. Addition of Urod and EA could effectively enhance the content of free amino group， suppress dicarbonyl compounds and advanced glycation end-products (AGEs) formation， alleviated tryptophan and protein oxidation， inhibited HSA amyloid-like aggregation. They could also trap MGO and scavenge dPPH· and ABTS·+. Molecular docking indicated that EA and UroA-Urod interact with HSA mainly through hydrogen bound and hydrophobic interaction， among which two or three hydrogen bonds were formed. The number of glycation sites were reduced from 11 to 10， 10， 7， and 10， respectively， when 90 μmol/L of EA， UroA， UroC and Urod were added. However， weak inhibition was observed on UroA and UroB. These findings can provide scientific evidence for the application of ellagitannins-rich foods in alleviating diabetic complications.

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Optical sensor array for the discrimination of liquors

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未来食品学报(英文) 2024年第1期4卷 48-60页

作者： Yang Yu Fangfang Shi Yi Zhang Fei Li Jinsong Han State Key Laboratory of Natural Medicines National R&D Center for Chinese Herbal Medicine ProcessingDepartment of Food Quality and SafetyCollege of EngineeringChina Pharmaceutical UniversityNanjing 210009China

The discrimination of liquors plays a vital role in our daily life as a large amount of cheap alcoholic beverages and low-quality counterfeits greatly damage the health of ***-based optical sensors have been developed as a fast and effective tool to discriminate multi-analytes or complex mixtures with similar structures,such as acids,esters,aldehydes and *** the past decades,optical sensor arrays have demonstrated remarkable capabilities in fast and accurate detection of diverse types,qualities,and authentic *** identification strategy mainly focuses on the specific/non-specific interactions of flavor compounds in liquors with sensor *** cross-reactive optical signal readouts from the combination of sensor elements with liquors and multiple machine learning algorithms are essential to ensure the discriminatory capability of sensing *** this review,we discuss the advantages and recent advances in pattern recognition of liquors in terms of the design of various types of sensing materials and the construction strategies of sensor arrays.

关键词： Sensor array Chemical tongue Chemical nose Liquors Fluorescent Colorimetric Pattern recognition Machine learning algorithm

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3-Epi-betulinic acid 3-O-β-d-glucopyranoside(eBAG)induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma

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food Science and Human Wellness 2024年第3期13卷 1453-1464页

作者： Mengjie Liu Xuqiang Liu Kaiyue He Yongping Jian Yujia Li Jinrong Guo Jingyu Yang Zhixiang Xu Wenyi Kang School of Life Sciences Henan UniversityKaifeng 475004China national r&d center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International research Laboratory of food&Medicine resource Function Kaifeng 475004China Shenzhen research Institute of Henan University Shenzhen 518000China

3-Epi-betulinic acid 3-O-β-d-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological ***,whether these functions are attributed to eBAG or additional components in these plants remain ***,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer *** induced non-apoptotic cell death in hepatocellular carcinoma *** eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux *** demonstrated that eBAG induced an autophagy-mediated cell *** of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of ***-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by *** further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in *** a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.

关键词： eBAG Autophagy ATP AMPK Hepatocellular carcinoma

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P-induced electron transfer interaction for enhanced selective hydrogenation rearrangement of furfural to cyclopentanone

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Journal of energy Chemistry 2024年第5期92卷 43-51页

作者： Weichen Wang Hongke Zhang Yidan Wang Fangyuan Zhou Zhiyu Xiang Wanbin Zhu Hongliang Wang center of biomass Engineering College of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China

Optimizing the intrinsic activity of non-noble metal by precisely tailoring electronic structure offers an appealing way to construct cost-effective catalysts for selective biomass ***,we reported a P-doping bifunctional catalyst(Ni-P/mSiO_(2))that achieved 96.6%yield for the hydrogenation rearrangement of furfural to cyclopentanone at mild conditions(1 MPaH_(2),150°C).The turnover frequency of Ni-P/mSiO_(2)was 411.9 h^(-1),which was 3.2-fold than that of Ni/mSiO_(2)(127.2 h^(-1)).detailed characterizations and differential charge density calculations revealed that the electron-deficient Niδ+species were generated by the electron transfer from Ni to P,which promoted the ring rearrangement *** functional theory calculations illustrated that the presence of P atoms endowed furfural tilted adsorb on the Ni surface by the C=O group and facilitated the desorption of *** work unraveled the connection between the localized electronic structures and the catalytic properties,so as to provide a promising reference for designing advanced catalysts for biomass valorization.

