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Bilateral meibomian gland morphological alterations in unilateral herpes simplex keratitis based on artificial intelligence analysis

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International Journal of Ophthalmology(English edition) 2024年第12期17卷 2153-2157页

作者： Xin-Xin Yu Xue-Wen Chen Qi Dai Shuang-Qing Wu national clinical research center for ocular diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To explore whether unilateral herpes simplex keratitis(HSK)can cause morphological changes of bilateral meibomian glands(MGs)based on artificial intelligence(AI)analytical ***:In the retrospective study,29 patients with unilateral HSK and 29 participants matched in terms of age and sex were included as control *** images of the upper eyelid using Keratograph 5M and assessed ocular surface parameters including tear meniscus height and tear break-up *** density and vagueness values were automatically analyzed and calculated using an AI analytical *** compared the differences between the affected and the contralateral unaffected eyes in HSK patients,and the normal control *** employed either the paired t-test or the Wilcoxon signed-rank test to compare significant difference between the affected and unaffected eyes in HSK patients or between the HSK group and control ***:The MG density was 0.19±0.09 in the HSKaffected eye and 0.18±0.07 in contralateral unaffected eye,which had no significant difference(P=0.616).The MG density between the affected eye with HSK and the normal control group was statistically significant(P=0.028).There was a significant difference in MG density between the contralateral unaffected eye and the normal control group(P=0.012).However,no significant difference in vagueness value was observed between the eye with HSK and the control group or between HSK eye and contralateral ***:The MG density between the HSKaffected eye and the contralateral unaffected eye don’t significantly differ,whereas there is a significant decrease in the HSK group compared to that of the normal *** HSV keratitis may suffer from bilateral changes of MG morphology indicating bilateral dry ***,the fellow eye of patients with unilateral HSK should be considered a potential case of MG dysfunction,necessitating early treatment for bilateral dry eye in the clinic.

关键词： herpes simplex keratitis artificial intelligence meibomian gland morphology bilateral alterations

clinical usefulness of the baby vision test in young children and its correlation with the Snellen chart

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 348-352页

作者： Ya-Lan Wang Jia-Jun Wang Xi-Cong Lou Han Zou Yun-E Zhao The Eye Hospital of Wenzhou Medical University Hangzhou 310000Zhejiang ProvinceChina national clinical research center for ocular diseases Wenzhou 325027Zhejiang ProvinceChina

AIM:To investigate the efficacy of a new visual acuity(VA)screening method,the baby vision test for young ***:A total 105 eyes of 65 children aged 2-8y were included in the *** testing was conducted using a standardized recognition acuity chart(Snellen visual chart:at 3 m)and the baby vision model *** baby vision device includes a screen,a near infrared camera and a *** were seated at a measured distance of 33-40 cm from a display for *** was estimated according to the highest resolution the children could *** VA data were converted to logarithm of the minimum angle of resolution(logMAR)for statistical *** VA results for each child were recorded and analyzed for ***:The mean VA measured using the Snellen visual chart was 0.62±0.32,and that assessed using the baby vision test was 0.66±*** 95%limit of agreement was-0.609 to 0.695,with 95.2%(100/105)plots within the 95%limits of *** values of the baby vision test were significantly correlated with those of the Snellen chart(R=0.274,P=0.005).CONCLUSION:The baby vision test can be used as a relatively reliable method for estimating VA in young *** new acuity assessment might be a valid predictor of optotype-measured acuity later in preverbal children.

关键词： baby vision test acuity assessment fix-and-follow system Snellen chart

Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 852-860页

作者： Hai-Jian Hu Ping Li Bin Tong Yu-Lian Pang Hong-Dou Luo Fei-Fei Wang Chan Xiong Yu-Lin Yu Hai He Xu Zhang Affiliated Eye Hospital of Nanchang University Jiangxi Research Institute of Ophthalmology and Visual ScienceJiangxi Clinical Research Center for Ophthalmic DiseaseJiangxi Branch of National Clinical Research Center for Ocular DiseasesNanchang 330006Jiangxi ProvinceChina Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital) Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430015Hubei ProvinceChina

AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced ***:Totally 127 eyes from 89 participants(36 eyes of 19 healthy participants,45 eyes of 31 early glaucoma patients and 46 eyes of 39 advanced glaucoma patients)were *** relationships between the optical coherence tomography(OCT)-derived parameters and VF sensitivity were *** with early glaucoma were divided into eyes with or without central 10°of the VF damages(CVFDs),and the diagnostic performances of OCT-derived parameters were ***:In early glaucoma,the mGCIPLT was significantly correlated with 10-2 VF pattern standard deviation(PSD;with average mGCIPLT:β=-0.046,95%CI,-0.067 to-0.024,P<0.001).In advanced glaucoma,the mGCIPLT was related to the 24-2 VF mean deviation(MD;with average mGCIPLT:β=0.397,95%CI,0.199 to 0.595,P<0.001),10-2 VF MD(with average mGCIPLT:β=0.762,95%CI,0.485 to 1.038,P<0.001)and 24-2 VF PSD(with average mGCIPLT:β=0.244,95%CI,0.124 to 0.364,P<0.001).Except for the minimum and superotemporal mGCIPLT,the decrease of mGCIPLT in early glaucomatous eyes with CVFDs was more severe than that of early glaucomatous eyes without *** area under the curve(AUC)of the average mGCIPLT(AUC=0.949,95%CI,0.868 to 0.982)was greater than that of the average circumpapillary retinal nerve fiber layer thickness(cpRNFLT;AUC=0.827,95%CI,0.674 to 0.918)and rim area(AUC=0.799,95%CI,0.610 to 0.907)in early glaucomatous eyes with CVFDs versus normal ***:The 10-2 VF and mGCIPLT parameters are complementary to 24-2 VF,cpRNFLT and ONH parameters,especially in detecting early glaucoma with CVFDs and evaluating the severity of advanced glaucoma in group level.

关键词： 10-2 visual field ganglion cell-inner plexiform layer retinal nerve fiber layer thickness glaucoma

Commentary review:challenges of intraocular lens implantation for congenital cataract infants

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 923-930页

作者： Qi-Hui Zhao Yun-E Zhao Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina national clinical research center for ocular diseases Wenzhou 325027Zhejiang ProvinceChina

As an indispensable part of congenital cataract surgery,intraocular lens(IOL)implantation in infantile patients has long-term positive impacts on visual rehabilitation,as well as postoperative complications *** of IOL implantation in infantile congenital cataract patients is not simply a point-in-time but a personalized decision that comprehensively takes age at surgery,risks of postoperative complications,and economic condition of family in consideration,and combines with choosing suitable IOL type and *** infants with well-developed eyeballs and good systemic conditions,IOL implantation at six months of age or older is safe and ***,secondary IOL implantation may be a safer choice.

关键词： timing of surgery intraocular lens implantation congenital cataract infants

Development of a new 17-item Asthenopia Survey Questionnaire using Rasch analysis

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1867-1875页

作者： Na Lin Xiao-Man Li Mao-Yuan Yang Li Tian Zhi-Hua Li Jie-Li Mao Jia-Fang Zhang Jie Chen Fan Lyu Ru-Zhi Deng national clinical research center for ocular diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina

AIM:To develop the 17-item Asthenopia Survey Questionnaire(ASQ)-17 by Rasch analysis,and to generate a predictiveness ***:Totally 739 participants were recruited and 680 were involved in the result analysis in this prospective,cross-sectional *** rounds of Rasch analysis were used to analyze the psychometric characteristics of items and ***:Phase 1 assessed the original ASQ-19,adjusted the item scoring mode to a four-point Likert response rating scale and combined the 18th and 19th items into a new *** 2 deleted the 11th *** 3 and 4 assessed the new *** the evaluation indexes of ASQ-17 were *** Infit and Outfit MnSq values of items were 0.67-1.48,the variance explained by the principal component and the unexplained variance explained by the first contrast were 53.90%-59.40%and 1.50-1.80 in three *** curve peaks of scores in each dimension were separated and in the same *** PSR and PSI values were 2.80 and 0.89,*** mean scores of dimensions A(9.5±4.1 vs 3.5±3.2),B(7.3±3.3 vs 2.5±2.7),C(4.3±2.2 vs 1.4±2.0)and total(21.1±8.1 vs 7.4±7.0)in asthenopia participants were significantly higher than those without asthenopia(all P<0.001).The area under the curve in two groups was 0.899(P<0.001).Youden’s index was up to the maximum value of 0.784 when the cut-off value was ***:ASQ-17 has stronger option sorting and suitability than *** is an effective assessment tool for asthenopia with an optimal cut-off threshold value of 12.5,which is suitable for diagnosis and curative effect evaluation.

关键词： asthenopia 17-item Asthenopia Survey Questionnaire Rasch analysis scoring mode

Assessment of anterior chamber angle changes after phacoemulsification with swept-source OCT

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1527-1532页

作者： Qian Zheng Man Hu Zhang-Liang Li Ping-Jun Chang Yun-E Zhao Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina national clinical research center for ocular diseases Wenzhou 325027Zhejiang ProvinceChina

