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Two Photosensitive Dermatitis Outbreaks Caused by Cordierites frondosus—Chuxiong Yi Autonomous Prefecture,Yunnan Province,China,2023

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China CDC weekly 2024年第24期6卷 580-584页

作者： Jiaju Zhong Hongshun Zhang Chengmin Yu Jipin Li Yizhe Zhang Jiaqi Liang Chengye Sun Qunmei Yao national Institute of Occupational Health and poison Control Chinese Center for Disease Control and PreventionBeijingChina Department of Emergency Medicine The People’s Hospital of Chuxiong Yi Autonomous PrefectureChuxiong CityYunnan ProvinceChina

What is already known about this topic?Cordierites frondosus(***)is a species of toxic mushroom known to induce symptoms of photosensitive *** is added by this report?In the months of May and June 2023,a total of four patients in Chuxiong Yi Autonomous Prefecture,Yunnan Province,were affected by *** poisoning,occurring over two distinct *** condition of two patients deteriorated after they were re-exposed to sunlight on the seventh day following the initial ***,an additional two patients reported experiencing a mild,needle-like sensation on areas of their skin exposed to the sun,recorded on the twelfth day subsequent to the *** are the implications for public health practice?Given that symptoms of photosensitive dermatitis,a potential severe consequence of *** poisoning,can manifest up to a week post-sun exposure,it is advisable to avoid sunlight for a minimum of two weeks following poisoning.

关键词： Prefecture poisoning breaks

Mapping global research trends: Nutrition associations with nonalcoholic fatty liver disease - a Scopus bibliometric analysis

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World Journal of Gastroenterology 2024年第24期30卷 3106-3119页

作者： Muna Shakhshir Sa'ed H Zyoud Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Public Health College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine poison Control and Drug Information center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research center An-Najah National University HospitalNablus 44839Palestine

BACKGROUND Several bibliometric analyses have been carried out to identify research hotspots and trends in nonalcoholic fatty liver disease(NAFLD)***,there are still significant knowledge gaps that must be filled to advance our understanding of and ability to treat *** To evaluate,through bibliometric and visual analysis,the current status of related research,related research frontiers,and the developmental trends in the field of diet and *** We retrieved publications about diet and NAFLD published between 1987 and 2022 from ***,we used VOSviewer 1.6.20 to perform bibliometric analysis and *** We found a total of 1905 studies,including 1637(85.93%)original articles and 195(10.24%)reviews,focused on the examination of NAFLD and its correlation with diet that were published between 1987 and *** the remaining five types of documents,38 were letters,notes,editorials,meeting minutes,or brief surveys,representing 1.99%of the total *** countries with the most publications on this topic were China(n=539;28.29%),followed by the United States(n=379;19.90%),Japan(n=133;6.98%),and South Korea(n=127;6.6%).According to the citation analysis,the retrieved papers were cited an average of 32.3 times and had an h-index of 106,with 61014 total *** two main clusters on the map included those related to:(1)Inflammation and oxidative stress;and(2)Dietary interventions for *** This was the first study to use data taken from Scopus to visualize network mapping in a novel bibliometric analysis of studies focused on diet and *** 2017,the two domains that received the most attention were“dietary interventions for NAFL”’and“‘inflammation and oxidative stress implicated in NAFLD and its correlation with diet.”We believe that this study provides important information for academics,dietitians,and doctors,and that additional research on dietary interventions and NAFLD is warranted.

关键词： Dietary Nutrition Bibliometric Nonalcoholic fatty liver Scopus VOSviewer

Development and validation of a novel non-invasive test for diagnosing nonalcoholic fatty liver disease in Chinese children

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World Journal of Pediatrics 2024年第4期20卷 413-421页

作者： Zhe-Wen Qin Qian-Nan Ren Hong-Xi Zhang Ya-Ru Liu Ke Huang Wei Wu Guan-Ping Dong Yan Ni Jun-Fen Fu Division of Endocrinology National Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalDepartment of EndocrinologyNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalZhejiang University School of MedicineHangzhou310052China

