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The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review

Burns & Trauma 2016年第3期4卷 169-179页

作者： Jon Hazeldine Peter Hampson Janet M.Lord nihr surgical reconstruction and microbiology research centre Institute of Inflammation and AgeingBirmingham University Medical SchoolBirmingham B152TTUK nihr surgical reconstruction and microbiology research centre Institute of Inflammation and AgeingBirmingham University Medical SchoolBirmingham B152TTUK Healing Foundation centre for Burns research Queen Elizabeth HospitalBirmingham B152WBUK

As secondary complications remain a significant cause of morbidity and mortality amongst hospitalised trauma patients,the need to develop novel approaches by which to identify patients at risk of adverse outcome is becoming increasingly *** on the idea that patients who experience"poor"outcome post trauma elicit a response to injury that is distinct from those who experience"good"outcome,tailored therapeutics is an emerging concept aimed at improving current treatment regimens by promoting patient-specific *** use of recent advancements in the fields of genomics,proteomics and metabolomics,numerous groups have undertaken a systems-based approach to analysing the acute immune and inflammatory response to major traumatic and thermal injury in an attempt to uncover a single or combination of biomarkers that can identify patients at risk of adverse *** results are encouraging,with all three approaches capable of discriminating patients with"good"outcome from those who develop nosocomial infections,sepsis and multiple organ failure,with differences apparent in blood samples acquired as early as 2 h post *** particular,genomic data is proving to be highly informative,identifying patients at risk of"poor"outcome with a higher degree of sensitivity and specificity than statistical models built upon data obtained from existing anatomical and physiological scoring ***,focussing predominantly upon human-based research,we provide an overview of the findings of studies that have investigated the immune and inflammatory response to major traumatic and thermal injury at the genomic,protein and metabolite level,and consider both the diagnostic and prognostic potential of these approaches.

关键词： Burns Cytokines Genomics Inflammation Mortality Sepsis Trauma

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Patient experience of scar assessment and the use of scar assessment tools during burns rehabilitation:a qualitative study

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Burns & Trauma 2021年第1期9卷 441-453页

作者： Kate Price Naiem Moiemen Laura Nice Jonathan Mathers College of Medical and Dental Sciences University of BirminghamBirminghamUK Scar Free Foundation centre for Conflict Wound research Queen Elizabeth HospitalUniversity Hospitals Birmingham NHS Foundation TrustBirminghamUK nihr surgical reconstruction and microbiology research centre Queen Elizabeth HospitalBirminghamUK Institute of Applied Health research University of BirminghamBirminghamUK

Background:Scar assessment plays a key role during burns aftercare,to monitor scar remodelling and patients’psychosocial *** aid assessment,subjective scar assessment scales are available that use health-care professionals’and patients’opinions to score scar *** subjective scales are more widely used in clinical practice over objective scar *** date,there is no research that considers patients’views on scar assessment and the role of subjective and objective assessment ***,the aim of this qualitative study was to explore patients’perspectives on scar assessment and the utility of scar assessment tools during burns ***:Semi-structured interviews were conducted with 10 adult burn patients who were being reviewed in clinic for *** were recruited via their clinical care team and research nurses at the Queen Elizabeth Hospital,Birmingham,*** covered during interview included patient experience of scar assessment,the use of scar assessment tools and discussion surrounding important factors to be addressed when assessing scars.A thematic analysis using the Framework Method was ***:Participants identified key subthemes that contribute towards the overarching theme of patient-centred scar *** are:patient-led care;continuity in care;learning how to self-manage scarring;and psychological *** were demonstrated between these subthemes and the remaining themes that describe scar assessment strategies,indicating their potential patient-centred *** subjective opinions of clinicians were found to be valued above the use of subjective or objective scar assessment *** assessment scales were perceived to be a beneficial method for self-reflection in relation to psychosocial ***,minimal feedback and review of completed assessment scales led to uncertainty regarding their *** perceived objective tools to be of

