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Wuhan University Journal of Natural Sciences 2005年第1期10卷 183-185页

作者： FUXiao-tong XIAOHong XIAOGuo-zhen Nationa｜KeyLaboratoryofIntegratedServiceNetworks XidianUniversityXi＇an710071ShaanxiChina

We ayptanalyze Kim et. al's one-time proxy signature scheme used in mobileagents, and then a successful forgery is introduced It is showed that a dishonest customer cansuccessfully forge a valid one-time proxy signature by impersonating the stiver Furthermore, he canrequest the server with responsibility for the forged bidding information.

关键词： cryptanalysis proxy signature one-time proxy signature

High-order harmonic generation spectrum of an excited one-dimensional Coulomb atom in an intense laser field

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Chinese Physics B 2007年第3期16卷 675-679页

作者：周兆妍袁建民 Department of Physics Nationa/University of Defense Technology Changsha 410073 China

Response of the wave packet of a one-dimensional Coulomb atom to an intense laser field is calculated using the symmetrized split operator fast Fourier method. The high-order harmonic generation （HHG） of the initial state separately being the ground and excited states is presented. When the hardness parameter a in the soft Coulomb potential V（x） =-1√x^2＋α is chosen to be small enough, the so-called hard Coulomb potential V（x）=1/｜x｜ can be obtained. It is well known that the hard one-dimensional Coulomb atom has an unstable ground state with an energy eigenvalue of - 0.5 and it has no states corresponding to physical states in the true atoms, and has the first and second excited states being degenerate. The parity effects on the HHG can be seen from the first and second excited states of the hard one-dimensional Coulomb atom. The HHG spectra of the excited states from both the soft and hard Coulomb atom models are shown to have more complex structures and to be much stronger than the corresponding HHG spectrum of the ground state of the soft Coulomb model with a = 2 in the same laser field. Laser-induced non-resonant one-photon emission is also observed.

关键词： high order harmonic generation intense laser field one-dimensional Coulomb atom

Role of inhibiting LIM-kinase2 in improving erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury

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Asian Journal of Andrology 2018年第4期20卷 372-378页

作者： Juhyun Park Sung Yong Cho Kwanjin Park Ji Sun Chai Hwancheol Son Soo Woong Kim Jae-Seung Paick Min Chul Cho Department of Urology Seoul National University College of Medicine SMG-SNU Boramae Medical Center Seoul 03080 Korea Department of Urology Seoul Nationa University College of Medicine Seoul National University Hospital Seoul 07061 Korea

We evaluated whether LIM-kinase 2 inhibitor （LIMK2i） could improve erectile function by suppressing corporal fibrosis through the normalization of the Rho-associated coiled-coil protein kinase 1 （ROCK1）/LIMK2/Cofilin pathway in a rat model of cavernous nerve crush injury （CNCl）. Sixty 11-week-old male Sprague-Dawley rats were divided equally into five groups： sham surgery （S）, CNCl （I）, and CNCl treated with low-dose （L）, medium-dose （M）, and high-dose （H） LIMK2i. The L, M, and H groups were treated with a daily intraperitoneal injection of LIMK2i （2.5, 5.0, and 10.0 mg kg-1 body weight, respectively） for 1 week after surgery. The erectile response was assessed using electrostimulation at 1 week, postoperatively. Penile tissues were processed for Masson＇s trichrome staining, double immunofluorescence, and Western blot assay. Erectile responses in the H group improved compared with the I group, while the M group showed only partial improvement. A significantly decreased smooth muscle/collagen ratio and an increased content of fibroblasts positive for phospho-/IMK2 were noted in the I group. The M and H groups revealed significant improvements in histological alterations and the dysregulated LIMK2/Cofilin pathway, except for LIMK2 phosphorylation in the M group. The inhibition of LIMK2 did not affect the ROCK1 protein expression. The content of fibroblasts positive for phospho-LIMK2 in the H group returned to the level found in the S group, whereas it did not in the M group. However, the L group did not exhibit such improvements. Our data suggest that the inhibition of LIMK2, particularly with administration of 10.0 mg kg^-1 body weight LIMK2i, can improve corporal fibrosis and erectile function by normalizing the LIMK2/Cofilin pathway.

