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Analysis of the efficacy of transcatheter arterial infusion chemotherapy in the treatment of pancreatic carcinoma

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Journal of Interventional Medicine 2021年第1期4卷 21-26页

作者： Chunhui Nie Yuelin Zhang Guanhui Zhou Tanyang Zhou Tongyin Zhu Baoquan Wang Shengqun Chen Hongliang Wang Ziniu Yu Li Jing Junhui Sun Hepatobiliary and Pancreatic Interventional Treatment center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou310003Zhejiang ProvinceChina Zhejiang Provincial research center for Diagnosis and Treatment of Hepatobiliary diseases Hangzhou310003Zhejiang ProvinceChina Zhejiang clinical research center of Hepatobiliary and Pancreatic diseases Hangzhou310003Zhejiang ProvinceChina

Objective:To evaluate the clinical efficacy of infusion of gemcitabine(GEM) and fluorouracil(5-FU)through the celiac artery and superior mesenteric artery in the treatment of pancreatic carcinoma(PC).Methods:We analyzed 20 patients diagnosed clinically or pathologically with PC,without metastases,who had an estimated survival duration of>3 months in our department from May 2009 to December *** patients were treated directly without surgical resection of the tumor,while the other 11 patients were treated after *** all patients,the femoral artery was punctured using the Seldinger technique,and a catheter was placed in the opening of the celiac artery or the superior mesenteric *** administered 500 mg/m2 GEM and 500 mg/m2 *** data included data on clinical efficacy and survival rates during the follow-up period of 3-72 ***:Twenty patients were treated 85 times with transcatheter arterial infusion chemotherapy(TAI).The survival rates were 80%,40%,35%,20%,10%,and 5% at 3,6,12,24,and 72 months,***: TAI chemotherapy with GEM and 5-FU may be a therapeutic option for the treatment of PC.

关键词： Transcatheter arterial infusion Chemotherapy Pancreatic carcinoma

Multimode imaging characteristics and treatment of uveal schwannoma

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 446-452页

作者： Ting Zhang Lu-Jia Feng You Wang Yun-Hong Shi Li Wang Yi-Meng Sun Yan-Tao Wei Shao-Chong Zhang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina Ophthalmology Shenzhen Eye Hospital Affiliated to Jinan UniversityShenzhen Key Laboratory of OphthalmologyShenzhen 518040Guangdong ProvinceChina

AIM: To delineate the different imaging characteristics of uveal schwannoma from melanoma and discuss the optimal treatment strategy for intraocular ***: Case series of three patients diagnosed with intraocular schwannoma was collected at Zhongshan Ophthalmic center, Guangzhou, China from July 2014 to December *** the study patients underwent ultrasonography and magnetic resonance imaging(MRI).The clinical features, therapeutic strategies, and prognoses of all patients were ***: Ultrasonography of all three patients(all females, mean age, 39y, age range, 23-54y) showed low to medium reflectivity with a homogeneous internal *** of all three patients demonstrated isointensity on T1-weighted imaging spin-echo(T1WI SE) images and hypointense on fast spin-echo T2-weighted images(FSE T2WI) images with respect to the *** invasive pars plana vitrectomy(PPV) and local resection of the tumor was performed for all patients, and the diagnosis of schwannoma was confirmed by histopathological ***: The present study indicates that ultrasonography and MRI features of uveal schwannoma may contribute to the differentiation of uveal schwannoma from melanoma, and the optimal therapy for intraocular schwannoma is minimally invasive PPV and local resection.

关键词： uveal schwannoma ultrasonography magnetic resonance imaging imaging characteristics pars plana vitrectomy

Effectiveness and the nomogram of small incision lenticule extraction in the correction of myopic anisometropia in adults

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1838-1844页

作者： Tong Zhang Lu Zhu Hang-Jia Zuo Zhi-Jun Chen Yan Ji Xin Yang Xiao-Rong Lu Qiong Wu Qing Wang Jiu-Yi Xia Meng Li Chun-Jiang Zhou Yao Wang Ke Hu Wen-Juan Wan Nomogram of SMILE surgery for adult anisometropia 1Chongqing Medical University Chongqing 400000China The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of OphthalmologyChongqing Eye InstituteChongqing Branch(Municipality Division)of National Clinical Research Center for Ocular DiseasesChongqing 400000China

