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Discrimination of signal oscillations in the in vitro olfactory bulb with microelectrode array

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Chinese Science Bulletin 2013年第24期58卷 3015-3018页

作者： CHEN QingMei DONG Qi HU Liang LING ShuCai YIN YiFei LIU QingJun WANG Ping biosensor National Special laboratory Key Laboratory of Biomedical Engineering of Ministry of Education Department of Biomedical Engineering Zhejiang University Department of Biomedical Engineering Jiangxi University of Traditional Chinese Medicine Institute of Anatomy and Cell Biology School of Medicine Zhejiang University

The aim of the present study was to investigate the electrophysiological characteristics of the different layers of the olfactory bulb (OB). We used an in vitro OB slice coupled onto a microelectrode array (MEA) for simultaneous detection of spontaneous activities of OB neurons at different sites. Different frequency oscillations dominated the different layers of the OB slice, and the gamma frequency oscillations mainly appeared in the glomerular layer. The waves consisted of negative, positive, and bidirectional spikes, and were distributed at the different layers of the OB slice. Thus, combination of the OB slice with MEA is a useful technique for identifying signal oscillations by multi-site synchronous measurement, and will allow further studies on olfactory information coding and processing function.

关键词：微电极阵列低频振荡信号嗅球体外电生理特性自发活动同时检测

Strain of 2D materials via substrate engineering

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Chinese Chemical Letters 2022年第1期33卷 153-162页

作者： Yangwu Wu Lu Wang Huimin Li Qizhi Dong Song Liu Institute of Chemical Biology and nanomedicine(ICBN) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China State Key laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Two-dimensional(2D)materials have received extensive attention in the fields of electronics,optoelectronics,and magnetic devices attributed to their unique electronic structures and physical *** application of strain is a simple and effective strategy to change the lattice structure of 2D materials thus modulating their physical properties,which further facilitate their applications in carrier mobility transistor,magnetic sensor,single-photon emitter *** this short review,we focus on the strain applied via substrate ***,the relationship between the strain and physical properties has been ***,the methods for achieving substrate engineering-induced strain have been ***,the latest applications of strained 2D materials have been *** addition,the future challenges and development prospects of strain-modulated 2D materials have also been proposed.

关键词： 2D materials Strain engineering Substrate engineering Substrate structures Substrate functions

Wearable battery-free theranostic dental patch for wireless intraoral sensing and drug delivery

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npj Flexible Electronics 2022年第1期6卷 518-528页

作者： Zhenghan Shi Yanli Lu Shuying Shen Yi Xu Chang Shu Yue Wu Jingjiang Lv Xin Li Zupeng Yan Zijian An Chaobo Dai Lingkai Su Fenni Zhang Qingjun Liu biosensor National Special laboratory Key Laboratory for Biomedical Engineering of Education MinistryDepartment of Biomedical EngineeringZhejiang UniversityHangzhou 310027P.R.China Stomatology Hospital School of MedicineZhejiang UniversityHangzhou 310016P.R.China

Dental caries caused by oral microbiome dysbiosis with the elevation of acidogenic bacteria is the most prevalent noncommunicable disease *** prevention and timely fluoride treatment are crucial for caries lesion ***,to address the challenges of in situ sensing and topical drug delivery within the oral cavity,a miniaturized,battery-free,and wearable dental patch system was developed for microenvironment monitoring and controlled fluoride *** the integration of near-field communication,the dental patch realizes wireless energy harvesting and data transmission with mobile terminals like smartphones when attached conformally to the tooth *** acidic microenvironment caused by bacterial metabolism are electrochemically detected,while fluorides can be delivered locally from the electric-responsive drug delivery electrode for on-demand *** flexible electronics armed to the teeth,this intraoral theranostic wearable system provides an inspiring platform for point-of-care monitoring and treatment of dental caries and oral diseases.

关键词： metabolism prevention patch

A Heavy Metal Analysis Device Based on Light-addressable Potentiometric Sensor

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稀有金属材料与工程 2006年第A3期35卷 230-231页

作者： Hong Men Jianguo Wang Jing Gao Ping Wang College of Automation Engineering Northeast Dianli University Jilin 132012 China Department of Basic Courses Jilin Medical and Pharmaceutical College Jilin 132013 China biosensor National Special laboratory Zhejiang University Hangzhou 310027 China