关键词： erectile dysfunction fibrosis LIM kinase penis prostatectomy

Testosterone replacement therapy： dilemmas and challenges in China and Asia

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Asian Journal of Andrology 2018年第2期20卷 149-151页

作者： Qi An Yi-Qun Gu Graduate School Peking Union Medical College Beijing 100730 China Nationa Health and Family Planning Key Laboratory of Male Reproductive Health National Research Institute for Family Planning Beijing 100081 China

Late-onset hypogonadism （LOH） has been described as a clinical syndrome comprising symptoms consistent with androgen deficiency and a circulating concentration of testosterone in the low-to-normal range in some middle-aged and elderly men. The presence of symptoms may affect the health and quality of life in aging men and it has become a hot spot in global medical research, diagnosis, and treatment in the recent years.

关键词： LATE-ONSET HYPOGONADISM CARDIOVASCULAR RISKS ANDROGEN DEFICIENCY MEN METAANALYSIS EVENTS AGE

Genetics and genomics of prostate cancer

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Asian Journal of Andrology 2013年第3期15卷 309-313页

作者： Michael Dean Hong LOU Cancer and Inflammation Program National Cancer Institute National Institutes of Health Frederick MD 21702 USA Basic Science Program SAIC-Frederick Nationa Cancer Institute National Institutes of Health Frederick MD 21702 USA

Prostate cancer （PCa） is one of the most common malignancies in the world with over 890 000 cases and over 258 000 deaths worldwide each year. Nearly all mortalities from PCa are due to metastatic disease, typically through tumors that evolve to be hormone-refractory or castrate-resistant. Despite intensive epidemiological study, there are few known environmental risk factors, and age and family history are the major determinants. However, there is extreme heterogeneity in PCa incidence worldwide, suggesting that major determining factors have not been described. Genome-wide association studies have been performed and a considerable number of significant, but low-risk loci have been identified. In addition, several groups have analyzed PCa by determination of genomic copy number, fusion gene generation and targeted resequencing of candidate genes, as well as exome and whole genome sequencing. These initial studies have examined both primary and metastatic tumors as well as murine xenografts and identified somatic alterations in TP53and other potential driver genes, and the disturbance of androgen response and cell cycle pathways. It is hoped that continued characterization of risk factors as well as gene mutation and misregulation in tumors will aid in understanding, diagnosing and better treating PCa.

关键词： androgen receptor cancer progression chromatin remodeling metastasis prostate cancer （PCa） risk factor somaticmutation tumor heterogeneity

Age differences in associations of serum alkaline phosphatase and mortality among peritoneal dialysis patients

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Chinese Medical Journal 2019年第2期132卷 232-236页

作者： Juan Wu Xin-Hui Liu Rong Huang Hai-Shan Wu Qun-Ying GUO Chun-Yan Yi Xue-Qing YU Xiao Yang Department of Nephrology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Nephrology Nationa[Health Commission and Guangdong ProvinceGuangzhouGuangdong 510080China Department of Nephrology Zhejiang Provincial People's HospitalHangzhouZhejiang 310014China

To the Editor:Serum alkaline phosphatase (ALP) is an important bone turnover marker in chronic kidney disease (CKD) patients, with studies indicating that higher serum ALP levels are associated with increased mortality in hemodialysis (HD) patients.[1] Our previous study also showed that higher serum ALP levels were independently associated with all-cause and cardiovascular mortality in peritoneal dialysis (PD) patients.

关键词： Serum alkaline phosphatase turnover chronic kidney

Berberine induced autophagic cell death by elevating GRP78 level in cancer cells

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Berberine induced autophagic cell death by elevating GRP78 l...

Effects of Rhizosphere Dissolved Oxygen Content and Nitrogen Form on Root Traits and Nitrogen Accumulation in Rice

2017第七届泛环渤海生物化学与分子生物学会学术交流会

作者： Xiaoqin La Zhuoyu Li Institute of Biotechnology Key Laboratory of Chemical Biology and Molecular Engineering of Nationa1 Ministry of EducationShanxi University Institutes of Biomedical Sciences Shanxi University School of Life Science Shanxi University