AIM:To evaluate the safety,effectiveness,and predictability of small incision lenticule extraction(SMILE)for the treatment of anisometropia,and to explore the personalized design scheme of SMILE in correcting adult myopia anisometropia based on the ***:It’s a prospective cohort *** with anisometropic myopia of refractive difference≥2.0 diopters(D)who underwent SMILE between September 2020 and March 2021 were *** features and visual function were assessed preoperatively and at 1wk,1,3,and 6mo after the *** examination included tests for uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),refractive errors,effectiveness index(preoperative CDVA/postoperative UDVA),safety index(postoperative CDVA/preoperative CDVA),nomogram and stereoscopic *** t-test,Wilcoxon signed-rank test and repeated-measures analyses of variance were used for continuous variables,and Pearson Chi-squared test was used for categorical ***:The study involved 45 consecutive patients(average age:25.0±6.9y;82 out of 90 eyes underwent SMILE,while 8 eyes were not operated).The average preoperative spherical equivalent(SE)was-4.74±0.22 *** months after surgery,the effectiveness index was 1.05±0.12,and the safety index was 1.09±*** eyes(85.4%)exhibited SE correction error within±0.5 *** percentage of eyes with Titmus stereoscopic function equal to or less than 200”significantly increased from 55.6%preoperatively to 88.9%postoperatively(P<0.05).There was statistically significant difference between higher myopia eyes and contralateral eyes in average nomogram value/spherical refraction ***:SMILE is safe,effective and predictable in correcting myopic anisometropia,and it improves stereoscopic visual function of anisometropia *** precise and individualized design of the nomogram is a vital element to ensure the balance of both eyes after SMILE.

关键词： refractive surgery small incision lenticule extraction anisometropia nomogram

ALYREF mediates RNA m^(5)C modification to promote hepatocellular carcinoma progression

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1375-1377页

作者： Chen Xue Xinyu Gu Qiuxian Zheng Qingmiao Shi Xin Yuan Yuanshuai Su Junjun Jia Jianwen Jiang Juan Lu Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

Dear Editor,The incidence of hepatocellular carcinoma(HCC)is increasing in many countries due to hepatic virus infection and unhealthy diet habits,and the unsatisfactory overall survival rate calls for novel treatments with higher efficacy.1 Recent studies have shown that RNA modifications are likely to participate in the progression of HCC,2 suggesting new methods for tumor growth ***,5-methylcytosine(m5C)is one of the most interesting RNA modification types,as accumulating evidence suggests its role in the promotion of HCC tumorigenesis.3 The RNA methyltransferase Aly/REF export factor(ALYREF)is considered one type of“reader”protein located in the nucleus that recognizes and binds directly with m5C sites in RNA and facilitates the export of RNA from the nucleus to the cytoplasm.4 Notably,ALYREF is considered a promising target for diagnosis and prognosis prediction.5 However,until now,the low number of related studies has limited the understanding of the mechanism of the HCC-promoting effects of ALYREF.

关键词： hepatocellular diagnosis likely

Metabolic memory:mechanisms and diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1086-1114页

作者： Hao Dong Yuezhang Sun Lulingxiao Nie Aimin Cui Pengfei Zhao Wai Keung Leung Qi Wang State Key Laboratory of Oral diseases&national center for Stomatology&national clinical research center for Oral diseases West China Hospital of StomatologySichuan UniversityChengduChina Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengduChina Periodontology and Implant Dentistry division Faculty of DentistryThe University of Hong KongHong KongChina

Metabolic diseases and their complications impose health and economic burdens *** from past experimental studies and clinical trials suggests our body may have the ability to remember the past metabolic environment,such as hyperglycemia or hyperlipidemia,thus leading to chronic inflammatory disorders and other diseases even after the elimination of these metabolic *** long-term effects of that aberrant metabolism on the body have been summarized as metabolic memory and are found to assume a crucial role in states of health and *** molecular mechanisms collectively participate in metabolic memory management,resulting in different cellular alterations as well as tissue and organ dysfunctions,culminating in disease progression and even affecting *** elucidation and expansion of the concept of metabolic memory provides more comprehensive insight into pathogenic mechanisms underlying metabolic diseases and complications and promises to be a new target in disease detection and ***,we retrace the history of relevant research on metabolic memory and summarize its salient *** provide a detailed discussion of the mechanisms by which metabolic memory may be involved in disease development at molecular,cellular,and organ levels,with emphasis on the impact of epigenetic ***,we present some of the pivotal findings arguing in favor of targeting metabolic memory to develop therapeutic strategies for metabolic diseases and provide the latest reflections on the consequences of metabolic memory as well as their implications for human health and diseases.