关键词： Burns Scarring Scar assessment Scar assessment scales Qualitative research Interviews Objective scar assessment

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Dehydroepiandrosterone:a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient

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Burns & Trauma 2019年第1期7卷 248-260页

作者： Conor Bentley Jon Hazeldine Carolyn Greig Janet Lord Mark Foster nihr surgical reconstruction and microbiology research centre University Hospital BirminghamBirmingham B152WBUK School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirminghamUK MRC-Arthritis research UK centre for Musculoskeletal Ageing research Institute of Inflammation and AgeingBirmingham University Medical SchoolBirmingham B152TTUK nihr Biomedical research centre University Hospital BirminghamBirminghamUK Royal centre for Defence Medicine Birmingham Research ParkBirmingham B152SQUK.

Severe injuries are the major cause of death in those aged under 40,mainly due to road traffic ***,metabolic and immune pathways respond to limit the tissue damage sustained and initiate wound healing,repair and regeneration ***,depending on age and sex,the response to injury and patient prognosis differ *** are catabolic and immunosuppressive and are produced as part of the stress response to injury leading to an intra-adrenal shift in steroid biosynthesis at the expense of the anabolic and immune enhancing steroid hormone dehydroepiandrosterone(DHEA)and its sulphated metabolite dehydroepiandrosterone sulphate(DHEAS).The balance of these steroids after injury appears to influence outcomes in injured humans,with high cortisol:DHEAS ratio associated with increased morbidity and *** models of trauma,sepsis,wound healing,neuroprotection and burns have all shown a reduction in proinflammatory cytokines,improved survival and increased resistance to pathological challenges with DHEA *** supplementation studies,which have focused on post-menopausal females,older adults,or adrenal insufficiency have shown that restoring the cortisol:DHEAS ratio improves wound healing,mood,bone remodelling and psychological ***,there are no DHEA or DHEAS supplementation studies in trauma patients,but we review here the evidence for this potential therapeutic agent in the treatment and rehabilitation of the severely injured patient.

关键词： Dehydroepiandrosterone Dehydroepiandrosterone sulphate Traumatic injury Intensive care Immune Rehabilitation

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Heparin resistance in severe thermal injury:a prospective cohort study

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Burns & Trauma 2021年第1期9卷 157-169页

作者： Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison Scar Free Foundation Birmingham centre for Burns research University Hospitals Birmingham Foundation TrustQueen Elizabeth Hospital BirminghamMindelsohn WayBirminghamB152WBUK Department of Haematology University Hospitals Birmingham Foundation TrustMindelsohnWayBirminghamB152WBUK Institute of Inflammation and Ageing University of BirminghamBirminghamB152TTUK nihr surgical reconstruction and microbiology research centre University Hospitals Birmingham Foundation TrustMindelsohn WayBirminghamB152WBUK

Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for *** studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically *** hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa ***:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and *** anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were *** effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and ***:A total of 30 patients with severe burns were *** TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin *** levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the *** final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of ***:Heparin resistance is a prevalent issue in severe *** levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they ma

关键词： Burn Heparin resistance Low molecular-weight heparin Nucleosomes Neutrophil extracellular traps Factor-Xa Thrombosis Enoxaparin NETosis

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Traumatic injury is associated with reduced deoxyribonuclease activity and dysregulation of the actin scavenging system

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Burns & Trauma 2021年第1期9卷 558-572页

作者： Jon Hazeldine Robert J.Dinsdale David N.Naumann Animesh Acharjee Jonathan R.B.Bishop Janet M.Lord Paul Harrison Institute of Inflammation and Ageing University of BirminghamEdgbastonBirminghamWest MidlandsB152TTUnited Kingdom National Institute for Health research surgical reconstruction and microbiology research centre Heritage BuildingQueen Elizabeth Hospital BirminghamMindelsohnWayEdgbastonBirminghamWest MidlandsB152THUnited Kingdom Scar Free Foundation Birmingham centre for Burns research University Hospital Birmingham Foundation TrustQueen Elizabeth Hospital BirminghamMindelsohnWayEdgbastonBirminghamWest MidlandsB152THUnited Kingdom Academic Department of Military Surgery and Trauma Royal Centre for Defence MedicineQueen Elizabeth Hospital BirminghamMindelsohnWayEdgbastonBirminghamWest MidlandsB152THUnited Kingdom Institute of Cancer and Genomic Sciences Centre for Computational BiologyUniversity of BirminghamEdgbastonBirminghamWest MidlandsB152TTUnited Kingdom

