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A multifunctional nanoaggregate-based system for detection of rheumatoid arthritis via Optoacoustic/NIR-Ⅱ fluorescent imaging and therapy via inhibiting JAK-STAT/NF-κB/NLRP3 pathways

Aggregate

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Aggregate 2024年第1期5卷 353-366页

作者： Junjie Chen Longqi Chen Zunpan She Fang Zeng Shuizhu Wu Biomedical Division State Key Laboratory of Luminescent Materials and DevicesGuangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesCollege of Materials Science and EngineeringSouth China University of TechnologyGuangzhouChina

Rheumatoid arthritis(RA)is a debilitating autoimmune disease that causes chronic pain and serious complications,presenting a significant challenge to *** approaches for treating RA involve signaling pathways modulation and targeted *** this end,a multifunctional nanosystem,TPC-U@HAT,has been designed for RA therapy,featuring multitargeting,dual-stimuli response,and on-demand drug release ***-U@HAT is composed of a probe/prodrug TPC,a JAK1 kinase inhibitor upadacitinib,and the drug carrier *** is composed of an aggregation-induced emission(AIE)-active NIR-II chromophore TPY and an NF-κB/NLRP3 inhibitor caffeic acid phenethyl ester(CAPE),connected via boronic ester bond which serves as the reactive-oxygen-species-responsive *** carrier,HAT,is created by grafting bone-targeting alendronate and hydrophobic tocopheryl succinate onto hyaluronic acid chains,which can encapsulate TPC and upadacitinib to form TPC-U@*** intravenous injection into mice,TPC-U@HAT accumulates at inflamed lesions of RA through both active and passive targeting,and the overexpressed hyaluronidase and H_(2)O_(2) therein cleave the hyaluronic acid polymer chains and boronate bonds,*** generates an AIE-active chromophore for detection and therapeutic evaluation of RA via both optoacoustic imaging and NIR-II fluorescent imaging and concomitantly releases CAPE and upadacitinib to exert efficacious therapy by inhibiting NF-κB/NLRP3 and JAK-STAT pathways.

关键词： aggregation-induced emission dual-stimuli response multispectral optoacoustic tomography imaging multitargeting NIR-II fluorescence imaging rheumatoid arthritis

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Two-color emissive AIEgens with anti-Kasha property for dual-organelle imaging and phototherapy

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Science China Chemistry 2024年第5期67卷 1740-1752页

作者： Pu Chen Guogang Shan Qingli Nie Yuting Yan Pengfei Zhang Zujin Zhao Hai-Tao Feng Ben Zhong Tang AIE Research center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Institute of Functional Material Chemistry and National&Local United Engineering Lab for Power Battery Faculty of ChemistryNortheast Normal UniversityChangchun 130024China College of Chemistry&Materials Science Northwest UniversityXi’an 710127China Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-induced emission luminogens(AIEgens)with donor-π-acceptor structures were designed and synthesized, namely QT-1 and QF-2. Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha's rule, and could stain lipid droplets(LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species(ROS) generation efficiency of QT-1, it was chosen as a photodynamic therapy agent to selectively kill cancer cells from normal cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential(MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo. This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dualorganelle targeting-based phototheranostics.

关键词： aggregation-induced emission anti-Kasha luminescence fluorescent probe bioimaging photodynamic therapy

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Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy

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Nano Research 2024年第5期17卷 4314-4328页

作者： Hongmei Liu Jiming Xu Mengjie Ye Hengbo Zhang Linlin Han Jingting Wang Peng Xue Yuejun Kang Zhigang Xu Key Laboratory of luminescence Analysis and molecular Sensing Ministry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China Yibin Academy of Southwest University Yibin 644000China

Photothermal therapy(PTT)may lead to healthy tissue damage,tumor metastasis,and recurrence,which makes mild photothermal therapy(mild PTT)stand ***,overcoming heat resistance,insufficient therapeutic effect,and poor photothermal conversion efficiency has become new ***,we report a dynamic supramolecular nanocarrier formed from amide-sericin and aldehyde-polyhydroxy glucan(denoted as SDA),the loose cavity of which can be filled by using the pharmaceutical combination of lonidamine(LND)and NIR-II photothermal agent of IR-1061,producing SDLI with a tighter inner hole,smaller and uniform particle size and excellent stability due to multiple pulling ***,the intricate internal network structure prevents the hydrophobic IR-1061 from forming aggregates in the small cavity,and the photothermal conversion efficiency(PCE)can reach 48.9%.At the acidic tumor microenvironment of pH 6.5,the controlled release of LND can solve the problem of heat resistance of NIR-II mild PTT and significantly improve the therapeutic effect of NIR-II mild ***,SDLI also shows a reasonable tumor inhibition rate,so the synergistic strategy of inhibiting tumor energy metabolism and NIR-II mild PTT to magnify mitochondrial oxidative stress,continuous cell stress state-induced immunogenic cell death to promote the induction of tumor apoptosis is proposed to achieve more effective cancer treatment.

