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A method to predict rockburst using temporal trend test and its application

Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 909-923页

作者： Yarong Xue Zhenlei Li Dazhao Song Xueqiu He Honglei Wang Chao Zhou Jianqiang Chen Aleksei Sobolev School of Civil and Resources Engineering University of Science and Technology BeijingBeijing100083China Zhong-an Academy of Safety Engineering Beijing100083China China Energy group Xinjiang Energy Co. LtdUrumqi830027China Khabarovsk Federal research Center of the Far Eastern Branch of the Russian Academy of Sciences(KhFRC FEB RAS) 51 Turgenev StreetKhabarovsk680000Russia

Rockbursts have become a significant hazard in underground mining,underscoring the need for a robust early warning model to ensure safety *** study presents a novel approach for rockburst prediction,integrating the Mann-Kendall trend test(MKT)and multi-indices fusion to enable real-time and quantitative assessment of rockburst *** methodology employed in this study involves the development of a comprehensive precursory index library for *** MKT is then applied to analyze the real-time trend of each index,with adherence to rockburst characterization laws serving as the warning *** employing a confusion matrix,the warning effectiveness of each index is assessed,enabling index preference ***,the integrated rockburst hazard index Q is derived through data *** results demonstrate that the proposed model achieves a warning effectiveness of 0.563 for Q,surpassing the performance of any individual ***,the model’s adaptability and scalability are enhanced through periodic updates driven by actual field monitoring data,making it suitable for complex underground working *** providing an efficient and accurate basis for decision-making,the proposed model holds great potential for the prevention and control of *** offers a valuable tool for enhancing safety measures in underground mining operations.

关键词： Rockburst Microseismicity Early warning Mann-Kendall trend test Confusion matrix Multi-indices fusion

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Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution

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Bio-Design and Manufacturing 2024年第3期7卷 292-306页

作者： Giuliana Grasso Valentina Onesto Stefania Forciniti Eliana D’Amone Francesco Colella Lara Pierantoni Valeria Famà Giuseppe Gigli Rui L.Reis J.Miguel Oliveira Loretta L.del Mercato nstitute of Nanotechnology National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly Department of Mathematics and Physics“Ennio De Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3B’s research group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal Department of Experimental Medicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-sensing matrices are promising tools for the live monitoring of extracellular O_(2) consumption levels in long-term cell *** this study,ratiometric O_(2)-sensing membranes were prepared by electrospinning,an easy,low-cost,scalable,and robust method for fabricating ***(ε-caprolactone)and poly(dimethyl)siloxane polymers were blended with tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II)dichloride,which was used as the O_(2)-sensing probe,and rhodamine B isothiocyanate,which was used as the reference *** functionalized scaffolds were morphologically characterized by scanning electron microscopy,and their physicochemical profiles were obtained by Fourier transform infrared spectroscopy,thermogravimetric analysis,and water contact angle *** sensing capabilities were investigated by confocal laser scanning microscopy,performing photobleaching,reversibility,and calibration curve studies toward different dissolved O_(2)(DO)*** sensing nanofibers showed a high response to changes in DO concentrations in the physiological-pathological range from 0.5%to 20%and good stability under ratiometric *** addition,the sensing systems were highly biocompatible for cell growth promoting adhesiveness and growth of three cancer cell lines,namely metastatic melanoma cell line SK-MEL2,breast cancer cell line MCF-7,and pancreatic ductal adenocarcinoma cell line Panc-1,thus recreating a suitable biological environment in *** O_(2)-sensing biomaterials can potentially measure alterations in cell metabolism caused by changes in ambient O_(2)content during drug testing/validation and tissue regeneration processes.

