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三维重建超声组织多普勒成像测量左室功能:活体动物实验研究

第六届全国冷冻电子显微学与结构生物学专题研讨会

作者：吴雄武 Laboratory of Computational Biology NHLBINIH

Cryo-electron microscopy and other imaging technique opened new windows to study large biomolecular assemblies under biologically relevant conditions. Ionotropic glutamate receptors(i GluRs) are cation channels that mediate signal transmission in the central nervous system by depolarizing the post-dynaptic membrane in response to L-glutamate release from the presynaptic neuron. GluA2 is a subunit ofα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-sensitive ionotropic glutamate receptors, a major subtypes of i GluRs, which harbors a modular

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中国医学影像技术 2002年第12期18卷 1224-1226页

作者：王慧芳 Xiaokui Li David J Sahn Michael Jones Crispin H Davies Rosemary A Rusk Arthur D Zetts 暨南大学医学院附属第二医院超声科广东深圳518020 Oregon Health & Science University nhlbi bethesda Maryland

目的　用三维重建超声组织多普勒成像 ( 3DTDI)方法 ,研究左室壁运动特点及左室不同部分的射血分数(EF)。方法　用重建的 3DTDI的方法 ,对 8只心尖部心肌梗死的活体羊模型在四种不同的血流状态下进行左室壁运动的测定和左室不同部分的E... 详细信息

目的　用三维重建超声组织多普勒成像 ( 3DTDI)方法 ,研究左室壁运动特点及左室不同部分的射血分数(EF)。方法　用重建的 3DTDI的方法 ,对 8只心尖部心肌梗死的活体羊模型在四种不同的血流状态下进行左室壁运动的测定和左室不同部分的EF测量。结果　在四种不同的血流状态下 ,左室梗塞区域的室壁运动振幅明显低于正常部分 (P<0 .0 0 1) ,整个左室、左室正常部分的EF明显高于梗塞部分 (P <0 .0 0 1) ,左室正常部分的EF明显高于整个左室 ( 0 .0 0 0 1

关键词：三维重建超声组织多普勒成像左室功能活体动物实验三维超声心动图缺血性心脏病室壁运动

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Stem cell gene therapy:the risks of insertional mutagenesis and approaches to minimize genotoxicity

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Frontiers of Medicine 2011年第4期5卷 356-371页

作者： Chuanfeng Wu Cynthia E.Dunbar Hematology Branch National HeartLung and Blood InstituteNational Institutes of HealthBethesdaMD 20892USA

Virus-based vectors are widely used in hematopoietic stem cell(HSC)gene therapy,and have the ability to integrate permanently into genomic DNA,thus driving long-term expression of corrective genes in all hematopoietic *** date,HSC gene therapy has been successfully employed in the clinic for improving clinical outcomes in small numbers of patients with X-linked severe combined immunodeficiency(SCID-X1),adenosine deaminase deficiency(ADA-SCID),adrenoleukodystrophy(ALD),thalassemia,chronic granulomatous disease(CGD),and Wiskott-Aldrich syndrome(WAS).However,adverse events were observed during some of these HSC gene therapy clinical trials,linked to insertional activation of proto-oncogenes by integrated proviral vectors leading to clonal expansion and eventual development of *** studies have been performed to understand the molecular basis of vector-mediated genotoxicity,with the aim of developing safer vectors and lower-risk gene therapy *** review will summarize current information on the mechanisms of insertional mutagenesis in hematopoietic stem and progenitor cells due to integrating gene transfer vectors,discuss the available assays for predicting genotoxicity and mapping vector integration sites,and introduce newlydeveloped approaches for minimizing genotoxicity as a way to further move HSC gene therapy forward into broader clinical application.

关键词： gene therapy hematopoietic stem cells insertional mutagenesis genotoxicity induced pluripotent stem cell

三维重建组织多普勒成像测量心肌梗死面积的实验研究

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中华超声影像学杂志 2002年第11期11卷 679-682页

作者：王慧芳 Xiaokui Li David J.Sahn Michael Jones Crispin H.Davies Rosemary A.Rusk Arthur D.Zetts 518000 深圳暨南大学医学院附属第二教学医院超声科 Oregon Health & Science University Portland Oregon USA. nhlbi Bethesda Maryland USA.