关键词： self-shrinkage dynamic supramolecular nanoparticles tumor energy metabolism NIR-II mild photothermal therapy mitochondrial oxidative stress

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New sustainable polymers with on-demand depolymerization property

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Science China Chemistry 2024年第9期67卷 2803-2841页

作者： Yangyang Sun Zesheng An Yanshan Gao Rongrong Hu Ye Liu Hua Lu Xiao-Bing Lu Xuan Pang Anjun Qin Yong Shen Youhua Tao Yu-Zhong Wang Junpeng Wang Gang Wu Guang-Peng Wu Tie-Qi Xu Xing-Hong Zhang Yuetao Zhang Zhenbiao Zhang Jian-Bo Zhu Miao Hong Zhibo Li State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates South China University of Technology State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Dalian University of Technology Beijing National Laboratory for molecular Sciences Center for Soft Matter Science and Engineering Key Laboratory of Polymer Chemistry and Physics of Ministry of Education College of Chemistry and Molecular Engineering Peking University Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences State Key Laboratory Base of Eco-Chemical Engineering College of Chemical Engineering Qingdao University of Science and Technology The Collaborative Innovation center for Eco-Friendly and Fire-Safety Polymeric Materials (Mo 5 National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan) College of Chemistry State Key Laboratory of Polymer Materials Engineering Sichuan University School of Polymer Science and Polymer Engineering the University of Akron MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis College of ChemistryChemical Engineering and Materials Science Soochow University

To combat the crisis of today's synthetic polymers arising from unsustainable production and disposal, it is essential for the synthetic polymer community to reshape the current polymer industry with sustainable polymers. As an emerging class of sustainable polymers, the development of chemically depolymerizable polymers(CDPs), which can undergo closed-loop depolymerization/repolymerization cycles to reproduce virgin polymers without the loss of properties from recovered monomers, offers an ideal solution to preserve finite natural resources, provides a feasible solution to the end-of-life issue of polymer waste, and thereby establishes a circular materials economy. However, two grand key challenges have been encountered in the establishment of practically useful CDPs: how to balance polymerization and depolymerization ability and how to unify conflicted depolymerizability and physical properties. Accordingly, this critical review article presents our vision for summarizing feasible strategies to overcome the above two significant challenges and the design principles for constructing an ideal CDP by highlighting selected major progress made in this rapidly expanding field.

关键词： chemically depolymerizable polymers sustainable polymers depolymerization monomer recovery degradation plastics

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ASBase:The universal database for aggregate science

聚集体(英文)

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聚集体(英文) 2023年第1期4卷 148-157页

作者： Junyi Gong Wanjun Gong BoWu Haoran Wang Wei He Zhongyang Dai Yangzhong Li Yong Liu Zhiming Wang Xiaojun Tuo Jacky W.Y.Lam Zijie Qiu Zheng Zhao Ben Zhong Tang Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhenGuangdongChina AIE-Institute State Key Laboratory of Luminescence Materials and DevicesCenter of Aggregation-induced EmissionKey Laboratory of Luminescence from Molecular Aggregates of Guangdong ProvinceSouth China University of Technology(SCUT)GuangzhouChina High Performance Computing Department National Supercomputing Center in ShenzhenShenzhenChina Department of Chemistry Hong Kong University of Science and TechnologyKowloonHong KongChina

This paper reports the first universal and versatile database on aggregate materials for the field of aggregate science *** the current stage,the database(http://119.***.135.188:8080/)contains over 1000 entries of organic aggregate material systems(mainly luminescent systems at the current stage)with a unique data structure which is designed particularly for aggregate materials and containing the photophysics and physicochemical properties of the compounds in different statuses of aggregation,including dilute solution form,pristine solid-state,stable crystalline,and nanoaggregates formed in *** web-based interface of the database provided functions to index,search,manipulate,fetch and deposit data *** addition,a background calculation service optimizes the chemical structure of new entries on different levels of *** database also provided background API for interactive developments of prediction or regression models based on machine-learning algorithms.

