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Chinese Journal of Aeronautics 2023年第2期36卷 241-255页

作者： Peiran LI Xin WEN Haiying LIU Yuping LU Department of Astronautics Nanjing University of Aeronautics and AstronauticsNanjing 211100China Nanjing Center for Applied Mathematics Nanjing 211135China

This paper presents a discrete-time attitude control strategy with equi-global practical stabilizability for aligning the attitude of multiple spacecraft to a predesigned configuration according to a time-variant reference.By utilizing the interference of the wireless channel,the communication scheme designed in this paper can save communication resources,amount of computation,and energy proportionally to the number of spacecraft.The exact discrete-time model and approximate discrete-time model of the consensus-based spacecraft tracking system are given.Then the framework for the design of an event-triggered control scheme for the exact discrete-time system via its approximate models is developed,which avoids the periodic actuation,and Zeno behavior is proved to be excluded.Furthermore,the control scheme can handle the presence of the unknown fading channel.Finally,simulation results are presented to demonstrate the effectiveness of the control strategy.

关键词： Attitude control Cooperative communication Discrete time control systems Multi agent systems Spacecraft

Evaluating the accuracy of two satellite-based Quantitative Precipitation Estimation products and their application for meteorological drought monitoring over the Lake Victoria Basin,East Africa

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Geo-Spatial Information Science 2022年第3期25卷 500-518页

作者： Priyanko Das Zhenke Zhang Hang Ren center of African Studies Nanjing UniversityNanjingChina and School of Geographic and Oceanographic SciencesNanjing UniversityNanjingChina center of African Studies Nanjing UniversityNanjingChina and School of Geographic and Oceanographic SciencesNanjing University Nanjing China Institute of Population Studies Nanjing University of Posts and TelecommunicationsNanjingJiangsu provinceChina

This study evaluates the high-resolution satellite estimated long-term precipitation data for monitor-ing the drought condition over the Lake Victoria Basin(LVB)from 1984 to 2020.Standardized Precipitation Indices(SPI)were used to capture the short,medium and long-term meteorological drought conditions at multiple time scales(i.e.3,6,and 12).For these,the following two primaries Quantitative Precipitation Estimation(QPEs)products were employed-1)Climate Hazards group Infra-Red Precipitation with Station(CHIRPS),and 2)the Precipitation Estimation from Remotely Sensed Information using Artificial Neural Network-Climate Data Record(PERSIANN-CDR).This dataset was compared based on the observation data obtained from the Climate Research Unit(CRU)over the nine selected regions surrounding lake basins.The performance of these two QPEs products was evaluated using seven statistical metrics.The findings of this study indicate that the CHIRPS and PERSIANN-CDR datasets could capture the behavior of drought magnitude based on the time scale of SPI-3,SPI-6,SPI-12.The results indicate that 2012 and 2017 are significant severe drought years in the recent decade over LVB.However,the CHIRPS datasets provide good agreement(Correlation Coefficient(CC)=0.65)with observation,whereas PERSIANN-CDR present satisfactory results(CC=0.54).In addition,Hurst(H)exponent was used to predict the future drought trend and found that the CHIRPS performed well to predict the degree of drought trend.Therefore,this study considers the CHIRPS product for near-real-time drought monitoring and PERSIANN-CDR for historical drought assessment.Moreover,the outcome from the H values is greater than 0.5,which indicates the future drought trend would be decreased over LVB.These results are useful for developing the strategies for drought hazards and water resource management in LVB.

关键词： CHIRPS CRU hurst exponent PERSIANN-CDR SPI

Magnetic-activated cell sorting of nonapoptotic spermatozoa with a high DNA fragmentation index improves the live birth rate and decreases transfer cycles of IVF/ICSI

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Asian Journal of Andrology 2022年第4期24卷 367-372页

作者： Jie Mei Lin-Jun Chen Xin-Xin Zhu Wen Yu Qing-Qiang Gao Hai-Xiang Sun Li-Jun Ding Jun-Xia Wang center for Reproductive Medicine Department of Obstetrics and GynecologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China center for Molecular Reproductive Medicine Nanjing UniversityNanjing 210008China Department of Andrology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Clinical center for Stem Cell Research The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China

