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In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

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Acta Pharmaceutica Sinica B 2021年第4期11卷 989-1002页

作者： Ana LMartínez-López Carlos JGonzález-Navarro Paula Aranaz JoséLVizmanos Juan MIrache NANO-VAC Research Group Department of Chemistry and Pharmaceutical TechnologySchool of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Center for Nutrition research School of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Department of Biochemistry&Genetics School of ScienceUniversity of NavarraPamplona 31080Spain Navarra Institute for Health research(IdiSNA) Pamplona 31080Spain

The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of insulin.These nanocarriers,based on the coating of zein nanoparticles with a polymer conjugate containing PEG,displayed a size of 260 nm with a negative surface charge and an insulin payload of 77 mg/mg.In intestinal pig mucus,the diffusivity of these nanoparticles(PPA-NPs)was found to be 20-fold higher than bare nanoparticles(NPs).These results were in line with the biodistribution study in rats,in which NPs remained trapped in the mucus,whereas PPA-NPs were able to cross this layer and reach the epithelium surface.The therapeutic effcacy was evaluated in Caenorhabditis elegans grown under high glucose conditions.In this model,worms treated with insulin-loaded in PPA-NPs displayed a longer lifespan than those treated with insulin free or nanoencapsulated in NPs.This finding was associated with a signifcant reduction in the formation of reactive oxygen species(ROS)as well as an important decrease in the glucose and fat content in worms.These effects would be related with the mucus-permeating ability of PPA-NPs that would facilitate the passage through the intestinal peritrophic-like dense layer of worms(similar to mucus)and,thus,the absorption of insulin.

关键词： nanoparticles Oral delivery Mucus-permeating Biodistribution Insulin Caenorhabditis elegans ROS

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Molecular modeling of oscillating GHz electric field influence on the kinesin affinity to microtubule

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Chinese Physics B 2015年第8期24卷 239-242页

作者： H.R.Saeidi S.S.Setayandeh A.Lohrasebi Department of Physics University of Isfahan Computational nano-Bioelectromagnetics research group School of Nano-Science Institute for Research in Fundamental Sciences (IPM)

Kinesin is a microtubule-associated motor protein which can respond to the external electric field due to its polarity.Using a molecular dynamics simulation method, the effect of such a field on the affinity of kinesin to the α β-tubulin is investigated in this study. To consider kinesin affinity, the system is exposed to an electric field of 0.03 V/nm with frequency values of 1, 2,..., 9, and 10 GHz. It is found that the applied electric field can change kinesin affinity to the microtubule.These changes could perturb the normal operation of kinesin, such as the processive motility of kinesin on the microtubule.

关键词： kinesin affinity,oscillating electric field,molecular dynamic,αβ-tubulin dimer

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摩擦搅拌焊参数对超细晶Al-0.2 wt%Sc合金薄板微观组织和热力学性能的影响

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Journal of Central South University 2023年第1期30卷 61-73页

作者： Valeh TALEBSAFA Mohammad YOUSEFIEH Ehsan BORHANI Ehsan GHARIBSHAHIYAN Faculty of Materials and Metallurgical Engineering Semnan UniversitySemnan 35131-19111Iran Department of nano Technology Nano-Materials Science and Engineering GroupSemnan UniversitySemnan 35196-45399Iran AFRA research and Development Company Semnan 35351-64142Iran

为了研究摩擦搅拌焊参数对超细晶粒Al-Sc合金薄板微观组织、热力学性能的影响,采用累积滚焊法(ARB)制备的超细晶粒Al-Sc合金薄板进行了摩擦搅拌焊数值模拟。此外,研究了刀具转速、焊接速度和刀具倾斜角等摩擦搅拌焊参数的最优条件。在SY... 详细信息

为了研究摩擦搅拌焊参数对超细晶粒Al-Sc合金薄板微观组织、热力学性能的影响,采用累积滚焊法(ARB)制备的超细晶粒Al-Sc合金薄板进行了摩擦搅拌焊数值模拟。此外,研究了刀具转速、焊接速度和刀具倾斜角等摩擦搅拌焊参数的最优条件。在SYSWELD和Visual-Environment软件中实现了数值模拟,并通过实验结果进行了验证。结果表明,摩擦搅拌焊是一种有利于保持超细晶(UFG)组织的技术,并在累积滚焊材料中具有较好的力学性能。刀具转速对热性能和力学性能的影响最大。在刀具转速为700 r/min、焊接速度为80 mm/min、刀具倾斜角度为3°时,Al-Sc合金的硬度和抗屈强度均达到最高。