目的　通过活体动物实验探讨三维重建组织多普勒超声成像测量心肌梗死面积的方法和可行性。方法　用三维重建组织多普勒显像的方法 ,对 8只开胸的心尖部心肌梗死和室壁瘤的活体羊模型在 4种不同的血流状态下进行心肌梗死面积的测量。结... 详细信息

目的　通过活体动物实验探讨三维重建组织多普勒超声成像测量心肌梗死面积的方法和可行性。方法　用三维重建组织多普勒显像的方法 ,对 8只开胸的心尖部心肌梗死和室壁瘤的活体羊模型在 4种不同的血流状态下进行心肌梗死面积的测量。结果　重建三维超声组织多普勒成像测量的活体羊心内膜梗死的面积与尸检标本测量的面积密切相关 (r =0 .90 ,Y =0 .83X +1 .33 ,s x =0 .92cm2 ,P <0 .0 0 0 1 )。结论　重建三维组织多普勒成像提供了一系列动态空间组织多普勒数据确定室壁异常运动区 ,并能定量测量心肌梗死面积 ,在缺血性心脏疾病中。

关键词：三维重建组织多普勒成像测量心肌梗死实验研究超声心动描记术

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肌肉来源的干细胞具有再生肌肉和造血潜能:克隆水平的直接证据

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肌肉来源的干细胞具有再生肌肉和造血潜能:克隆水平的直接证据

美国心肺血研究所认为医学影像的危险与裨益需要进一步研究

第九届全国实验血液学会议

作者：高春记 Elizábeth M.Kang Brian A.Agricola Robert E.Donahue John F.Tisdale Molecular and Clinical Hematology Branch NIDDK解放军总医院血液科北京 100853 Molecular and Clinical Hematology Branch NIDDK Hematology Branch NHLBI NIH Bethesda Maryland 20892 Hematology Branch NHLBI NIH Bethesda Maryland 20892 Molecular and Clinical Hematology Branch NIDDK

＜正＞长期以来,人们认为来源于某一组织的干细胞只能增殖、分化为该组织。但是近几年来,随着数篇文章的报道似乎打破了此观点。例如,Gussoni和Ferrari等均报道了在小鼠造血干细胞移植后,造血细胞分化为肌肉组织;另外一些学者还报道,...

＜正＞长期以来,人们认为来源于某一组织的干细胞只能增殖、分化为该组织。但是近几年来,随着数篇文章的报道似乎打破了此观点。例如,Gussoni和Ferrari等均报道了在小鼠造血干细胞移植后,造血细胞分化为肌肉组织;另外一些学者还报道,骨髓细胞还可以分化为神经细胞、心肌细胞、肝细胞、肾细胞以及骨组织等;反之亦然,Jackson报道小鼠肌肉来源的干细胞具有造血功能,另外也有人报道来源

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中国心脏起搏与心电生理杂志 2010年第2期24卷 110-110页

作者：余国膺 nhlbi

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Biochar and zero-valent iron sand filtration simultaneously removes contaminants of emerging concern and Escherichia coli from wastewater effluent

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Biochar 2023年第1期5卷 710-722页

作者： Linyan Zhu Suhana Chattopadhyay Oluwasegun Elijah Akanbi Steven Lobo Suraj Panthi Leena Malayil Hillary A.Craddock Sarah M.Allard Manan Sharma Kalmia E.Kniel Emmanuel F.Mongodin Pei C.Chiu Amir Sapkota Amy R.Sapkota Maryland Institute for Applied Environmental Health University of Maryland School of Public HealthCollege ParkMDUSA Department of Civil and Environmental Engineering University of DelawareNewarkDEUSA Department of Pediatrics University of California San DiegoSan DiegoCAUSA United States Department of Agriculture Agriculture Research ServiceNortheast AreaBeltsville Agriculture Research CenterEnvironmental Microbiology and Food Safety LaboratoryBeltsvilleMDUSA Department of Animal and Food Science University of DelawareNewarkDEUSA Institute for Genome Sciences and Department of Microbiology and Immunology University of Maryland School of MedicineBaltimoreMDUSA Department of Epidemiology and Biostatistics School of Public HealthUniversity of MarylandCollege ParkMDUSA Present Address:Division of Lung Diseases National Institutes of Health(NIH)National HeartLung and Blood Institute(NHLBI)BethesdaMDUSA