Background:Traumatic injury is associated with increased concentrations of cell-free DNA(cfDNA)in the circulation,which contribute to post-injury *** endonuclease deoxyribonuclease 1(DNase-1)is responsible for removing 90%of circulating ***,DNase activity was reported to be significantly reduced following major non-traumatic brain injury(TBI),but the processes responsible were not ***,it is not known how quickly following injury DNase activity is reduced and whether this also occurs after ***:At 3 post-injury time points(≤1,4–12 and 48–72 hours),blood samples were obtained from 155 adult trauma patients that had sustained an isolated TBI(n=21),TBI with accompanying extracranial injury(TBI^(+))(n=53)or an extracranial injury only(ECI)(n=81).In addition to measuring cfDNA levels and the activity and expression of DNase,circulating concentrations of monomeric globular action(G-actin),an inhibitor of DNase-1,and the actin scavenging proteins gelsolin(GSN)and vitamin D binding protein(VDBP)were determined and values compared to a cohort of healthy ***:Significantly elevated concentrations of plasma cfDNA were seen in TBI,TBI^(+)and ECI patients at all study time points when compared to healthy *** levels were significantly higher at≤1 hour post-injury in ECI patients who subsequently developed multiple organ dysfunction syndrome when compared to those who did *** DNase-1 protein was significantly elevated in all patient groups at all sampling time *** contrast,DNase enzyme activity was significantly reduced,with this impaired function evident in TBI^(+)patients within minutes of *** concentrations of G-actin were elevated in all patient cohorts in the immediate aftermath of injury and this was accompanied by a significant reduction in the levels of GSN and ***:The post-traumatic increase in circulating cfDNA that occurs following extracranial trauma and TBI

关键词： Cell-free DNA Deoxyribonuclease Extracellular actin scavenging system Pre-hospital Trauma

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Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis

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Cellular & Molecular Immunology 2024年第1期21卷 33-46页

作者： Anja Meyer Stephanie R.Zack Wes Nijim Adel Burgos Vishwa Patel Brian Zanotti Michael V.Volin M.Asif Amin Myles J.Lewis Costantino Pitzalis Shiva Arami Joseph A.Karam Nadera J.Sweiss Shiva Shahrara Jesse Brown VA Medical Center ChicagoILUSA Department of Medicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Department of microbiology and Immunology Midwestern UniversityDowners GroveILUSA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMIUSA centre for Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom centre for Experimental Medicine&Rheumatology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK Department of Biomedical Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly Department of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

A novel rheumatoid arthritis(RA)synovial fluid protein,Syntenin-1,and its receptor,Syndecan-1(SDC-1),are colocalized on RA synovial tissue endothelial cells and fibroblast-like synoviocytes(FLS).Syntenin-1 exacerbates the inflammatory landscape of endothelial cells and RA FLS by upregulating transcription of IRF1/5/7/9,IL-1β,IL-6,and CCL2 through SDC-1 ligation and HIF1α,or mTOR ***,Syntenin-1 orchestrates RA FLS and endothelial cell invasion via SDC-1 and/or mTOR *** Syntenin-1 reprogrammed endothelial cells,the dynamic expression of metabolic intermediates coincides with escalated glycolysis along with unchanged oxidative factors,AMPK,PGC-1α,citrate,and inactive oxidative ***,RA FLS rewired by Syntenin-1 displayed a modest glycolytic-ATP accompanied by a robust mitochondrial-ATP *** enriched mitochondrial-ATP detected in Syntenin-1 reprogrammed RA FLS was coupled with mitochondrial fusion and fission recapitulated by escalated Mitofusin-2 and DRP1 *** found that VEGFR1/2 and Notch1 networks are responsible for the crosstalk between Syntenin-1 rewired endothelial cells and RA FLS,which are also represented in RA *** to RA explants,morphological and transcriptome studies authenticated the importance of VEGFR1/2,Notch1,RAPTOR,and HIF1αpathways in Syntenin-1 arthritic mice and their obstruction in SDC-1 deficient ***,dysregulation of SDC-1,mTOR,and HIF1αnegated Syntenin-1 inflammatory phenotype in RA explants,while inhibition of HIF1αimpaired synovial angiogenic imprint amplified by *** conclusion,since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood,targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.