Autophagy is the cellular process that delivers damaged organelles and invasive bacteria to lysosomes for degradation so as to maintain the intracellular homeostasis during various cell stresses.These substrates are engulfed along with bulk cytoplasm by double-membrane,with the extension and fusion of membrane edge,which results in the formation of the autophagosome.After the fusion of autophagosome and lysosome,the degradation products are recycled back into cytosol and reused to enhance cell survival during nutrient deprivation.One potential regulator of autophagy is the activation of the unfolded protein response(UPR),an endoplasmic reticulum stress pathway.GRP78,a key upstream activator of the UPR,participates in promoting protein folding.assembly and degradation,endoplasmic reticulum stress sensing,and cellular calcium homeostasis.High level of GRP78 contributes to the stress-induced autophagy and functional blockade of the proteasome induces GRP78 to promote autophagosome formation.As a major active compound of Coptidis Rhizoma(Huanglian in Chinese),berberine is an isoquinoline alkaloid,which has long been used as a nonprescription oral drug in China for the treatment of gut infections and diarrhea.Importantly,the antineoplastic activities of berberine were intensive studied and reported since 1990s.A great portion of studies made effort on revealing of cytotoxicity,metastasis inhibition and antiangiogenic of berberine.Other studies focus on cell-cycle checkpoint control,DNA repair and regulation of initiating oxidative stress in cancer cells,which bring some new mechanisms underlying the antitumor of berberine to light.Recent studies have revealed the berberine can trigger autophagic cell death of tumor,and its beneficial effects are receded when the autophagy process is genetically or pharmacologically inactivated,which suggests that autophagy is indispensable for the protective effects of berberine.Here,we reported that berberine could induce autophagic cancer cell death by the elevation of GRP78.The res

关键词： berberine autophagy cancer cell death GRP78 VPS34

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Rice science 2011年第4期18卷 304-310页

作者： ZHAO Feng XU Chun-mei ZHANG Wei-jian ZHANG Xiu-fu LI Feng-bo CHEN Jian-ping WANG Dan-ying China Nationa l Rice Resea rch Institute Hangzhou 310006China Institute of Applied Ecology Nanjing Agricultura l Univer sityNanjing 210095China Institute of Food Crops Hubei Academy of Agricultura l SciencesWuhan 430064China

Dissolved oxygen and nitrogen form have important effects on rice root growth and nitrogen availability.An indica hybrid rice,Guodao 1,and a conventional japonica rice,Xiushui 09,were cultured in hypoxic nutrient solution with NH4NO3 or(NH4)2SO4 as the nitrogen source for six weeks in pools.A portion of the Guodao 1 seedlings after treatment in the pools for four weeks were transferred to a split-root system at different dissolved oxygen contents and cultured for an additional two weeks.Biomass,root morphological traits and nitrogen accumulation were recorded.Under the low rhizosphere dissolved oxygen content(0-1.0 mg/L),plant biomass was significantly increased under NH4NO3-N supply by about 69% in Guodao 1 and 41% in Xiushui 09 compared with those under NH4+-N alone.Similar results were observed for root number,maximum root length,root dry weight and root activity.Nitrogen accumulations in roots and shoots were increased by 60% and 52% for Guodao 1,and by 41% and 33% for Xiushui 09,respectively,in the NH4NO3-N treatment.In the split-root system,the high rhizosphere dissolved oxygen content(8.0-9.0 mg/L) promoted root growth and development.Root biomass was increased by 21.6%,root number by 27%,maximum root length by 14%,and root volume by 10%.Moreover,nitrogen accumulation in roots was increased by 11% under high rhizosphere oxygen conditions.In conclusion,enhanced dissolved oxygen content and combined ammonium-nitrate nitrogen source have positive effects on root growth and nitrogen accumulation of rice plants.

关键词： nitrogen form dissolved oxygen rice root nitrogen accumulation

A Hybrid Method of Solving the Electromagnetic Inverse Scattering Problem in Lossy Medium

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Chinese Physics Letters 2010年第5期27卷 113-116页

作者：杨曦张宇苟铭江史庆藩孙刚 School of Information and Electronics Beijing Institute of Technology Beijing 100081 School of Science Beijing Institute of Technology Beijing 100081 Beijing Nationa/Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190

在有损耗的媒介解决电磁的反的散布问题的一个混合方法被建议。坡度搜索方法首先被用来决定目标的空间分发，然后，蒙特卡罗方法被选择计算 scatterer 的传导性和介电常数。数字实验的结果证实联合二个方法的混合方法是高精确的，有效... 详细信息

在有损耗的媒介解决电磁的反的散布问题的一个混合方法被建议。坡度搜索方法首先被用来决定目标的空间分发，然后，蒙特卡罗方法被选择计算 scatterer 的传导性和介电常数。数字实验的结果证实联合二个方法的混合方法是高精确的，有效，并且适合到全球优化。[从作者抽象]

关键词：逆散射问题混合方法损耗介质电磁求解蒙特卡罗方法有损介质搜索方法