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Dysfunctions of the Iga system:a common link between intestinal and renal diseases

Cellular & Molecular Immunology 2011年第2期8卷 126-134页

作者： Christina Papista Laureline Berthelot Renato C Monteiro nserm U699 Paris 75018France Universite´Paris Diderot Paris 75018France

Immunoglobulin A(Iga)-isotype antibodies play an important role in immunity owing to their structure,glycosylation,localization and receptor *** in this system can lead to multiple types of *** review describes the characteristics of Iga and discusses the involvement of abnormalities in the Iga system on the development of celiac disease and Iga nephropathy.

关键词： celiac disease Iga nephropathy immunoglobulin A receptors

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STUDY ON BclI/St14 RFLPs IN CHINESE FOR DNA DIAGNOSIS FOR HEMOPHILIA A

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Science China Chemistry 1990年第4期33卷 430-434页

作者：沈岩吴冠芸王申五刘敬忠冯继宁刘毅孙念怙王风云吴玉珍宁阳龙桂芳李琪梁荣金琪苏承武林伟雄 M.GOOSSENS Institute of Basic Medical Sciences CAMS Beijing 100730 PRC PUMC Hospital Beijing 100730 PRC Guangxi Medical College Hospital Nanning 530072 PRC nserm U-91 France

The BclI polymorphism within DXS52 (St14) was reported. It was composed of 4 allelic fragments 4.0 kb, 3.3 kb, 3.0 kb and 2.3 kb, The frequency of these fragments were 0.09, 0.12, 0.44 and 0.35 respectively in the Chinese. The polymorphism provided the PIC of 0.66. DNA analysis of families, with hemophilia A showed that the confidence of the RFLPs was the same as the TaqI/St14 RFLPs and for carrier detection the former is much better than that of the TaqI/St14 RFLPs.

关键词： RFLPs DXS52 (St14) hemophilia A.

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Study of infectious conjunctivitis among children in rural areas of Qinghai province

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Science China(Life Sciences) 2016年第6期59卷 548-554页

作者： Qingfeng Liang Xinxin Lu Mei Wang Lei Tian Antoine Labbé Ailian Hu Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100005China Quinze-Vingts National Ophthalmology Hospital Paris and Versailles Saint-Quentin-en-Yvelines UniversityVersailles F-75002 France 31nserm U968UPMC Univ Paris 06UMR_S 968institut de la VisionCNRSUMR_7210Paris F-75012France

Infectious conjunctivitis is no longer a common eye disease in cities and developed areas, but in remote mountainous regions of China where living conditions are relatively under-developed, the occurrence of infectious conjunctivitis remains a public health issue. Here, we evaluate the ratio of infectious conjunctivitis among primary school students in the rural areas of Xunhua, Huangyuan, and Huzhu Counties in the Qinghai province of China, and report the microorganisms involved in causing infection. Of the 765 eligible primary school students, 694 participated to this study(a response rateof 90.7%), 381 boys and 313 girls, with a mean age of 7.52 years(range 7–9 years). A clinical diagnosis of infectious conjunctivitis was returned for 238 of the 694 children examined. The ratio of infectious conjunctivitis in Xunhua County(46.64%) was higher compared to that in Huangyuan(26.67%; P=0.03) and Huzhu Counties(23.61%; P=0.02). The leading cause of conjunctivitis was bacterial, followed by chlamydial and viral. Our results show that there is a high ratio of infectious conjunctivitis among rural primary school students in Qinghai province.

关键词：传染性结膜炎农村小学感染性青海省儿童公共卫生问题小学生高比例

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Effectiveness of a Single High Dose of Platelet-Rich Plasma (PRP) Injection Over Corticosteroid and Hyaluronic Acid Injections on Osteoarthritis, Chronic Tendinitis and Tennis Elbow Treatment

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Open Journal of Regenerative Medicine 2022年第2期11卷 41-53页

作者： Charbel Khalil Diana Chaker Albert Azar Elie El Kayem Rawad Salameh Mohamad Dar-Yahya Fadi Nader Alain Chebly Kamil Samaha Ahmad Ibrahim Reviva Stem Cell Platform for Research and Applications Center Bsalim Lebanon Middle East Institute of Health University Hospital Bsalim Lebanon Bone Marrow Transplant Unit Burjeel Medical City Abu Dhabi UAE Stem Cell Institute Faculty of Medical Sciences Lebanese University Beirut Lebanon nserm National Institute of Health and Medical Research Paris XI Paris France Faculty of Medicine Lebanese American University Beirut Lebanon Lebanese University Faculty of Medicine Beirut Lebanon Medical Genetics Unit (UGM) Faculty of Medicine Saint Joseph University Beirut Lebanon Higher Institute of Public Health Saint Joseph University Beirut Lebanon

