检索结果-南通市图书馆

Non-invasive gene delivery across the blood-brain barrier:present and future perspectives

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第4期17卷 785-787页

作者： Seigo Kimura Hideyoshi Harashima laboratory for Molecular Design of Pharmaceutics Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan laboratory of Innovative nanomedicine Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan

The aging of society has arrived,and is accompanied by an increase in the absolute numbers of patients with neurological disorders,such as Alzheimer's and Parkinson's diseases(Feigin et al.,2020).Such diseases,particularly Alzheimer's disease and other forms of dementia,affect not only the patients themselves,but also the people around them,including family members and care *** a result,such neurological disorders are thought to carry a larger social burden compared to other *** most critical point in the current situation is that there is no effective treatment despite the fact that the number of patients increase with the aging of the population.

关键词： diseases Alzheimer carry

Advancing cancer nanomedicine with machine learning

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第9期14卷 4183-4185页

作者： Xifeng Qin Tun Lu Zhiqing Pang School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China School of Computer Science Fudan UniversityShanghai 200438China

nanomedicine,a captivating and highly promising field in biomedicine,is driving the transformation of medical technologies and treatments,catalyzing revolutionary advancements in areas such as cancer therapy,drug delivery,diagnostics,and *** the notable progress in nanomedicine to tackle the complexities of various diseases,the biomedical sector is presented with abundant opportunities for innovation and *** this process,machine learning(ML)and artificial intelligence(AI)emerge as pivotal themes in the realm of science and *** are reshaping our lifestyles and workplaces with unparalleled rapidity and magnitude,while also providing fresh possibilities and potentials for the evolution of nanomedicine。

关键词： Machine learning Artificial intelligence nanomedicine Drug design Cancer treatment

Fabrication and application of arrays related to two-dimensional materials

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2022年第1期41卷 262-286页

作者： Hui-Li Jiang Jia Pan Wei Zhou Hui-Min Li Song Liu Institute of Chemical Biology and nanomedicine(ICBN) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

In recent years,two-dimensional(2D)materials have attracted extensive attention from researchers for their unique structures and electrical properties.2D materials have been widely applied in field effect transistors,sensors,and *** is extremely important for practical applications in devices,which requires both minimal crosstalk and high *** fabrication of patterned arrays of 2D materials can realize high-density *** addition,the properties of 2D materials can be also adjusted by the patterned *** this review,we summarize the emerging researches related to 2D materials and ***,the preparation strategies of different arrays have been ***,the applications of arrays have been investigated,such as physical unclonable functions,sensors,energy consumption,photoluminescence enhancement,quantum emitters and ***,the prospects and existing challenges have been proposed.

关键词： 2D materials 2D material arrays Sensors Quantum emitters Photodetectors

3D microgroove electrical impedance sensing to examine 3D cell cultures for antineoplastic drug assessment

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2020年第1期6卷 1199-1208页

作者： Yuxiang Pan Deming Jiang Chenlei Gu Yong Qiu Hao Wan Ping Wang biosensor National Special laboratory Key Laboratory for Biomedical Engineering of Education MinistryDepartment of Biomedical EngineeringZhejiang UniversityHangzhou 310027China State Key laboratory of Transducer Technology Chinese Academy of SciencesShanghai 200050China

In recent decades,three-dimensional(3D)cancer cell models have attracted increasing interest in the field of drug screening due to their significant advantages in more accurate simulations of heterogeneous tumor behavior in vivo compared to two-dimensional ***,drug sensitivity testing based on 3D cancer cell models can provide more reliable in vivo efficacy *** gold standard fluorescence staining is hard to achieve real-time and label-free viability monitoring in 3D cancer cell *** this study,a microgroove impedance sensor(MGIS)was specially developed for the dynamic and noninvasive monitoring of 3D cell viability.3D cancer cells were trapped in microgrooves with gold electrodes on opposite walls for in situ impedance *** change in the number of live cells caused inversely proportional changes to the impedance magnitude of the entire cell/Matrigel construct and reflected the proliferation and apoptosis of the 3D *** was confirmed that the 3D cell viability detected by the MGIS was highly consistent with the standard live/dead staining by confocal microscope ***,the accuracy of the MGIS was validated quantitatively using a 3D lung cancer model and sophisticated drug sensitivity *** addition,the parameters of the MGIS in the measurement experiments were optimized in detail using simulations and experimental *** results demonstrated that the MGIS coupled with 3D cell culture would be a promising platform to improve the efficiency and accuracy of cell-based anticancer drug screening in vitro.

