检索结果-南通市图书馆

Simulation training in endoscopic skull base surgery: A scoping review

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 73-81页

作者： Joel James Alexandria L.I race David A.Gudis Jonathan B.Overdevest City University of New York School of Medicine New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery Columbia University Vagelos College of Physicians and SurgeonsColumbia University Irving Medical CenterNew York-Presbyterian HospitalNew YorkNew YorkUSA

Objective:Proficiency in endoscopic endonasal skull base surgery requires both substantial baseline training and progressive lifelong *** simulation models continue to evolve in an effort to optimize trainee education and preoperative preparation and improve surgical *** current scoping review systematically reviews all available literature and synthesizes the current paradigms of simulation models for endoscopic skull base surgery training and skill ***:In accordance with Preferred Reporting Items for Systemic Review and Meta-Analyses guidelines,we systematically searched PubMed,Embase,CINAHL,and Cochrane *** were categorized according to the type of simulation models ***:We identified 238 unique references,with 55 studies ultimately meeting inclusion *** these,19 studies described cadaveric dissection models,17 discussed three-dimensional(3D)printed models,14 examined virtual surgical planning and augmented reality-based models,and five 5 articles described task ***:There are a wide variety of simulation models for endoscopic skull base surgery,including high-fidelity cadaveric,virtual reality,and 3D-printed *** models are an asset for trainee development and preoperative surgical preparation.

关键词： resident education skull base surgery surgical simulation training virtual reality virtual surgical planning

skull base chordomas review of current treatment paradigms

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第2期6卷 125-131页

作者： Dan Yaniv Ethan Soudry Yulia Strenov Marc A.Cohen Aviram Mizrachi Department of Otolaryngology-Head and Neck Surgery Rabin Medical CenterPetah Tikva and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Pathology Rabin Medical CenterPetah Tikva and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Head and Neck Service Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkNYUSA

Background:Chordomas are locally invasive neoplasms,arising from notochordal remnants and can appear anywhere along the axial *** recurrences are common,and distant metastases may occur years after the initial ***:Literature review of current treatment strategies for chordomas of the skull ***:Surgery is the mainstay of treatment and complete resection has paramount importance for *** complete resection is not achieved recurrent disease is *** anatomical complexity of the skull base makes resection *** endoscopic approaches to the clivus has become increasingly favored in recent years although addressing reconstruction of the skull base to prevent CSF leak may be *** suggests that radiotherapy should not be considered as a primary single modality when trying to achieve cure of the ***,immediate post-operative radiotherapy improves *** strategies have been suggested to preserve sensitive vital structures in the skull base during treatment but as for survival there is no evidence of advantage when comparing adjuvant therapy with photon radiotherapy,gamma knife surgery,proton beam therapy,and carbon ion radiation *** is no evidence to support cytotoxic chemotherapy in the treatment of chordomas but targeted therapies have started to show *** optional molecular targets *** is overexpressed in 95%of chordomas but not in other mesenchymal ***,its precise role in chordoma pathogenesis is currently unclear,and its cellular location in the nucleus makes it difficult to *** inhibition of brachyury in chordoma cell lines induces growth arrest and *** does not have clinical application to *** are retrospective results with different molecular targeted therapies for advanced chordomas with some ***:Despite improvements made in the past 10 years in our knowledge of chordoma bio

关键词： skull base Chordoma Surgery Review Targeted therapy

Pediatric sinonasal and skull base lesions

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第2期6卷 118-124页

作者： Charles A.Riley Christian P.Soneru Jonathan B.Overdevest Marc L.Otten David A.Gudis Department of Otolaryngology Head and Neck SurgeryNew York Presbyterian Hospital-Columbia University Medical CenterNew YorkNYUSA Department of Neurological Surgery New York Presbyterian Hospital-Columbia University Medical CenterNew YorkNYUSA

Pediatric skull base lesions are complex and challenging *** and comprehensive management of this diverse group of disorders requires the expertise of an experienced multidisciplinary skull base *** endoscopic skull base surgery has evolved due to technologic and surgical advancements,multidisciplinary team approaches,and continued *** principles continue to advance the care delivered to the pediatric *** approach and management of these lesions varies considerably based on tumor anatomy,pathology,and surgical *** understanding of the nuances of skull base reconstruction unique to the pediatric population is critical for successful outcomes.