关键词： Electrospinning Ruthenium(II)dichloride Oxygen sensors Ratiometric imaging Fluorescence

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Microstructure and water-swelling mechanism of red-bed mudstone in the Xining region,Northeastern Tibetan Plateau

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2537-2551页

作者： Huan Guan Yong Ren Sixiang Ling Xiyong Wu Tao Yu Xian Li Sen Wang Chunwei Sun School of Civil Engineering Southwest Jiaotong UniversityChengdu610031China Faculty of Geosciences and Engineering Southwest Jiaotong UniversityChengdu611756China Moe Key Laboratory of High-speed Railway Engineering Southwest Jiaotong UniversityChengdu610031China Guangzhou Metro Design and research Institute Co Ltd. Guangzhou510010China Chengdu City Construction Investment group Co Ltd. Chengdu610036China

This paper examines the effect of the microstructure and electrical conductivity(EC)on the swelling ratio and pressure in red-bed mudstone sampled from arid areas in the Xining region in the northeastern Tibetan Plateau.A series of laboratory tests,including swelling experiments,X-ray diffraction(XRD),and scanning electron microscope(SEM),was carried out for mechanical and microstructural *** coupled influence of the EC and microstructural parameters on the expansion ratio and pressure was investigated,and the weight coefficients were discussed by the entropy weight *** results revealed an increasing exponential trend in EC,and the maximum swelling speed occurred at an EC of approximately 10 mS/*** addition,a method for predicting the expansion potential is proposed based on the microstructure,and its reliability is verified by comparing with swelling experimental *** addition,according to the image analysis results,the ranges of the change in the clay minerals content(CMC),the fractal dimension(FD),the average diameter(AD)of pores,and the plane porosity(PP)are 23.75%e53%,1.08e1.17,7.53e22.45 mm,and 0.62%e1.25%,***,mudstone swelling is negatively correlated with the plane porosity,fractal dimension and average diameter and is linearly correlated with the clay mineral ***,the weight values prove that the microstructural characteristics,including FD,AD,and PP,are the main factors influencing the expansion properties of red-bed mudstones in the Xining *** on the combination of macro and micro-analyses,a quantitative analysis of the swelling process of mudstones can provide a better reference for understanding the mechanism of expansion behavior.

关键词： Mudstones Microstructure Swelling characteristics Electrical conductivity(EC) Scanning electron microscope Water-swelling

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Three-dimensional Modeling of Ore-forming Elements and Mineralization Prognosis for the Yechangping Mo Deposit,Henan Province,China

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 736-752页

作者： DING Gaoming JI Genyuan YAN Guolong XU Yongzhong WANG Kunming XIAO Chun WANG Quanle GUO Dongbao China National Administration of Coal Geology Beijing 100038China MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesCAGSBeijing 100037China China Gold group Geological Co. Ltd.Beijing 100011China China Gold group ZhongYuan Mining Co. Ltd.SanmenxiaHenan 472000China Lanzhou Mineral Exploration Institute of Gansu Nonferrous Metal Geological Exploration Bureau Lanzhou 730046China

Three-dimensional geochemical modeling of ore-forming elements is crucial for predicting deep *** approach provides key information for the quantitative prediction of deep mineral localization,three-dimensional fine interpolation,analysis of spatial distribution patterns,and extraction of quantitative mineral-seeking *** Yechangping molybdenum(Mo)deposit is a significant and extensive porphyry-skarn deposit in the East Qinling-Dabie Mo polymetallic metallogenic belt at the southern margin of the North China *** borehole data on oreforming elements underpin deep geochemical *** methodology includes the following steps:(1)Threedimensional geological modeling of the deposit was established.(2)Correlation,cluster,and factor analyses post delineation of mineralization stages and determination of mineral generation sequence to identify(Cu,Pb,Zn,Ag)and(Mo,W,mfe)assemblages.(3)A three-dimensional geochemical block model was constructed for Mo,W,mfe,Cu,Zn,Pb,and Ag using the ordinary kriging method,and the variational function was developed.(4)Spatial distribution and enrichment characteristics analysis of ore-forming elements are performed to extract geological information,employing the variogram and w(Cu+Pb+Zn+Ag)/w(Mo+W)as predictive indicators.(5)Identifying the western,northwestern,and southwestern areas of the mine with limited mineralization potential,contrasted by the northeastern and southeastern areas favorable for mineral exploration.