AIM:To assess the changes of anterior chamber angle in patients with shallow anterior chamber after phacoemulsification combined with intraocular lens(IOL)implantation,based on anterior segment swept-source optical coherence tomography(AS-SS-OCT)***:This was a prospective case control study;sixty eyes of sixty case were scheduled for cataract surgery with normal intraocular pressure(IOP).Based on anterior chamber depth(ACD)and gonioscopy findings,the eyes were divided into two groups:group of shallow anterior chamber and narrow angle(SAC group,30 eyes);and group of normal anterior chamber group with wide angle(NAC group,30 eyes).Measurements of ACD,anterior chamber volume(ACV),iris volume(IV),lens vault(LV),angle opening distance(AOD),angle recess area(ARA),trabecular iris space area(TISA),and trabecular iris angle(TIA)were conducted in each group before and 3mo after ***:There was no significant difference in age,axial length(AL),corneal curvature,corneal diameter,intraocular pressure,and IV between two groups before surgery,except for the LV(P=0.000).ACD and ACV were prominently larger in the NAC group than the SAC group 3mo after operation(3.69±0.38 vs 3.85±0.39 mm,P=0.025;161.37±19.47 vs 178.26±20.30 mm3,P=0.002).AOD750,ARA750 in nasal and inferior quadrants,TISA750 in all quadrants except temporal,and TIA750 in all quadrants in SAC group were significantly smaller than those in NAC group after operation(all P<0.05).CONCLUSION:Cataract surgery can deepen anterior chamber and increase the width of anterior chamber angle in Chinese subjects,but the angle related parameters including AOD750,ARA750,TISA750,TIA,TISA750,and ACV in patients with shallow anterior chamber and narrow angle do not reach the normal level.

关键词： anterior chamber parameters phacoemulsification shallow anterior chamber anterior segment swept-source optical coherence tomography

Investigation of lacrimal sac space-occupying lesions using color doppler ultrasound, computed tomography, and computed tomography dacryocystography

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1224-1230页

作者： Zhen-Bin Qian Bo Yu Ye Yang Wei Fang Jian-Li Dong Li-Qing Wei national clinical research center for ocular diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Sijiqing Street Community Health Service center Hangzhou 310000Zhejiang ProvinceChina

AIM:To observe the imaging features of color Doppler ultrasound(CDU)and computed tomography(CT)or computed tomography dacryocystography(CT-DCG)in different types of lacrimal sac space-occupying lesions(SOLs).METHODS:This retrospective case series study included 21 patients with lacrimal sac SOLs who underwent lacrimal sac surgery between January 2018 and March *** imaging features of CDU and CT or CT-DCG in these patients were extracted from the examination cloud *** images were observed and ***:The detection rate of lacrimal SOLs between CDU(21/21,100%)and CT or CT-DCG(20/21,95.2%)had no statistically significant difference(P=1.0).CDU could detect the blood flow signals in all SOLs except mucocele and mucopeptide *** them,polyps had characteristic imaging changes on CDU and *** mucoceles and mucopeptide concretions had characteristic imaging changes on CDU,which could provide more information for differential ***:The morphology and internal blood flow signals of lacrimal sac SOLs can be observed using *** or CT-DCG has advantages in observing structural damage around the lacrimal sac ***,CDU may be used as a routine examination to exclude lacrimal sac SOLs before dacryocystorhinostomy in the absence of preoperative CT or CT-DCG.

关键词： lacrimal sac computed tomography computed tomography dacryocystography color Doppler ultrasound space-occupying lesions

Two different autorefractors for vision screening in children and adolescents

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 331-338页

作者： Xiao-Jun Chen Lin-Jie Liu Bing Sun Dan-Dan Jiang Shu-Shu Zuo Yan-Hui Wang Chun-Hua Zhang Yan-Yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina national clinical research center for ocular diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and ***:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without *** data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were ***:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,***,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICCclinically acceptable *** J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable *** can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed ***,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.

关键词： refractive error autorefractors school-age myopia children

Transcapsular scleral fixation of the standard capsular tension ring and in-the-bag intraocular lens implantation for severely subluxated lenses

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International Journal of Ophthalmology(English edition) 2024年第12期17卷 2321-2326页

作者： Hong-Zhe Li Fu-Man Yang Ze-Hui Zhu Yin-Ying Zhao Ping-Jun Chang Yun-E Zhao School of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina national clinical research center for ocular diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To present a technique of transcapsular scleral fixation of the standard capsular tension ring(CTR)through equatorial capsulotomy and in-the-bag intraocular lens(IOL)implantation in subluxated ***:This retrospective consecutive case series included patients with subluxated lenses by more than 180 degrees who underwent lens extraction,transcapsular scleral fixation of the standard CTR through equatorial capsulotomy,in-the-bag IOL implantation and with at least 6mo *** and postoperative best corrected visual acuity(BCVA),intraocular pressure(IOP),complications,and postoperative IOL tilt and decentration were ***:Nine eyes of 7 patients with a mean followup of 11.0±3.7mo were included in this *** BCVA was significantly improved from 0.64±0.22 logMAR preoperatively to 0.21±0.19 logMAR postoperatively(P<0.001).The IOP was within the normal range *** mean tilt of the IOL was 4.30°±2.31°(range,1.0°to 8.9°)and the mean decentration of the IOL was 0.37±0.12 mm(range,0.14 to 0.50 mm).No visually threatened intraoperative and postoperative complications were detected during the follow-up ***:This is a safe and effective surgical technique for managing patients with severely subluxated *** has achieved favorable outcomes with fewer surgical manipulations and less need for advanced capsular support devices.

关键词： lens subluxation surgical technique capsular tension ring transcapsular scleral fixation in-thebag IOL implantation