关键词： Pediatrics Endoscopic sinus surgery Endoscopic skull base surgery Juvenile nasopharyngeal angiofibroma Meningoencephalocele Pituitary adenoma Craniopharyngioma Clival chordoma Chondrosarcoma

Orthotopic induction of CH157MN convexity and skull base meningiomas into nude mice using stereotactic surgery and MRI characterization

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2019年第1期2卷 58-63页

作者： Francesca La Cava Alberto Fringuello Mingo Pietro Irrera Aldo Di Vito Alessia Cordaro Chiara Brioschi Sonia Colombo Serra Claudia Cabella Enzo Terreno Luigi Miragoli Department of Molecular Biotechnologies and Health Sciences Center of Excellence for Preclinical Imaging (CEIP) University of Torino Bracco Research Centre Bracco Imaging SpA Department of Molecular Biotechnologies and Health Sciences Center of Excellence for Preclinical Imaging CEIP University of Torino

Meningioma in vivo research is hampered by the difficulty of establishing an easy and reproducible orthotopic model able to mimic the characteristics of a human meningioma. Moreover, leptomeningeal dissemination and high mortality are often associated with such orthotopical models, making them useless for clinical translation studies. An optimized method for inducing meningiomas in nude mice at two different sites is described in this paper and the high reproducibility and low mortality of the models are demonstrated. skull base meningiomas were induced in the auditory meatus and convexity meningiomas were induced on the brain surface of 23 and 24 nude mice, respectively. Both models led to the development of a mass easily observable by imaging methods. Dynamic contrast enhanced MRI was used as a tool to monitor and characterize the pathology onset and progression. At the end of the study, histology was performed to confirm the neoplastic origin of the diseased mass.

关键词： animal models neuroscience pharmaceutical development preclinical imaging solid tumors

Application and prospects of computer-assisted surgery in oral and maxillofacial oncology

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2023年第3期68卷 236-239页

作者： Xin Peng Julio Acero Guang-Yan Yu Department of Oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Department of Oral and Maxillofacial Surgery Ramón y Cajal and Puerta de Hierro University HospitalsUniversity of AlcalaRamón y Cajal Research Institute(IRYCIS)Madrid 28034Spain

The primary treatment modality for tumors affecting the oral and maxillofacial region is *** treatment of tumors affecting this region is a challenge and poses relatively high surgical risk,especially in lesions affecting the deep regions of the head and the neck due to the complex anatomy of this region including structures of great importance such as the internal carotid artery,the internal jugular vein,and the cavernous sinus at the skull base,the cranial nerves and the orbital contents with the eye globes,extraocular muscles,and the lacrimal *** resection often results in devastating defects in the oral and maxillofacial region,which adversely affect patients’facial appearance and important functions such as speech,chewing,deglutition,or vision and significantly impact patients’quality of *** order to obtain a good result concerning tumor excision in the oral and cranio-maxillofacial region as well as a correct aesthetic and functional reconstruction,an adequate presurgical evaluation of the patient and accurate planning of the surgical resection and the reconstructive approach must be carefully designed.

关键词： surgery anatomy computer

Cranial nerve monitoring in endoscopic endonasal surgery of skull base tumors (observing of 23 cases)

在线全文

学校读者我要写书评

暂无评论

Chinese Neurosurgical Journal 2019年第1期5卷 21-29页

作者： A.N.Shkarubo I.V.Chernov A.A.Ogurtsova V.E.Chernov O.V.Borisov K.V.Koval D.N.Andreev Department of Neurooncology Federal State Autonomous Institution"N.N.Burdenko National Medical Research Center of Neurosurgery"of the Ministry of Health of the Russian FederationMoscowRussia Department of Neurophysiology Federal State Autonomous Institution"N.N.Burdenko National Medical Research Center of Neurosurgery"of the Ministry of Health of the Russian FederationMoscowRussia Department of Neurosurgery N.N.Burdenko Main Military Clinical Hospital of the Ministry of Defense of the Russian FederationMoscowRussia Laboratory of Molecular Human Genetics Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological AgencyMoscowRussia

