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Parboiled rice supplementation alleviates high-fat diet-induced hyperlipidemia by regulating genes and gut microbiota in mice

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Food Science and Human Wellness 2024年第3期13卷 1422-1438页

作者： Xiuxiu Wu Tianyi Guo Biao Li Shuai Han Zuomin Hu Yi Luo Dandan Qin Yaping Zhou Feijun Luo Qinlu Lin national Research Center of Rice Deep Process and Byproducts Hunan Provincial Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Provincial Key Laboratory of Forestry Edible Resources Safety and ProcessingCentral South University of Forestry and TechnologyChangsha 410004China College of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004China Department of Clinical Medicine Medical College of XiangyaCentral South UniversityChangsha 410008China

Dietary parboiled rice(PR)has a low risk of disease,but little is known about the contribution of PR to the prevention of *** potential role and underlying mechanisms of PR in hyperlipidemia were evaluated in this *** C57BL/6J mice were fed with a normal diet,high-fat diet(HFD)containing refined rice(HFDRR)or PR(HFDPR).It was found that PR intervention improved lipid accumulation in *** data analysis revealed that 27 genes were up-regulated(mostly involved in lipid breakdown)and 86 genes were down-regulated(mostly involved in inflammatory responses)in the HFDPR group compared to the HFDRR *** 15 differentially expressed genes(DEGs)were validated by quantitative real-time PCR(RT-qPCR),while protein interaction network showed that protein tyrosine phosphatase receptor type C(PTPRC)has a central *** gut microbiota of mice was also altered after different dietary treatments,with higher ratio of Firmicutes and Bacteroidetes,increased abundances of Ruminococcaceae,Lachnospiraceae,Christensenellaceae,Porphyromonadaceae,Rikenellaceae and Prevotellaceae,and decreased abundances of Lactobacillaceae,Peptostreptococcaceae,Erysipelotrichaceae and Actinobacteria in the HFDRR *** addition,it was observed that PPAR signaling pathway may act as a bridge between DEGs and differential gut *** results suggested that PR can prevent hyperlipidemia by modulating liver genes and gut microbiota.

关键词： Parboiled rice Blood lipids Transcriptome Gut microbiota PPAR Signaling pathway

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Simultaneous quantification of trace heavy metals in mushrooms using a three-dimensional highly reduced graphene oxide/FeOnanocomposite-based electrochemical sensor

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Food Science and Human Wellness 2024年

作者： Yiming Tian Pingsheng Zhong Kai Zhou Lufei Zheng Jiali Ren Hunan Key laboratory of Forestry edible Resources Safety and Processing， Hunan Key laboratory of Grain-oil Deep Process and quality control， Central South University of Forestry and Technology Institute of quality Standard and Testing Technology for Agro-Products of CAAS

The accumulation of heavy metals in mushrooms has presented a significant risk to human health， underscoring the importance of devising a portable and cost-effective method for detecting heavy metals. Thus， we have developed an electrochemical sensor based on 3-dimensional highly reduced graphene oxide (3D-HRGO) in conjunction with Fe3O4nanoparticles， enabling the simultaneous quantification of Cd2+， Pb2+， Cu2+， and Hg2+. The 3D-HRGO/Fe3O4nano-particles material prepared in this study was characterized and confirmed by multiple techniques， then dispersed in a simple and environmental dispersant， consist of 75% ethanol and 0.1% Nafion， and coating on a glass carbon electrode (GCE) to preparing a 3D-HRGO/Fe3O4/GCE sensor. The limit of detection (LOD) of 3D-HRGO/Fe3O4/GCE sensor for Cd2+， Pb2+， Cu2+， and Hg2+in simultaneous detection were 0.2 μg/L， 0.6 μg/L， 0.6 μg/L， and 0.9 μg/L， respectively. The sensor demonstrates exceptional stability， reproducibility， anti-interference， and recovery rate. Furthermore， the electrochemical sensor was employed to detect heavy metals in actual mushrooms and validated through conventional methodologies. This study represents the pioneering utilization of 3D-HRGO/Fe3O4as a foundational material for an electrochemical sensor capable of simultaneous detection of multiple metals， thereby advancing the progress of on-site and expeditious detection techniques.

