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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Synthesis and characterization of highly-ordered barium-strontium titanate nanotube arrays fabricated by sol-gel method

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Chinese Physics B 2009年第9期18卷 3922-3927页

作者：陈煜程伟郭峰李美亚刘威赵兴中 Department of Physics Wuhan University nanoscience and nanotechnology Center Wuhan University

Highly uniformed barium-strontium titanate nanotube arrays were fabricated using a porous anodic aluminum oxide template from a barium-strontium titanate sol-gel solution. Electron microscope results showed that nanotubes with uniform length and diameter were obtained. The diameters and lengths of these nanotubes were dependent on the pore diameter and the thickness of the applied anodic aluminum oxide template. High resolution transmission electron microscopy and the selected-area electron diffraction pattern investigations demonstrated the perovskite structure and the polycrystalline of the fabricated barium-strontium titanate nanotubes. The characterization of the electrical and dielectric properties had also been made. Compared to thin film material, the intrinsic leakage current density is almost the same. Besides, at 30 ℃ the dielectric constant and dielectric loss of the fabricated nanotube is 80 and 0.027 at 1 MHz respectively.

关键词： nanotubes barium-strontium titanate sol-gel

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Nonlinear vibration analysis of laminated composite Mindlin micro/nano-plates resting on orthotropic Pasternak medium using DQM

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Applied Mathematics and Mechanics(English Edition) 2015年第8期36卷 1033-1044页

作者： A.G.ARANI G.S.JAFARI Faculty of Mechanical Engineering University of Kashan Institute of nanoscience & nanotechnology University of Kashan

The nonlocal nonlinear vibration analysis of embedded laminated micro- plates resting on an elastic matrix as an orthotropic Pasternak medium is investigated. The small size effects of micro/nano-plate are considered based on the Eringen nonlocal theory. Based on the orthotropic Mindlin plate theory along with the von Kármán geo- metric nonlinearity and Hamilton＇s principle, the governing equations are derived. The differential quadrature method （DQM） is applied for obtaining the nonlinear frequency of system. The effects of different parameters such as nonlocal parameters, elastic me- dia, aspect ratios, and boundary conditions are considered on the nonlinear vibration of the micro-plate. Results show that considering elastic medium increases the nonlinear frequency of system. F^lrthermore, the effect of boundary conditions becomes lower at higher nonlocal parameters.

关键词： nonlinear vibration laminated micro-plate orthotropic Pasternak medium,differential quadrature method

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Hierarchical hollow microspheres assembled from carbon nanosheets integrated with molybdenum carbide nanoparticles for boosting microwave absorption properties

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Nano Research 2025年第1期18卷 10-20页

作者： Zongsheng Chen Yahui Wang Yi Liu Zhigang Li Xiangyin Lv Liping Liu Yajing Chang Jiaming Shi Xiao Zhang State Key Laboratory of Pulsed Power Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Anhui Provincial Laboratory of Advanced Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Centre for Excellence in NanoscienceInstitute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

Hierarchical hollow structure has demonstrated potential for enhancing electromagnetic(EM)attenuation and improving impedance matching,garnering significant attention for ***,we have successfully implemented compositional and structural engineering to fabricate hollow Mo2C/C microspheres with controllable composition by coupling interaction between dopamine hydrochloride and ammonium *** the synergistic effect of composition and hollow structure,the strongest reflection loss intensity and broadest effective absorption of the optimized sample reach-70.2 dB and 6.2 GHz,*** formation of hollow heterogeneous structures not only favors impedance matching feature,but also generates considerable contribution to EM attenuation ***,radar cross-section simulation data indicate that hollow Mo2C/C microspheres with compositional optimization and heterogeneous structures have broad prospects for practical applications.