关键词： aggregate science aggregation-induced emission data-driven model database

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Visualization of supramolecular assembly by aggregation-induced emission

聚集体(英文)

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聚集体(英文) 2023年第2期4卷 102-122页

作者： Wu-Jie Guo Tuokai Peng Wenping Zhu Shixiang Ma Guang Wang Ying Li Bin Liu Hui-Qing Peng Beijing Advanced Innovation center for Soft Matter Science and Engineering State Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijingChina Innovation Research center for AIE Pharmaceutical Biology Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical PharmacologyThe NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and The Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of luminescence from molecular aggregates South China University of TechnologyGuangzhouChina

Supramolecular architectures are constructed by the self-assembly of small building blocks via the use of metal-ligand coordination,π–πstacking interactions,hydrogen bonding,host-guest interactions,and other noncovalent driving forces,which confer unique dynamic reversibility and stimulus responsiveness to the supramolecular materials and also lead to the demand of expensive and complex equipment for the characterization of supramolecular assembly ***,the self-assembly processes bring the monomeric chromophores together,offering possibilities to establish ties between the supramolecular assembly and aggregation-induced emission(AIE)*** to conventional luminescent molecules,AIE luminogens(AIEgens)exhibit significant fluorescence enhancement upon the restriction of molecular motions,thus displaying the advantages of signal amplification and low background *** the above,the real-time,sensitive,and in situ visualization of the formation of self-assemblies and their stimuli responsiveness based on AIE becomes ***,we review recent works that encompass the visualization of supramolecular assembly-related behaviors by means of AIE characteristics of *** organization of this review will be by different types of supramolecular architectures,including metallacycles/cages,micelles/vesicles,supramolecular polymers,and supramolecular *** overview of future opportunities and challenges for the real-time monitoring of supramolecular assembly by AIE is also provided.

关键词： aggregation-induced emission metallacycles/cages micelles/vesicles supramolecular gels supramolecular polymers visualization

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Highly specific characterization and discrimination of monosodium urate crystals in gouty arthritis based on aggregation-induced emission luminogens

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Bio-Design and Manufacturing 2023年第6期6卷 704-717页

作者： Wenjuan Wang Guiquan Zhang Ziyi Chen Hanlin Xu Bohan Zhang Rong Hu Anjun Qin Yinghui Hua Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhou 510640China center for Aggregation-Induced Emission AlE InstituteSouth China University of TechnologyGuangzhou 510640China School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China State Key Laboratory of Surface Physics Department of PhysicsFudan UniversityShanghai 200433China

Existing technologies used to detect monosodium urate(MSU)crystals for gout diagnosis are not ideal due to their low sensitivity and complexity of *** purpose of this study was to explore whether aggregation-induced emission luminogens(AIEgens)can be used for highly specific imaging of MSU crystals to assist in the diagnosis of ***,we developed a series of luminogens(i.e.,tetraphenyl ethylene(TPE)-NH_(2),TPE-2NH_(2),TPE-4NH_(2),TPE-COOH,TPE-2COOH,TPE-4COOH,and TPE-Ketoalkyne),each of which was then evenly mixed with MSU ***,optimal fluorescence imaging of each of the luminogens was characterized by a confocal laser scanning microscope(CLSM).This approach was used for imaging standard samples of MSU,hydroxyapatite(HAP)crystals,and mixed samples with 1:1 mass ratio of MSU/*** also imaged samples from mouse models of acute gouty arthritis,HAP deposition disease,and comorbidities of ***,CLSM imaging results were compared with those of compensated polarized light microscopy,and we assessed the biosafety of TPE-Ketoalkyne in the RAW264.7 cell ***,CLSM time series and three-dimensional imaging were performed on MSU crystal samples from human gouty synovial fluid and *** a promising candidate for MSU crystal labeling,TPE-Ketoalkyne was found to detect MSU crystals accurately and rapidly in standard samples,animal samples,and human samples,and could precisely distinguish gout from HAP deposition *** work demonstrates that TPE-Ketoalkyne is suitable for highly specific and timely imaging of MSU crystals in gouty arthritis and may facilitate future research on MSU crystal-related diseases.