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Bioactive peptides alleviating oxidative stress-associated diseases by targeting the Nrf2 signaling pathway

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Food Science and Human Wellness 2024年

作者： Dandan Qin Zuomin Hu Shuai Han Yi Luo Feiyan Yang Tiantian Xie Feijun Luo Hunan Key laboratory of Grain-oil Deep Process and quality control， Hunan Key laboratory of Forestry edible Resources Safety and Processing， College of Food Science and Engineering， Central South University of Forestry and Technology Department of Gastroenterology， Xiangya Hospital， Central South University

Oxidative stress is caused by an imbalance of the antioxidant defense system and excessive production of free radicals， which can damage biological macromolecules such as proteins， lipids and nucleic acids， which can cause aging， ischemia-reperfusion injury， inflammatory injury， liver and kidney injury and other diseases. The nuclear factor erytheroid-2-related factor 2 (Nrf2) is a major regulator of redox balance. The Nrf2 pathway also exerts a central function in cell apoptosis， oxidative stress damage and metabolic diseases. Bioactive peptides are small molecular peptides composed of amino acid residues. They have many biological activities and play important physiological roles in human body. Antioxidant peptide is a kind of peptide which can reduce oxidative stress damage. They are safe， non-toxic and easily absorbed. In this review， we summarized the mechanism of bioactive peptides in regulating oxidative stress， especially antioxidant peptides， through regulating the Nrf2 signaling pathway and the expressions of oxidative stress-related genes， to alleviate oxidative stress-induced damage. The paper will provide valuable reference to investigators in the antioxidant peptide field and also promote the applications of antioxidant peptides in the oxidative stress-associated diseases.

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Insights into Euphorbia diversity: Probing the contrasts between Euphorbia fischeriana Steud and Euphorbia ebracteolata Hayata

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Journal of Pharmaceutical Analysis 2024年第5期14卷 775-779页

作者： Kaicheng Du Yi Zhang Lei Sun Muke Tao Tiantian Zuo Yumeng Wang Zhengfeng Zhang Dali Meng School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang110016China NMPA Key laboratory for quality Monitoring of Narcotic Drugs and Psychotropic Substances Chongqing Institute for Food and Drug ControlChongqing401121China national Institutes for Food and Drug control Beijing100050China

In traditional Chinese medicine(TCM),Euphorbia fischeriana Steud(***)and Euphorbia ebracteolata Hayata(***),commonly referred to as“Langdu”,are widely extensively utilized for treating lymphatic tuberculosis and ringworm[1].Both plant species are perennial herbaceous plants mainly distributed in northeastern China,Mongolia,Russia(Siberia),and Republic of Korea[2].There have been many reports on the chemical constituents and pharmacological effects of the two plant species,which has made more and more researchers realize that there may be differences between *** and *** some cases,long-term improper use of herbal medicines can even lead to life-threatening conditions[3,4].Therefore,it is essential to employ an effective technology to differentiate between these two plants based on their chemical constituents and biological activities,so as to reduce the harm caused by the mixing and misuse of medicinal ***,the present paper describes a study of the differences between *** and ***,using untargeted plant metabolomics and biological activity *** study aims to provide valuable insight into their equivalence and potential interchangeability in TCM and clinical medication.

关键词： Euphorbia Siberia northeastern

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Citrinsorbicillin A,a novel homotrimeric sorbicillinoid isolated by LC-MS-guided with cytotoxic activity from the fungus Trichoderma citrinoviride HT-9

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Chinese Chemical Letters 2024年第8期35卷 299-303页

作者： Guo-Ping Yin Ya-Juan Li Li Zhang Ling-Gao Zeng Xue-Mei Liu Chang-Hua Hu Engineering Research Center of Coptis Development and Utilization(Ministry of Education) College of Pharmaceutical Sciences and Chinese MedicineSouthwest UniversityChongqing 400715China State Key laboratory of Natural medicines China Pharmaceutical UniversityNanjing 211198China NMPA Key laboratory for quality Monitoring of Narcotic Drugs and Psychotropic Substances Chongqing Institute for Food and Drug ControlChongqing 401121China