With the exploding prevalence of obesity,many children are at risk of developing nonalcoholic fatty liver *** anthropometric and laboratory parameters,our study aimed to develop a model to quantitatively evaluate liver fat content(LFC)in children with *** A well-characterized cohort of 181 children between 5 and 16 years of age were recruited to the study in the Endocrinology Department as the derivation *** external validation cohort comprised 77 *** assessment of liver fat content was performed using proton magnetic resonance *** and laboratory metrics were measured in all subjects.B-ultrasound examination was carried out in the external validation *** Kruskal-Wallis test,Spearman bivariate correlation analyses,univariable linear regressions and multivariable linear regression were used to build the optimal predictive *** The model was based on indicators including alanine aminotransferase,homeostasis model assessment of insulin resistance,triglycerides,waist circumference and Tanner *** adjusted R^(2)of the model was 0.589,which presented high sensitivity and specificity both in internal[sensitivity of 0.824,specificity of 0.900,area under curve(AUC)of 0.900 with a 95%confidence interval:0.783–1.000]and external validation(sensitivity of 0.918 and specificity of 0.821,AUC of 0.901 with a 95%confidence interval:0.818–0.984).Conclusions Our model based on five clinical indicators was simple,non-invasive,and inexpensive;it had high sensitivity and specificity in predicting LFC in ***,it may be useful for identifying children with obesity who are at risk for developing nonalcoholic fatty liver disease.

关键词： Biochemical markers Children Magnetic resonance spectroscopy Nonalcoholic fatty liver disease Pediatric obesity

A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

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Nano Research 2024年第6期17卷 5424-5434页

作者： Jinna Ren Jingying Hu Fan Dong Yan Xu Yang Peng Yuping Qian Guanmeng Zhang Min Wang Yuguang Wang Department of Prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China Department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIP Department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic ***,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune *** this basis,the editor can be combined with optical therapy to improve patient *** this study,the metal ratio was regulated in response to the nanocarrier of acid response ***,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell *** on these results,the nanoparticles were cracked in an acidic environment and then released copper ***,the nanoparticles contributed to cuprotosis and immunogenic *** addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without *** rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for ***,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell *** all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

Incidence and Mortality of Cancers in Female Genital Organs—China,2022

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China CDC weekly 2024年第10期6卷 195-202,I0003,I0004页

作者： Kexin Sun Bingfeng Han Hongmei Zeng Shaoming Wang Li Li Ru Chen Rongshou Zheng Wenqiang Wei national Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Introduction:This study presented the incidence and mortality rates of cancers affecting the female genital organs in China,along with their trends spanning from 2010 to ***:700 population-based cancer registries provided relevant cancer incidence and mortality data for the year *** these,106 registries had continuous monitoring data suitable for trend analysis from 2010 to *** focused specifically on cancers affecting female genital organs(ICD10=C51-C54,C56)and projected their incidences and mortalities in China for 2022 based on data from 2018 and the trends observed from 2010 to ***-standardized incidence rate(ASIR)and mortality rate(ASMR)were calculated using Segi’s world standard ***:In 2022,there were an estimated 296,300 new cases and 104,900 deaths from female cancers in *** for vulva(C51),vagina(C52),cervix uteri(C53),corpus uteri(C54),and ovary(C56)were 0.32,0.23,13.83,6.84,and 5.68 per 100,000 *** for corpus uteri and ovary cancers were higher in urban *** for vulva,vagina,cervix,corpus uteri,and ovary cancers were 0.14,0.08,4.54,1.05,and 2.64 per 100,000 population,*** for ovarian cancer was higher in urban *** and ASMRs for most female genital organ cancers increased from 2010 to 2018,although the rate of increase for vulvar and cervical cancers in rural areas has slowed ***:Tailored cancer prevention and control programs specific to each region are necessary to address the growing disease burden.

关键词： ICD10 mortality organs

The Burden of Hypertension-Related Chronic Kidney Disease—China,2010–2019

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China CDC weekly 2024年第14期6卷 282-288页

作者： Youyuan Bu Yueru Liu Maigeng Zhou Peng Yin Kejun Liu Yamin Bai Xuancheng Lu Chinese center for Disease Control and Prevention BeijingChina national center for Chronic and Non-Communicable Disease Control and Prevention Chinese Center For Disease Control and PreventionBeijingChina China national Health Development Research center BeijingChina

What is already known about this topic?The global burden of chronic kidney disease(CKD)is on the *** is added by this report?In 2019,5.58 million individuals in China were affected by CKD related to hypertension,leading to 70,260 fatalities and 1.69 million disability-adjusted life years(DALYs).The most affected groups were men,older individuals,and residents of western *** the period from 2010–2019,the age-standardized prevalence rate(ASPR)remained constant,and the agestandardized mortality rate(ASMR)and agestandardized DALY rate(ASDR)showed a decreasing ***,there was an increase in the number of cases,deaths,and DALYs associated with this *** are the implications for public health practice?Hypertension significantly contributes to the burden of CKD;therefore,raising awareness and implementing early screening measures are essential.

