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The value of toxicological analysis in acute poisoning patients with uncertain exposure histories:a retrospective and descriptive study from an institute of poisoning

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World Journal of Emergency Medicine 2024年第2期15卷 98-104页

作者： Qifang Shi gen Ba Zhenyu Xia Zhengsheng Mao Hao Sun Jinsong Zhang Institute of Poisoning Nanjing Medical UniversityNanjing 211100China Department of Emergency Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Forensic Medicine Nanjing Medical UniversityNanjing 211166China The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical UniversityNanjing 211166China

BACKGROUND:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison *** aim of this study was to use toxicological analysis to examine the clinical characteristics of patients with acute poisoning whose exposure history was uncertain from a toxicological analysis ***:This was a retrospective and descriptive study from an institute of *** registration information and test reports spanning the period from April 1,2020 to March 31,2022,were *** with uncertain exposure histories and who underwent toxicological analysis were *** manifestations and categories of toxics were ***:Among the 195 patients with positive toxicological analysis results,the main causes of uncertain exposure history was disturbance of consciousness(62.6%),unawareness(23.6%)and unwillingness or lack of cooperation(13.8%).The predominant clinical manifestations were disturbed consciousness(62.6%),followed by vomiting and nausea(14.4%)and liver function abnormalities(8.7%).A comparison of clinical manifestations between patients with positive and negative(n=99)toxicological analyses results revealed significantly different proportions of disturbances in consciousness(63%vs.21%),dizziness(1.5%vs.5.1%),multi-organ failure(1.5%vs.7.1%),and local pain(0 vs 4%).The main categories of substances involved were psychiatric medications(23.1%),sedatives(20.5%),insecticides(13.8%),and herbicides(12.8%).CONCLUSION:The clinical manifestations of acute poisoning in patients with an uncertain exposure history are diverse and nonspecific,and toxicological analysis plays a pivotal role in the diagnosis and differential diagnosis of such patients.

关键词： Acute poisoning Toxic exposure Toxicological analysis Clinical manifestation

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Sample generation for Security Region Boundary Identification Based on Topological Features of Historical Operation Data

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1087-1095页

作者： Xiaokang Wu Wei Xu Feng Xue College of Energy and Electrical Engineering Hohai UniversityNanjingChina NARI Group Corporation NanjingChina State Grid Electric Power Research Institute NanjingChina

Since the scale and uncertainty of the power sys-tem have been rapidly increasing,the computation efficiency of constructing the security region boundary(SRB)has become a prominent *** on the topological features of histori-cal operation data,a sample generation method for SRB identi-fication is proposed to generate evenly distributed samples,which cover dominant security *** boundary sample pair(BSP)composed of a secure sample and an unsecure sam-ple is defined to describe the feature of *** resolution,sampling,and span indices are designed to evaluate the cover-age degree of existing BSPs on the SRB and generate samples closer to the *** on the feature of flat distribution of BSPs over the SRB,the principal component analysis(PCA)is adopted to calculate the tangent vectors and normal vectors of ***,the sample distribution can be expanded along the tangent vector and corrected along the normal vector to cover different security ***,a sample set is randomly gen-erated based on the IEEE standard example and another new sample set is generated by the proposed *** results in-dicate that the new sample set is closer to the SRB and covers different security modes with a small calculation time cost.

关键词： Clustering analysis principal component analysis(PCA) sample generation security region boundary(SRB)

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Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway

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World Journal of Gastroenterology 2024年第20期30卷 2709-2725页

