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China medical Abstracts(Internal medicine) 2024年第1期41卷 45-46页

作者：蒋冲 Dept Nucl med Nanjing Drum Tower HospNanjing Univ Med SchNanjing 210008

Objective To explore whether baseline PET metabolic parameters combined with B-cell lymphoma-2(Bcl-2)/cellular-myelocytomatosis viral oncogene (cMyc) dual expression (DE) can improve the prognostic stratification of p... 详细信息

关键词： lymphoma patients gastrointestinal

Effect of programmed comprehensive nursing on delirium incidence in intensive care unit children following severe cardiac surgery

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World Journal of Psychiatry 2024年第9期14卷 1301-1307页

作者： Qiu-Yue Wang Xiang Wang Ming-Xiong Li Department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina

BACKGROUND Programmed comprehensive nursing was adopted for intensive care unit(ICU)children following severe cardiac surgery to improve respiratory function and delirium *** To explore how programmed comprehensive nursing impacts respiratory func-tion and delirium incidence in ICU children post cardiac *** Between January 2022 and January 2024,180 pediatric patients from the Chil-dren’s Hospital of nanjing were admitted to the ICU after cardiac surgery and randomly *** control group comprised 90 patients and received routine nursing *** observation group comprised 90 patients and received program-med comprehensive *** groups received continuous nursing care until *** respiratory function,incidence of delirium,and clinical outcomes were *** memory state and sleep quality of both groups were *** The incidence of delirium was 5.56%in the observation group when admitted to ICU,which was lower than that in the control group(20.00%;Pmed comprehensive nursing in ICU patients following severe cardiac surgery can reduce the impact on respiratory function,improve sleep quality,and alleviate postoperative delirium,showing significant promise for clinical application.

关键词： Programmed comprehensive nursing Intensive care unit Cardiac surgery Respiratory function Delirium

Preliminary clinical application of novel magnetic navigation and ultrasound-guided percutaneous transhepatic cholangiography drainage through the right liver duct for malignant obstructive jaundice

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China medical Abstracts(Internal medicine) 2024年第2期41卷 111-112页

作者：卓晗 Hepatobil Center 1st Affil HospNanjing Med UnivNanjing 210029

Objective To analyze the clinical application value of a novel magnetic navigation ultrasound (MNU)combined with digital subtraction angiography (DSA)dual-guided percutaneous transhepatic biliary drainage(PTCD) throug... 详细信息

关键词： routine diagnosis finally

Microstructure development of Ti scaffold by laser powder bed fusion with chemical polishing and its mechanical properties, biocompatibility

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BIOSURFACE AND BIOTRIBOLOGY 2024年第2期10卷 52-62页

作者： Lu, Changfu Chen, Jing Ma, Teng Chen, Yuxin Zeng, Da Gan, Yiliang Yang, Youwen Double med Technol Inc Xiamen Peoples R China Jiangxi Univ Sci & Technol Inst Addit Mfg Nanchang Peoples R China Tongling Univ Key Lab Construct Hydraul Robots Anhui Higher Educ Tongling Peoples R China nanjing Univ Coll Engn & Appl Sci Nanjing Peoples R China

Titanium (Ti) dental scaffolds are widely used in dental prosthetics due to their excellent mechanical properties and biocompatibility. However, conventional Ti scaffolds manufactured through machining often do not fit perfectly with the bone defect site. Laser powder bed fusion (LPBF) technology enables the personalised manufacturing of custom-made Ti scaffolds. A custom-made Ti scaffold was prepared using LPBF and its surface roughness was improved through chemical polishing. To enhance the surface roughness, a nitric acid mixed solution with a specific composition of HF: HNO3:C3H6O3 = 2:2:3 was used. The polishing mechanism was investigated by adjusting the F/Ti ratio to control the formation and dissolution of the oxide film. As a result, the surface of the Ti scaffold after polishing exhibited a smooth and flat appearance compared to the LPBF part, with a reduced surface roughness (Ra) of 1.23 +/- 0.19 mu m. The custom-made Ti scaffold also demonstrated favourable mechanical properties, with a bending strength of 335.18 +/- 33.62 MPa and stiffness of 2.13 +/- 0.21 GPa. Furthermore, in vitro cell tests confirmed the excellent biocompatibility of the custom-made Ti scaffold. The authors present a feasible strategy for the further clinical application of custom-made Ti scaffolds, offering enhanced surface properties and addressing the limitations of conventional machining methods.

关键词： additive manufacturing dental material property surface roughness GUIDED BONE REGENERATION ALLOY OPTIMIZATION PARAMETERS MEMBRANE BEHAVIOR

The diagnostic value of salivary pepsin test in gastroesophageal reflux disease

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China medical Abstracts(Internal medicine) 2024年第1期41卷 49-50页

作者：陈蓉蓉 Dept Gastroenterol 1st Affil HospNanjing Med UnivNanjing 210029

Objective To explore the clinical application value of salivary pepsin test (Peptest) in the diagnosis of gastroesophageal reflux disease (GERD).Methods From April to October 2022,at the Department of Gastroenterology... 详细信息

关键词： salivary diagnosis clinical

Comparative study of ^(18)F-PSMA-1007,^(18)F-FDG PET/CT and mpMRI in the diagnosis of prostate cancer

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China medical Abstracts(Internal medicine) 2024年第2期41卷 66-67页

