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Rapid and sensitive detection of urinary KIM-1 using fully printed photonic crystal microarrays

Nano Research 2024年第5期17卷 4329-4337页

作者： Yang Liu Xuwei He Zewei Lian Qian Guo Jimei Chi Xiaoxue Lin Liyue Zhang Zheng Liu Yingyuan Liu Meng Su Keyu Wang Qiangguo Ao Qingli Cheng Department of Nephrology The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China Chinese PLA Medical School Beijing 100853China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesBeijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing 100190China Department of Rheumatology and Immunology Peking University International HospitalBeijing 102206China Department of clinical Laboratory The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China

Urinary kidney injury molecule 1(uKIM-1)serves as a reliable marker for the early diagnosis of acute kidney injury(AKI).The rapid and facile detection of changes in uKIM-1 is essential for early AKI diagnosis,ultimately improving the prognosis of *** this study,we developed a fully printed photonic crystal-integrated microarray with photonic crystal-enhanced fluorescence properties,which can detect uKIM-1 levels at the *** confirmed its efficacy in the early diagnosis of AKI using clinical urine *** quantitative detection of uKIM-1 was achieved within 10 *** lowest limit of detection is 8.75 pg·mL^(-1) with an accuracy of 94.2%.The diagnostic efficacy was validated using 86 clinical urine samples,highlighting the high sensitivity and stability of the photonic crystal ***,a facile and reliable immunoassay was designed and prepared for the rapid quantitative detection of uKIM-1,which is crucial for the early identification and convenient detection of AKI in hospital or community ***,convenient,cost-effective,and long-term monitoring of changes in uKIM-1 levels can assist clinicians in making timely adjustments to treatment regimens,preventing the transition from AKI to chronic kidney disease(CKD),improving the quality of life of patients with AKI,and reducing healthcare *** highlights the advantages of utilizing urine samples as a noninvasive and easily accessible medium for early detection and monitoring of kidney-related conditions.

关键词： photonic crystal point-of-care testing urine kidney injury molecule-1(KIM-1) acute kidney injury

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COVID-19 and liver injury in individuals with obesity

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World Journal of Gastroenterology 2023年第6期29卷 908-916页

作者： Ioannis G Lempesis Eleni Karlafti Petros Papalexis George Fotakopoulos Kyriakos Tarantinos Vasileios Lekakis Stavros P Papadakos Evangelos Cholongitas Vasiliki E Georgakopoulou Institute of Metabolism and Systems Research University of BirminghamBirminghamB152TTUnited Kingdom Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical CentreMaastricht 6166200Netherlands Department of Emergency AHEPA University HospitalAristotle University of ThessalonikiThessaloniki 54621Greece Unit of Endocrinology First Department of Internal MedicineLaiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece Department of Biomedical Sciences University of West AtticaAthens 12243Greece Department of Neurosurgery General University Hospital of LarisaLarisa 41221Greece First Pulmonology Department Sismanogleio HospitalAthens 15126Greece Department of Gastroenterology Laiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece First Department of Internal Medicine Laiko General HospitalMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Department of Infectious Diseases-COVID-19 Unit Laiko General HospitalAthens 11527Greece

Coronavirus disease 2019 is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 that manifests as a variety of clinical manifestations,including liver damage commonly detected by a hepatocellular pattern from liver function *** injury is associated with a worse prognosis *** associated with the severity of the disease include obesity and cardiometabolic comorbidities,which are also associated with nonalcoholic fatty liver disease(NAFLD).The presence of NAFLD,similarly to obesity,is associated with an unfavourable impact on the coronavirus disease 2019 *** with these conditions could present with liver damage and elevated liver function tests due to direct viral cytotoxicity,systemic inflammation,ischemic or hypoxic liver damage or drug side ***,liver damage in the setting of NAFLD could also be attributed to a pre-existing chronic low-grade inflammation associated with surplus and dysfunctional adipose tissue in these *** we investigate the hypothesis that a pre-existing inflammatory status is exacerbated after severe acute respiratory syndrome coronavirus 2 infection,which embodies a second hit to the underestimated liver damage.

