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Leveraging proficiency and preference for online Karaoke recommendation

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Frontiers of Computer Science 2020年第2期14卷 273-290页

作者： Ming HE Hao GUO Guangyi LV Le WU Yong GE Enhong CHEN Haiping MA Anhui Province Key Laboratory of Big Data Analysis and Application University of Science and Technology of ChinaHefei 230027China School of Computer and Information Hefei University of TechnologyHefei 230026China Eller College of Management The University of ArizonaArizona 85721-0108USA iFlyTek Research Hefei 230026China

Recently,many online Karaoke(KTV)platforms have been released,where music lovers sing songs on these *** the meantime,the system automatically evaluates user proficiency according to their singing *** approximate songs to users can initialize singers5 participation and improve users,loyalty to these ***,this is not an easy task due to the unique characteristics of these ***,since users may be not achieving high scores evaluated by the system on their favorite songs,how to balance user preferences with user proficiency on singing for song recommendation is still ***,the sparsity of the user-song interaction behavior may greatly impact the recommendation *** solve the above two challenges,in this paper,we propose an informationfused song recommendation model by considering the unique characteristics of the singing ***,we first devise a pseudo-rating matrix by combing users’singing behavior and the system evaluations,thus users'preferences and proficiency are *** we mitigate the data sparsity problem by fusing users*and songs'rich information in the matrix factorization process of the pseudo-rating ***,extensive experimental results on a real-world dataset show the effectiveness of our proposed model.

关键词： KTV matrix factorization recommendation system

Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model

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Acta Pharmaceutica Sinica B 2020年第1期10卷 123-135页

作者： Xiaoyu Fan Xinxin Ding Qing-Yu Zhang Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA Wadsworth Center New York State Department of HealthSchool of Public HealthUniversity at AlbanyAlbanyNY 12201USA

We examined the impact of gut inflammation on the expression of cytochrome P450(P450)and other biotransformation genes in male mice using a dextran sulfate sodium(DSS)-induced colitis *** P450 isoforms,including CYPIA,CYP2B,CYP2C,and CYP3A,were downregulated,accompanied by decreases in microsomal metabolism of diclofenac and nifedipine,in the liver and small *** impact of the colitis on in vivo clearance of oral drugs varied for four different drugs tested:a small decrease for nifedipine,a relatively large decrease for lovastatin,but no change for pravastatin,and a large decrease in the absorption of cyclosporine *** further assess the scope of influence of gut inflammation on gene expression,we performed genome-wide expression analysis using RNA-seq,which showed down-regulation of many CYPs,non-CYP phase-Ⅰenzymes,phase-Ⅱenzymes and transporters,and up-regulation of many other members of these gene families,in both liver and intestine of adult C57BL/6 mice,by DSS-induced ***,our results indicate that gut inflammation suppresses the expression of many P450s and other biotransformation genes in the intestine and liver,and alters the pharmacokinetics for some but not all drugs,potentially affecting therapeutic efficacy or causing adverse effects in a drug-specific fashion.

关键词： Cytochrome P450 CYP Colitis Intestine Inflammatory bowel disease Drug metabolism Pharmacokinetics Gene expression

Sodium and water perturbations in patients who had an acute stroke:clinical relevance and management strategies for the neurologist

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Stroke & Vascular Neurology 2022年第3期7卷 258-266页

作者： Kevin C J Yuen Valerie Sharf Elizabeth Smith Minhwan Kim Alissya S M Yuen Paul R MacDonald Departments of Neuroendocrinology and Neurosurgery Barrow Neurological InstitutePhoenixArizonaUSA university of arizona College of Medicine and Creighton School of Medicine PhoenixArizonaUSA Department of Neurology Barrow Neurological InstitutePhoenixArizonaUSA Midwestern university GlendaleIllinoisUSA Creighton university School of Medicine PhoenixArizonaUSA university of California Davis DavisCaliforniaUSA

Sodium and water perturbations,manifesting as hyponatraemia and hypernatraemia,are common in patients who had an acute stroke,and are associated with worse outcomes and increased *** non-stroke related causes of sodium and water perturbations in these patients include underlying comorbidities and concomitant ***,hospitalised patients who had an acute stroke may receive excessive intravenous hypotonic solutions,have poor fluid intake due to impaired neurocognition and consciousness,may develop sepsis or are administered drugs(eg,mannitol);factors that can further alter serum sodium *** and water perturbations can also be exacerbated by the development of endocrine consequences after an acute stroke,including secondary adrenal insufficiency,syndrome of inappropriate antidiuretic hormone secretion and diabetes ***,COVID-19 infection has been reported to increase the risk of development of sodium and water perturbations that may further worsen the outcomes of patients who had an acute *** there are currently no accepted consensus guidelines on the management of sodium and water perturbations in patients who had an acute stroke,we conducted a systematic review of the literature published in English and in peer-reviewed journals between January 2000 and December 2020,according to PRISMA guidelines,to assess on the current knowledge and clinical practices of this *** this review,we discuss the signs and symptoms of hyponatraemia and hypernatraemia,the pathogenesis of hyponatraemia and hypernatraemia,their clinical relevance,and we provide our recommendations for effective treatment strategies for the neurologist in the management of sodium and water perturbations in commonly encountered aetiologies of patients who had an acute stroke.

