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Macroalgal deep genomics illuminate multiple paths to aquatic,photosynthetic multicellularity

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Molecular Plant 2024年第5期17卷 747-771页

作者： David R.Nelson Alexandra Mystikou Ashish Jaiswal Cecilia Rad-Menendez Michael J.Preston Frederik De Boever Diana C.El Assal Sarah Daakour Michael W.Lomas Jean-Claude Twizere David H.Green William C.Ratcliff Kourosh Salehi-Ashtiani Division of Science and Math New York University Abu DhabiAbu DhabiUAE center for Genomics and Systems biology(CGSB) New York University Abu DhabiAbu DhabiUAE Biotechnology Research center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE Culture Collection of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK national center for marine Algae and Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interactomes GIGA InstituteUniversity of LiegeLiegeBelgium School of Biological Sciences Georgia Institute of TechnologyAtlantaGAUSA

Macroalgae are multicellular,aquatic autotrophs that play vital roles in global climate maintenance and have diverse applications in biotechnology and eco-engineering,which are directly linked to their multicellularity ***,their genomic diversity and the evolutionary mechanisms underlying multicellularity in these organisms remain *** this study,we sequenced 110 macroalgal genomes from diverse climates and phyla,and identified key genomic features that distinguish them from their microalgal *** for cell adhesion,extracellular matrix formation,cell polarity,transport,and cell differentiation distinguish macroalgae from microalgae across all three major phyla,constituting conserved and unique gene sets supporting multicellular *** genes show phylum-and climate-specific expansions that may facilitate niche ***,our study reveals genetic determinants of convergent and divergent evolutionary trajectories that have shaped morphological diversity in macroalgae and provides genome-wide frameworks to understand photosynthetic multicellular evolution in aquatic environments.

关键词： macroalgae multicellularity comparative genomics evolution adhesome endogenous viral elements

Role of fullerenols derivative 3HFWC in the treatment of Alzheimer's disease

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Neural Regeneration Research 2024年第8期19卷 1641-1642页

作者： Sanja Ivkovic Djuro Koruga Department of Molecular biology and Endocrinology “VINCA”Institute of Nuclear Sciences-National Institute of Republic of SerbiaUniversity of BelgradeBeogradSrbija TFT Nano center BelgradeSerbia

Fullerenes:The extensive development of nanoscience that has marked this century continues to evolve,producing new materials,structures,and devices for the treatments of diverse *** are a family of nanoparticles with great applicative promise due to their small size(approximately 1 nm in diameter),structure,and capacity to cross biological barriers.

关键词： treatment evolve size

Spontaneous mutations and mutational responses to penicillin treatment in the bacterial pathogen Streptococcus pneumoniae D39

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marine Life Science & Technology 2024年第2期6卷 198-211页

作者： Wanyue Jiang Tongtong Lin Jiao Pan Caitlyn ERivera Clayton Tincher Yaohai Wang Yu Zhang Xiang Gao Yan Wang Ho‑Ching T.Tsui Malcolm E.Winkler Michael Lynch Hongan Long Institute of Evolution and marine Biodiversity KLMMEOcean University of ChinaQingdao 266003China Laboratory for marine biology and Biotechnology Laoshan LaboratoryQingdao 266237China Department of biology Indiana UniversityBloomingtonIN 47405USA School of Mathematics Science Ocean University of ChinaQingdao 266000China State Key Laboratory of Microbial Technology Microbial Technology InstituteSchool of Life ScienceShandong UniversityQingdao 266237China Biodesign center for Mechanisms of Evolution Arizona State UniversityTempeAZ 85281USA

Bacteria with functional DNA repair systems are expected to have low mutation rates due to strong natural selection for genomic ***,our study of the wild-type Streptococcus pneumoniae D39,a pathogen responsible for many common diseases,revealed a high spontaneous mutation rate of 0.02 per genome per cell division in mutation-accumulation(MA)*** rate is orders of magnitude higher than that of other non-mutator bacteria and is characterized by a high mutation bias in the A/T *** high mutation rate may have resulted from a reduction in the overall efficiency of selection,conferred by the tiny effective population size in *** line with this,*** D39 also exhibited the lowest DNA mismatch-repair(MMR)efficiency among *** with the antibiotic penicillin did not elevate the mutation rate,as penicillin did not induce DNA damage and *** lacks a stress response *** findings suggested that the MA results are applicable to within-host scenarios and provide insights into pathogen evolution.

