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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina international Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi Jiang Jingqi Chen Institute of science and technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers center for Brain science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan international Innovation center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

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Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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international Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou Ke Yajing Zhao Xin Min Yanghong Li Ruiyu Mi Yangai Liu Xiaowen Wu Minghao Fang Zhaohui Huang Engineering research center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

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Understanding the local structure and thermophysical behavior of Mg–La liquid alloys via machine learning potential

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international Journal of Minerals,Metallurgy and Materials 2025年第02期 439-449页

作者： Jia Zhao Taixi Feng Guimin Lu national Engineering research center for Integrated Utilization of Salt Lake Resource East China University of Science and Technology Joint international Laboratory for Potassium and Lithium Strategic Resources East China University of Science and Technology

The local structure and thermophysical behavior of Mg–La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg–La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results; the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg–La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg–La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg–La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg–La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

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Structure and electrochemical performance of delafossite AgFeO_(2)nanoparticles for supercapacitor electrodes

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international Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 201-213页

作者： Choulong Veann Thongsuk Sichumsaeng Ornuma Kalawa Narong Chanlek Pinit Kidkhunthod Santi Maensiri School of Physics Institute of ScienceSuranaree University of TechnologyNakhon Ratchasima 30000Thailand SUT center of Excellence on Advanced Functional Materials Suranaree University of TechnologyNakhon Ratchasima 30000Thailand Synchrotron Light research Institute Nakhon Ratchasima 30000Thailand Department of Physics Universitas Negeri MalangMalang 65145Indonesia

Delafossite AgFeO_(2)nanoparticles with a mixture of 2H and 3R phases were successfully fabricated by using a simple co-precipitation *** resulting precursor was calcined at temperatures of 100,200,300,400,and 500℃to obtain the delafossite AgFe0_(2)*** morphology and microstructure of the prepared AgFeO_(2)samples were characterized by using field emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM),N_(2) adsorption/desorption,X-ray absorption spectroscopy(XAS),and Xray photoelectron spectroscopy(XPS)techniques.A three-electrode system was employed to investigate the electrochemical properties of the delafossite AgFeO_(2)nanoparticles in a 3 M KOH *** delafossite AgFeO_(2)nanoparticles calcined at 100℃(AFO100)exhibited the highest surface area of 28.02 m^(2)·g^(-1)and outstanding electrochemical performance with specific capacitances of 229.71 F·g^(-1)at a current density of 1 A·g^(-1)and 358.32 F·g^(-1)at a scan rate of 2 mV·s^(-1).This sample also demonstrated the capacitance retention of 82.99% after 1000 charge/discharge cycles,along with superior specific power and specific energy values of 797.46 W·kg^(-1)and 72.74Wh·kg^(-1),*** findings indicate that delafossite AgFeO_(2)has great potential as an electrode material for supercapacitor applications.

关键词： nanoparticles delafossite electrochemical properties X-ray absorption spectroscopy co-precipitation supercapacitor

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research status and prospects of the fractal analysis of metal material surfaces and interfaces

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international Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu Xin Ma Shaojie Tian Qinghe Cui Beijing Advanced Innovation center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

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Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic science Letters 2025年第01期 3-7页

作者： Yang Liu Huopo Chen Nansen-Zhu international research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Collaborative Innovation center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and Technology

晚春西北地区干旱的发生对西北地区气候和农业生产等具有重要的影响,但在近几十年,西北干旱状况呈现出缓解的趋势.本文研究了前期北极海冰异常对5月中国西北地区(降水短缺引起的)干旱异常的影响.进一步研究表明,二至四月格陵兰海海冰偏... 详细信息

晚春西北地区干旱的发生对西北地区气候和农业生产等具有重要的影响,但在近几十年,西北干旱状况呈现出缓解的趋势.本文研究了前期北极海冰异常对5月中国西北地区(降水短缺引起的)干旱异常的影响.进一步研究表明,二至四月格陵兰海海冰偏多时,西北地区干旱有所缓解.偏多的格陵兰海海冰可激发出经向环流异常,环流异常通过海–气相互作用在北大西洋产生海温异常,主要表现为格陵兰岛以南和北大西洋副热带海温偏高,亚速尔群岛以西海温偏低.这种海温异常可持续到5月,并引发从北大西洋经斯堪的纳维亚半岛和中亚至中国西北地区的纬向波列,并在西北地区产生气旋环流异常,从而导致该地区水汽辐合,干旱状况有所缓解.