Background: Corticosteroid, hyaluronic acid (HA) injections and Anti-inflammatory agents are considered as non-invasive treatments for knee osteoarthritis (OA), Chronic Tendinitis (CT) and Tennis elbow (TE) that are supposed to provide symptomatic relief and to help surgical delay intervention. Platelet rich plasma (PRP) is a biological component shown to be beneficial for different orthopedic dysfunctionalities treatment. The presence of GFs in PRPs such as transforming growth factor-β, insulin-like growth factor 1co-stimulate the mesenchymal stem cells and fibroblasts secretions and promotes the fibrin matrix formation which effectively drive the healing process, induces regenerative response and lead to the damage structure repair in orthopedics trauma. Methods: Three groups of a total of 30 patients presenting OA, CT and TE diagnosis, non-responding to corticosteroid, HA and non-steroid anti-inflammatory treatments were randomized to undergo one intra-articular injections of single high dose of PRP. The efficacy of Intra-articular PRP Injections was evaluated before the injection and one month after. The efficiency assessment score was based on [1] Knee injury and Osteoarthritis Outcome Score, [2] Physical Function Short Form (KOOS-PS) Arabic (KSA) version LK 1.0, [3] HOOS-Physical Function Short form (HOOS-PS), and [4] Macdermid patient-rated Tennis Elbow. Results: A significant reduction of pain and a marked improvement in movements was observed in the 3 patient’s groups, PRP-injected patients showed significantly higher values compared with baseline: (p < 0.005 vs baseline), improve functional status and reduce clearly the articular dysfunctions over the time. In our study, single High dose injection of PRP provided an overall superior clinical improvement compared with HA and corticosteroid treatments over the time and the different follow-up checkpoints of the study.

关键词： Platelet Rich Plasma (PRP) Osteoarthritis Chronic Tendinitis Tennis Elbow Corticosteroid Hyaluronic Acid Non-Steroid Anti-Inflammatory

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Antioxidants from Syrah Grapes (Vitis vinifera L.cv. Syrah). Extraction Process through Optimization by Response Surface Methodology

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Food and Nutrition Sciences 2013年第12期4卷 1209-1220页

作者： Youssef El Hajj Espérance Debs Catherine Nguyen Richard G. Maroun Nicolas Louka Department of Biology Faculty of Sciences University of Balamand Tripoli Lebanon. nserm U928 Technological Advances for Genomics and Clinics Laboratory Marseille France Unité Technologies et Valorisation Alimentaire Centre d’Analyses et de Recherche Faculté des Sciences Université Saint-Joseph de Beyrouth Beirut Lebanon Unité Technologies et Valorisation Alimentaire Centre d’Analyses et de Recherche Faculté des Sciences Université Saint-Joseph de Beyrouth Beirut Lebanon Inserm U928 Technological Advances for Genomics and Clinics Laboratory Marseille France

In this work, optimization of phenolic compounds (PC) and monomeric anthocyanins (MA) extraction from Syrah (Sy) wine grapes (Vitis vinifera L. cv. Syrah) using response surface methodology was conducted. The comparisons between two extraction mixtures, Acetone/Water (A/W) as well as Methanol/Water (M/W) and the effects of three critical variables, Extraction Time (between 8 and 88 h), Extraction Temperature (between 1℃ and 35℃) and Solvent Content (between 63% and 97%), on Phenolic Compounds Yield (PCY), Monomeric Anthocyanins Yield (MAY) and the DPPH Free Radical Inhibition Potential (DFRIP) were studied. The highest PCY was obtained in 63% A/W solvent content after 88 h incubation at 35℃. The highest MAY was acquired in 97% M/W solvent content after 8 h incubation at 17℃. The highest DFRIP of the extract was attained using 97% A/W solvent content after 16 h incubation at 35℃. The low cost of this process, on economic and environmental levels, could lead to interesting applications on an industrial scale. It could be used to obtain bioactive phytochemicals from direct material or byproducts for either therapeutic or nutritional purposes.

关键词： Phenolic Compounds Monomeric Anthocyanins Antiradical Scavenging Potential Extraction Optimization Grape Time Solvent and Temperature

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