关键词： patients impaired consequences

The Subtelomere of Oryza sativa Chromosome 3 Short Arm as a Hot Bed of New Gene Origination in Rice

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Molecular Plant 2008年第5期1卷 839-850页

作者： Chuanzhu Fana Yong Zhang Yeisoo Yu Steve Rounsley Manyuan Long Rod A. Wing arizona Genomics Institute Department of Plant Sciences University of Arizona Tucson AZ 85721 USA Department of Ecology and Evolution University of Chicago Chicago IL 60637 USA BIO5 Institute for Collaborative Research University of Arizona Tucson AZ 85721 USA

Despite general observations of non-random genomic distribution of new genes, it is unclear whether or not new genes preferentially occur in certain genomic regions driven by related molecular mechanisms. Using 1.5 Mb of genomic sequences from short arms of chromosome 3 of Oryza glaberrima and O. punctata, we conducted a comparative genomic analysis with the reference O. sativa ssp. japonica genome. We identified a 60-kb segment located in the middle of the subtelomeric region of chromosome 3, which is unique to the species O. sativa. The region contained gene duplicates that occurred in Asian cultivated rice species that diverged from the ancestor of Asian and African cultivated rice one million years ago （MYA）. For the 12 genes and one complete retrotransposon identified in this segment in O. sativa ssp. japonica, we searched for their parental genes. The high similarity between duplicated paralogs further supports the recent origination of these genes. We found that this segment was recently generated through multiple independent gene recombination and transposon insertion events. Among the 12 genes, we found that five had chimeric gene structures derived from multiple parental genes. Nine out of the 12 new genes seem to be functional, as suggested by Ka/Ks analysis and the presence of cDNA and/or MPSS data. Furthermore, for the eight transcribed genes, at least two genes could be classified as defense or stress response-related genes. Given these findings, and the fact that subtelomeres are associated with high rates of recombination and transcription, it is likely that subtelomeres may facilitate gene recombination and transposon insertions and serve as hot spots for new gene origination in rice genomes.

关键词： comparative genomics gene duplication Oryza sativa subtelomere new genes.

Dark mode plasmonic optical microcavity biochemical sensor

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Photonics Research 2019年第8期7卷 939-947页

作者： CHENG LI LEI CHEN EUAN MCLEOD JUDITH SU College of Optical Sciences University of ArizonaTucsonArizona85721USA State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing100876China Department of Biomedical Engineering University of ArizonaTucsonArizona85721USA

Whispering gallery mode(WGM) microtoroid optical resonators have been effectively used to sense low concentrations of biomolecules down to the single molecule limit. Optical WGM biochemical sensors such as the microtoroid operate by tracking changes in resonant frequency as particles enter the evanescent near field of the ***, gold nanoparticles have been coupled to WGM resonators to increase the magnitude of resonance shifts via plasmonic enhancement of the electric field. However, this approach results in increased scattering from the WGM, which degrades its quality(Q) factor, making it less sensitive to extremely small frequency shifts caused by small molecules or protein conformational changes. Here, we show using simulation that precisely positioned trimer gold nanostructures generate dark modes that suppress radiation loss and can achieve high (> 10~6) Q with an electric-field intensity enhancement of 4300, which far exceeds that of a single rod(~2500 times). Through an overall evaluation of a combined enhancement factor, which includes the Q factor of the system, the sensitivity of the trimer system was improved 105× versus 84× for a single rod. Further simulations demonstrate that unlike a single rod system, the trimer is robust to orientation changes and has increased capture area. We also conduct stability tests to show that small positioning errors do not greatly impact the result.

关键词： WGM Dark mode plasmonic microcavity

Simulating robust far-field coupling to traveling waves in large three-dimensional nanostructured high-Q microresonators

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Photonics Research 2019年第9期7卷 967-976页

作者： LEI CHEN CHENG LI YU-MIN LIU JUDITH SU EUAN MCLEOD State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing100876China College of Optical Sciences University of ArizonaTucsonArizona85721USA Department of Biomedical Engineering University of ArizonaTucsonArizona85721USA

Ultra-high quality(Q) whispering gallery mode(WGM) microtoroid optical resonators have demonstrated highly sensitive biomolecular detection down to the single molecule limit;however, the lack of a robust coupling method has prevented their widespread adoption outside the laboratory. We demonstrate through simulation that a phased array of nanorods can enable free-space coupling of light both into and out of a microtoroid while maintaining a high Q. To simulate large nanostructured WGM resonators, we developed a new approach known as FloWBEM,which is an efficient and compact 3D wedge model with custom boundary conditions that accurately simulate the resonant Fano interference between the traveling WGM waves and a nanorod array. Depending on the excitation conditions, we find loaded Q factors of the driven system as high as 2.1 × 10~7 and signal-to-background ratios as high as 3.86%, greater than the noise levels of many commercial detectors. These results can drive future experimental implementation.