关键词： Furfural Hydrogenation rearrangement P-doping Electron transfer biomass valorization

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The biosynthesis of asiaticoside and madecassoside reveals tandem duplication-directed evolution of glycoside glycosyltransferases in the Apiales

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Plant Communications 2024年第10期5卷 166-179页

作者： Xiaoyang Han Jingyi Zhao Hong Zhou Xuan Zhou Zixin deng Zhenhua Liu Yi Yu department of Gastroenterology Zhongnan Hospital of Wuhan UniversityHubei Clinical Center and Key Laboratory of Intestinal and Colorectal DiseaseSchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Joint center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of non-food biomass and Enzyme Technology Guangxi Academy of SciencesNanning 530007China

Certain plant species within the Apiales order accumulate triterpenoid saponins that feature a distinctive glucose-glucose-rhamnose(G-G-r)sugar chain attached at the C-28 position of the pentacyclic triterpene *** recently,the genomic basis underlying the biosynthesis and evolution of this sugar chain has remained *** this study,we identified two novel glycoside glycosyltransferases(GGTs)that can sequentially install the sugar chain’s second d-glucose and third L-rhamnose during the biosynthesis of asiaticoside and madecassoside,two representative G-G-r sugar chain-containing triterpenoid saponins produced by Centella *** assays revealed the remarkable substrate promiscuity of the two GGTs and the key residues crucial for sugar-donor selectivity of the glucosyltransferase and rhamnosyl*** further identified syntenic tandem gene duplicates of the two GGTs in the Apiaceae and Araliaceae families,suggesting a well-conserved genomic basis underlying sugar chain assembly that likely has evolved in the early ancestors of the Apiales ***,expression patterns of the two GGTs in pierced leaves of *** were found to be correlated with the production of asiaticoside and madecassoside,implying their involvement in host defense against herbivores and *** work sheds light on the biosynthesis and evolution of complex saponin sugars,paving the way for future engineering of diverse bioactive triterpenoids with unique glycoforms.

关键词： triterpenoid saponin glycoside glycosyltransferases biosynthesis asiaticoside madecassoside Centella asiatica

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Herpetrione, a New Type of PPArα Ligand as a Therapeutic Strategy Against nonalcoholic Steatohepatitis

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research 2024年第3期2023卷 513-527页

作者： Lang Linghu Wei Zong Yixuan Liao Qianyu Chen Fancheng Meng Guowei Wang Zhihua Liao Xiaozhong Lan Min Chen Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Scholof Pharmacy Zunyi Medical UniversityZunyi 563000China School of Life Sciences Integrative Science center of Germplasm Creation in Western China(CHONGQING)Science City and Southwest University TAAHC SWU Medicinal Plant Joint R&D CentreSouthwest UniversityChongqing 400715China TAAHC-SWU Medicinal Plant r&d center Tibet Agricultural and Animal Husbandry UniversityNyingchiTibet 860000China.

non-alcoholic fatty liver disease, especially nonalcoholic steatohepatitis (NASH), is a leading cause of cirrhosis and liver cancer worldwide;nevertheless, there are no food and drug Administration-approved drugs for treating NASH until now. Peroxisome proliferator-activated receptor alpha (PPArα) is an interesting therapeutic target for treating metabolic disorders in the clinic, including NASH. Herpetrione, a natural lignan compound isolated from Tibetan medicine Herpetospermum caudigerum, exerts various hepatoprotective effects, but its efficacy and molecular mechanism in treating NASH have not yet been elucidated. Here, we discovered that herpetrione lessened lipid accumulation and inflammation in hepatocytes stimulated with oleic acid and lipopolysaccharide, and effectively alleviated NASH caused by a high-fat diet or methionine-choline-deficient diet by regulating glucolipid metabolism, insulin resistance, and inflammation. Mechanistically, rNA-sequencing analyses further showed that herpetrione activated PPAr signaling, which was validated by protein expression. Furthermore, the analysis of molecular interactions illustrated that herpetrione bound directly to the PPArα protein, with binding sites extending to the Arm III domain. PPArα deficiency also abrogated the protective effects of herpetrione against NASH, suggesting that herpetrione protects against hepatic steatosis and inflammation by activation of PPArα signaling, thereby alleviating NASH. Our findings shed light on the efficacy of a natural product for treating NASH, as well as the broader prospects for NASH treatment by targeting PPArα.

关键词： PPArα protective metabolism

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Nitrogen removal Improvement by Adding Peat in deep Soil of Subsurface Wastewater Infi ltration System

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Journal of Integrative Agriculture 2014年第5期13卷 1113-1120页

作者： CHEN Pei-zhen CUI Jian-yu HU Lin ZHENG Miao-zhuang CHENG Shan-ping HUANG Jie-wen MU Kang-guo College of resources and Environmental Sciences China Agricultural University national energy r&d center for non-food biomass of China China Agricultural University