Advanced treated municipal wastewater is an important alternative water source for agricultural ***,the possible persistence of chemical and microbiological contaminants in these waters raise potential safety concerns with regard to reusing treated wastewater for food crop *** low-cost and environmentally-friendly filter media,biochar(BC)and zero-valent iron(ZVI),have attracted great interest in terms of treating reused ***,we evaluated the efficacy of BC-,nanosilver-amended biochar-(Ag-BC)and ZVI-sand filters,in reducing contaminants of emerging concern(CECs),Escherichia coli(***)and total bacterial diversity from wastewater *** experiments were conducted with control quartz sand and sand columns containing BC,Ag-BC,ZVI,BC with ZVI,or Ag-BC with *** filtration,Ag-BC,ZVI,BC with ZVI and Ag-BC with ZVI demonstrated more than 90%(>1 log)removal of *** from wastewater samples,while BC,Ag-BC,BC with ZVI and Ag-BC with ZVI also demonstrated efficient removal of tested *** bacterial diversity was also observed after filtration;however,differences were marginally *** addition,significantly(p<0.05)higher bacterial diversity was observed in wastewater samples collected during warmer versus colder *** of silver ions occurred from Ag-BC columns;however,this was prevented through the addition of *** conclusion,our data suggest that the BC with ZVI and Ag-BC with ZVI sand filters,which demonstrated more than 99%removal of both CECs and *** without silver ion release,may be effective,low-cost options for decentralized treatment of reused wastewater.

关键词： Biochar Zero-valent iron Wastewater reuse Contaminants of emerging concern Recycled water E.coli

Hypertrophic cardiomyopathy Is an unneglectable cause of chronic aortic regurgitation:an echocardiography and cardiac magnetic resonance imaging study

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中国循环杂志 2018年第S1期 159-160页

作者： Zixian Chen Chen Cui Gang Yin Junqiang Lei Shunlin Guo Zheng Zhang Sirajuddin Arlene ANDrew E.Arai Shihua Zhao Minjie Lu State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Radiology The First Hospital of Lanzhou University Department of Cardiology The First Hospital of Lanzhou University Department of Health and Human Services National Heart Lung and Blood Institute NHLBI National Institutes of Health NIH

Objective We sought to investigate the prevalence, primary reason and risk factors of aortic regurgitation (AR) in hypertrophic cardiomyopathy (HCM) patients, using echo and cardiac magnetic

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预防心血管疾病,生活方式干预才是王道

糖尿病天地(临床) 2014年第1期8卷 26-27页

作者：戴中 ACC/AHA/nhlbi 北京大学人民医院

心脏专科和其他医疗领域的专家已经花费数年,等待美国国家心脏、肺和血液研究所(nhlbi)最新的成人血脂、血压和肥胖管理指南。赶在步入2014年之前,大部分更新的资料以两份指南的形式发布,一份评价心血管风险和另一份针对经常讨论的话题... 详细信息

心脏专科和其他医疗领域的专家已经花费数年,等待美国国家心脏、肺和血液研究所(nhlbi)最新的成人血脂、血压和肥胖管理指南。赶在步入2014年之前,大部分更新的资料以两份指南的形式发布,一份评价心血管风险和另一份针对经常讨论的话题——生活方式。由Robert Eckel博士(美国科罗拉多大学安舒茨医学院)和John Jakicic博士(美国匹兹堡大学)医生主编的生活方式管理降低心血管风险2013年AHA/ACC指南,连同ACC/AHA发布的另外三

关键词：摄入量 AHA ACC 植物油血压血脂血浆脂类饮食结构心血管疾病管理指南低脂奶制品含糖饮料王道