关键词： domain Simulating robust far-field coupling to traveling waves in large three-dimensional nanostructured high-Q microresonators WGM

Internal States Influence the Representation and Modulation of Food Intake by Subthalamic Neurons

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Neuroscience Bulletin 2020年第11期36卷 1355-1368页

作者： Haichuan Wu Xiang Yan Dongliang Tang Weixin Gi Yiwen Luan Haijiang Cai Chunyi Zhou Cheng Xiao School of Anesthesiology Xuzhou Medical UniversityXuzhou 221004China Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical UniversityXuzhou 221004China Department of Neuroscience University of ArizonaTucsonAZ 85721USA

Deep brain stimulation of the subthalamic nucleus(STN)is an effective therapy for motor deficits in Parkinson’s disease(PD),but commonly causes weight gain in late-phase PD patients probably by increasing feeding *** is unclear how STN neurons represent and modulate feeding behavior in different internal *** the present study,we found that feeding caused a robust activation of STN neurons in mice(GCaMP6 signal increased by 48.4%±7.2%,n=9,P=0.0003),and the extent varied with the size,valence,and palatability of food,but not with the repetition of ***,energy deprivation increased the spontaneous firing rate(8.5±1.5 Hz,n=17,versus 4.7±0.7 Hz,n=18,P=0.03)and the depolarization-induced spikes in STN neurons,as well as enhanced the STN responses to *** experiments revealed that stimulation and inhibition of STN neurons respectively reduced(by 11%±6%,n=6,P=0.02)and enhanced(by 36%±15%,n=7,P=0.03)food intake only in the dark *** conclusion,our results support the hypothesis that STN neurons are activated by feeding behavior,depending on energy homeostatic status and the palatability of food,and modulation of these neurons is sufficient to regulate food intake.

关键词： Subthalamic nucleus Food intake Fiber photometry Optogenetics

A modified method of discontinuity trace mapping using three-dimensional point clouds of rock mass surfaces

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第3期12卷 571-586页

作者： Keshen Zhang Wei Wu Hehua Zhu Lianyang Zhang Xiaojun Li Hong Zhang Department of Geotechnical Engineering Tongji UniversityShanghai200092China Department of Civil Engineering and Engineering Mechanics University of ArizonaTucsonAZ85721USA Department of Hydraulic Engineering Tongji UniversityShanghai200092China

This paper presents an automated method for discontinuity trace mapping using three-dimensional point clouds of rock mass ***,the method consists of five steps:(1)detection of trace feature points by normal tensor voting theory,(2)co ntraction of trace feature points,(3)connection of trace feature points,(4)linearization of trace segments,and(5)connection of trace segments.A sensitivity analysis was then conducted to identify the optimal parameters of the proposed *** field cases,a natural rock mass outcrop and two excavated rock tunnel surfaces,were analyzed using the proposed method to evaluate its validity and *** results show that the proposed method is more efficient and accurate than the traditional trace mapping method,and the efficiency enhancement is more robust as the number of feature points increases.

关键词： Rock mass Discontinuity Three-dimensional point clouds Trace mapping

Wireless,battery-free,and fully implantable electrical neurostimulation in freely moving rodents

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Microsystems & Nanoengineering 2021年第4期7卷 127-138页

作者： Alex Burton Sang Min Won Arian Kolahi Sohrabi Tucker Stuart Amir Amirhossein Jong Uk Kim Yoonseok Park Andrew Gabros John A.Rogers Flavia Vitale Andrew G.Richardson Philipp Gutruf Department of Biomedical Engineering University of ArizonaTucsonAZ 85721USA Department of Electrical and Computer Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Neurosurgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Center for Bio-Integrated Electronics Northwestern UniversityEvanstonIL 60208USA Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA Department of Neurological Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Department of Neurology BioengineeringPhysical Medicine&RehabilitationCenter for Neuroengineering and TherapeuticsUniversity of PennsylvaniaPhiladelphiaPA 19104USA Bio5 Institute and Neuroscience GIPP University of ArizonaTucsonAZ 85721USA Department of Electrical and Computer Engineering University of ArizonaTucsonAZ 85721USA

Implantable deep brain stimulation(DBS)systems are utilized for clinical treatment of diseases such as Parkinson's disease and chronic ***,long-term efficacy of DBS is limited,and chronic neuroplastic changes and associated therapeutic mechanisms are not well *** and mechanistic investigation,typically accomplished in small animal models,is difficult because of the need for chronic stimulators that currently require either frequent handling of test subjects to charge battery-powered systems or specialized setups to manage tethers that restrict experimental paradigms and compromise *** overcome these challenges,we demonstrate a fully implantable,wireless,battery-free platform that allows for chronic DBS in rodents with the capability to control stimulation parameters digitally in real *** devices are able to provide stimulation over a wide range of frequencies with biphasic pulses and constant voltage control via low-impedance,surface-engineered platinum *** devices utilize off-the-shelf components and feature the ability to customize electrodes to enable broad utility and rapid *** of the system is demonstrated with a readout of stimulation-evoked neural activity in vivo and chronic stimulation of the medial forebrain bundle in freely moving rats to evoke characteristic head motion for over 36 days.

关键词： stimulation battery moving