In order to enhance the nitrogen removal, a subsurface wastewater infiltration system （SWIS） was improved by adding peat in deep soil as carbon source for denitrification process. The effects of addition of carbon source in the underpart of the SWIS on nitrogen removal at different influents （with the total nitrogen （TN） concentration 40 and 80 mg L^-1, respectively） were investigated by soil column simulating experiments. When the relatively light pollution influent with 40 mg L^-1 TN was used, the average concentrations of NO3-N and TN in effluents were （4.69±0.235）, （6.18±0.079） mg L^-1, respectively, decreased by 32 and 30.8% than the control; the NO3--N concentration of all effluents was below the maximum contaminant level of 10 mg L^-1; as high as 92.67% of the TN removal efficiency was achieved. When relatively heavy pollution influent with 80 mg LITN was used, the average concentrations of NO3--N and TN in effluents were （10.2±0.265）, （12.5±0.148） mg L^-1 respectively, decreased by 20 and 21.2% than the control; the NO3--N concentration of all effluents met the grade Ⅲ of the national quality standard for ground water of China （GB/T 14848-1993） with the values less than 20 mg L^-1; the TN removal efficiency of 94.1% was achieved. In summary, adding peat in the underpart of the SWIS significantly decreased TN and NO3- -N concentration in effluents and the nitrogen removal efficiency improved significantly.

关键词： peat addition nitrogen removal efficiency denitrification subsurface wastewater infiltration system

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Molten metal-organic complex to synthesize versatile ultrathin nonlayered oxides

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Nano research 2024年第4期17卷 3147-3155页

作者： Kaisi Liu Jiabin Wu Qun Li Hongrun Jin Yongxin Luo Bei Qi Simin dai Jianquan Zhao Liang Huang Jun Zhou Hubei Key Laboratory of biomass Fibers and Eco-dyeing&Finishing Wuhan Textile UniversityWuhan 430200China Wuhan national Laboratory for Optoelectronics School of Optical and Electronic InformationHuazhong University of Science and TechnologyWuhan 430074China Analytical and Testing center Huazhong University of Science and TechnologyWuhan 430074China

Two-dimensional(2d)materials have attracted a great deal of research interest because of their unique electrical,magnetic,optical,mechanical,and catalytic properties for various *** date,however,it is still difficult to fabricate most functional oxides as 2d materials unless they have a layered ***,we report a one-step universal strategy for preparing versatile non-layered oxide nanosheets by directly annealing the mixture of metal nitrate and dimethyl imidazole(2-MI).The 2-MI plays the key role for 2d oxides since 2-MI owns a very low molten point and sublimation temperature,in which its molten liquid can coordinate with metal ions,forming a metal-organic framework,and easily puffing by its gas molecules.A total of 17 materials were prepared by this strategy,including non-layered metal oxide nanosheets as well as metal/metal oxide loaded nitrogen-doped carbon *** as-prepared cobalt particle-loaded nitrogen-doped carbon nanosheets(Co@N/C)exhibit remarkable bifunctional oxygen reduction reaction(Orr)and oxygen evolution reaction(OEr)electrocatalytic activity and ***,the Zn-air battery utilizing a Co@N/C catalyst exhibits high power density of 174.3 mW·cm^(-2).This facile strategy opens up a new way for large-scale synthesis of 2d oxides that holds great potential to push 2d oxides for practical applications.

关键词： non-layered oxide nanosheet metal/metal oxide@N/C oxygen evolution reaction(OEr) oxygen reduction reaction(Orr) Zn-air battery

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Tb^(3+)-nucleic acid probe-based label-free and rapid detection of mercury pollution in food

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food Science and Human Wellness 2024年第2期13卷 993-998页

作者： Xuhan Xia Chenxi Zhou Yulin Zhu Yi dong Qiang He Mohammad rizwan Khan Yuanlong Chi rosa Busquets ruijie deng Yao ren College of biomass Science and Engineering Healthy Food Evaluation Research CenterSichuan UniversityChengdu 610065China department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia School of Life Sciences Pharmacy and ChemistryKingston University LondonKingston Upon Thames KT12EEUK

Mercury is a threatening pollutant in food,herein,we developed a Tb^(3+)-nucleic acid probe-based label-free assay for mix-and-read,rapid detection of mercury *** assay utilized the feature of light-up fluorescence of terbium ions(Tb^(3+))via binding with single-strand *** ion,Hg^(2+)induced thymine(T)-rich dNA strand to form a double-strand structure(T-Hg^(2+)-T),thus leading to fluorescence *** on the principle,Hg^(2+)can be quantified based on the fluorescence of Tb^(3+),the limit of detection was 0.0689μmol/L and the linear range was 0.1-6.0μmol/*** to the specificity of T-Hg^(2+)-T artificial base pair,the assay could distinguish Hg^(2+)from other metal *** recovery rate was ranged in 98.71%-101.34%for detecting mercury pollution in three food *** assay is low-cost,separation-free and mix-to-read,thus was a competitive tool for detection of mercury pollution to ensure food safety.

关键词： Mercury pollution food safety Nucleic acid probe Label-free Terbium

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