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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu key lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Some Notes on Generalized Cyclotomic Sequences of Length pq

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Journal of Computer Science & Technology 2008年第5期23卷 843-850页

作者：陈智雄李胜强 key lab of Applied Mathematics Putian University key lab of Network Security and Cryptology Fujian Normal University national key lab of communication University of Electronic Science and Technology of China

We review the constructions of two main kinds of generalized cyclotomic binary sequences with length pq （the product with two distinct primes）. One is the White-generalized cyclotomic sequences, the other is the Ding-Helleseth（DH, for short）-generalized cyclotomic sequences. We present some new pseudo-random properties of DH-generalized cyclotomic sequences using the theory of character sums instead of the theory of cyclotomy, which is a conventional method for investigating generalized cyclotomic sequences.

关键词： stream cipher generalized cyclotomic sequence pseudo-random binary sequence character sum correlation

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Multi-channel blind deconvolution algorithm for multiple-input multiple-output DS/CDMA system

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Journal of Systems Engineering and Electronics 2007年第3期18卷 454-461页

作者： Cheng Hao Guo Wei Jiang Yi national key lab of communication Univ. of Electronic Science and Technology Chengdu 610054 P. R. China

Direct sequence spread spectrum transmission can be realized at low SNR, and has low probabilityof detection. It is aly problem how to obtain the original users＇ signal in a non-cooperative context. In practicality, the DS/CDMA sources received are linear convolute mixing. A more complex multichannel blind deconvolution MBD algorithm is required to achieve better source separation. An improved MBD algorithm for separating linear convolved mixtures of signals in CDMA system is proposed. This algorithm is based on minimizing the average squared cross-output-channel-correlation. The mixture coefficients are totally unknown, while some knowledge about temporal model exists. Results show that the proposed algorithm can bring about the exactness and low computational complexity.

关键词： DS/CDMA signal non-cooperative MBD stochastic gradient algorithms for MBD.

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Leakage-based user scheduling in MU-MIMO broadcast channel

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Science in China(Series F) 2009年第12期52卷 2259-2268页

作者： XIA Xin WU Gang LIU Jing LI ShaoQian national key lab of communication University of Electronic Science and Technology of China Chengdu 611731 China

This paper investigates user scheduling in multi-user MIMO broadcast channel. We propose a leakagebased user scheduling scheme, in which a user＇s leakage power to other users is an important factor to determine whether the user should be selected. The accuracy of closed-form solution of SLNR （signal to leakage plus noise ratio） makes the proposed scheme outperform the traditional scheduling method based on SlNR （signal to interference plus noise ratio）. The proposed algorithms can work in case of perfect or limited feedback of CSI （channel state information） at transmitter, and the advantage is verified with numerical results. A tradeoff relation among feedback bits number, active user number and transmit/receive antennas number is analyzed, which serves as a system design guideline.

关键词： multi-user MIMO scheduling precoding SLNR

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Local prediction of the chaotic fh-code based on LS-SVM

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Journal of Systems Engineering and Electronics 2008年第1期19卷 65-70页

作者： Wang Yi Guo Wei national key lab of communication Univ. of Electronic Science and Technology of China Chengdu 610054 P. R. China

Support vector machine （SVM） is powerful to solve some problems such as nonlinear classification, function estimation and density estimation. To consider the chaotic fh （frequency hopping）-code＇s characters in chaotic dynamic system, the forecasting model of the support vector machine in combination with Takens＇ delay coordinate phase reconstruction of chaotic times is established and the least squares model for large-scale problems is used in local training for this model. Finally, a fh-code series generated by Logistic-Kent mapping is applied to verify the local prediction model. Simulation results show that the high accuracy and fault tolerant SVM model has an excellent performance in predicting the fh code, with a very low mean square error and a high relative coefficient.