关键词： impedance walls electrical

Neurochip based on light-addressable potentiometric sensor with wavelet transform de-noising

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 323-331页

作者： Qing-jun LIU Wei-wei YE Hui YU Ning HU Li-ping DU Ping WANG biosensor National Special laboratory Key Laboratory of Biomedical Engineering of Ministry of Education Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China State Key laboratory of Transducer Technology Chinese Academy of Sciences Shanghai 200050 China

Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well *** we report a kind of neurochip with rat pheochromocytoma(PC12) cells hybrid with LAPS and a method of de-noising signals based on wavelet *** were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals de-noised according to decomposition in the time-frequency *** signal was decomposed into various scales,and coefficients were processed based on the properties of each *** last,signal was reconstructed based on the new *** results show that after de-noising,baseline drift is removed and signal-to-noise ratio is *** suggests that the neurochip of PC12 cells coupled to LAPS is stable and suitable for long-term and non-invasive measurement of cell electrophysiological properties with wavelet transform,taking advantage of its time-frequency localization analysis to reduce noise.

关键词： Neurochip Light-addressable potentiometric sensor(LAPS) Wavelet transform Threshold De-noising

Controllable preparation of 2D metal-semiconductor layered metal dichalcogenides heterostructures

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2019年第3期62卷 295-298页

作者： Gonglei Shao Yanyan Xu Song Liu Institute of Chemical Biology and nanomedicine (ICBN) State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering College of Biology Hunan University

1 Introduction Graphene is the first demonstration of a truly 2D atomic layer crystal, and has shown various excellent properties (e.g., ultrahigh carrier mobility, superior toughness, unique thermal conductivity, and good optics performance). The family of 2D crystals has grown to include metals (e.g., NbS2, VS2, TaS2), semiconductors (e.g., MoS2, WS2, ZrS2), and insulators (e.g., hexagonal boron nitride (hBN)), many of which are stable at ambient conditions [1]. 2D layered metal dichalcogenides (LMDs) materials [2].

关键词： Introduction Graphene the first demonstration shown

A novel multi-functional cell-based microphysiometer

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2006年第8期16卷 808-816页

作者： XU Ying, XU Gaixia, LIU Qingjun, CAI Hua, LI Yan, LI Rong and WANG Ping (biosensor National Special laboratory, Key laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China State Key laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai 200050, China) biosensor National Special laboratory Key Laboratory of Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China. State Key laboratory of Transducer Technology Chinese Academy of Sciences Shanghai 200050 China

This paper presents a novel multi-functional microphysiometer for simultaneous measurements of several extracellular ion concentrations and action potential measurement in living cells based on MLAPS (multi-light addressable potentiometric sensor). In the microphysiometer, sorts of sensitive membranes are illuminated in parallel with n light sources at working frequencies, and the response amplitudes of each frequency component can be measured on-line by parallel processing algorithm. In the experiments, the relations of the extracellular environmental H+, Na+, K+, Ca2+ under the effects of western medicines (dilantin, phenobarbital sodium) and Chinese drugs (scutellaria, medlar, hemlock parsley) were analyzed, and the effects of several drugs were evaluated. Moreover, the action potential signals of different cell types (cardiac myocytes and neurons) could be measured and analyzed by LAPS. By detecting these parameters, the system can monitor the real-time process of the cell metabolism and action potential, observe the functional responses of different kinds of membrane-bound receptors, and evaluate the activities of drugs.

关键词： multi-functional microphysiometer cell-based biosensor cellular ion concentration measurement cellular action potential.

Chiral coating-mediated interactions of bacteria with diverse biointerfaces

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2023年第12期66卷 3594-3601页

作者： Hejin Jiang Rui Liu Ying Liu Huilong Luo Zhenping Cao Jinyao Liu Shanghai Key laboratory for Nucleic Acid Chemistry and nanomedicine Institute of Molecular MedicineState Key Laboratory of Systems Medicine for CancerRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Bacteria,as living agents,have been widely used for microbial therapy due to their inherent ability to colonize different in vivo microenvironments,particularly in the gut and *** interaction with diverse biointerfaces plays a critical role in bacterial colonization,and thereby determine the ultimate efficacy of microbial *** surface modification of bacteria with exogenous functional motifs can vary their interaction with surroundings,the effects of surface chirality of modified bacteria on mucous adhesion,tumor cell binding,and bacterial competition remain ***,we describe surface chirality-dependent selective interactions of bacteria to mucins,tumor cells,and *** coating bacteria with cationic polyethyleneimine modified with different chiral amino acids through electrostatic interaction,we find that bacteria coated with a D-chiral surface structure exhibit greatly increased adhesion to both mucins and tumor cells compared with those of L-and *** addition,by adjusting the chirality of the coating,wrapped probiotic bacteria can selectively resist pathogenic bacteria,showing great potential to enhance colonization and positively modulate the gut and tumor *** work discloses surface chirality-dependent interaction of bacteria with different biointerfaces,showing a potential to tune the colonization and therapeutic effect of living bacterial agents for disease treatment.

关键词： bacteria coating chiral adhesion living agents

Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第6期67卷 1881-1903页

作者： Dayang Wang Xiaohua Li Huanchen Yao Xin Liu Yan Gao Hailin Cong Bing Yu Youqing Shen College of Chemistry and Chemical Engineering College of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Key laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific *** have the characteristics of wide sources,excellent biocompatibility,and *** addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar *** polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for ***,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of *** is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

关键词： polysaccharide hydrophobic modification micelle drug delivery biomedicine