A full automatic device to detect heavy metal Hg,Fe,Cr elements based on thin-film sensitive materials prepared on surface of light-addressable potentiometric sensors (LAPS) by means of pulsed laser deposition PLD) technique is developed. High-purity chemical compound AgI:Ag_2S:HgI synthesized were used as target of PLD,thin film sensitive to Hg~ (2+) ion was prepared on the surface of ***-solide-state chalcogenide glass ion-selective electrodes ISE) ,Fe-ISE and Cr-ISE,were also used as targets of PLD,and thin-film sensors on different LAPS sensitive to Fe~ (3+) and Cr~ (6+) ions were *** heavy metal analysis device with characteristics of collect sample in-site,real-time determination,communication and multifunction software were *** design of the device mainly includes control and measurement *** detected limits of Hg,Fe,Cr ions are 3.44×10~ (-7) mol/L,6.31×10~ (-6) mol/L and 2.09×10~ (-7) mol/L,respectively.

关键词： analysis chemistry sensor heavy metal LAPS PLD

Activatable nanoscale metal-organic framework for ratiometric photoacoustic imaging of hydrogen sulfide and orthotopic colorectal cancer in vivo

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Science China Chemistry 2020年第9期63卷 1315-1322页

作者： Wenmin Zhang Jun Wang Lichao Su Hui Chen Lan Zhang Lisen Lin Xiaoyuan Chen Jibin Song Huanghao Yang College of Chemical Engineering Fuzhou UniversityFuzhou 350116China Key laboratory for Analytical Science of Food Safety and Biology Ministry of EducationCollege of ChemistryFuzhou UniversityFuzhou 350116China laboratory of Molecular Imaging and nanomedicine National Institute of Biomedical Imaging and BioengineeringNational Institutes of HealthBethesdaMD 20892USA

Nanoscale metal-organic frameworks(nano MOFs)have emerged as a promising biomedical nanoplatform because of their unique ***,the exploration of nano MOFs in photoacoustic(PA)imaging is still ***,a novel hydrogen sulfide(H2 S)-activated nano copper-based MOF(Cu-MOF)was developed as a near-infrared(NIR)ratiometric PA probe for in vivo monitoring of endogenous H2 S level and orthotopic colorectal cancer imaging via in situ reaction of nano Cu-MOFs with endogenous H2 S that is closely associated with tumor growth and proliferation in colon *** synthesized nano Cu-MOFs displayed excellent PA responsiveness towards tumor H2 S level with high selectivity and rapid *** result suggests the developed probe may provide a unique opportunity to investigate the malignant behaviors of H2 S-associated events in vivo.

关键词： PA imaging MOFs ratiometric probe H2S orthotopic colorectal cancer

Distribution- and Metabolism-Based Drug Discovery: A Potassium-Competitive Acid Blocker as a Proof of Concept

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Research 2022年第4期2022卷 609-620页

作者： Ming-Shu Wang Yi Gong Lin-Sheng Zhuo Xing-Xing Shi Yan-Guang Tian Chang-Kang Huang Wei Huang Guang-Fu Yang Key laboratory of Pesticide e Chemical Biology of Ministry of Education International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Nanjing Shuohui Pharmatechnology Co. Ltd.Nanjing 210046China

Conventional methods of drug design require compromise in the form of side effects to achieve sufficient efficacy because targeting drugs to specific organs remains ***,new strategies to design organ-specific drugs that induce little toxicity are *** on characteristic tissue niche-mediated drug distribution(TNMDD)and patterns of drug metabolism into specific intermediates,we propose a strategy of distribution-and metabolism-based drug design(DMBDD);through a physicochemical property-driven distribution optimization cooperated with a well-designed metabolism pathway,SH-337,a candidate potassium-competitive acid blocker(P-CAB),was ***-337 showed specific distribution in the stomach in the long term and was rapidly cleared from the systemic ***,SH-337 exerted a comparable pharmacological effect but a 3.3-fold higher no observed adverse effect level(NOAEL)compared with FDA-approved *** study contributes a proof-of-concept demonstration of DMBDD and provides a new perspective for the development of highly efficient,organ-specific drugs with low toxicity.