关键词： Syntenin-1 Syndecan-1 RA FLS RA explants immunometabolism

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Using statistics and mathematical modelling to understand infectious disease outbreaks:COVID-19 as an example

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Infectious Disease Modelling 2020年第1期5卷 409-441页

作者： Christopher E.Overton Helena B.Stage Shazaad Ahmad Jacob Curran-Sebastian Paul Dark Rajenki Das Elizabeth Fearon Timothy Felton Martyn Fyles Nick Gent Ian Hall Thomas House Hugo Lewkowicz Xiaoxi Pang Lorenzo Pellis Robert Sawko Andrew Ustianowski Bindu Vekaria Luke Webb Department of Mathematics University of ManchesterUK IBM research Hartree CentreSciTech DaresburyUK Department of Global Health and Development London School of Hygiene and Tropical MedicineUK Emergency Response Department Public Health EnglandUK Division of Infection Immunity and Respiratory MedicineNIHR Biomedical Research CentreUniversity of ManchesterUK Department of Virology Manchester Medical Microbiology PartnershipManchester Foundation TrustUK Regional Infectious Diseases Unit North Manchester General HospitalUK School of Medical Sciences University of ManchesterUK Intensive Care Unit Wythenshawe HospitalManchester University NHS Foundation TrustUK Department of Health Sciences University of ManchesterUK Department of Mathematical Sciences University of LiverpoolUK The Alan Turing Institute UK Manchester Academic Health Sciences centre UK Critical Care Unit Salford Royal HospitalNorthern Care Alliance NHS GroupUK

During an infectious disease outbreak,biases in the data and complexities of the underlying dynamics pose significant challenges in mathematically modelling the outbreak and designing *** by the ongoing response to COVID-19,we provide a toolkit of statistical and mathematical models beyond the simple SIR-type differential equation models for analysing the early stages of an outbreak and assessing *** particular,we focus on parameter estimation in the presence of known biases in the data,and the effect of non-pharmaceutical interventions in enclosed subpopulations,such as households and care *** illustrate these methods by applying them to the COVID-19 pandemic.

关键词： COVID-19 Epidemic modelling Parameter estimation Outbreak Bias Intervention

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Diagnostic performance of different specimens in detecting enterovirus A71 in children with hand,foot and mouth disease

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Virologica Sinica 2023年第2期38卷 268-275页

作者： Yonghong Zhou Chongchen Zhou Kai Wang Qi Qiu Yibing Cheng Yu Li Peng Cui Lu Liang Peng Li Xiaowei Deng Lili Wang Wen Zheng Hui Gong Fang Wang Meng Xu Justin Jang Hann Chu Lance Turtle Hongjie Yu School of Public Health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghai200032China Hospital Affiliated to Zhengzhou University Henan Children's HospitalZhengzhou450003China Division of Infectious Disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Centre for Disease Control and PreventionBeijing102206China West China School of Public Health Sichuan UniversityChengdu610041China Laboratory of Molecular RNA Virology and Antiviral Strategies Department of Microbiology and Immunology and Infectious Disease Translational Research ProgrammeYong Loo Lin School of MedicineNational University of SingaporeSingapore117597Singapore nihr Health Protection research Unit for Emerging and Zoonotic Infections Institute of InfectionVeterinary and Ecological Sciences University of LiverpoolLiverpoolL697BEUK Tropical&Infectious Disease Unit Royal Liverpool University Hospital(member of Liverpool Health Partners)LiverpoolL78XPUK