Citrinsorbicillin A(1),a novel homotrimeric sorbicillinoid,along with two new monomers citrinsor-bicillins B(2)and C(3),were isolated from the Coptis chinensis endophyte Trichoderma citrinoviride HT-9 by liquid chromatograph mass spectrometer(LC-MS)-guided strategy.1 was the first trimeric-example from terrestrial fungi,which possessed a unique carbon skeleton with two bicyclo[2.2.2]octanedione ring connected through an enolated carbon forming by[4+2]*** structures were elucidated by spectroscopic analysis and X-ray diffraction.1 exhibited moderate cytotoxicity against human colon cancer HT29 cells,and it induced significant cell cycle arrest by reducing the protein expression of cyclin D1.

关键词： Citrinsorbicillin A Trimeric sorbicillinoid Coptis chinensis endophyte Trichoderma citrinoviride [4+2]Cycloaddition Cytotoxic activity

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Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 795-807页

作者： Yongchun Pan Xiaowei Luan Fei Zeng Xuyuan Wang Shurong Qin Qianglan Lu Guanzhong He Yanfeng Gao Xiaolian Sun Xin Han Bangshun He Yujun Song Department of laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China State Key laboratory of Natural medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 211198China School of Medicine&Holistic Integrative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene ***,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor ***,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer *** this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are *** intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as *** the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target *** tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation ***,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

关键词： CRISPRdelivery Enzymeencapsulation Logic gate Hybridmaterial Hypoxia Gene editing Precise nanomedicine Multimodal therapy

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Cyclocarysaponins A–J, dammarane-type triterpenoid glycosides from the leaves of Cyclocarya paliurus

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Chinese Journal of Natural medicines 2024年第10期22卷 955-964页

作者： XI Huiting YUAN Mingming XIE Jianhua WANG Yuanxing State Key laboratory of Food Science and Resources Nanchang University Jiangxi Institute for Drug control NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality

Ten previously undescribed dammarane-type triterpenoid glycosides, cyclocarysaponins A–J(1–10), were isolated from the leaves of Cyclocarya paliurus(Batal.) Iljinskaja. The structures of these compounds were characterized through detailed spectroscopic analysis, including 1D and 2D nuclear magnetic resonance(NMR) and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS). The cytotoxic activities of all isolates were assessed against five human cancer cell lines(Bel-7402, Caski, BGC-823, A2780, and HCT-116). Of the tested compounds, compounds 1, 7, and 9 exhibited selective cytotoxicity against one or more human cancer cell lines.

关键词： Cyclocarya paliurus Cyclocarysaponin Cytotoxic activities Juglandaceae Triterpenoid glycosides

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Adaptability of two cellulase producing strains Bacillus sp. SH and Aspergillus oryzae Y21 in whole wheat dough and impact on the quality of whole wheat bread

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Food Science and Human Wellness 2024年

作者： Yingli Liu Shengjie Zhong Xiaoming Wei Maosi Fan Min Cai Zhengkai Wang Jing Wang national Center of Technology Innovation for Grain Industry (Comprehensive Utilization of edible By-products)， Key laboratory of Special Food Supervision Technology for State Market Regulation，Beijing Technology and Business University

Compared to refined wheat flour， whole wheat flour contains higher nutrients， but its high content of dietary fiber can have a significant impact on the quality of the final product. Therefore， how to enable consumers to obtain health benefits from whole wheat flour and improve the processing performance of whole wheat products has become a concern. The purpose of this study is to apply two strains Bacillus sp. SH and Aspergillus oryzae Y21 with cellulase production capacity and study their adaptability in whole wheat dough. The results indicate that the addition of cellulase-producing strains enhanced the acid production ability of whole wheat dough， rapidly reduced its pH value and insoluble dietary fiber content， and significantly increased the water-soluble arabinoxylan and water-soluble dietary fiber content. During the fermentation process， the viscoelasticity of the dough decreased， free sulfhydryl content increased， wet gluten content decreased， and the degree of reduction was consistent with the degree of acidification. Moreover， the proteolytic activity of the dough was increased， and the hydrolysis of gliadin was the most extensive. Bacillus sp. SH showed a higher advantage and has been used in whole wheat bread making. Increasing the proportion of strain SH in whole wheat bread can improve the structural characteristics and texture of the bread. When SH (5 × 107CFU/g) is added to whole wheat bread， its hardness， elasticity， chewiness， and resilience can be similar to those of bread made from control group wheat flour， far exceeding that of whole wheat bread without adding SH. The addition of cellulase producing strains has obvious advantages in the development of whole-wheat dough， and also promote the development of whole wheat fermented foods as staple foods.