关键词： 3D geochemical model ore-forming elements geostatistics deep mineralization prediction Yechangping Mo deposit

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Study on the preservation effects of the amputated forelimb by machine perfusion at physiological temperature

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Chinese Journal of Traumatology 2024年第2期27卷 114-120页

作者： Sheng-Feng Chen Bo-Yao Yang Tie-Yuan Zhang Xiang-Yu Song Zhi-Bo Jia Lei-Jia Chen Meng-Yi Cui Wen-Jing Xu Jiang Peng Guizhou Medical University Guiyang550025China Medical School of PLA Beijing100048 China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLADepartment of OrthopedicsThe Fourth Medical CenterChinese PLA General HospitalBeijing100048China Hebei North Universiy Zhangjiakou075000Hebei ProvinceChina

Purpose:Ischemia and hypoxia are the main factors limiting limb replantation and *** cold storage(SCS),a common preservation method for tissues and organs,can only prolong limb ischemia time to 4-6 *** normothermic machine perfusion(NMP)is a promising method for the preservation of tissues and organs,which can extend the preservation time in vitro by providing continuous oxygen and *** study aimed to evaluate the difference in the efficacy of the 2 limb preservation ***:The 6 forelimbs from beagle dogs were divided into 2 *** the SCS group(n=3),the limbs were preserved in a sterile refrigerator at 4°C for 24 h,and in the NMP group(n=3),the perfusate prepared with autologous blood was used for the oxygenated machine perfusion at physiological temperature for 24 h,and the solution was changed every 6 *** effects of limb storage were evaluated by weight gain,perfusate biochemical analysis,enzyme-linked immunosorbent assay,and histological *** statistical analyses and graphs were performed using GraphPad Prism 9.0 one-way or two-way analysis of *** p value of less than 0.05 was considered to indicate statistical ***:In the NMP group,the weight gained percentage was 11.72%±4.06%;the hypoxia-inducible factor-1αcontents showed no significant changes;the shape of muscle fibers was normal;the gap between muscle fibers slightly increased,showing the intercellular distance of(30.19±2.83)μm;and the vascularα-smooth muscle actin(α-SMA)contents were lower than those in the normal blood *** creatine kinase level in the perfusate of the NMP group increased from the beginning of perfusion,decreased after each perfusate change,and remained stable at the end of perfusion showing a peak level of 4097.6 U/*** lactate dehydrogenase level of the NMP group increased near the end of perfusion and reached the peak level of 374.4 U/*** the SCS group,the percentage of weight gain was 0.18%±0.10%,a

关键词： Traumatic amputation Machine perfusion Static cold storage Limb replantation

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Electroacupuncture ameliorates blood-brain barrier disruption after ischemic stroke through histone acetylation regulation at the matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 2 genes

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Journal of Traditional Chinese Medicine 2024年第4期44卷 734-744页

作者： CHEN Yonglin OUYANG Ling MENG Lingling WU Bufan PENG Rou LIU Sitong HOU Dan WANG Yaling JING Xinyue LU Shengfeng FU Shuping Key Laboratory of Acupuncture and Medicine research of Ministry of Education Nanjing University of Chinese Medicine

OBJECTIVE: To explore whether the regulation of matrix metalloproteinase 9(MMP-9)/tissue inhibitors of MMPs(TIMPs) gene expression through histone acetylation is a possible mechanism by which electroacupuncture(EA)protects blood-brain barrier(BBB) integrity in a middle cerebral artery occlusion(MCAO) rat ***: Male Sprague-Dawley rats were divided into four groups: the sham group, the MCAO group, the MCAO + EA(MEA) group, and the MCAO + EA + HAT inhibitor(HATi) group. The MCAO model was generated by blocking the middle cerebral artery. EA was applied to Baihui(GV20). Samples were collected 1 or 3 d after reperfusion. Neurological function scores and Evans blue extravasation were employed to evaluate the poststroke injury. The effect of EA on MMP-9/TIMPs gene expression was assessed by real-time fluorescence quantitative polymerase chain reaction(RT-qPCR) and chromatin immunoprecipitation(ChIP). RESULTS: Our results showed that EA treatment prominently improved neurological function and ameliorated BBB disruption. The RT-qPCR assay showed that EA reduced the expression of MMP-9 and promoted TIMP-2 mRNA expression, but HATi reversed these effects of EA. In addition, ChIP results revealed that EA decreased the enrichment of H3K9ace/H3K27ace at MMP-9 promoters and notably stimulated the recruitment of H3K9ace/H3K27ace at TIMP-2 promoter. CONCLUSION: EA treatment at Baihui(GV20) regulates the transcription of MMP-9 and TIMP-2 through histone acetylation modification in the acute stage of stroke, which preserves the structural integrity of the BBB in MCAO rats. These findings suggested that the histone acetylation-mediated transcriptional activity of target genes may be a crucial mechanism of EA treatment in stroke.