Hand,foot and mouth disease(HFMD)is a major public health problem among children in the Asia-Pacific *** optimal specimen for HFMD virological diagnosis remains *** A71(EV-A71)neutralizing antibody titres detected in paired sera were considered the reference standard for calculating the sensitivity,specificity,positive and negative predictive value of throat swabs,rectal swabs,stool,blood samples and cerebrospinal fluid(CSF)by RT-PCR or ELISA *** this study,clinical samples from 276 HFMD patients were collected for analysing the sensitivity of different kind of *** results showed that stool had the highest sensitivity(88%,95%CI:74%–96%)and agreement with the reference standard(91%).The order of diagnostic yield for EV-A71 infection was stool samplerectal swab>throat swab>blood sample>CSF sample,and using a combination of clinical samples improved sensitivity for enterovirus *** sensitivity of ELISA for IgM antibody detection in sterile-site specimens was significantly higher than that of RT-PCR(serum/plasma:62%vs.2%,CSF:47%vs.0%)(P<0.002).In conclusion,our results suggest that stool has the highest diagnostic yield for EV-A71-infected *** stool is unavailable,rectal swabs can be collected to achieve a similar diagnostic ***,throat swabs may be useful in detecting positive *** IgM in blood or CSF is diagnostically accurate,it lacks sensitivity,missing 40%–50%of *** higher proportion of severe cases and shorter interval between onset and sampling contributed to the increase in congruency between clinical testing and the serological reference standard.

关键词： Hand,foot and mouth disease(HFMD) Enterovirus A71(EV-A71) Sensitivity Specificity Evaluation of diagnostic methods

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Taxonomy,phylogeny,molecular dating and ancestral state reconstruction of Xylariomycetidae(Sordariomycetes)

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Fungal Diversity 2022年第1期112卷 1-88页

作者： Milan C.Samarakoon Kevin D.Hyde Sajeewa S.N.Maharachchikumbura Marc Stadler E.B.Gareth Jones Itthayakorn Promputtha Nakarin Suwannarach Erio Camporesi Timur S.Bulgakov Jian-Kui Liu School of Life Science and Technology Center for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China research Center in Bioresources for Agriculture Industry and MedicineChiang Mai UniversityChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Fungal research Mae Fah Luang UniversityChiang Rai 57100Thailand Mushroom research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Institute of microbiology Technische Universität BraunschweigSpielmannstraße 738106 BrunswickGermany Department of Botany and microbiology College of ScienceKing Saud UniversityP.O Box 2455Riyadh 11451Kingdom of Saudi Arabia research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand A.M.B.Gruppo Micologico Forlivese"Antonio Cicognani"Via Roma 18ForliItaly Department of Plant Protection Federal Research Centre the Subtropical Scientific Centre of the Russian Academy of SciencesYana Fabritsiusa Street 2/28SochiKrasnodar RegionRussia 354002