关键词： Gout Monosodium urate Hydroxyapatite TPE-Ketoalkyne Aggregation-induced emission Confocal laser scanning microscope imaging

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Functional Hyperbranched Polythioamides Synthesized from Catalyst-free Multicomponent Polymerization of Elemental Sulfur

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Chinese Journal of Chemistry 2022年第6期40卷 725-733页

作者： Shangrun Liu Fengting Li Wenxia Cao Rongrong Hu Ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhouGuangdong 510640China Shenzhen Institute of molecular Aggregate Science and Engineering School of Science and EngineeringThe Chinese University of Hong KongShenzhen CityGuangdong 518172China AIE Institute GuangzhouGuangdong 510530China Hong Kong Branch of Chinese National Engineering Research center for Tissue Restoration and Reconstruction The Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina

Hyperbranched polymers with unique topological structures,large number of branching sites and terminal groups have attracted much attention,and are expected to possess advanced functionalities compared with their linear polymer *** devel-opment of hyperbranched polymers is hence highly desired but challenging,especially for sulfur-containing polymers which are at-tractive metal absorbents,optical materials,dielectric materials,and self-healing *** this work,six hyperbranched polythi-oamides with various topological structures,well-defined repeating units,satisfying yields(up to 99%),and high molecular weights(up to 101400 g/mol)were successfully designed and synthesized from the catalyst-free multicomponent polymerization of ele-mental sulfur,aromatic alkynes and aliphatic amines,through different monomer combination strategies based on the designed three-or four-functional alkyne and amine *** hyperbranched polythioamides possess unique luminescence property,and strong affinity toward Hg^(2+),which can be utilized in the fluorescence detection of Hg^(2+),as well as mercury removal from aque-ous solutions with high efficiency of 99.99%and low mercury residue of 0.1 *** polythioamides with unique struc-tures may be developed to a group of fascinating materials and find their potential applications as metal absorbents and optoelec-tronic materials.

关键词： Hyperbranched polymer Polythioamide Polymerization Sulfur Mercury

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Responsive hyperbranched poly(formyl-1,2,3-triazole)s toward quadruple-modal information security protection

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Science China Chemistry 2022年第4期65卷 771-777页

作者： Baixue Li Zhen Li Kai You Anjun Qin Ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesCenter for Aggregation Induced EmissionSouth China University of TechnologyGuangzhou 510640China Shenzhen Institute of molecular Aggregate Science and Engineering School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China Hong Kong Branch of Chinese National Engineering Research center for Tissue Restoration and Reconstruction The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China Foshan Nanhai Guangdong Technology University CNC Equipment Cooperative Innovation Institute Foshan 528225China

Secrecy has received tremendous attention in modern information society. Innovative polymer-based fluorescent materials with multiple mode emission are quite desirable to achieve multistage data security. Herein, a series of soluble and thermally stable hyperbranched poly(formyl-1,2,3-triazole)s(hb-PFTAs) with high molecular weights were facilely prepared by catalyst-free polycycloaddition of aldehyde-activated internal triyne and diazides. Functional moieties of triphenylamine and binaphthyl could be incorporated into the polymers to offer them with unique fluorescence and circular dichroism properties, *** taking advantage of activated ethynyl and aldehyde groups on their peripheries and in the internal branch chains, the hbPFTAs can undergo efficient single-and double-stage post-functionalization. More importantly, based on the remarkable fluorescence responses to hydrazine and hydrochloric acid, the hyperbranched polymers are featured with triple-mode fluorescent patterns and have been applied in quadruple-modal information encryption and storage with enhanced security and density. Collectively, this work not only enriches the structural diversity of the existing triazole-based material library, but also provides new polymeric materials for data and information security application.

关键词： activated internal triyne hyperbranched poly(formyl-1,2,3-triazole)s post-polymerization modification multilevel information security

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Activated Internal Alkyne-Based Polymerization

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Chinese Journal of Chemistry 2022年第16期40卷 2001-2013页

作者： Baixue Li Jia Wang Benzhao He Anjun Qin Ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesCenter for Aggregation Induced EmissionAIE InstituteSouth China University of TechnologyGuangzhouGuangdong510640 China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdong518172 China Hong Kong Branch of Chinese National Engineering Research center for Tissue Restoration and Reconstruction The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina center for Advanced Materials Research Advanced Institute of Natural SciencesBejing Normal University at ZhuhaiZhuhaiGuangdong 519085China

As an emerging and efficient polymerization methodology,activated internal alkyne-based polymerization has been considered as a powerful tool for the construction of polymers with diverse architectures and versatile *** review focuses on the recent progresses in the polymerization using mono-activated,di-activated,in-situ generated,ring-strained ethynyl groups as substrates,coupling with post-modification on premade polymers containing activated internal ethynyl *** examples are used to illustrate the fundamental design strategy,the development of polymerization and post-functionalization,along with the properties and potential applications of the prepared ***,the challenges and perspectives in terms of new-type active alkynes,green polymerization methodology,tailored regio-/stereoselectivity modulation,and potentially expanded application in this area are also discussed.

关键词： Alkynes Polymerization Polymers Post-functionalization Property and application

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