关键词： Neutral evolution Mutation spectrum Antibiotics DNA mismatch repair Oxidative damage repair

Differences in spring precipitation over southern China associated with multiyear La Ni?a events

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Acta Oceanologica Sinica 2024年第2期43卷 1-10页

作者： Guangliang Li Licheng Feng Wei Zhuang Fei Liu Ronghua Zhang Cuijuan Sui national marine Environmental Forecasting center Ministry of Natural ResourcesBeijing 100081China State Key Laboratory of marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Southern marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Key Laboratory of Tropical Atmosphere-Ocean System of Ministry of Education/School of Atmospheric Sciences Sun Yat-Sen UniversityZhuhai 519082China School of marine Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

Composite analyses were performed in this study to reveal the difference in spring precipitation over southern China during multiyear La Ni?a events during 1901 to 2015. It was found that there is significantly below-normal precipitation during the first boreal spring, but above-normal precipitation during the second year. The difference in spring precipitation over southern China is correlative to the variation in western North Pacific anomalous cyclone(WNPC), which can in turn be attributed to the different sea surface temperature anomaly(SSTA) over the Tropical Pacific. The remote forcing of negative SSTA in the equatorial central and eastern Pacific and the local air-sea interaction in the western North Pacific are the usual causes of WNPC formation and *** in the first spring is stronger than those in the second spring. As a result, the intensity of WNPC in the first year is stronger, which is more likely to reduce the moisture in southern China by changing the moisture transport, leading to prolonged precipitation deficits over southern China. However, the tropical SSTA signals in the second year are too weak to induce the formation and maintenance of WNPC and the below-normal precipitation over southern China. Thus, the variation in tropical SSTA signals between two consecutive springs during multiyear La Ni?a events leads to obvious differences in the spatial pattern of precipitation anomaly in southern China by causing the different WNPC response.

关键词： multiyear La Nina precipitation anomaly anomalous western North Pacific cyclone southern China

Inversion of Seabed Geotechnical Properties in the Arctic Chukchi Deep Sea Basin Based on Time Domain Adaptive Search Matching Algorithm

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Journal of Ocean University of China 2024年第4期23卷 933-942页

作者： AN Long XU Chong XING Junhui GONG Wei JIANG Xiaodian XU Haowei LIU Chuang YANG Boxue Jiangsu Automation Research Institute Lianyungang 222061China Key Laboratory of Submarine Geosciences and Prospecting Techniques MOE and College of Marine GeosciencesOcean University of ChinaQingdao 266100China Laboratory for marine Mineral Resources Qingdao Marine Science and Technology CenterQingdao 266071China

The chirp sub-bottom profiler,for its high resolution,easy accessibility and cost-effectiveness,has been widely used in acoustic *** this paper,the acoustic impedance and grain size compositions were obtained based on the chirp sub-bottom profiler data collected in the Chukchi Plateau area during the 11th Arctic Expedition of *** time-domain adaptive search matching algorithm was used and validated on our established theoretical *** misfit between the inversion result and the theoretical model is less than 0.067%.The grain size was calculated according to the empirical relationship between the acoustic impedance and the grain size of the *** average acoustic impedance of sub-seafloor strata is 2.5026×10^(6) kg(s m^(2))^(-1)and the average grain size(θvalue)of the seafloor surface sediment is 7.1498,indicating the predominant occurrence of very fine silt sediment in the study *** of the inversion results and the laboratory measurements of nearby borehole samples shows that they are in general agreement.

关键词： time domain adaptive search matching algorithm acoustic impedance inversion sedimentary grain size Arctic Ocean Chukchi Deep Sea Basin

Effects of Different Culture Conditions and Growth States on the Structure and Hemostatic Properties of Coscinodiscus sp.

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Journal of Ocean University of China 2024年第4期23卷 1121-1134页

作者： HE Zheng LI Qinfeng LIU Jinfeng HUI Guangyan FENG Chao CHENG Xiaojie CHEN Xiguang College of marine Life Science Sanya Oceanographic InstitutionOcean University of ChinaQingdao 266003China Laboratory for marine Drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao 266237China Department of Stomatology Qingdao Women and Children’s HospitalQingdao 266034China Department of Stomatology Qingdao Special Servicemen Recuperation Center of PLA NavyQingdao 266071China

As a renewable marine inorganic material,Coscinodiscus *** significant potential in the field of rapid ***,the low yield of Coscinodiscus *** limits the *** this study,two new culture modes were adopted to increase the production of Coscinodiscus sp.,the effect of changes in culture conditions and growth status on the hemostatic activity of diatoms was *** prevent Coscinodiscus *** sinking in culture,the suspension culture mode was realized by adding0.5%*** semi-continuous high nutrient concentration culture mode increased the cell density of Coscinodiscus *** 11000cells mL^(-1)and shorten the culture cycle to 5 *** terms of coagulation activity,the addition of frustules reduced the in vitro coagulation time by half and the activation time of coagulation by 70%.The hemolysis rate and cytotoxicity of frustules harvested in the two culture modes did not change *** results showed that suspension culture mode and high nutrient concentration culture mode only changed the growth state of Coscinodiscus sp.,while the hemostatic performance remained stable.