关键词：搅拌摩擦焊超细晶铝合金机械性能有限元建模

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A robust QRS detection and accurate R-peak identification algorithm for wearable ECG sensors

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Science China(Information Sciences) 2021年第8期64卷 213-229页

作者： Kai ZHAO Yongfu LI Guoxing WANG Yu PU Yong LIAN Department of Micro and nano Electronics Shanghai Jiao Tong University Alibaba group

This paper presents a robust QRS detection algorithm that is capable of detecting QRS complexes as well as accurately identifying R-peaks. The proposed bilateral threshold scheme combined with QRS watchdog greatly improves the detection accuracy and robustness, resulting in consistent detection performance on 9 available ECG databases. Simulations show that the proposed algorithm achieves good results on the datasets from both QTDB healthy database and MITDB arrhythmia database, i.e. the sensitivity of99.99% and 99.88%, the precision of 99.98% and 99.88%, and the detection error rate of 0.04% and 0.31%,respectively. Furthermore, it also outperforms many existing algorithms on six other ECG databases, such as NSTDB, TWADB, STDB, SVDB, AFTDB, and FANTASIADB.

关键词： signal processing QRS detection R-peak detection wearable ECG sensors bilateral threshold

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High speed phase modulators for silicon photonic integrated circuits:a role for lithium niobate?

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Advanced Photonics 2019年第3期1卷 3-5页

作者： Roel Baets Bart Kuyken Ghent University–imec Photonics Research GroupGentBelgium Ghent University Center for Nano-and BiophotonicsGentBelgium

Lithium niobate(LN)has been and still is a prominent material for high speed optical modulators.The performance of such LN-modulators—as a stand-alone building block for optical systems—has been unchallenged for many years.But in many ways it has proven to be very hard to integrate lithium niobate modulators with other functions on a single optical chip.As a result,scientific interest in this material has been fading away.

关键词： lithium integrate alone

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纳米限域超流的化学反应和信息传输

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Science Bulletin 2022年第15期67卷 1509-1512页

作者：陈林峰 Dicky Pranantyo 夏帆 State Key Laboratory of Biogeology and Environmental Geology Engineering Research Center of Nano-Geomaterials of Ministry of EducationFaculty of Material Science and ChemistryChina University of GeosciencesWuhan 430074China Antimicrobial Resistance Interdisciplinary research group Singapore-MIT Alliance for Research and TechnologySingapore 138602Singapore

Biological systems are featured by ultralow energyconsumption and ultrahigh efficiency in terms of biosynthesis,energy conversion,and signal transmission(e.g.,signal propagation along the neuronal axon).

关键词：信息传输 signal 超流

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含垂直裂纹的厚热障涂层的热稳定性及力学性能(英文)

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 29-35页

作者： Zhe LU Min-Sik KIM Sang-Won MYOUNG Je-Hyun LEE Yeon-Gil JUNG In-Soo KIM Chang-Yong JO School of nano & Advanced Materials Engineering Changwon National University High Temperature Materials research group Korea Institute of Materials Science

采用循环热暴露及热震试验研究含或不含垂直裂纹的厚热障涂层的热稳定性和失效机制。先采用空气等离子喷涂技术在基体表面制备150μm厚的连接涂层,再在该涂层上采用空气等离子喷涂技术制备2000μm厚的热障涂层。含或不含垂直裂纹的热障... 详细信息

采用循环热暴露及热震试验研究含或不含垂直裂纹的厚热障涂层的热稳定性和失效机制。先采用空气等离子喷涂技术在基体表面制备150μm厚的连接涂层,再在该涂层上采用空气等离子喷涂技术制备2000μm厚的热障涂层。含或不含垂直裂纹的热障涂层的粘附强度分别为24.7和11.0 MPa,表明含垂直裂纹的热障涂层的界面稳定性更高。循环热暴露及热震试验表明其热稳定性更高。含或不含垂直裂纹的热障涂层的硬度分别为6.6和5.3GPa,经循环热暴露试验后分别升高至9.5和5.5 GPa。实验表明上层涂层中垂直裂纹的存在有利于延长热障涂层高温环境的寿命。