作者： Kai-Di Chen Kui-Ling Wang Chen Chen Yi-Jia Zhu Wen-Wen Tang Yu-Ji Wang Ze-Peng Chen Lin-Hai He Yu-gen Chen Wei Zhang Jiangsu Province hospital of Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina The No.1 Clinical Medical College Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Collaborative Innovation Center of Chinese Medicine in Prevention and Treatment of Tumor The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND Constipation,a highly prevalent functional gastrointestinal disorder,induces a significant burden on the quality of patients'life and is associated with substantial healthcare ***,identifying efficient therapeutic modalities for constipation is of paramount *** stress is a pivotal contributor to colonic dysmotility and is the underlying pathology responsible for constipation ***,we postulate that hydrogen therapy,an emerging and promising intervention,can serve as a safe and efficacious treatment for *** To determine whether hydrogen-rich water(HRW)alleviates constipation and its potential *** Constipation models were established by orally loperamide to Sprague-Dawley *** freely consumed HRW,and were recorded their 24 h total stool weight,fecal water content,and charcoal propulsion *** samples were subjected to 16S rDNA gene *** non-targeted metabolomic analysis,malondialdehyde,and superoxide dismutase levels were *** tissues were stained with hematoxylin and eosin,Alcian blue-periodic acid-Schiff,reactive oxygen species(ROS)immunofluorescence,and immunohistochemistry for cell growth factor receptor kit(c-kit),PGP 9.5,sirtuin1(SIRT1),nuclear factor-erythroid-2-related factor 2(Nrf2),and heme oxygenase-1(HO-1).Quantitative real-time PCR and western blot analysis were conducted to determine the expression level of SIRT1,Nrf2 and HO-1.A rescue experiment was conducted by intraperitoneally injecting the SIRT1 inhibitor,EX527,into constipated ***460 cells were induced with H2O2 and treated with the metabolites to evaluate ROS and SIRT1 *** HRW alleviated constipation symptoms by improving the total amount of stool over 24 h,fecal water content,charcoal propulsion rate,thickness of the intestinal mucus layer,c-kit expression,and the number of intestinal *** modulated intestinal microbiota imbalance and abnormaliti

关键词： Hydrogen-rich water Constipation Sirtuin1 Oxidative stress Gut microbiota Serum metabolites

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Prognostic stratification of baseline PET metabolic parameters combined with Bcl-2/c-Myc dual expression in patients with primary gastrointestinal diffuse large B-cell lymphoma

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 45-46页

作者：蒋冲 Dept Nucl Med Nanjing Drum Tower HospNanjing Univ Med SchNanjing 210008

Objective To explore whether baseline PET metabolic parameters combined with B-cell lymphoma-2(Bcl-2)/cellular-myelocytomatosis viral oncogene (cMyc) dual expression (DE) can improve the prognostic stratification of p... 详细信息

关键词： lymphoma patients gastrointestinal

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Hepatic ectopic pregnancy with hemorrhage secondary diaphragmatic adhesion:A case report

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World Journal of Hepatology 2024年第9期16卷 1289-1296页

作者： Xiu-Ci Yang Miao Fang Yi-gen Peng Liang Wang Rong Ju Department of Emergency The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 211100Jiangsu ProvinceChina Department of Gynecology and Obstetrics Nanjing Medical UniversityNanjing 211100Jiangsu ProvinceChina Department of Hepatological Surgery The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 211100Jiangsu ProvinceChina Department of Gynecology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 211100Jiangsu ProvinceChina

BACKGROUND Primary abdominal pregnancy is an extremely rare form of ectopic *** pregnancies that occur in the liver and diaphragm are even rarer,limited case reports are available in the *** SUMMARY A woman of childbearing age was transferred to the emergency department due to lumbar and abdominal pain radiating to the back toward the lower *** a series of physical and auxiliary examinations,she was clinically diagnosed with hepatic ectopic *** surgery was performed to remove the pregnancy tissue and achieve *** a period of follow-up,the patient was successfully *** Paying attention to the patient's signs and utilizing imaging examination methods can help avoid missed diagnoses of liver pregnancy.

