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NIR-Ⅱ成像引导的精准光动力治疗通过干扰糖代谢重编程增强肿瘤饥饿治疗

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Science Bulletin 2024年第9期69卷 1263-1274页

作者：吴夏维凡勇王楷若缪云秋常永亮明江王欣月陆晟威刘芮池张凡张扬秦环龙施剑林 Nanomedicine and Intestinal Microecology Research Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsState Key Laboratory of Molecular Engineering of Polymers and iChemFudan UniversityShanghai 200433China State Key Laboratory of High Performance Ceramics and Superﬁne Microstructure Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050China

Metabolic reprogramming is a mechanism by which cancer cells alter their metabolic patterns to promote cell proliferation and growth, thereby enabling their resistance to external stress. 2-Deoxy-Dglucose(2DG) can eliminate their energy source by inhibiting glucose glycolysis, leading to cancer cell death through starvation. However, a compensatory increase in mitochondrial metabolism inhibits its efficacy. Herein, we propose a synergistic approach that combines photodynamic therapy(PDT) with starvation therapy to address this challenge. To monitor the nanodrugs and determine the optimal triggering time for precise tumor therapy, a multifunctional nano-platform comprising lanthanide-doped nanoparticle(Ln NP) cores was constructed and combined with mesoporous silicon shells loaded with2DG and photosensitizer chlorin e6(Ce6) in the mesopore channels. Under 980 nm near-infrared light excitation, the downshifted 1550 nm fluorescence signal in the second near-infrared(NIR-II, 1000–1700 nm) window from the Ln NPs was used to monitor the accumulation of nanomaterials in ***, upconverted 650 nm light excited the Ce6 to generate singlet oxygen for PDT, which damaged mitochondrial function and enhanced the efficacy of 2DG by inhibiting hexokinase 2 and lactate dehydrogenase A expressions. As a result, glucose metabolism reprogramming was inhibited and the efficiency of starvation therapy was significantly enhanced. Overall, the proposed NIR-II bioimaging-guided PDT-augmented starvation therapy, which simultaneously inhibited glycolysis and mitochondria, facilitated the effects of a cancer theranostic system.

关键词： Metabolic reprogramming Colorectal cancer Glycolytic inhibition Photodynamic therapy NIR-II imaging

Syntheses and lyotropic liquid crystal properties of a series of sandwich-type tungstoarsenates heteropoly compounds with As/W ratio of 4/30

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Chinese Science Bulletin 1999年第21期44卷 1964-1967页

作者： Rudan Huang Lihua Bi Enbo Wang Baoli Fei Lin Xu Changwen Hu ne Normal univ Dept Chem Changchun 130024 Peoples R China

A series of sandwich-type tungstoarsenates heteropoly compounds with As/W ratio of 4/30, Na16[As4W30M4(H2O)2O112]·XH2O (M = Zn,Cu,Co,Ni,Mn and Cd), have been synthesized for the first time and structurally characterized by elemental analysis, IR and 183W NMR spectra. The crystal structure of Na16[As4W30Cu4(H2O)2O112]·63H2O was determined to be a triclinic system, of P1 symmetry, a = 1.2721(3) nm, b = 2.451 6(5) nm, c = 2.6450(5) nm,

关键词： tungstoarsenate heteropoly compounds synthesis lyotropic liquid crystal.

OPTIMAL A POSTERIORI ERROR ESTIMATES OF THE LOCAL DISCONTINUOUS GALERKIN METHOD FOR CONVECTION- DIFFUSION PROBLEMS IN One SPACE DIMENSION

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Journal of Computational Mathematics 2016年第5期34卷 511-531页

作者： Mahboub Baccouch Department of Mathematics University of Nebraska at Omaha Omaha NE 68182

In this paper, we derive optimal order a posteriori error estimates for the local dis- continuous Galerkin （LDC） method for linear convection-diffusion problems in one space dimension. One of the key ingredients in our analysis is the recent optimal superconver- gence result in [Y. Yang and C.-W. Shu, J. Comp. Math., 33 （2015）, pp. 323-340]. We first prove that the LDG solution and its spatial derivative, respectively, converge in the L2-norm to （p ＋ 1）-degree right and left Radau interpolating polynomials under mesh re- finement. The order of convergence is proved to be p ＋ 2, when piecewise polynomials of degree at most p are used. These results are used to show that the leading error terms on each element for the solution and its derivative are proportional to （p ＋ 1）-degree right and left Radau polynomials. We further prove that, for smooth solutions, the a posteriori LDG error estimates, which were constructed by the author in an earlier paper, converge, at a fixed time, to the true spatial errors in the L2-norm at （.9（hp＋2） rate. Finally, we prove that the global effectivity indices in the L2-norm converge to unity at （9（h） rate. These results improve upon our previously published work in which the order of convergence for the a posteriori error estimates and the global effectivity index are proved to be p＋3/2 and 1/2, respectively. Our proofs are valid for arbitrary regular meshes using PP polynomials with p ≥ 1. Several numerical experiments are performed to validate the theoretical results.

