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laboratory diagnosis for malaria in the elimination phase in China:efforts and challenges

Frontiers of Medicine 2022年第1期16卷 10-16页

作者： Jianhai Yin Mei Li He Yan Shuisen Zhou Zhigui Xia National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai 200025China

Malaria remains a global health challenge,although an increasing number of countries will enter pre-elimination and elimination *** prompt and precise diagnosis of symptomatic and asymptomatic carriers of Plasmodium parasites is the key aspect of malaria *** the launch of the China Malaria Elimination Action Plan in 2010,China has formulated clear goals for malaria diagnosis and has established a network of malaria diagnostic laboratories within medical and health institutions at all *** external quality assessments were implemented,and a national malaria diagnosis reference laboratory network was established to strengthen the quality assurance in malaria ***,no indigenous malaria cases have been reported since 2017,but the risk of re-establishment of malaria transmission cannot be *** review summarizes the lessons about malaria diagnosis in the elimination phase,primarily including the establishments of laboratory networks and quality control in China,to better improve malaria diagnosis and maintain a malaria-free status.A reference is also provided for countries experiencing malaria elimination.

关键词： malaria laboratory diagnosis quality control malaria elimination China

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Epidemiological Characteristics of Dengue Fever-China,2005–2023

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China CDC weekly 2024年第41期6卷 1045-1048页

作者： Zhuowei Li Xiaoxia Huang Aqian Li Shanshan Du Guangxue He Jiandong Li National key laboratory of Intelligent Tracking and Forecasting for Infectious diseases NHC Key Laboratory of BiosafetyNHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Diseases Control and PreventionBeijingChina

Introduction:The global incidence of dengue fever has increased significantly over the past two decades,and China faces a significant upward trend in dengue control ***:Data were obtained from China’s NNDRS from 2005 to *** regression software was used to analyze temporal trends,while SaTScan software was used to analyze spatial,seasonal,and spatiotemporal *** software was used to visualize ***:A total of 117,892 dengue cases were reported from 2005 to 2023,with significant fluctuation in annual reported *** was not endemic in *** outbreaks most likely occurred in the southwestern,southeastern coastal,and inland areas of *** outbreaks have occurred between June and November,generally peaking in September or October,around epidemiological week(EW)***:Dengue challenges in China are *** case monitoring,proactive control interventions,and staff mobilization should be implemented before June to ensure a timely response to autochthonous outbreaks.

关键词： inland likely southwestern

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Sentinel Surveillance of Schistosomiasis—China,2021

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China CDC weekly 2023年第12期5卷 278-282页

作者： Suying Guo Hui Dang Yinlong Li Lijuan Zhang Fan Yang Junyi He Chunli Cao Jing Xu Shizhu Li National Institute of Parasitic diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchNHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina

Introduction:This report analyzes the national surveillance data for schistosomiasis in 2021 to understand the current status and provide evidence for further policy actions to promote *** analysis is in line with the National Surveillance Plan of Schistosomiasis,which was revised in 2020 to adapt to the new stage of moving towards ***:Data from the 2021 national surveillance of schistosomiasis in humans,livestock,and snails were collected from 13 provincial-level administrative divisions(PLADs)and analyzed using descriptive epidemiological *** antibody-positive rate and area of newly discovered and re-emergent snail habitats were ***:In 2021,a total of 31,661 local residents and 101,558 transient population were screened for antibodies using indirect hemagglutination assay(IHA).Of those who tested positive,745 local residents and 438 transient population underwent further parasitological examination,with only one stool-positive result in the transient ***,12,966 livestock were examined using the miracidia hatching test,with no positives *** total area of newly discovered and re-emergent snail habitats was 957,702 m^(2) and 4,381,617 m^(2),*** infected snails were found using the microscopic dissection method,but six pooled snail samples were reported as positive using the loopmediated isothermal amplification method for detecting specific sequences of ***,in Anhui and Jiangxi ***:The prevalence of schistosomiasis among humans and livestock was found to be low,however,a potential transmission risk was identified in certain *** reduce the risk of transmission,a comprehensive control strategy should be continued and new techniques should be implemented in the surveillance and early warning system.

关键词： transient elimination Anhui

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Assessment of Tick-Borne diseases in Hainan Province, China

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China CDC weekly 2023年第37期5卷 822-828,I0009-I0015页

作者： Weiqing Zheng Guangyuan Zhao Qianfeng Xia key laboratory of tropical Translational Medicine of Ministry of Education NHC Key Laboratory of Tropical Disease ControlSchool of Tropical MedicineHainan Medical UniversityHaikou CityHainan ProvinceChina

China’s six tropical regions include Guangdong Province,Yunnan Province,Hainan Province,Hong Kong Special Administrative Region(SAR),Macao SAR,and Taiwan,***,seated in the southernmost tropical region of China,is home to ticks that remain active throughout all four *** heightens their potential to transmit tick-borne diseases to both animals and *** study provides a succinct overview of the prevailing tick species’spatial distribution and offers an outline of the range and dispersion of emerging tick-borne infections in tick vectors,animal hosts,and human populations within Hainan,China.

关键词： China Hainan prevailing

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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina nhc key laboratory of Prevention and treatment of Cerebrovascular diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan key laboratory of Cerebrovascular diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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