关键词： Ectopic pregnancy Liver Diaphragm Diagnosis Case report

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Fossil organic carbon weathering:A nexus in global biogeochemical cycles

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Science China Earth Sciences 2024年第6期67卷 2068-2072页

作者： Gaojun LI gen KLI Department of Earth and Planetary Sciences Nanjing UniversityNanjing 210023China Department of Earth Science University of CaliforniaSanta Barbara CA 93106USA

The participation of life processes represents a fundamental feature of geochemical cycles on the planet *** of primary processes is that the carbon-based life utilizes photosynthesis to convert atmospheric CO_(2) int... 详细信息

关键词： weathering Earth geochemical

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Preliminary clinical application of novel magnetic navigation and ultrasound-guided percutaneous transhepatic cholangiography drainage through the right liver duct for malignant obstructive jaundice

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 111-112页

作者：卓晗 Hepatobil Center 1st Affil HospNanjing Med UnivNanjing 210029

Objective To analyze the clinical application value of a novel magnetic navigation ultrasound (MNU)combined with digital subtraction angiography (DSA)dual-guided percutaneous transhepatic biliary drainage(PTCD) throug... 详细信息

关键词： routine diagnosis finally

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The diagnostic value of salivary pepsin test in gastroesophageal reflux disease

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 49-50页

作者：陈蓉蓉 Dept Gastroenterol 1st Affil HospNanjing Med UnivNanjing 210029

Objective To explore the clinical application value of salivary pepsin test (Peptest) in the diagnosis of gastroesophageal reflux disease (GERD).Methods From April to October 2022,at the Department of Gastroenterology... 详细信息

关键词： salivary diagnosis clinical

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On the Specificity of Nanozymes: A Perspective

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Chinese Journal of Chemistry 2024年第13期42卷 1515-1522页

作者： gen Wei Shuje Liu Yung-Kang Peng Hui Wei Department of Biomedical Engineering College of Engineering and Applied SciencesNanjing National Laboratory of MicrostructuresJiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjingJiangsu 21023China Department of Chemistry.City University of Hong Kong Hong Kong 999077Hong Kong SARChina State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjingJiangsu 210023China NMPA Key Laboratory for Biomedical Optics HangzhouZhejiang 310018China

We have compiled eight promising strategies for enhancing the specificity and selectivity of nanozymes,as depicted in the comprehensive summary *** exhibit intricate and sophisticated structures,including substrate channels and active sites,which can inform the design of *** of these structural features and the application of facet engineering/doping techniques can significantly enhance the catalytic specificity of ***,the use of Molecularly Imprinted Polymers(MiPs)to coat nanozymes represents an effective approach to impart substrate ***,several straightforward stopgap strategies have been devised to improve nanozyme specificity for analytical applications,such as the integration of biorecognition elements and nanozyme sensor arrays through surface modification.

关键词： Nanozymes Enzymes Catalytic activity Specificity Perspective

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Low intramuscular adipose tissue index is a protective factor of all-cause mortality in maintenance dialysis patients

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 117-118页

作者：郑婧 Instit Nephrol Zhongda HospSoutheast UnivNanjing 210009

Objective To investigate the relationship between intramuscular adipose tissue index(IATI)calculated from computed tomography images at transverse process of the first lumbar and all-cause mortality in maintenance dialysis patients,and to provide a reference for improving the prognosis in these *** It was a multicenter retrospective cohort *** clinical data of patients who received maintenance hemodialysis or peritoneal dialysis treatment from January 1,2017 to December 31,2019 in 4 grade I hospitals including Zhongda hospital Affiliated to Southeast University,Taizhou People's hospital Affliated to nanjing Medical University,Affiliated hospital of Yangzhou University,and the Third Affiliated hospital of Soochow University were retrospectively *** was calculated by low attenuation muscle(LAM)density/skeletal muscle *** receiver-operating characteristic curve was used to determine the optimal cut-off value of IATI,and the patients were divided into high IATI group and low IATI group according to the optimal cut-off *** differences of baseline clinical data and measurement parameters of the first lumbar level between the ttwo groups were ***-upended on December 23,2022.

关键词： dialysis patients protective

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