作者：姜一逸 Dept Nucl med Affil Taizhou People's HospNanjing Med UnivTaizhou 225300

Objective To compare the diagnostic efficacy of ^(18)Fprostate specific membrane antigen(PSMA)-1007 PET/CT,18F-FDG PET/CT and multi-parameter MRI(mpMRI)in prostate cancer(PCa).Methods Retrospective analysis was conducted on data from 22 patients((72.6±6.2)years)with pathologically confirmed PCa in the Affiliated Taizhou People's Hospital of nanjing medical University between April 2021 and September *** patients underwent 18F-PSMA-1007 PET/CT,18F-FDG PET/CT,and mpMRI examination within 30 d,and the imaging parameters were collected,including PSMASUVnax FDG-SUV_(max),minimum apparent diffusion coefficient(ADC_(min)),mean apparent diffusion coefficient(ADC_(mean)),PSMA-SUV_(max)/ADCm,in PSMA-SUV ma ADC_(mean),FDG-SUV_(max)/ADC_(min),FDG-SUVmV_(max)/ADC,nean Patientswere divided into groupsbasedonthe International Society of Urological Pathology(ISUP)grading(≤3 vs>3)and serum total prostate specific antigen(TPSA;≤20μg/L us>20μg/L).

关键词： PET/CT PSMA diagnosis

Association between different obesity indicators and carotid intima-media thickness in patients with type 2 diabetes mellitus

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China medical Abstracts(Internal medicine) 2024年第1期41卷 27-28页

作者：崔茜 Dept Endocrinol Affil Changzhou No.2 People's HospNanjing Med UnivChangzhou 213000

Objective To explore the relationship between different obesity indicators and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 1 762 T2DM patients who visited the Endocrinology Department of Changzhou Second People’s Hospital Affiliated to nanjing medical University and the Integrated Traditional Chinese and Western medicine Hospital Affiliated to nanjing University of Traditional Chinese medicine from January2019 to February 2022 were enrolled in this study.

关键词： obesity T2DM patients

Association of hemoglobin levels with bone mineral density and osteoporosis in patents with type 2 diabetes

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China medical Abstracts(Internal medicine) 2024年第2期41卷 90-91页

作者：谭娟 Dept General Practice Affil Huaian No.1 People's HospNanjing Med UnivHuaian 223300

Objective To explore the association of hemoglobin(HGB) levels with bone mineral density (BMD) and osteoporosis in patients with type 2 diabetes mellitus(T2DM).Methods A cross-sectional study was conducted in 364 patients with T2DM who were hospitalized in the Department of Endocrinology and Geriatrics of the Affiliated Huaian No.1 People's Hospital of nanjing medical University from September 2019 to September 2020.

关键词： osteoporosis diabetes T2DM

Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3218-3231页

作者： Wen Zhang Yihui Zhai Ying Cai Xiang Gong Yunxuan Jiang Rong Rong Chao Zheng Binyu Zhu Helen He Zhu Hao Wang Yaping Li Pengcheng Zhang China State Institute of Pharmaceutical Industry Shanghai 201203China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Biomedical Engineering&State Key Laboratory of Advanced medical Materials and Devices ShanghaiTech UniversityShanghai 201210China School of Chinese Materia medica Nanjing University of Chinese MedicineNanjing 210023China Yantai Institute of Materia medica Shandong 264000China State Key Laboratory of Oncogenes and Related Genes Renji-Med-X Stem Cell Research CenterDepartment of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127China University of Chinese Academy of Sciences Beijing 100049China

Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with triple-negative breast cancer(TNBC).Here,we create a LCL161-loaded macrophage membrane decorated nanoparticle(LMN)for immunotherapy of MHC-I-deficient *** on the macrophage membrane helps LMNs recognize CD47-expressing cancer cells for targeted delivery of LCL161,which induces the release of high mobility group protein 1 and proinflammatory cytokines from cancer *** released cytokines and high mobility group protein 1 activate antitumor immunity by increasing the intratumoral density of the phagocytic macrophage subtype by 15 times and elevating the intratumoral concentration of CTL lymphotoxin by 4.6 *** also block CD47-mediated phagocytosis *** inhibit the growth of MHC-I-deficient TNBC tumors,as well as those resistant to combined therapy of anti-PDL1 antibody and albumin-bound paclitaxel,and prolong the survival of animals,during which process CTLs also play important *** macrophage membrane-decorated nanoparticle presents a generalizable platform for increasing macrophagemediated antitumor immunity for effective immunotherapy of MHC-I-deficient cancers.

关键词： MHC-I deficiency Macrophage CD47 Immunotherapy Triple-negative breast cancer Phagocytosis Immune checkpoint Innate immunity

Research progress of severe acute respiratory syndrome coronavirus 2 on aerosol collection and detection

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Chinese Chemical Letters 2024年第1期35卷 108-115页

作者： Xinyu Zhang Yuting Chen Yueying Pan Xinye Ma Gui Hu Song Li Yan Deng Zhu Chen Hui Chen Yanqi Wu Zhihong Jiang Zhiyang Li Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China State Key Laboratory of Quality Research in Chinese medicine Macao University of Science and TechnologyMacao 999078China Shenzhen Lemniscare med Technol Co.Ltd. Shenzhen 518000China Department of Clinical Laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China

The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in late 2019 has negatively affected people's lives and *** the mode of transmission of SARS-CoV-2 is of great concern,this review discusses the sources of virus aerosols and possible transmission ***,we discuss virus aerosol collection methods,including natural sedimentation,solid impact,liquid impact,centrifugal,cyclone and electrostatic adsorption ***,we review common virus aerosol detection methods,including virus culture,metabolic detection,nucleic acid-based detection and immunology-based detection ***,possible solutions for the detection of SARS-CoV-2 aerosols are ***-of-care testing has long been a focus of *** the near future,the development of an instrument that integrates sampling and output results will enable the real-time,automatic monitoring of patients.

关键词： Virus aerosol Aerosol transmission Aerosol collection Aerosol detection Protective measure