The present study aimed to evaluate the clinical outcomes of magnetic-activated cell sorting(MACS)in sperm preparation for male subjects with a sperm DNA fragmentation index(DFI)≥30%.A total of 86 patients who had undergone their first long-term long protocol were selected.The protocol involved in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI)cycles,and the patients were divided into the MACS or control groups.The MACS group included sperm samples analyzed with MACS that were combined with density gradient centrifugation(DGC)and the swim-up(SU)technique(n=39),and the control group included sperm samples prepared using standard techniques(DGC and SU;n=41).No differences were noted with regard to basic clinical characteristics,number of oocytes retrieved,normal fertilization rate,cleavage rate,or transplantable embryo rate between the two groups in IVF/ICSI.In addition,the clinical pregnancy and implantation rates of the first embryo transfer cycles indicated no significant differences between the two groups.However,there was a tendency to improve the live birth rate(LBR)of the first embryo transfer cycle(63.2%vs 53.9%)and the cumulative LBR(79.5%vs 70.7%)in the MACS group compared with the control group.Moreover,the number of transferred embryos(mean±standard deviation[s.d.]:1.7±0.7 vs 2.3±1.6)and the transfer number of each retrieved cycle(mean±s.d.:1.2±0.5 vs 1.6±0.8)were significantly lower in the MACS group than those in the control group.Thus,the selection of nonapoptotic spermatozoa by MACS for higher sperm DFI could improve assisted reproductive clinical outcomes.

关键词： cumulative live birth rate fertility rate intracytoplasmic sperm injection sperm DNA fragmentation index sperm DNA integrity

Impact of inactivated COVID-19 vaccines on viral shedding in B.1.617.2(Delta)variant-infected patients

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Science China(Life Sciences) 2022年第12期65卷 2556-2559页

作者： Zhiliang Hu Yi Yin Kai Wang Miaomiao Xu Chengyuan Ding Yan Song Changhua Yi Junwei Li Yongxiang Yi Zhihang Peng nanjing Infectious Disease center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003 China center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166 China School of Public Health Nanjing Medical UniversityNanjing 211166China The First Affiliated Hospital of nanjing Medical University Nanjing 210029China

Dear Editor,The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2)has waged a global pandemic. As of April 15, 2022, more than 500 million cases of COVID-19 had been reported, with more than 6 million deaths. The ultimate arsenal to fight against this pandemic is highly effective vaccines (Bok et al.,2021;Sadarangani et al., 2021).

关键词： vaccines acute

Anisotropic superconducting properties of FeSe_(0.5)Te_(0.5) single crystals

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Chinese Physics B 2022年第9期31卷 519-526页

作者：赵佳铭王智河 School of Physics Nanjing UniversityNanjing 210093China center for Superconducting Physics and Materials Collaborative Innovation Center of Advanced Microstructures and National Laboratory of Solid State MicrostructuresNanjing UniversityNanjing 210093China

We investigated the anisotropic electrical transport and magnetic properties of FeSe_(0.5)Te_(0.5) single crystals grown by the self-flux method.The in-plane resistivity shows a metallic-like temperature dependence,while the out-of-plane resistivity shows a broad hump with a maximum at around 64 K.The magnetization loops for H//c-axis and H//ab-plane are also different,for example,there is a typical second peak for H//c-axis.The in-plane critical current density is larger than the out-of-plane one.The coherence length and penetration depth were estimated by the Ginzburg-Landau theory.The anisotropic parameterγdepends on the applied magnetic field and the temperature.The coupling of superconducting FeSe(Te)layers and the flux pinning mechanism relevant to anisotropy are also discussed.

