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Discovery and structure-activity relationship studies of novel tetrahydro-β-carboline derivatives as apoptosis initiators for treating bacterial infections

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Journal of Integrative Agriculture 2024年第4期23卷 1259-1273页

作者： Shanshan Su Hongwu Liu Junrong Zhang Puying Qi Yue Ding Ling Zhang Linli Yang Liwei Liu Xiang Zhou Song Yang national key laboratory of Green Pesticide/key laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education/Center for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China

Developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food *** this paper,to discover the new bactericide candidates,we designed,prepared a new type of1,2,3,4-tetrahydro-β-carboline(THC)derivatives and evaluated the in vitro and in vivo bioactivities against the Xanthomonas oryzae ***(Xoo),Xanthomonas axonopodis ***(Xac),and Pseudomonas syringae ***(Psa).The in vitro bioassay results exhibited that most title molecules possessed good activity toward the three plant pathogenic bacteria,the compound A17 showed the most active against Xoo and Xac with EC50 values of 7.27 and 4.89 mg mL^(-1)respectively,and compound A8 exhibited the best inhibitory activity against Psa with EC50value of 4.87 mg mL^(-1).Pot experiments showed that compound A17 exhibited excellent in vivo antibacterial activities to manage rice bacterial leaf blight and citrus bacterial canker,with protective efficiencies of 52.67 and 79.79%at 200 mgmL^(-1),***,compound A8 showed good control efficiency(84.31%)against kiwifruit bacterial canker at 200 mg mL^(-1).Antibacterial mechanism suggested that these compounds could interfere with the balance of the redox system,damage the cell membrane,and induce the apoptosis of Xoo *** together,our study revealed that tetrahydro-β-carboline derivatives could be a promising candidate model for novel broadspectrum bactericides.

关键词： tetrahydro-β-carboline derivatives antibacterial activity ROS cell apoptosis

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Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification

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Plant Diversity 2024年第3期46卷 372-385页

作者： Shanni Cao Xue Zhao Zhuojin Li Ranran Yu Yuqi Li Xinkai Zhou Wenhao Yan Dijun Chen Chao He State key laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China national key laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China

Plant morphogenesis relies on precise gene expression programs at the proper time and position which is orchestrated by transcription factors(TFs)in intricate regulatory networks in a cell-type specific *** we introduced a comprehensive single-cell transcriptomic atlas of Arabidopsis *** atlas is the result of meticulous integration of 63 previously published scRNA-seq datasets,addressing batch effects and conserving biological *** integration spans a broad spectrum of tissues,including both below-and above-ground *** a rigorous approach for cell type annotation,we identified 47 distinct cell types or states,largely expanding our current view of plant cell *** systematically constructed cell-type specific gene regulatory networks and uncovered key regulators that act in a coordinated manner to control cell-type specific gene *** together,our study not only offers extensive plant cell atlas exploration that serves as a valuable resource,but also provides molecular insights into gene-regulatory programs that varies from different cell types.

关键词： Arabidopsis Single cell transcriptome Gene regulatory network Data integration Plant cell atlas

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Simulating a Chern Insulator with C = ±2 on Synthetic Floquet Lattice

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Chinese Physics Letters 2024年第9期41卷 4-11页

作者：雷凌霄王伟臣黄光耀胡顺曹希张鑫方邓明堂陈平形 Institute for Quantum Science and Technology College of ScienceNational University of Defense Technology Institute for Quantum Information & State key laboratory of High Performance Computing College of Computer Science and Technology National University of Defense Technology Greatwall Quantum laboratory Hefei national laboratory

The synthetic Floquet lattice, generated by multiple strong drives with mutually incommensurate frequencies,provides a powerful platform for quantum simulation of topological phenomena. In this study, we propose a 4-band tight-binding model of the Chern insulator with a Chern number C = ±2 by coupling two layers of the half Bernevig-Hughes-Zhang lattice and subsequently mapping it onto the Floquet lattice to simulate its topological properties.

关键词： Quantum computers

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Elaborative collection of condensed combustion products of solid propellants:Towards a real Solid Rocket Motor(SRM)operational environment

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Chinese Journal of Aeronautics 2024年第1期37卷 77-88页

作者： Wenchao ZHANG Zhimin FAN Dongliang GOU Yao SHU Peijin LIU Aimin PANG Wen AO national key laboratory of Solid Rocket Propulsion Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Aerospace Chemical Power laboratory Xiangyang 441003China