关键词： electromagnetic absorption Mo2C/C microwave absorption hollow structure

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Interconnected MXene/Graphene Network Constructed by Soft Template for Multi‑Performance Improvement of Polymer Composites

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Nano-Micro Letters 2022年第8期14卷 164-180页

作者： Liyuan Jin Wenjing Cao Pei Wang Na Song Peng Ding Research Center of nanoscience and nanotechnology College of SciencesShanghai UniversityShanghai 200444

The multi-functionalization of polymer composites refers to the ability to connect multiple properties through simple structural design and simultaneously achieve multi-performance *** large-scale design and mass production to realize the reasonable structure design of multifunctional polymer composites are urgently remaining ***,the multifunctional MXene/graphene/polymer composites with three-dimensional thermally and electrically conductive network structures are fabricated via the utilization of the microstructure of the soft template,and a facile dispersion dip-coating *** a result,the polymer composites have a multiperformance *** the MXene and graphene content of 18.7 wt%,the superior throughplane thermal conductivity of polymer composite is 2.44 W m^(−1)K^(−1),which is 1118%higher than that of the polymer *** electromagnetic interference(EMI)shielding effectiveness of the sample reaches 43.3 dB in the range of *** the mechanical property of the sample has advanced 4 times compared with the polymer *** excellent EMI shielding and thermal management performance,along with the effortless and easy-to-scalable producing techniques,imply promising perspectives of the polymer composites in the next-generation smart electronic devices.

关键词： Structural design MXene/graphene network Soft-template Thermal conductivity Electromagnetic interference shielding

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Nonlocal buckling of embedded magnetoelectroelastic sandwich nanoplate using refined zigzag theory

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Applied Mathematics and Mechanics(English Edition) 2018年第4期39卷 529-546页

作者： A.GHORBANPOUR-ARANI F.KOLAHDOUZAN M.ABDOLLAHIAN Faculty of Mechanical Engineering University of Kashan Institute of nanoscience & nanotechnology University of Kashan

This paper is concerned with a buckling analysis of an embedded nanoplate integrated with magnetoelectroelastic(MEE) layers based on a nonlocal magnetoelectroelasticity theory. A surrounding elastic medium is simulated by the Pasternak foundation that considers both shear and normal loads. The sandwich nanoplate(SNP) consists of a core that is made of metal and two MEE layers on the upper and lower surfaces of the core made of Ba Ti O3/Co Fe2 O4. The refined zigzag theory(RZT) is used to model the SNP subject to both external electric and magnetic potentials. Using an energy method and Hamilton’s principle, the governing motion equations are obtained, and then solved analytically. A detailed parametric study is conducted, concentrating on the combined effects of the small scale parameter, external electric and magnetic loads, thicknesses of MEE layers, mode numbers, and surrounding elastic medium. It is concluded that increasing the small scale parameter decreases the critical buckling loads.

关键词： sandwich nanoplate(SNP) refined zigzag theory(RZT) nonlocal magnetoelectroelasticity theory buckling magnetostrictive layer

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Solvothermal Synthesis of TiO2/Bi2WOs Heterojunction Photocatalyst with Optimized Interface Structure and Enabled Photocatalytic Performance

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Chinese Journal of Chemistry 2017年第2期35卷 183-188页

作者： Linpeng Jiang Shujie Wang Liyi Shi Yin Zhao Zhuyi Wang Meihong Zhang Shuai Yuan Research Center of nanoscience and nanotechnology Shanghai University Shanghai 200444 China

TiO2/Bi2WO6 （TB） heterojunction photocatalyst was successfully synthesized and characterized by XRD, SEM, TEM, UV-Vis and photoluminescence measurement. The heterojunction interface structure of TB heterojunction photocatalyst was optimized via adjusting the ethylene glycol/water （EG/W） ratio. Based on XRD, SEM and TEM, the crystal size of Bi2WO6 reduced from 14.6 nm to 8.8 nm, and the interface structure between Bi2WO6 nanosheets and TiO2 particle significantly changed with increasing EG concentration. Furthermore, the photoeatalytic activity and the related mechanism of TB heterojunction photocatalyst were systematically discussed. Among them, TBEG/w sample shows the highest normalized apparent rate constant, which is attributed to its highest electron-hole pairs separation ability driven by optimized heterojunction interface between two semiconductors.