关键词： diseases metabolism alterations

Prevalence and inconformity of refractive errors and ocular biometry of 3573 medical university freshman students for 4 consecutive years

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 807-812页

作者： Hui-Juan Gao Hong-Mei Zhang Wei-Yu Dang Lin Liu Yun Zhu Qing He Xin Wang Yan-Hui Chen Fei Gao Qing-Xin Wang Hua Rong Shu-Ling Niu Rui-Hua Wei Tianjin Key Laboratory of Retinal Functions and diseases Tianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjinChina Tianjin Third Central Hospital-Branch TianjinChina Department of Epidemiology and Biostatistics Tianjin Medical UniversityTianjinChina Tangshan Eye Hospital TangshanHebei ProvinceChina

AIM:To evaluate the prevalence of refractive errors and ocular biometry in 3573 freshman students at Tianjin Medical University for 4 consecutive ***:In this university-based, cross-sectional study, comprising 3573 students, visual acuity(VA), slitlamp examination, non-cycloplegic auto-refraction, and ocular biometry were ***:The prevalence of myopia increased annually, from 2017 to 2020 were 93.5%, 94.5%, 95.9%, and 96.2%, respectively(P=0.03), and the prevalence of high myopia was 25.7%, 26.9%, 28.6%, and 28.6%, respectively. Males tended to have a higher percentage of total astigmatism than females, with astigmatism ≥0.75 and ≥1.0 D criteria. The percentage of with-the-rule astigmatism, against-therule astigmatism, and oblique astigmatism was 90.3%, 5.8%, and 3.9%, respectively, with astigmatism ≥1.00 D criteria. The mean spherical equivalent, axial length(AL), central corneal thickness(CCT), anterior chamber depth(ACD), lens thickness(LT), corneal radius(CR), and lens position(LP) were 4.37±2.52 D, 25.28±1.24 mm, 539.49±34.98 μm, 3.31±0.34 mm, 3.47±0.21 mm, 7.8±0.28 mm, and 5.04±0.32 mm, respectively. With diopter increase in myopia, the AL became longer, CR became steeper, ACD became deeper, LT became thinner, and LP became more posterior(all Pocular biometry existed in some students. Attention should be paid to the ocular biometry

关键词： refractive errors myopia prevalence ocular biometry astigmatism

Neuroprotective effect of mesenchymal stem cellderived extracellular vesicles on optic nerve injury in chronic ocular hypertension

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Neural Regeneration research 2023年第10期18卷 2301-2306页

作者： Fei Yu Yao Wang Chang-Quan Huang Si-Jie Lin Ru-Xin Gao Ren-Yi Wu Department of Glaucoma Eye Institute and Affiliated Xiamen Eye Center of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenFujian ProvinceChina Fujian Provincial Key Laboratory of Corneal&ocular Surface diseases XiamenFujian ProvinceChina Shaanxi Provincial Key Lab of Ophthalmology Shaanxi Clinical Study Center for Ocular DiseaseShaanxi Institute of OphthalmologyFirst Affiliated HospitalMedical SchoolNorthwest UniversityXi’anShaanxi ProvinceChina Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceXiamenFujian ProvinceChina Department of Glaucoma Shanghai Peace Eye HospitalShanghaiChina

Mesenchymal stem cells have neuroprotective effects that limit damage to the retina and photoreceptors,and which may be mediated by extracellular vesicles(or exosomes)released by mesenchymal stem *** investigate the neuroprotective effect of extracellular vesicles derived from umbilical cord mesenchymal stem cells on glaucoma,we established rat models of chronic ocular hypertension by injecting conjunctival fibroblasts into the anterior chamber to mimic optic nerve injury caused by *** week after injury,extracellular vesicles derived from umbilical cord-derived mesenchymal stem cells were injected into the vitreous *** found that extracellular vesicles derived from mesenchymal stem cells substantially reduced retinal damage,increased the number of retinal ganglion cells,and inhibited the activation of *** findings suggest that mesenchymal stem cell-derived extracellular vesicles can help alleviate optic nerve injury caused by chronic ocular hypertension,and this effect is achieved by inhibiting cell apoptosis.