A novel constant-pressure and constant-quenching distance Condensed Combustion Products(CCPs)collection system was developed,coupled with a timing control system,to collect the CCPs formed in the course of burning of aluminum-based composite *** effects of adiabatic graphite plating,collection zone,quenching distance,time series of collection,and propellant burning rate on the microscopic morphology,particle size distribution and unburned aluminum content of CCPs were *** was verified that the graphite plating can provide a high-fidelity high-temperature environment for propellant *** combustion efficiency is improved by 2.44% compared to the bare propellant *** time series of collection has a significant effect on the combustion efficiency of aluminum,and the combustion efficiency of aluminum in the thermal state(1.2-2.4 s)is 2.75% higher than that in the cold state(0-1.2 s).Similarly,the characteristics of the CCPs in different collection zones are *** the quenching distance of 5 mm,the combustion efficiency of aluminum in the core zone(85.39%)is much lower than that in the outer zone(92.07%),while the particle size of the CCPs in the core zone(172μm)is larger than that in the outer zone(41μm).This indicates that the core zone is more likely to produce large-sized and incompletely burned agglomerates during the propellant combustion *** burning rates also lead to a significant difference in particle size distribution and combustion *** burning rates result in higher combustion efficiency.A detailed sequence of the elaborative collection process of CCPs is proposed,mainly including the setting of ignition delay time,burning rate,working pressure,plating length and time series of *** findings of this study are expected to provide a reliable tool for the evaluation of the combustion efficiency of solid propellants.

关键词： Composite propellants Condensed combustion products Aluminum Combustion efficiency Particle size distribution

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Full bandwidth statistical properties of the Raman random fiber laser

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Chinese Optics Letters 2024年第6期22卷 142-147页

作者： Jiaojiao Zhang Shengtao Lin Xingyu Bao Pan Wang Yifei Qi Han Wu Jing Liang Zinan Wang key laboratory of Optical Fiber Sensing and communications University of Electronic Science and Technology of ChinaChengdu 611731China College of Electronics and Information Engineering Sichuan UniversityChengdu 610064China

The Raman random fiber laser (RRFL) is a typical complex physical system due to the intrinsic random feedback of the fiber,which causes complexity in the RRFL output. So far, the time-domain statistical attributes of the RRFL are still not fully characterized. In this paper, the temporal statistical properties of the RRFL are investigated comprehensively for the first time under the full bandwidth condition. First, the time-domain intensity statistical characteristics of the RRFL under the full bandwidth condition are theoretically studied: the results demonstrate that the intensity probability density function of the RRFL is related to the pump power and observing position and deviates inward from the exponential distribution, indicating that correlation exists between the different frequency components in the spectrum. Afterward, in the validation experiment, an elaborate structure is designed to realize a narrow-bandwidth 1053 nm RRFL, and its full bandwidth temporal intensity statistical features manifest an identical variation pattern to the simulation results. This work fills a vacancy in the study of RRFL temporal statistical features and rigorously reveals the different physical mechanisms between RRFL and amplified spontaneous emission light sources, providing instructions for the application of the RRFL.

关键词： random-distributed-feedback fiber laser Raman gain Rayleigh scattering statistical analysis

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Global optimization of double protograph LDPC codes for JSCC scheme

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Science China(Information Sciences) 2024年第6期67卷 455-456页

作者： Qiwang CHEN Chen CHEN Yu-Cheng HE Zhiping XU Xiamen key laboratory of Mobile Multimedia communications College of Information Science and EngineeringHuaqiao University key laboratory of Underwater Acoustic Communication and Marine Information Technology (Xiamen University) Ministry of Education School of Ocean Information Engineering Jimei University

A double low-density parity-check (D-LDPC) coding system was proposed in[1]as a typical joint source-channel coding(JSCC) scheme[1–5].In this system,two LDPC coding matrices perform source and channel coding,*** important concept in a D-LDPC coding system is the introduction of a linking matrix between the check nodes (CNs)of the source coding matrix and the variable nodes (VNs) of the channel LDPC coding matrix.

关键词： JOINT SOURCE DESIGN

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Chain Dynamics Heterogeneity in Plasticized Poly(vinyl butyral)(PVB) as Elucidated by Solid-State NMR

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Chinese Journal of Polymer Science 2024年第1期42卷 113-124,I0010页

作者： Jing Lv Xu Chen Zi-Shuo Wu Ya-Hui Li Wei Chen national Synchrotron Radiation laboratory Anhui Provincial Engineering Laboratory of Advanced Functional Polymer FilmCAS Key Laboratory of Soft Matter ChemistryUniversity of Scienceand Technology of ChinaHefei 230026China

The chain dynamics heterogeneity of the poly(vinyl butyral)(PVB) plasticized by triethylene glycol bis(2-ethylhexa noate)(TEG-EH) was investigated by various solid-state NMR *** plasticized PVB shows two domains in distinct molecular dynamics differences,namely,rigid and soft domains,where the latter is the plasticizer-rich *** time domain low field NMR was first used to investigate the dynamics heterogeneity of the plasticized PVB,and the results show the decreasing activated energy of components in the soft domain of plasticized PVB(E_a=20.2 kJ/mol) as compared with that of the pristine one(E_a=24.3 kJ/mol).Detailed dynamics heterogeneity was obtained by high-field NMR with site-specific *** quadrupole-echo ~2H-NMR was adopted to elucidate the dynamics heterogeneity of the vinyl alcohol(VA) units,where only the hydroxyl group of VA is *** ~1H-^(13)C WISE NMR spectra show that there is not much difference in the mobility of the VB unit in PVB with and without plasticizer,whereas the glass transition temperature differed by approximately 53℃.This is further supported by Torchia's T_1 relaxation *** origin of such an unusual phenomenon is attributed to the critical role of the remaining VA(~22%) in the soft domain,where the VA units locally aggregate through hydrogen ***,the existence of a mobility gradient in the VB unit has been ***,the mobility difference for VB with different stereo-geometry(meso or racemic conformation) is observed for the first *** indicates the importance of modulating the ratio of meso over racemic VB for controlling the macroscopic perfo rmance of PVB.