关键词：热障涂层空气等离子喷涂垂直裂纹热稳定性

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Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor

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Bioactive Materials 2022年第2期7卷 35-48页

作者： Hyung Shik Kim Seung Jae Lee Dong Yun Lee Department of Bioengineering College of Engineeringand BK FOUR Biopharmaceutical Innovation Leader for Education and Research GroupHanyang UniversitySeoul04763Republic of Korea Institute of nano Science and Technology Hanyang UniversitySeoul04763Republic of Korea

Orally absorbable gold nanoparticles(AuNP)having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme(GBM)for patients with its highest incidence rate.Here,we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin(Lf)and lactoferrin receptor(LfR)that is highly expressed in the intestine,blood-brain barrier and GBM.For stability and long circulation of AuNP,glutathione and polyethylene glycol(PEG)is introduced,which is called to Lf-PEG-AuNP.When Lf-PEG-AuNP are orally administered to orthotopic GBM-bearing mice,11-fold and 8-fold higher concentrations of AuNP are measured in bloodstreams and GBM in the brain,respectively,compared with unconjugated-AuNP.Therefore,orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor volume.Collectively,we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption,and that its efficient photothermal therapy is possible.

关键词： intestine absorption gastrointestinal

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Optical leaky fin waveguide for long-range optical antennas on high-index contrast photonic circuit platforms

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Photonics research 2023年第9期11卷 1570-1582页

作者： LUKAS VAN ISEGHEM WIM BOGAERTS Photonics research group Department of Information TechnologyGhent University-IMECGhentBelgium Center for nano-and Biophotonics(NB Photonics) Ghent UniversityGhentBelgium

Long-distance light detection and ranging(LiDAR)applications require an aperture size in the order of 30 mm to project 200–300 m.To generate such collimated Gaussian beams from the surface of a chip,this work presents a novel waveguide antenna concept,which we call an“optical leaky fin antenna,”consisting of a tapered waveguide with a narrow vertical“fin”on top.The proposed structure(operating aroundλ=1.55μm)overcomes fundamental fabrication challenges encountered in weak apodized gratings,the conventional method to create an offchip wide Gaussian beam from a waveguide chip.We explore the design space of the antenna by scanning the relevant cross section parameters in a mode solver,and their sensitivity is examined.We also investigate the dispersion of the emission pattern and angle with the wavelength.The simulated design space is then used to construct and simulate an optical antenna to emit a collimated target intensity profile.Results show inherent robustness to crucial design parameters and indicate good scalability of the design.Possibilities and challenges to fabricate this device concept are also discussed.This novel antenna concept illustrates the possibility to integrate long optical antennas required for long-range solid-state LiDAR systems on a high-index contrast platform with a scalable fabrication method.

关键词： waveguide antenna optical

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Collaborative learning via social computing

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 265-282页

作者： Ricardo S.ALONSO Javier PRIETO óscar GARCíA Juan M.CORCHADO BISITE research group University of Salamanca

Educational innovation is a field that has been greatly enriched by using technology in its processes, resulting in a learning model where information comes from numerous sources and collaboration takes place among multiple students. One attractive challenge within educational innovation is the design of collaborative learning activities from the social computing point of view, where collaboration is not limited to student-to-student relationships, but includes student-to-machine interactions. At the same time, there is a great lack of tools that give support to the whole learning process and are not restricted to specific aspects of the educational task. In this paper, we present and evaluate context-aware framework for collaborative learning applications(CAFCLA) as a solution to these problems. CAFCLA is a flexible framework that covers the entire process of developing collaborative learning activities, taking advantage of contextual information and social interactions. Its application in the experimental case study of a collaborative WebQuest within a museum has shown that, among other benefits, the use of social computing improves the learning process, fosters collaboration, enhances relationships, and increases engagement.

关键词： Context-awareness Collaborative learning Social computing Virtual organizations Wireless sensor networks Real time location system

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