关键词： support vector machine(SVM) fh code least squares(LS) prediction

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Price-based time and energy allocation in cognitive radio multiple access networks with energy harvesting

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Science China(Information Sciences) 2017年第10期60卷 258-260页

作者： Ding XU Qun LI Wireless communication key lab of Jiangsu Province Nanjing University of Posts and Telecommunications

Cognitive radio(CR),a concept that can solve the conflict between spectrum scarcity and low spectrum utilization,has been researched widely recently[1].There are mainly three CR models:interweave,overlay and underlay[... 详细信息

关键词： CBS Price-based time and energy allocation in cognitive radio multiple access networks with energy harvesting

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Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng Li Zhuoran Yang Ziming Yan Huibin Shi Zhanli Liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

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Modified Omega-K algorithm for processing helicopter-borne frequency modulated continuous waveform rotating synthetic aperture radar data

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Journal of Systems Engineering and Electronics 2015年第3期26卷 476-485页

作者： Dong Li Guisheng Liao Yong Liao Lisheng Yang key laboratory of Aerocraft Tracking Telemetering & Command and communication Ministry of EducationChongqing University national lab of Radar Signal Processing Xidian University

With appropriate geometry configuration, helicopter- borne rotating synthetic aperture radar （ROSAR） can break through the limitations of monostatic synthetic aperture radar （SAR） on forward-looking imaging. With this capability, ROSAR has extensive potential applications, such as self-navigation and self-landing. Moreover, it has many advantages if combined with the frequency modulated continuous wave （FMCW） technology. A novel geometric configuration and an imaging algorithm for helicopter-borne FMCW-ROSAR are proposed. Firstly, by per- forming the equivalent phase center principle, the separated trans- mitting and receiving antenna system is equalized to the case of system configuration with antenna for both transmitting and receiving signals. Based on this, the accurate two-dimensional spectrum is obtained and the Doppler frequency shift effect in- duced by the continuous motion of the platform during the long pulse duration is compensated. Next, the impacts of the velocity approximation error on the imaging algorithm are analyzed in de- tail, and the system parameters selection and resolution analysis are presented. The well-focused SAR image is then obtained by using the improved Omega-K algorithm incorporating the accurate compensation method for the velocity approximation error. FJnally, correctness of the analysis and effectiveness of the proposed al- gorithm are demonstrated through simulation results.

关键词： helicopter-borne rotating synthetic aperture radar(ROSAR) frequency modulated continuous wave (FMCW) improved Omega-K algorithm two-dimensional spectrum.

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Comparison between several satellite constellation schemes for MEO-TDRSS of China

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Journal of Systems Engineering and Electronics 2008年第5期19卷 907-913页

作者： Wu Tingyong Wu Shiqi The national key lab. of communication Univ. of Electronic Science and Technology of China Chengdu 610054 P. R. China

The satellite constellation classes, which are suitable for the medium earth orbit tracking and data relay satellite system （MEO-TDRSS） of China, are investigated. On the basis of the functionality and the traffic distribution characteristic of MEO-TDRSS, the coverage performance and inter-satellite link properties of four different constellation schemes are compared by simulations. Simulation results indicate that the rosette and common-track constellations, whose satellites are distributed on the celestial sphere more uniformly, are appropriate for the implementation of MEO-TDRSS of China.

关键词： medium earth orbit tracking and data relay satellite system (MEO-TDRSS) satellite constellation,inter-satellite links.

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Subspace decomposition-based correlation matrix multiplication

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Journal of Systems Engineering and Electronics 2008年第2期19卷 241-245页

作者： Cheng Hao Guo Wei Yu Jingdong national key lab of communication Univ. of Electronic Science and Technology of China Chengdu 610054 P. R. China

The correlation matrix, which is widely used in eigenvalue decomposition （EVD） or singular value decomposition （SVD）, usually can be denoted by R = E[yiy＇i]. A novel method for constructing the correlation matrix R is proposed. The proposed algorithm can improve the resolving power of the signal eigenvalues and overcomes the shortcomings of the traditional subspace methods, which cannot be applied to low SNR. Then the proposed method is applied to the direct sequence spread spectrum （DSSS） signal＇s signature sequence estimation. The performance of the proposed algorithm is analyzed, and some illustrative simulation results are presented.

关键词： subspace theory correlation matrix eigenvalue decomposition direct sequence spread spectrum signal

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