关键词： TiO2/Bi2WO6 heterojunction interface structure carriers separation photocatalytic

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A Fully Self-Healing Piezoelectric Nanogenerator for Self-Powered Pressure Sensing Electronic Skin

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Research 2021年第1期2021卷 876-884页

作者： Maosen Yang Jinmei Liu Dong Liu Jingyi Jiao Nuanyang Cui Shuhai Liu Qi Xu Long Gu Yong Qin School of Advanced Materials and nanotechnology Xidian UniversityXi’an 710071China Institute of nanoscience and nanotechnology Lanzhou UniversityGansu 730000China

As an important way of converting mechanical energy into electric energy,a piezoelectric nanogenerator(PENG)has been widely applied in energy harvesting as well as self-powered sensors in recent ***,its robustness and durability are still severely challenged by frequent and inevitable mechanical impacts in real application ***,a fully selfhealing PENG(FS-PENG)as a self-powered pressure sensing electronic skin is *** self-healing piezoelectric composite and self-healing Ag NW electrode fabricated through mixing piezoelectric PZT particles and conductive Ag NWs into self-healing polydimethylsiloxane(H-PDMS)are assembled into the sandwich structure *** FS-PENG could not only effectively convert external stimulation into electrical signals with a linear response to the pressure but also retain the excellent self-healing and stable sensing property after multiple cycles of cutting and self-healing ***,a self-healing pressure sensor array composed of 9 FS-PENGs was attached on the back of the human hand to mimic the human skin,and accurate monitoring of the spatial position distribution and magnitude of the pressure was successfully realized.

关键词： piezoelectric healing generator

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Chinese Physics Letters 2009年第7期26卷 369-371页

作者：于爱芳祁琼江鹏江潮 National Center for nanoscience and nanotechnology No. 11 Beiyitiao Zhongguancun Beijing 100190

Carrier mobifity enhancement from 0.09 to 0.59cm2/Vs is achieved for pentacene-based thin-film transistors （TFTs） by modifying the Hf02 gate dielectric with a polystyrene （PS） thin film. The improvement of the transistor＇s performance is found to be strongly related to the initial film morphologies of pentacene on the dielectrics. In contrast to the three-dimensional island-like growth mode on the HI02 surface, the Stranski- Krastanov growth mode on the smooth and nonpolar PS/HfO2 surface is believed to be the origin of the excellent carrier mobility of the TFTs. A large well-connected first monolayer with fewer boundaries is formed via the Stranski-Krastanov growth mode, which facilitates a charge transport parallel to the substrate and promotes higher carrier mobility.

关键词： LOW-VOLTAGE PERFORMANCE INSULATORS LAYER

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Dynamic surface wettability of three-dimensional graphene foam

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Chinese Physics B 2014年第4期23卷 472-475页

作者：黄文斌王广龙高凤岐乔中涛王刚陈闽江陶立邓娅孙连峰 Institute of nanotechnology and Microsystems Mechanical Engineering College National Center for nanoscience and Technology

In this work, three-dimensional graphene foams （GFs） are synthesized and characterized by scanning electron micro- scope （SEM） and Raman spectroscopy. The SEM images indicate that after the growth of graphene, the graphene covers the surface of nickel （Ni） foam uniformly. Raman spectra show that the percentages of monolayer, bilayer, trilayer, and multilayer graphenes are - 58%, - 32%, - 8%, and ,.o 2%, respectively. The contact angle （CA）（-- 12°） of water droplet （3 p-L） on GF is found to be larger than that on Ni foam （,- 107°）, indicating that graphenes have changed the surface wettability of the Ni foam. Meanwhile, the dynamic characteristics of CA of water droplet on GF are different from those on Ni foam. The mechanisms for different behaviors are discussed, which are attributed to volatilization and seepage of water droplets.

关键词： graphene foam CVD surface wettability contact angle

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