Xylariomycetidae(Ascomycota)is a highly diversified group with variable stromatic *** research focused on inconspicuous stromatic xylarialean taxa from China,Italy,Russia,Thailand and the United *** morpho-logical descriptions,illustrations and combined ITS-LSU-rpb2-tub2-tef1 phylogenies revealed 39 taxa from our collections belonging to Amphisphaeriales and Xylariales.A new family(Appendicosporaceae),five new genera(Magnostiolata,Mela-nostictus,Neoamphisphaeria,Nigropunctata and Paravamsapriya),27 new species(Acrocordiella photiniicola,Allocryp-tovalsa sichuanensis,Amphisphaeria parvispora,Anthostomella lamiacearum,Apiospora guiyangensis,***,Biscogniauxia magna,Eutypa camelliae,Helicogermslita clypeata,Hypocopra zeae,Magnostiolata mucida,Melanostictus longiostiolatus,***,Nemania longipedicellata,***,***,***,Neoamphispha-eria hyalinospora,Neoanthostomella bambusicola,Nigropunctata bambusicola,***,***,Occul-titheca rosae,Paravamsapriya ostiolata,Peroneutypa leucaenae,Seiridium italicum and Vamsapriya mucosa)and seven new host/geographical records are introduced and *** time estimates indicate that Delonicicolales diverged from Amphisphaeriales+Xylariales at 161(123-197)*** and Xylariales diverged 154(117-190)MYA with a crown age of 127(92-165)MYA and 147(111-184)MYA,***(Amphisphaeriales)has a stem age of 89(65-117)*** character state reconstruction indicates that astromatic,clypeate ascomata with aseptate,hyaline ascospores that lack germ slits may probably be ancestral Xylariomycetidae having plant-fungal endo-phytic *** Amphisphaeriales remained mostly astromatic with common septate,hyaline *** variations may have developed mostly during the Cretaceous *** ascospores are common in Xylariales,but they first appeared in Amphisphaeriaceae,Melogrammataceae and Sp

关键词： 33 new taxa Amphisphaeriales Appendicosporaceae Evolution Stromata Xylariales

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Accuracy and reliability of orthogonal polynomials in representing corneal topography

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Medicine in Novel Technology and Devices 2022年第3期15卷 124-133页

作者： Junjie Wang Xuefei Li Zheng Wang Pinakin G.Davey Yiyu Li Lanting Yang Mao Lin Xiaobo Zheng Fangjun Bao Ahmed Elsheikh Eye Hospital Wenzhou Medical UniversityWenzhouChina The Institution of Ocular Biomechanics Wenzhou Medical UniversityWenzhouChina College of Optometry Western University of Health SciencesPomonaCAUSA School of Engineering University of LiverpoolLiverpoolUK National Institute for Health research(nihr)Biomedical research centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijingChina No.270 Xueyuan West Road Wenzhou CityZhejiang Province325027China

Fitting of corneal topography data to analytical surfaces has been necessary in many clinical and experimental applications,yet absolute superiority of fitting methods was still unclear,and their overfitting risks were not well *** study aimed to evaluate the accuracy and reliability of orthogonal polynomials as fitting routines to represent corneal *** orthogonal polynomials,namely,Zernike polynomials(ZPs),pseudo-Zernike polynomials(PZPs),Gaussian-Hermite polynomials(GHPs)and Orthogonal Fourier-Mellin polynomials(OFMPs),were employed to fit anterior and posterior corneal topographies collected from 200 healthy and 174 keratoconic eyes using Pentacam *** fitting performance of these polynomials were compared,and the potential overfitting risks were assessed through a prediction *** results showed that,except for low orders,the fitting performance differed little among polynomials with orders10 regarding surface reconstruction(RMSEs~0.3μm).Anterior surfaces of normal corneas were fitted more efficiently,followed by those of keratoconic corneas,then posterior corneal *** results,however,revealed an alarming fact that all polynomials tended to overfit the data beyond certain ***,closely followed by ZPs,were the most robust in predicting unmeasured surface locations;while PZPs and especially OFMPs overfitted the surfaces *** 10 appeared to be optimum for corneal surfaces with 10-mm diameter,ensuring accurate reconstruction and avoiding *** optimum order however varied with topography diameters and data *** study concluded that continuing to use ZPs as fitting routine for most topography maps,or using GHPs instead,remains a good *** polynomial orders close to the topography diameters(millimeters)is generally suggested to ensure both reconstruction accuracy and prediction reliability and avoid overfitting for both normal and complex(e.g.,keratoconic)corneal surfac

关键词： Corneal topography Orthogonal polynomials Optimum order Overfitting Pentacam

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