关键词： FeSe_(1-x)Te_(r)single crystal anisotropy resistivity magnetization

Raman imaging analysis of intracellular biothiols independent of the aggregation of sensing substrates

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Science China Chemistry 2023年第8期66卷 2416-2424页

作者： Min Zhang Zijun Li Mengyang Zhang Hang Heng Shiying Xu Zhaoyin Wang Zhihui Dai Jiangsu Collaborative Innovation center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023China center for Analysis and Testing Nanjing Normal UniversityNanjing210023China School of Chemistry and Molecular Engineering Nanjing Tech UniversityNanjing211816China

The content of biothiols in cells is highly associated with the occurrence and development of several diseases.However,due to their active chemical properties,thiol-contained molecules are normally volatile during the detection process,rendering precise analysis of intracellular biothiols challenging.In this study,5,5’-dithiobis-(2-nitrobenzoic acid)(DTNB)is covalently modified on the surface of gold nanorods(AuNRs),constructing sensing substrates for in situ Raman imaging analysis of biothiols in cells.Au NRs are able to serve as ideal surface-enhanced Raman scattering substrates,and thus Raman signals of DTNB are greatly amplified by AuNRs.Meanwhile,the disulfide bond of DTNB can be broken by thiols,thereby releasing part of DTNB from the surface of AuNRs.As a result,three kinds of main biothiols are sensitively quantified with DTNB-modified AuNRs according to the variation of Raman signals,and DTNB-modified Au NRs exhibit far better analytical performance than a commercial probe.In addition,the sensing substrates can be readily delivered to cytoplasm with the transmembrane of Au NRs,and are capable of responding to biothiols in cells.Notably,the Raman approach is established by the breaking of chemical bonds rather than the aggregation of substrates,which is more inclined to analyze intracellular biothiols with a desirable spatial resolution.Therefore,fluctuation of biothiols in glioma cells is evidently observed via Raman imaging.Overall,this work provides an alternative strategy for designing Raman sensors to visualize active molecules in cells.

关键词： AuNRs SERS biothiols imaging disulfide bond

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

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Frontiers of Medicine 2022年第2期16卷 227-239页

作者： Ming Hou Suji Wang Dandan Yu Xinyi Lu Xiansen Zhao Zhangpeng Chen Chao Yan State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China Institute of Artificial Intelligence Biomedicine Nanjing UniversityNanjing 210023China Chemistry and Biomedicine Innovation center Nanjing UniversityNanjing 210023China Engineering Research center of Protein and Peptide Medicine Ministry of EducationNanjing 210023China

Chronic stress impairs radial neural stem cell(rNSC)differentiation and adult hippocampal neurogenesis(AHN),whereas promoting AHN can increase stress resilience against depression.Therefore,investigating the mechanism of neural differentiation and AHN is of great importance for developing antidepressant drugs.The nonpsychoactive phytocannabinoid cannabidiol(CBD)has been shown to be effective against depression.However,whether CBD can modulate rNSC differentiation and hippocampal neurogenesis is unknown.Here,by using the chronic restraint stress(CRS)mouse model,we showed that hippocampal rNSCs mostly differentiated into astrocytes under stress conditions.Moreover,transcriptome analysis revealed that the FoxO signaling pathway was involved in the regulation of this process.The administration of CBD rescued depressive-like symptoms in CRS mice and prevented rNSCs overactivation and differentiation into astrocyte,which was partly mediated by the modulation of the FoxO signaling pathway.These results revealed a previously unknown neural mechanism for neural differentiation and AHN in depression and provided mechanistic insights into the antidepressive effects of CBD.

关键词： cannabidiol depression radial neural stem cells neurogenesis

Potential impact of COVID-19 pandemic on endometriosis

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生殖与发育医学（英文） 2022年第3期06卷 138-143页

作者： Chen-Yang Huang Hai-Xiang Sun Jie Mei China center for Molecular Reproductive Medicine Nanjing University Nanjing 210008 China210008

The impact of coronavirus disease 2019 (COVID-19) on endometriosis (EM) is currently unclear. Here, we aimed to describe the potential influence of COVID-19 on the pathogenesis, clinical symptoms, and treatment of EM. The cytokine storm caused by COVID-19 may induce the occurrence and progression of EM, and immunosuppression of COVID-19 may help the ectopic endometrium escape from immune clearance. Consequently, the forced social isolation and the cancelation of non-emergency medical treatment during the COVID-19 pandemic aggravate anxiety and psychological pressure, which can aggravate the symptoms related to EM and delay routine medical services.