关键词： drugs organs Potassium

Dynamic changes of protein corona compositions on the surface of zinc oxide nanoparticle in cell culture media

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 90-97页

作者： Vo-Van Giau Yoon-Hee Park Kyu-Hwan Shim Sang-Wook Son Seong-Soo A. An Department of Bionanotechnology and Gachon Medical Research Institute Gachon University and Gachon Medical Research Institute Seongnam Korea laboratory of Cell Signaling and nanomedicine Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science Korea University College of Medicine Seoul Korea

The potential applications of nanomaterials used in nanomedicine as ingredients in drug delivery systems and in other products continue to expand. When nanomaterials are introduced into physiological environments and driven by energetics, they readily associate proteins forming a protein corona (PC) on their surface. This PC could result in an alteration of the nanomatcrial's surface characteristics, affecting their interaction with cells due to conformational changes in adsorbed protein molecules. However, our current understanding of nanobiological interactions is still very limited. Utilizing a liquid chromatography-mass spectroscopy/mass spectroscopy technology and a Cytoscape plugin (ClueGO) approach, we examined the composition of the PC for a set of zinc oxide nanoparticles (ZnONP) from cell culture media typically and further analyzed the biological interaction of identified proteins, respectively. In total, 36 and 33 common proteins were investigated as being bound to ZnONP at 5 min and 60 min, respectively. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Proteins bound to the surface of nanoparticles that may modify the structure, therefore the function of the adsorbed protein could be consequently affect the complicated biological processes.

关键词： ZnONPs nanoparticles protein corona ClueGO

A Bifunctional-Blocker-Aided Hybridization Chain Reaction Lighting-Up Self-calibrating Nanocluster Fluorescence for Reliable Nucleic Acid Detection

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Journal of Analysis and Testing 2024年第2期8卷 160-169页

作者： Dan Zhang Guobao Zhou Hongyan Yang Yi Wang Lijun Shen Yuxuan Qiu Lei Li Longhua Guo College of Chemistry and Materials Science Zhejiang Normal UniversityJinhua321004China Jiaxing Key laboratory of Molecular Recognition and Sensing College of BiologicalChemical Sciences and EngineeringJiaxing UniversityJiaxing314001China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou314000China

In this work,we proposed a ratiometric silver nanoclusters(AgNCs)fluorescent assay by designing a bifunctional-blockeraided hybridization chain reaction(HCR).Hairpin probe 1(HP1)containing two special DNA fragments(5′-CAC CGC T-3′and 5′-ATT TGC CTT TTG GGG ACG GATA-3′)at two terminals creates a red-emitting AgNC nucleation sequence(rNS,5′-CAC CGC TAT TTG CCT TTT GGG GAC GGATA-3′).We found that the presence of a toehold fragment(5′-TGCCC-3′)in HP1 could silence the *** the addition of a target nucleic acid,HCR of HP1 and hairpin probe 2(HP2)could be initiated,resulting in the formation of long chain of DNA duplexes with multibranched *** the toehold fragment in HP1participated in generating duplexes,a strong emission of rNS-templated AgNCs was observed at 670 *** significantly,a bifunctional blocker was introduced not only to reduce the background red-emitting fluorescence but also to play as an internal green-emitting AgNCs nucleation *** the one hand,the blocker could increase the signal-to-noise-ratio of the constructed biosensor,and on the other hand,the blocker also helped to prepare ratiometric HCR-AgNCs assay with self-calibrating ability to strengthen its *** with the traditional HCR-AgNCs sensors,the developed ratiometric assay based on the bifunctional-blocker-aided HCR has higher reliability,which is important for the fabrication of biosensors in various fields for practical biosensing applications.

关键词： Ratiometric fluorescence Hybridization chain reaction Silver nanocluster biosensor Bifunctional blocker

Oxidations of two-dimensional semiconductors:Fundamentals and applications

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Chinese Chemical Letters 2022年第1期33卷 177-185页

作者： Junqiang Yang Xiaochi Liu Qianli Dong Yaqi Shen Yuchuan Pan Zhongwang Wang Kui Tang Xianfu Dai Rongqi Wu Yuanyuan Jin Wei Zhou Song Liu Jian Sun School of Physics and Electronics Central South UniversityChangsha 410083China State Key laboratory of Chemical Biosensing and Chemometrics College of Chemistry and Chemical EngineeringInstitute of Chemical Biology and Nanomedicine(ICBN)Hunan UniversityChangsha 410082China

Since the discovery of graphene,two-dimensional(2D)semiconductors have been attracted intensive interest due to their unique *** have exhibited potential applications in next generation electronic and optoelectronic ***,most of the 2D semiconductor are known to suffer from the ambient oxidation which degrade the materials and therefore hinder us from the intrinsic materials’properties and the optimized performance of *** this review,we summarize the recent progress on both fundamentals and applications of the oxidations of 2D *** begin with the oxidation mechanisms in black phosphorus,transition metal dichalcogenides and transition metal monochalcogenides considering the factors such as oxygen,water,and *** we show the commonly employed passivation *** the end,the emerging applications utilizing controlled oxidations will be introduced.

关键词： Two-dimensional materials Oxidation Passivation Surface modification Doping