关键词： Local discontinuous Galerkin method Convection-diffusion problems Super-convergence Radau polynomials A posteriori error estimation.

基于序贯蒙特卡洛方法的高风电渗透下电力系统可靠性与成本分析

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山西电力 2024年第5期 14-17页

作者：王宇轩英国纽卡斯尔大学泰恩-威尔泰恩河畔纽卡斯尔NE17RU

为研究风电渗透率增加对电力系统运行可靠性的影响,提出了一种通过序贯蒙特卡洛方法进行仿真,结合可靠性指标与发电成本的综合分析方法,基于单区域RTS96系统开展仿真分析。结果表明,在缺乏储能设备等可靠性保障措施的情况下,系统的电量... 详细信息

为研究风电渗透率增加对电力系统运行可靠性的影响,提出了一种通过序贯蒙特卡洛方法进行仿真,结合可靠性指标与发电成本的综合分析方法,基于单区域RTS96系统开展仿真分析。结果表明,在缺乏储能设备等可靠性保障措施的情况下,系统的电量不足期望值和缺电时间期望值随着风电渗透率的提升呈现近似指数型增长。该方法在保证系统可靠性的同时可以找到最大化发电成本效益的风电渗透率,为电力系统规划提供参考。

关键词：电力系统可靠性评估序贯蒙特卡洛方法 MATLAB仿真风电渗透率

An epidemiological study of collagenous colitis in southern Sweden from 2001-2010

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World Journal of Gastroenterology 2012年第22期18卷 2821-2826页

作者： Lina Vigren Martin Olesen Cecilia Benoni Klas Sjberg Division of Gastroenterology Department of Clinical Sciences Skne University Hospital Lund University SE-205 02 Malm Sweden university and Regional Laboratories Region Sk ne Department of Pathology Skne University Hospital SE-205 02 Malm Sweden

AIM： To estimate the incidence of collagenous colitis （CC） in southern Sweden during 2001-2010. METHODS： Cases were identified by searching for CC in the diagnostic registers at the Pathology Departments in the county of Skane. The catchment area comprised the south-west part of the county （394 307 inhabitants in 2010） and is a mixed urban and rural type with limited migration. CC patients that had under- gone colonoscopy during the defined period and were living in this area were included in the study regardless of where in Skane they had been diagnosed. Medical records were scrutinized and uncertain cases were re- assessed to ensure that only newly diagnosed CC cases were included. The diagnosis of CC was based on both clinical and histopathological criteria. The clinical crite-rion was non-bloody watery diarrhoea. The histopatho- logical criteria were a chronic inflammatory infiltrate in the lamina propria, a thickened subepithelial collagen layer ≥10 micrometers （um） and epithelial damage such as flattening and detachment. RESULTS： During the ten year period from 2001-2010, 198 CC patients in the south-west part of the county of Skane in southern Sweden were newly diagnosed. Of these, 146 were women and 52 were men, i.e., a female： male ratio of 2.8：1. The median age at diag- nosis was 71 years （range 28-95/inter-quartile range 59-81）, for women median age was 71 （range 28-95） years and was 73 （range 48-92） years for men. The mean annual incidence was 5.4/105 inhabitants. During the time periods 2001-2005 and 2006-2010, the mean annual incidence rates were 5.4/105 for both periods [95% confidence interval （CI）： 4.3-6.5 in 2001-2005 and 4.4-6.4 in 2006-2010, respectively, and 4.7-6.2 for the whole period]. Although the incidence varied over the years （minimum 3.7 to maximum 6.7/105） no increase or decrease in the incidence could be identi- fied. The odds ratio （OR） for CC in women compared to men was estimated to be 2.8 （95% CI： 2.0-3.7）. The OR for women 65 year

关键词： Collagenous colitis Epidemiology Incidence Microscopic colitis

The application of Graphic information analysis in land use change

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The application of Graphic information analysis in land use ...

An open-label multiyear study of sargramostim-treated Parkinson’s disease patients examining drug safety,tolerability,and immune biomarkers from limited case numbers

International Conference on Info-Tech and Info-net (ICII 2001)

作者： Liu, XN Xu, HM ne Normal univ Sch Urban & Environm Sci Changchun 130024 Peoples R China

ISBN: (纸本)7900081585

Land use or land cover change is the focus of the global environmental changes. Land use is a number of heterogeneous spatial patterns under complex driving forces. Land use does not only show itself in terms of quantity change and quality modification, but also in terms of spatial pattern change. Furthermore, spatial pattern change is an important content in the study field of land use change. In this article we select Qianguo County of Jilin Province as a study area, detect land use changes based on the Landsat TM with the post-classification method, and calculate the transition matrix based on GIS. We then analyze spatial pattern change of land use in study area based on the combination of geography graphic information theory, statistic analyses and spatial analysis tools of GIS. The results indicate that we can use several graphic parameters to depict the patches of every land use type, and the curve of the graphic parameters changing with the area of the graph can in effect disclose the characteristics of different land use class. Furthermore, we can use VCM curves to express the land use spatial pattern and its change.