关键词： COVID-19 SARS-CoV-2 Non-alcoholic fatty liver disease Obesity Inflammation Liver Adipose tissue

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稳定性心绞痛的治疗：NICE指南概要

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英国医学杂志中文版 2011年第6期14卷 369-371页

作者： Ritter J M O'Flynn Norma Timmis Adam Henderson Robert Rajesh Sharangini Fenu Elisabetta 杨旭(译者) 高润霖(审校者) national clinical guideline centre acute and chronic conditions Royal College of Physicians London NW1 4LE UK Barts and the London Queen Mary's School of Medicine and Dentistry London E1 2AD Trent Cardiac centre Nottingham University Hospitals Nottingham NG5 1PB UK 中国医学科学院阜外心血管病医院高干特需病房

稳定性心绞痛很常见，在英格兰，55～64岁的人群中约有8％的男性和3％的女性发生或曾经发生过稳定性心绞痛，而在65～74岁的人群中，分别有14％的男性及8％的女性遭受到稳定性心绞痛的困扰。稳定性心绞痛的确会增加患者将来发生急性冠... 详细信息

稳定性心绞痛很常见，在英格兰，55～64岁的人群中约有8％的男性和3％的女性发生或曾经发生过稳定性心绞痛，而在65～74岁的人群中，分别有14％的男性及8％的女性遭受到稳定性心绞痛的困扰。稳定性心绞痛的确会增加患者将来发生急性冠状动脉事件的风险，尽管该风险并非很高，此外患者总的死亡率也会增加。

关键词：稳定性心绞痛 NICE 急性冠状动脉事件指南治疗英格兰死亡率女性

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COVID-19 and Liver Dysfunction:Current Insights and Emergent Therapeutic Strategies

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Journal of clinical and Translational Hepatology 2020年第1期8卷 18-24页

作者： Gong Feng Kenneth I.Zheng Qin-Qin Yan Rafael S.Rios Giovanni Targher Christopher D.Byrne Sven Van Poucke Wen-Yue Liu Ming-Hua Zheng Xi’an Medical University Xi’anChina NAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Southampton national Institute for Health Research Biomedical Research Center University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Ziekenhuis Oost-Limburg Department of AnesthesiologyCritical CareEmergency Medicine and Pain TherapyGenkBelgium Department of Endocrinology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of Diagnosis and Treatment for The Development of chronic Liver Disease in Zhejiang Province WenzhouChina

The outbreak of coronavirus disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has attracted increasing worldwide *** of liver damage or dysfunction(mainly characterized by moderately elevated serum aspartate aminotransferase lev-els)have been reported among patients with ***,it is currently uncertain whether the COVID-19-related liver damage/dysfunction is due mainly to the viral infection per se or other coexisting conditions,such as the use of potentially hepatotoxic drugs and the coexistence of sys-temic inflammatory response,respiratory distress syndrome-induced hypoxia,and multiple organ *** on the current evidence from case reports and case series,this review article focuses on the demographic and clinical characteristics,potential mechanisms,and treatment options for COVID-19-related liver *** review also describes the geo-graphical and demographic distribution of COVID-19-related liver dysfunction,as well as possible underlying mechanisms linking COVID-19 to liver dysfunction,in order to facilitate future drug development,prevention,and control measures for COVID-19.

关键词： COVID-19 Liver dysfunction SARS-CoV-2

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高血压的治疗：NICE指南概要

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英国医学杂志中文版 2011年第6期14卷 365-368页

作者： Krause Taryn Lovibond Kate Caulfield Mark McCormack Terry Williams Bryan 梁拓(译者) 彭猛(译者) 蒋雄京(审校者) national clinical guideline centre acute and chronic conditions Royal College of Physicians London NW1 4LE UK William Harvey Research Institute Barts and the London School of Medicine and NIHR Cardiovascular Biomedical Research Unit Queen Mary University of London London EC1M 6BQ Whitby Group Practice Spring Vale Medical Centre Whitby YO21 1SD UK Department of Cardiovascular Sciences University of Leicester Leicester LE3 9QP UK Leicester NIHR Cardiovascular Biomedical Research Unit Glenfield Hospital Leicester LE3 9QP 中国医学科学院阜外心血管病医院高血压诊治中心

高血压是全球最重要的可预防的致死病因之一，也是英国初级保健中治疗的最为常见的疾病，见于1／4以上的成年人和半数65岁以上的老年人群。

关键词：高血压 NICE 治疗指南致死病因初级保健老年人群成年人

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