关键词： COVID-19 Endometriosis Pathogenesis Pelvic pain Infertility

Analysis of clinical characteristics of 66 pediatric patients with B.1.617.2(Delta)variant of COVID-19

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World Journal of Pediatrics 2022年第5期18卷 343-349页

作者： Jing Hao Xiao-Chen Hu Ming-Xing Fan Jun Chen Qi-Rui Cheng Zhuo Li Zhi-Liang Hu Xu-Hua Ge Pediatric Intensive Care Unit Children's Hospital of Nanjing Medical UniversityNo 72 Guangzhou RoadNanjingChina nanjing Infectious Disease center The Second Hospital of NanjingNanjing University of Chinese MedicineNanjingChina

Background The aim of this study was to analyze the clinical characteristics of 66 pediatric patients with B.l.617.2(Delta)variant of coronavirus disease 2019(COVID-19).Methods Sixty-six pediatric patients with B.1.617.2(Delta)variant of COVID-19 admitted to the hospital from July to August 2021 were classified into mild(n=41)and moderate groups(n=25).Clinical characteristics,laboratory data and dynamic trends in different time periods were analyzed retrospectively.Results There were no statistically significant differences in age,gender ratios and clinical symptoms between the mild group and the moderate group.All the patients in the moderate group had clusters of onsets,and the incubation period was shorter than that of the mild group.Within 24 hours of admission,the levels of erythrocyte sedimentation rate,cardiac troponin I,D-dimer in the moderate group were higher than that in the mild group(P<0.05).The titers of immunoglobulin(Ig)G and IgM antibodies gradually increased after disease onset.Thirty-five(53.03%)children were tested positive for antibodies in 4-12 days.IgG increased gradually,while IgM decreased obviously in about 15 days after disease onset.The cycle threshold values of open reading frame lab and nucleocapsid protein gene in the severe acute respiratory syndrome coronavirus 2 genomes in creased gradually on the 3rd,6th,9th,and 12th days after disease onset,compared with those in day 0.Conclusions The symptoms of children with B.l.617.2(Delta)variant of COVID-19 were mild.The description and analysis of the clinical characteristics and laboratory data can help medical stafiF to evaluate the condition of children with COVID-19 and to accumulate more clinical experience.

关键词： B.1.617.2(Delta) Children Clinical features Coronavirus disease 2019(COVID-19)

FeS@LAB-35@Ti_(3)C_(2)as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing

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Nano Research 2023年第2期16卷 2840-2850页

作者： Gaoqi Sun Xuefeng Jiang Cheng Liu Saijie Song Jun Zhang Jian Shen National and Local Joint Engineering Research center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Medical School Nanjing UniversityNanjing 210093China Jiangsu Engineering Research center of Interfacial Chemistry Nanjing UniversityNanjing 210023China

The abuse of antibiotics leads to a significant increase in bacterial resistance,which makes it difficult to treat bacterial infections.Therefore,it is urgent to develop new strategies for efficient antibacterial and wound healing.Recently,nanozymes based antibacterial agents have attracted increasing attention for their multifunction and high efficiency.In this study,we report a FeS@lauramidopropyl betaine(LAB-35)@Ti_(3)C_(2)nanozyme as a high-efficiency antibacterial agent for near infrared(NIR)light induced photothermal enhanced chemodynamic antibacteria and wound healing.The FeS@LAB-35@Ti_(3)C_(2)nanozyme possesses peroxidase-like catalysis activity,which can promote the generation of hydroxyl radicals(·OH)through catalyzing the decomposition of H_(2)O_(2).FeS@LAB-35@Ti_(3)C_(2)has photothermal conversion efficiency(η=65.1%),and it exhibits enhanced catalytic activity under NIR light irradiation.The in vitro antibacterial experiments demonstrate the excellent antibacterial activity of FeS@LAB-35@Ti_(3)C_(2)against representative Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus.The animal experiments indicate that FeS@LAB-35@Ti_(3)C_(2)nanozyme can effectively inhibit wound ulceration and promote wound healing.Overall,this study proposes FeS@LAB-35@Ti_(3)C_(2)nanozyme that integrates chemodynamic and photothermal therapy,which provides an efficient strategy for bacterial inhibition and wound healing.

关键词： MXene FeS nanozyme photothermal enhanced chemodynamic antibacterial activity wound healing