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ENDOFEM INTEGRATED METHODOLOGY FOR FATIGUE CRACK GROWTH

Acta Mechanica Sinica 2002年第2期18卷 89-94页

作者： C.F.Lee L.T.Hsiao DepartmentofEngineeringScienceNationalCheng-KungUniversityTainan Taiwan10617R.O.C. nan-jonginst.oftechnology

In this paper, the FEM with the incremental endochronic cyclic plasticity (EndoFEM) and the rc controlled node-released strategy are employed to study the fatigue crack opened/closed load (Pop) of A1 2024-T3 CCT specimens provided by Mageed and Pandey under several crack lengths and the constant amplitude with various load ratio (R). After statisfactory results are achieved by comparisons of computed Pop values and cited experimental data, the simulations will be extended to the crack lengths with significant bending effect due to short ligaments or high peak (Pmax) or high positive or very low negative R cyclic loads. Through these simulations, the complete map of Pop/Pmax vs. Kmax and R can be constructed and thereafter its correspondant empirical formulae can be proposed. Using these formulae and selecting the traditional fatigue crack growth parameter ΔKeff, the A1 2024-T3 fatigue crack growth rate da/dN vs. ΔK and R data, provided by Hiroshi and Schijve, can be employed to proposed empirical formulae of da/dN vs. ΔKeff and R. After integration, fatigue-crack-growth length a vs. N curves computed by EndoFEM can be obtained. The results are agreed very well with the existing experimental curves. According to the above procedures of simulation and steps of comparions with experiment, this paper may provides an integrate methodology of numerical simulation in the studies of fatigue crack growth for academic and industrial researches and design analysis.

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Serum uric acid levels correlate with recurrence of paroxysmal atrial fibrillation after catheter ablation

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Chinese Medical Journal 2013年第5期126卷 860-864页

作者： HE Xiao-nan LI Song-nan ZHAN Jin-liang XIE Shuang-lun ZHANG Zhi-jun DONG Jian-zeng YU Rong-hui LONG De-yong TANG Ri-bo MA Chang-sheng Department of Cardiology Beijing Anzhen Hospital CapitalMedical University Beijing 100029 China Department of Cardiology Tianjin Chest Hospital Tianjin 300051China School of Management and Economics Beijing Institute ofTechnology Beijing 100081 China Department of Cardiology Sun Yat-sen Memorial Hospital of SunYat-sen University Guangzhou Guangdong 510000 China

Background Recently there has been a great deal of interest in the role of serum uric acid （SUA） in atrial fibrillation （AF）. The objective of this study was to establish whether there is a relationship between levels of SUA and recurrence of paroxysmal AF after catheter ablation. Methods Three hundred and thirty patients diagnosed with paroxysmal AF were analyzed. Patients were categorized into quartiles on the basis of their pre-operative SUA measurement and follow-up, and Kaplan-Meier estimation with a Log-rank test was used for the analysis of the influence of SUA on the recurrence of AF. Pre-procedural clinical variables were correlated with the clinical outcome after ablation using multivariate Logistic analysis. A Cox proportional hazards model was used to estimate the relationship between SUA and the recurrence of AF. Results After a mean follow-up of （9.341＋3.667）（range 3.0-16.3） months, recurrence rates from the lowest SUA quartile to the highest SUA quartile were 16.0%, 26.4%, 28.3%, and 29.3% respectively （P=0.014）. After adjustment for gender, body mass index （BMI）, hypertension, serum levels of high sensitivity C-reactive protein （hsCRP）, triglyceride （TG）, left atrial diameter （LA）, estimated glomerular filtration rate （eGFR）, and SUA, there was an increased risk of recurrence in subjects in the highest SUA quartile compared with those in the lowest quartile （hazard ratio 2.804, 95% confidence interval 1.466-5.362, P=0.002）. Following multivariate Logistical analysis, SUA was found to be an independent predictor of recurrence （hazard ratio 1.613, 95% confidence interval 1.601-1.625, P=0.014）. Conclusion In a retrospective study of patients with paroxysmal AF undergoing catheter ablation, elevated preoperative SUA levels were associated with a hiaher rate of recurrence of AF.

关键词： atrial fibrillation catheter ablation recurrence uric acid

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