关键词： Kidney mortality burden

Review on Security Defense Technology Research in Edge Computing Environment

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Chinese Journal of Electronics 2024年第1期33卷 1-18页

作者： Ke SHANG Weizhen HE Shuai ZHANG national Digital Switching System Engineering and Technological R&D center

Edge computing, which achieves quick data processing by sinking data computing and storage to the network edge, has grown rapidly along with the Internet of things. The new network architecture of edge computing brings new security challenges. Based on this, this paper investigates the edge computing security literature published in recent years and summarizes and analyzes research work on edge computing security from different attack surfaces. We start with the definition and architecture of edge computing. From the attack surface between device and edge server, as well as on edge servers, the research describes the security threats and defense methods of edge computing. In addition, the cause of the attack and the pros and cons of defense methods is introduced. The challenges and future research directions of edge computing are given.

关键词： Cloud computing Systems architecture Computer architecture Network architecture Data processing Security Servers

Recent progress in functional modification and crosslinking of bioprosthetic heart valves

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Regenerative Biomaterials 2024年第1期3卷 1-16页

作者： Cheng Zheng Li Yang Yunbing Wang national Engineering Research center for Biomaterials Sichuan UniversityChengdu 610064China

Valvular heart disease(VHD),clinically manifested as stenosis and regurgitation of native heart valve,is one of the most prevalent cardiovascular diseases with high *** valve replacement surgery has been recognized as golden standard for the treatment of *** to the clinical application of transcatheter heart valve replacement technic and the excellent hemodynamic performance of bioprosthetic heart valves(BHVs),implantation of BHVs has been increasing over recent years and gradually became the preferred choice for the treatment of ***,BHVs might fail within 10-15 years due to structural valvular degeneration(SVD),which was greatly associated with drawbacks of glutaraldehyde crosslinked BHVs,including cytotoxicity,calcification,component degradation,mechanical failure,thrombosis and immune *** prolong the service life of BHVs,much effort has been devoted to overcoming the drawbacks of BHVs and reducing the risk of *** this review,we summarized and analyzed the research and progress on:(i)modification strategies based on glutaraldehyde crosslinked BHVs and(ii)nonglutaraldehyde crosslinking strategies for BHVs.

关键词： bioprosthetic heart valves modification crosslinking anticalcification antithrombosis

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in underdoped Bi2Sr2CaCu2O8+δ

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national Science Review 2024年第5期11卷 142-152页

作者： Shiyuan Wang Yijun Yu Jinxiang Hao Keyi Liang Bingke Xiang Jinjiang Zhu Yishi Lin Yinping Pan Genda Gu Kenji Watanabe Takashi Taniguchi Yang Qi Yuanbo Zhang Yihua Wang State Key Laboratory of Surface Physics and Department of Physics Fudan University Condensed Matter Physics and Materials Science Department Brookhaven National Laboratory Research center for Functional Materials National Institute for Materials Science International center for Materials Nanoarchitectonics National Institute for Materials Science Shanghai Research center for Quantum Sciences

Superconducting phase transitions in two dimensions lie beyond the description of the Ginzburg-Landau symmetry-breaking paradigm for three-dimensional *** are Berezinskii-KosterlitzThouless（BKT） transitions of paired-electron condensate driven by the unbinding of topological excitations,*** recently discovered monolayers of layered high-transition-temperature（TC）cuprate superconductor Bi2Sr2CaCu2O8+δ（Bi2212） meant that this 2D superconductor promised to be ideal for the study of unconventional *** inhomogeneity posed challenges for distinguishing BKT physics from charge correlations in this ***,we utilize the phase sensitivity of scanning superconducting quantum interference device microscopy susceptometry to image the local magnetic response of underdoped Bi2212 from the monolayer to the bulk throughout its phase *** monolayer segregates into domains with independent phases at elevated temperatures below *** a single domain,we find that the susceptibility oscillates with flux between diamagnetism and paramagnetism in a Fraunhofer-like pattern up to *** finite modulation period,as well as the broadening of the peaks when approaching Tc from below,suggests well-defined vortices that are increasingly screened by the dissociation of vortex-antivortex plasma through a BKT *** the multilayers,the susceptibility oscillation differs in a small temperature regime below TC,consistent with a dimensional crossover led by interlayer *** as strong evidence for BKT transition in the bulk,we observe a sharp jump in phase stiffness and paramagnetism at small fields just below *** results unify the superconducting phase transitions from the monolayer to the bulk underdoped Bi2212,and can be collectively referred to as the BKT transition with interlayer coupling.

关键词： cuprate superconductor monolayer Berezinskii-Kosterlitz-Thouless transition scanning SQUID paramagnetic Meissner effect