Background:Preservation of anatomic integrity and function of the cranial nerves during the removal of skull base tumors is one of the most challenging procedures in endoscopic endonasal *** is possible to use intraoperative mapping and identification of the cranial nerves in order to facilitate their *** purpose of this study was to evaluate the effectiveness of intraoperative trigger electromyography in prevention of iatrogenic damage to the cranial ***:Twenty three patients with various skull base tumors(chordomas,neuromas,pituitary adenomas,meningiomas,cholesteatomas)underwent mapping and identification of cranial nerves during tumor removal using the endoscopic endonasal approach in Department of Neurooncology of Federal State Autonomous Institution"*** National Medical Research center of Neurosurgery"of the Ministry of Health of the Russian Federation from 2013 to *** the surgical interventions,mapping and identification of the cranial nerves were carried out using electromyography in triggered *** effectiveness of the method was evaluated based on a comparison with a control group(41 patients).Results:In the main group of patients,44 nerves were examined during surgery using triggered *** the study,the III,V,VI,VII,and XII cranial nerves were identified *** cranial nerve deficiency was observed in 5 patients in the study group and in 13 patients in the control *** average length of hospitalization was 9 ***:We did not receive statistically significant data supporting the fact that intraoperative identification of cranial nerves using trigger electromyography reduces the incidence of postoperative complications in the form of cranial nerve deficits(p=0.56),but the odds ratio(0.6)suggests a less frequent occurrence of complications in the study *** on our experience,the trigger electromyography methodology appears quite promising and req

关键词： Electromyography T-EMG Intraoperative cranial nerve identification Endoscopic endonasal approach skull base tumor surgery

Application of endoscopic endonasal approach in skull base surgeries: summary of 1886 cases in a single center for 10 consecutive years

在线全文

学校读者我要写书评

暂无评论

Chinese Neurosurgical Journal 2020年第3期6卷 133-140页

作者： Chuzhong Li Haibo Zhu Xuyi Zong Xinsheng Wang Songbai Gui Peng Zhao Chunhui Liu Jiwei Bai Lei Cao Yazhuo Zhang Beijing Neurosurgical Institute Capital Medical UniversityBeijingChina Department of Neurosurgery Beijing Tiantan Hospital affiliated to Capital Medical UniversityBeijingChina Beijing Institute for Brain Disorders Brain Tumor center BeijingChina China National Clinical Research center for Neurological Diseases No.119 South 4th Ring West RoadFengtai DistrictBeijing 100050China

Background:Endonasal endoscopic skull base surgery has undergone rapid technological developments and is now widely performed,but its strengths and weaknesses deserve further investigation and *** study was performed to investigate the surgical indications,complications,and technical advantages and disadvantages of endonasal endoscopic skull base ***:The clinical data of 1886 endoscopic endonasal skull base surgeries performed in our ward at Beijing Tiantan Hospital from June 2006 to June 2016 were retrospectively ***:One thousand ninety-three(73.4%,1490)pituitary adenomas,54(24.9%,217)chordomas,28(80.0%,35)craniopharyngiomas,and 15(83.3%,18)meningiomas underwent total *** patients died postoperatively,both having pituitary *** postoperative complications included olfactory disorders(n=226,11.9%),postoperative cerebrospinal fluid leakage(n=78,4.1%),hypopituitarism(n=74,3.9%),diabetes insipidus(n=64,3.4%),intracranial infection(n=36,1.9%),epistaxis(n=24,1.3%),vascular injury(n=8,0.4%),optic nerve injury(n=8,0.4%),and oculomotor movement impairment(n=4,0.2%).In total,1517(80.4%)patients were followed up for 6 to 126 months(average,42.5 months)postoperatively.A total of 196(13.2%)pituitary adenomas and 13(37.1%)craniopharyngiomas recurred but no meningiomas *** recurred in 97(44.7%)patients,in whom 5-year survival rate was 65%.Conclusion:Endoscopic surgery is an innovative surgical technique and the first choice for most midline extradural lesions such as chordomas,and an excellent choice for pituitary *** probably will be a good technique for many kinds of craniopharyngiomas and a common technique for most of skull base meningiomas,so the surgical indications of these cases should be chosen carefully to make good use of its respective advantages.