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Characterization of blueberry exosome-like nanoparticles and miRNAs with potential cross-kingdom human gene targets

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Food Science and Human Wellness 2024年第2期13卷 869-878页

作者： Yangfan Leng Liubin Yang Siyi Pan Leilei Zhan Fang Yuan College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Hubei Key laboratory of Fruit&Vegetable Processing&quality control Huazhong Agricultural UniversityWuhan 430070China Wuhan GeneCreate Biological Engineering Co. Ltd.Wuhan 430070China

edible plant derived exosome-like nanoparticles(ELNs)have been shown to have multiple nutraceutical ***,the diversity of plant materials makes the plant derived ELN study *** efforts are still needed to explore the feasible isolation methods of edible plant derived ELNs and the possible roles of food-derived ELNs in improving human *** this study,a size exclusion chromatography based method was compared with the traditional ultracentrifugation method to isolate blueberry derived ELNs(B-ELNs),and the miRNA profile of B-ELNs was analyzed by high-throughput sequencing.A total of 36 miRNAs were found to be enriched in B-ELNs compared with berry tissue,and their potential cross-kingdom human gene targets were further *** showed that size exclusion chromatography was effective for B-ELN *** most abundant miRNAs in B-ELNs mainly belonged to the miR166 family and miR396 *** gene prediction indicated that B-ELNs could potentially regulate pathways related to the human digestive system,immune system and infectious diseases.

关键词： edible plant derived exosomes-like nanoparticles Size exclusion chromatography miRNA Target gene prediction Blueberry

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铜基催化剂用于一氧化碳电还原为多碳产品

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Science China Materials 2024年第6期67卷 1684-1705页

作者：赵雯刘娟王光滔王新天杨传举李剑王鋙葶孙晓莲林日琛左淦丞朱文磊 State Key laboratory of Pollution control and Resource Reuse Frontiers Science Center for Critical Earth Material CyclingState Key Laboratory of Pollution Control and Resource Reusethe Frontiers Science Center for Critical Earth Material CyclingSchool of the EnvironmentNanjing UniversityNanjing 210023China State Key laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China State Key laboratory of Natural medicines Key Laboratory of Drug Quality Control and PharmacovigilanceSchool of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China Key laboratory of Energy Thermal Conversion and control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 211189China Jiangsu Engineering Lab of Water and Soil Eco-remediation School of EnvironmentNanjing Normal UniversityNanjing 210023China

电化学二氧化碳还原(ECO_(2)R)是一种将碳和可再生能源的能量储存在多碳产品(C_(2+))的化学键中的有效途径.然而,反应涉及的复杂步骤为CO_(2)直接转化为C_(2+)设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO_(2)R和电化学CO还... 详细信息

电化学二氧化碳还原(ECO_(2)R)是一种将碳和可再生能源的能量储存在多碳产品(C_(2+))的化学键中的有效途径.然而,反应涉及的复杂步骤为CO_(2)直接转化为C_(2+)设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO_(2)R和电化学CO还原(ECOR)以提高生产C_(2+)的选择性和反应速率的策略引起了人们的广泛关注.本文总结了铜基电催化剂在ECOR中催化特定C_(2+)生成的设计策略.其次,从各个方面总结了催化剂工程的代表性设计策略,并介绍了电解反应器改进方面的最新进展.最后,阐述了该研究领域面临的主要挑战和未来前景.这些见解和观点将为铜基电催化剂的设计提供有益指导.

关键词： CO electroreduction Cu-based catalysts multi-car-bon products

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