关键词： GIS graphic information theory remote sensing change detection

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Translational neurodegeneration 2023年第1期12卷 529-545页

作者： Katherine E.Olson Mai M.Abdelmoaty Krista L.Namminga Yaman Lu Helen Obaro Pamela Santamaria R.Lee Mosley Howard E.Gendelman Department of Pharmacology and Experimental neuroscience Center for Neurodegenerative DisordersUniversity of Nebraska Medical CenterOmahaNE 68198USA Great Plains Center for Clinical and Translational Research Nebraska MedicineOmahaNEUSA neurology Consultants of nebraska PC and Nebraska MedicineOmahaNEUSA

Background The clinical utility and safety of sargramostim has previously been reported in cancer,acute radiation syndrome,autoimmune disease,inflammatory conditions,and Alzheimer’s *** safety,tolerability,and mecha-nisms of action in Parkinson’s disease(PD)during extended use has not been *** As a primary goal,safety and tolerability was assessed in five PD patients treated with sargramostim(Leukine®,granulocyte-macrophage colony-stimulating factor)for 33 *** goals included numbers of CD4+T cells and monocytes and motor ***,metabolic,immune,and neurological evaluations were assessed during a 5-day on,2-day off therapeutic regimen given at 3μg/*** 2 years,drug use was discon-tinued for 3 *** was then followed by an additional 6 months of *** Sargramostim-associated adverse events included injection-site reactions,elevated total white cell counts,and bone *** drug,blood analyses and metabolic panels revealed no untoward side effects linked to long-term *** Parkinson’s Disease Rating Scale scores remained stable throughout the study while regulatory T cell number and function were *** the initial 6 months of treatment,transcriptomic and proteomic mono-cyte tests demonstrated autophagy and sirtuin *** finding paralleled anti-inflammatory and antioxidant activities within both the adaptive and innate immune profile *** Taken together,the data affirmed long-term safety as well as immune and anti-inflammatory responses reflecting clinical stability in PD under the sargramostim *** in larger patient populations is planned in a future phase II evaluation.

关键词： Parkinson’s disease Granulocyte-macrophage colony-stimulating factor Unified Parkinson’s Disease Rating Scale Regulatory T cells neuroprotection Sargramostim therapy

Determination of Carbon by Means of Microwave Plasma Torch Atomic Emission Spectrometry

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Chemical Research in Chinese universities 1996年第1期12卷 32-36页

作者： ZHANG Han-qi YUAN Xiang-lin YE Dong-mei ZHAO Xiao-jun and JIN Qin-han (Department Of Chemistry, Jilin university, Changchun, 130023)ZHU Zhi-ping(Department of Chemistry, Northeast Normal university, Changchun, 130024) JILIN univ DEPT CHEM CHANGCHUN 130023 PEOPLES R CHINA ne NORMAL univ DEPT CHEM CHANGCHUN 130024 PEOPLES R CHINA

The determination of carbon by means of microwave plasma torch atomic emission spectrometry(MPT-AES) was studied. Aqueous samples were introduced with a pneumatic nebulization system. The detection limit for carbon wa... 详细信息

关键词： Microwave plasma torch Atomic emission spectrometry Carbon

Pharmacodynamics of aminoglycosides and tetracycline derivatives against Japanese encephalitis virus

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 236-240页

作者： Rashmee Topno Siraj Ahmed Khan Pritom Chowdhury Jagadish Mahanta Regional Medical Research Centre ICMR(NE Region)

Objective:To explore the antiviral activity of antibiotic compounds,mainly aminoglycosides and tetracyclines against Japanese encephalitis virus(JEV) induced infection in ***:Antiviral activity were evaluated against JEV using cytopathic effect inhibition assay,virus yield reduction assay,caspase 3 level,extracellular viral detection by antigen capture ELISA and viral RNA ***:JEV induced cytopathic effect along with reduction of viral progeny plaque formation indicated antiviral potential of the compounds suggesting that antibiotics had broad spectrum *** and kanamycin administration in dose dependent manner declined viral RNA ***:The present study shows kanamycin and doxycyclinc can affect virion structure and alter replication causing inhibition of JEV induced pathogenesis in vitro.

关键词： Japanese encephalitis virus 2 DOS aminoglycoside Doxycycline Kanamycin