关键词： Complication Indication Neuroendoscopy skull base surgery Endonasal approach

在线全文

学校读者我要写书评

暂无评论

曲霉所致鼻面及鼻眶脑真菌病

菌物学报 2020年第12期39卷 2218-2240页

作者：胡建刚李东明 G.Sybren de Hoog 北京大学第三医院皮肤科真菌实验室北京100191 center of Expertise in Mycology of Radboud University Medical center/Canisius Wilhelmina Hospital Nijmegenthe Netherlands

鼻面及鼻眶脑真菌病(rhinofacial and rhino-orbital-cerebral mycosis,ROCM)是一种病死率高的暴发性真菌感染疾病,主要由毛霉目、虫霉目、蛙粪霉目真菌引起。曲霉属真菌多引起真菌性鼻窦炎,如果侵入邻近的鼻、面、眼眶组织,真菌可能会... 详细信息

鼻面及鼻眶脑真菌病(rhinofacial and rhino-orbital-cerebral mycosis,ROCM)是一种病死率高的暴发性真菌感染疾病,主要由毛霉目、虫霉目、蛙粪霉目真菌引起。曲霉属真菌多引起真菌性鼻窦炎,如果侵入邻近的鼻、面、眼眶组织,真菌可能会延伸到颅底和/或神经系统,从而危及生命。由于该类感染早期临床表现缺乏特异性,误诊率可能较高;此外,对曲霉的有效抗真菌治疗与其他真菌的抗真菌治疗有很大的不同。本文对PubMed和中文文献数据库的相关文献进行了系统的Meta分析,全面总结了引起ROCM的相关曲霉菌种类、分布、危险因素、临床表现、诊断和治疗。

关键词：曲霉曲霉病鼻眶脑真菌病鼻面真菌病皮肤和皮肤结构感染

Proton beam therapy of periorbital sinonasal squamous cell carcinoma: Two case reports and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2020年第8期11卷 655-672页

作者： Yi-Lan Lin Department of Radiation Oncology Rinecker Proton Therapy CenterMunich 81371Germany

BACKGROUND Sinonasal malignancies are rare but demanding due to complex anatomy,usually late diagnosis,and inconsistent therapy strategy based on multimodality *** cell carcinoma(SCC)is the most common histology,with poorer *** the setting of orbital invasion,an orbital exenteration may be ***,in case of primary rejection of disfiguring surgery or unresectable disease,proton beam therapy(PBT)should be largely considered,allowing for better sparing of neighboring critical structures and improved outcomes by dose *** SUMMARY A 62-year-old male presented with a recurrent SCC in the nasal septum abutting frontal skull base and bilateral orbits at 7 mo after primary partial nasal *** of refusal of face-deforming surgery and considerable adverse effects of conventional radiotherapy,the patient underwent a PBT by hyperfractionated accelerated scheme,resulting in complete response and moderate *** 2 years,a nasal reconstruction was implemented with satisfactory appearance and recurrence-freedom to *** patient with an initially extended sinonasal SCC,invading right orbit and facial soft tissue,declined an orbital exenteration and was treated with a normofractionated PBT to the gross tumor and elective cervical *** follow-up showed a continuous tumor remission with reasonable late toxicities,such as cataract and telangiectasia on the *** T4a stage and disapproval of concurrent chemotherapy owing to individual choice,both patients still achieved outstanding treatment outcomes with PBT *** PBT enabled orbit preservation and excellent tumor control without severe adverse effects on both presented patients with locally advanced sinonasal SCC.

关键词： Proton beam therapy Intensity modulated proton therapy Sinonasal malignancies Squamous cell carcinoma orbital exenteration Case report