关键词： diatom culture Coscinodiscus sp frustule hemostatic material hemorrhage control

The Burden of Hypertension-Related Chronic Kidney Disease—China,2010–2019

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China CDC weekly 2024年第14期6卷 282-288页

作者： Youyuan Bu Yueru Liu Maigeng Zhou Peng Yin Kejun Liu Yamin Bai Xuancheng Lu Chinese center for Disease Control and Prevention BeijingChina national center for Chronic and Non-Communicable Disease Control and Prevention Chinese Center For Disease Control and PreventionBeijingChina China national Health Development Research center BeijingChina

What is already known about this topic?The global burden of chronic kidney disease(CKD)is on the *** is added by this report?In 2019,5.58 million individuals in China were affected by CKD related to hypertension,leading to 70,260 fatalities and 1.69 million disability-adjusted life years(DALYs).The most affected groups were men,older individuals,and residents of western *** the period from 2010–2019,the age-standardized prevalence rate(ASPR)remained constant,and the agestandardized mortality rate(ASMR)and agestandardized DALY rate(ASDR)showed a decreasing ***,there was an increase in the number of cases,deaths,and DALYs associated with this *** are the implications for public health practice?Hypertension significantly contributes to the burden of CKD;therefore,raising awareness and implementing early screening measures are essential.

关键词： Kidney mortality burden

Expression and Characterization of a Novelλ-Carrageenase Cgl150A_Wa from Wenyingzhuangia aestuarii

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Journal of Ocean University of China 2024年第1期23卷 209-215页

作者： SUN Yuhao CAO Siqi ZHANG Yuying XUE Changhu XIAO Hang CHANG Yaoguang College of Food Science and Engineering Ocean University of ChinaQingdao 266003China marine Life Research center Laoshan National LaboratoryQingdao 266237China Department of Food Science University of Massachusetts AmherstMA 01003United States

λ-Carrageenan is a highly sulfated polysaccharide alternating of 1,4-O-α-D-galactopyranose-2,6-sulfate(D2S,6S)and 1,3-O-β-D-galactopyranose-2-sulfate(G2S).λ-Carrageenases are desirable tools forλ-carrageenan *** on the genome mining,a novelλ-carrageenase Cgl150A_Wa was cloned from the bacterium Wenyingzhuangia aestuarii and expressed in Escherichia ***150A_Wa was an endo-acting enzyme and exhibited its maximum activity at 30℃and pH *** employing a glycomics strategy that combined ultra-performance liquid chromatography-mass spectrometry analysis and glycoinformatics,Cgl150A_Wa was proven to degradeλ-carrageenan octaose and hexaose,and the major hydrolysis product of Cgl150A_Wa wasλ-carrageenan *** addition to the typicalλ-carrageenan motifs,the active center of Cgl150A_Wa might tolerate desulfatedλ-carrageenan ***150A_Wa is a potential biotechnological tool for preparingλ-carrageenan oligosaccharides and structural investigation.

关键词： carrageenan λ-carrageenase LC-MS oligosaccharide GH150

Review on Security Defense Technology Research in Edge Computing Environment

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Chinese Journal of Electronics 2024年第1期33卷 1-18页

作者： Ke SHANG Weizhen HE Shuai ZHANG national Digital Switching System Engineering and Technological R&D center

Edge computing, which achieves quick data processing by sinking data computing and storage to the network edge, has grown rapidly along with the Internet of things. The new network architecture of edge computing brings new security challenges. Based on this, this paper investigates the edge computing security literature published in recent years and summarizes and analyzes research work on edge computing security from different attack surfaces. We start with the definition and architecture of edge computing. From the attack surface between device and edge server, as well as on edge servers, the research describes the security threats and defense methods of edge computing. In addition, the cause of the attack and the pros and cons of defense methods is introduced. The challenges and future research directions of edge computing are given.

关键词： Cloud computing Systems architecture Computer architecture Network architecture Data processing Security Servers