关键词： Poly(vinyl butyral) Dynamics heterogeneity Plasticizer Solid state NMR

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Pressure-induced color change arising from transformation between intra-and inter-band transitions in LuH_(2±x)N_(y)

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 161-166页

作者： Zhe Liu Yingjie Zhang Shenyang Huang Xue Ming Qing Li Chenghao Pan Yaomin Dai Xiaoxiang Zhou Xiyu Zhu Hugen Yan Hai-Hu Wen Center for Superconducting Physics and Materials National Laboratory of Solid State Microstructures and Department of PhysicsNational Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China State key laboratory of Surface Physics Key Laboratory of Micro and Nano-Photonic Structures of the Ministry of EducationDepartment of PhysicsFudan UniversityShanghai 200433China

The pressure-induced color change in the nitrogen-doped lutetium hydride has triggered extensive discussions about the underlying physics and potential ***,we study the optical response of LuH_(2±x)N_(y)in a broad frequency range at ambient pressure and its evolution with pressure in the visible spectral *** broad-band optical spectra at ambient pressure reveal a Drude component associated with intra-band electronic transitions and two Lorentz components(L1 and L2)arising from inter-band electronic *** application of pressure causes a spectral weight transfer from L1 to the Drude component,leading to a blue shift of the plasma edge in the reflectivity spectrum alongside a reduction of the high-frequency *** results suggest that the pressure-induced color change in LuH_(2±x)N_(y)is closely related to the transformation between intra-and inter-band electronic transitions,providing new insights into the mechanism of the pressure-induced color change in LuH_(2±x)N_(y).

关键词： nitrogen-doped lutetium hydride optical spectroscopy high-pressure technique color change

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Multi-stream signals separation based on space-time-isomeric (SPATIO) array using metasurface antennas

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Science China(Information Sciences) 2024年第2期67卷 181-200页

作者： Yangming LOU Liang JIN Huiming WANG Zhou ZHONG Junyan DAI PLA Strategic Support Force Information Engineering University School of Information and communications Engineering Xi'an Jiaotong University 3. State Key Laboratory of Millimeter WavesSoutheast University

In spatial domain signal processing, it is necessary to equip more antennas at the receiver to improve spatial demultiplexing capability. However, increasing the number of antennas under restricted space will reduce antenna spacing and raise the channel correlation, making the number of signal streams spatially demultiplexed much smaller than that of antennas. This paper proposes a method to design a space-timeisomeric(SPATIO) array based on metasurface antennas under wireless multipath conditions. Each antenna in this array has a different pattern and varies independently with time, reducing the channel correlation by superposing multipath at distinct positions and moments. Based on the SPATIO array, we present an array parameter design scheme based on infinity norm minimization, which can maximize the received energy of each stream while separating multi-stream received signals. Simulation results illustrate the performance of the SPATIO array for multi-stream signal reception. Compared with conventional multiple-input multipleoutput arrays, the proposed array can reduce the bit error rate by one order of magnitude under the same simulation conditions.

关键词： multiple-input multiple-output metasurface antenna space-time-isomeric array multipath channel degree of freedom

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An Icy Worlds life detection strategy based on Exo-AUV

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Science China Earth Sciences 2024年第11期67卷 3515-3535页

作者： Bin WANG Hongde QIN national key laboratory of Autonomous Marine Vehicle Technology Harbin Engineering University Shipbuilding Engineering College Harbin Engineering University

In the solar system, Icy Worlds such as Europa and Enceladus hold great potential for extraterrestrial life and may provide humanity an answer, within this century, to the age-old question of life beyond Earth. Exo-AUV technology shows promise in life detection in the icy shell, at the ice-water interface and on the seafloor of exo-ocean. Space agencies, including NASA and DLR, are enthusiastic about deploying Exo-AUVs to explore life in these regions. However, the where and how to find life, the technologies to be utilized and the goals to be achieved are crucial aspects for future Exo-AUV life detection missions on Icy Worlds. This study delves into a hypothetical mission of life detection on Europa, discussing science goals,detectable objects, potential regions and biogenic analysis for Icy Worlds. It proposes a life detection strategy for Icy Worlds based on Exo-AUVs, presents key contextual elements for Exo-AUV operations, outlines technological requirements for hull,payloads and autonomy, introduces the current state of Exo-AUV research and addresses existing challenges. This study also suggests a roadmap for conceptual development of Exo-AUV and a Concept of Operations for Multiple Exo-AUV System(ConOps for MEAS). This system aims to assist planetary scientists and astrobiologists in exploring Icy Worlds, identifying robust biosignatures and potentially discovering extant organisms, even prebiotic chemical systems.

关键词： Icy Worlds Europa Life detection Biological potential Exo-AUV

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