关键词：北极海冰格陵兰海北大西洋海温干旱中国西北

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Fabrication and luminescence of KGdF_4:Yb^(3+)/Er^(3+) nanoplates and their improving performance for polymer solar cells

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science Bulletin 2018年第4期63卷 216-218页

作者： Jiqing Jiao Yao Li Wenfei Shen Shasha Gai Jianguo Tang Yao Wang Linjun Huang Jixian Liu Wei Wang Laurence A.Belfiore College of Materials science and Engineering National Center of International Joint Research for Hybrid Materials Technology National Base of International Science &Technology Cooperation Qingdao University Department of Chemical and Biological Engineering Colorado State University

Solar energy remains the most abundant renewable energy resource available to us[1].Continuous efforts have been invested to enhance the conversion of light to electricity by the diverse range of applications[2].Espec... 详细信息

关键词：太阳能电池聚合物制造表演变换效率 PSC PCE 光性质

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Characterization of( Nb,Ti,Mo) C Precipitates in an Ultrahigh Strength Martensitic Steel

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Journal of Iron and Steel research international 2016年第5期23卷 495-500页

作者： Biao JU Hui-bin WU Di TANG Ning DANG national Engineering research center for Advanced Rolling technology University of Science and Technology Beijing

A study on ultrahigh strength steel plate subjected to novel thermo-mechanical control process was presented. The mechanical properties examination showed that the investigated steel exhibited excellent combination of ultra-high strength（ 2 200 MPa） and toughness（ 26 J）. The microstructure of the experimental steel was observed by scanning electron microscope and transmission electron microscope. Desired martensitic lath with width of about 180- 250 nm was obtained. Nanostructured carbide precipitates with sizes of 20-50 nm,which contained Nb,Ti and Mo,were observed in the lath martensitic microstructure,and confirmed to be MC-type carbides with B1 structure by means of selected area electron *** compositional characteristics revealed by energy dispersive X-ray spectrometer mapping implied that the carbide forming elements Nb,Ti and Mo distributed in the precipitates evenly. Three-dimensional atom probe tomography reconstruction further indicated that Mo incorporated into the precipitates without enrichment in the carbide-matrix interface and probably substituted for Nb and Ti to form the（ Nb,Ti,Mo） C carbides.

关键词： ultrahigh strength steel precipitate (Nb Ti Mo) C compositional characteristic structural characteristic

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Element distribution and difusion behavior in Q&P steel during partitioning

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international Journal of Minerals,Metallurgy and Materials 2013年第11期20卷 1050-1059页

作者： Hai-tao Jiang Bao-tong Zhuang Xiao-ge Duan Yan-xin Wu Zheng-xu Cai national Engineering research center for Advanced Rolling technology University of Science and Technology Beijing

Carbon, manganese, and silicon distribution in quenching and partitioning （Q＆P） steel during partitioning process was investigated to reveal the diffusion behavior. The microstructure and chemical composition were analyzed by means of scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, and three-dimensional atom probe. It is shown that the studied Q＆P steel consisted of martensite laths and thin, film-like retained austenite showing extraordinary phase transformation stability. Carbon atoms mostly diffused to the retained austenite from martensite at a higher partitioning temperature. In the experimental steel partitioned at 400℃ for 10-60 s, carbides or cementite formed through carbon segregation along martensite boundaries or within the martensite matrix. As a result of carbon atom diffusion from martensite to austenite, the carbon content in martensite could be ignored. When the partitioning process completed, the constrained carbon equilibrium （CCE） could be simplified. Results calculated by the simplified CCE model were similar to those of CCE, and the difference between the two optimum quenching temperatures, where the maximum volume fraction of the retained austenite can be obtained by the Q＆P process, was little.

关键词： steel heat treatment quenching partitioning element distribution diffusion microstructure

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