关键词： animal model apoptosis chronic glaucoma chronic ocular hypertension extracellular vesicles mesenchymal stem cells neuroprotection rat retinal ganglion cells umbilical cord

A novel analysis of Scheimpflug total corneal refractive power following corneal cross-linking in mild to moderate keratoconus

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 728-735页

作者： Chao Pan Wei-Na Tan Dan Chen Yu Liu Hao-Yu Wang Deng-Feng Liang Yan-Jun Hua Xiao-Hua Lei Qing-Yan Zeng Shao-Zhen Zhao Tianjin Key Laboratory of Retinal Functions and diseases Tianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjinChina Hankou Aier Eye Hospital WuhanHubei ProvinceChina School of Ophthalmology Central South UniversityChangshaHunan ProvinceChina Department of Ophthalmology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina

AIM:To detect an earlier improvement in mild to moderate keratoconus following corneal cross-linking(CXL)with total corneal refractive power(TCRP)using ray tracing ***:A total of 40 eyes of 30 consecutive patients who underwent CXL for progressive keratoconus were retrospectively *** following keratometric parameters provided by Pentacam HR,including maximum keratometry(Kmax),steepest keratometry(Ksteep),3 mm zonal TCRP centered over corneal apex(TCRPapex,zone 3 mm),zonal mean keratometry and TCRP centered over corneal cone(Kmcone,zone and TCRPcone,zone 1,2,3 mm)were evaluated preoperatively and 1,3,6,and 12 mo *** 1 and 2 were defined based on Kmax at postoperative 1 mo as improved(the initial improvement group)or worsen(the initial deterioration group)compared to the preoperative ***:In the overall group,only keratometric parameters based on ray tracing method displayed significant improvement early at 3 mo postoperatively,in which TCRPcone,zone 1 mm and 2 mm exhibited the largest flattening(0.57 D and 0.53 D,respectively).In Group 1,only Kmax,Kmcone,zone 2 mm and TCRPcone,zone 2 mm showed significant improvement initially at 1 mo postoperatively,in which Kmax exhibited the largest improvement(1.05 D),followed by TCRPcone,zone 2 mm(0.82 D).In Group 2,only keratometric parameters based on ray tracing method and Kmcone,zone 3 mm showed slight but not significant improvement early at 3 mo,in which TCRPcone,zone 3 mm displayed the most improvement(0.19 D),followed by TCRPcone,zone 2 mm(0.15 D).CONCLUSION:The findings indicate that a 2 mm zonal TCRP centered over Kmax could earlier detect keratometric improvement by CXL compared to other commonly used parameters in mild to moderate keratoconic eyes.

关键词： keratoconus corneal cross-linking keratometry total corneal refractive power ray tracing

Orthodontic retreatment of an adult woman with mandibular backward positioning and temporomandibular joint disorder:A case report

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World Journal of clinical Cases 2022年第2期10卷 691-702页

作者： Li-Yuan Yu Kai Xia Wen-Tian Sun Xin-Qi Huang Jing-Yu Chi Ling-Jie Wang Zhi-He Zhao Jun Liu State Key Laboratory of Oral diseases&national clinical research center for Oral diseases Department of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Stomatology Strategic Support Force Medical Center of PLABeijing 10010China Department of Stomatology Qingyang People's HospitalQingyang 745000Gansu ProvinceChina

BACKGROUND The role of occlusal factors on the occurrence of temporomandibular joint disorders(TMDs)is still unclear and it is tricky for orthodontists to treat malocclusions in patients with *** report the case of the second orthodontic treatment of an adult female with Class II division 2 malocclusion associated with *** the removal of anterior occlusal interference,TMD symptoms were alleviated and cone beam computed tomography(CBCT)images showed the bilateral condyles shifted *** SUMMARY This case report presented an orthodontic retreatment of an adult female with TMD and mandibular backward positioning based on CBCT examination and Joint Space Index(JSI)*** left and right JSI values of-38.5 and-52.6 indicated that the position of bilateral condyles had posterior *** years prior to this evaluation,she underwent orthodontic treatment resulting in the extraction of two upper premolars and one lower central *** joint symptoms,including pain and sounds,were alleviated along with verified mandibular forward repositioning by extraction of another lower central *** Mandibular backward positioning could be associated with *** analysis based on CBCT is a convenient way to examine condylar positions quantitatively.

关键词： Cone beam computerized tomography Joint Space Index Temporomandibular joint disorder Case report