关键词： blood-brain barrier electroacupuncture histone acetylation matrix metalloproteinase 9 tissue inhibitor of metalloproteinases

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Does topical vancomycin prevent fracture-related infections in closed fractures undergoing open reduction and internal fixation?A randomised controlled trial

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Chinese Journal of Traumatology 2024年第2期27卷 71-76页

作者： Mohit Gandhi Gopisankar Balaji Jagdish Menon Ruben Raj Thomas Department of Orthopaedics Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia Department of Preventive and Social Medicine Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia

Purpose:The role of topical vancomycin in fracture-related infection(FRI)is *** few studies have reported their efficacy in open and high-risk extremity *** study aimed to assess topical vancomycin's role in reducing FRI in closed fractures undergoing open surgical intervention with an ***:This prospective randomized cohort study was carried out between February 2021 to January *** with isolated closed fractures,who were planned for open reduction and internal fixation within 2 weeks from the time of injury were included for this *** data collected included age,gender,socioeconomic status,mechanism of injury,diagnosis,Tscherne classification,and time interval to take up for *** were randomized into the intervention and control groups using the block randomization *** control group received only systemic antibiotic prophylaxis,whereas the intervention group received topical application of vancomycin powder in the surgical wound alongside systemic antibiotic *** primary outcome measure was the incidence of FRI among these *** and radiological findings and culture reports(in cases with infection)were recorded during the post-operative period and at 6 weeks of *** relevant statistical calculations were done using STATA statistical/data analysis-parallel edition version 16.0(StataCorp LLC).The quantitative variables like age and duration of the surgery were assessed for normalcy by Shapiro-Wilk W *** independent samples t-test with equal variances was applied to the age ***'s exact test was used for the analysis of the primary outcome measure(presence of FRI following surgery),and"Risk of FRI"and"Risk difference"between the 2 groups was *** strength of the association between qualitative variables was assessed using the Fisher's exact and Chi-square tests,***:There were 88 patients included in this *** statistical si

关键词： Infections Antibiotics Vancomycin Fractures

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Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state

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Neural Regeneration research 2024年第10期19卷 2229-2239页

作者： Yubo Wang Ling Zhang Tianjie Lyu Lu Cui Shunying Zhao Xuechun Wang Meng Wang Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain research BeijingChina research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering research Center of Digital Healthcare for Neurological Diseases BeijingChina

Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome. We constructed a mouse model of transient middle cerebral artery occlusion and treated the mice with lipopolysaccharide to induce a hyperinflammatory state. To investigate the effect of DNA methylation on stroke, we used small molecule inhibitors to restrain the function of key DNA methylation and demethylation enzymes. 2,3,5-Triphenyltetrazolium chloride staining, neurological function scores, neurobehavioral tests, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot assay were used to evaluate the effects after stroke in mice. We assessed changes in the global methylation status by measuring DNA 5-mc and DNA 5-hmc levels in peripheral blood after the use of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tissue 2,3,5-triphenyltetrazolium chloride staining showed an increase in infarct volume, which was accompanied by a decrease in neurological scores and worsening of neurobehavioral performance. The levels of inflammatory factors interleukin 6 and interleukin-1 beta in ischemic brain tissue and plasma were elevated, indicating increased inflammation. Related inflammatory pathway exploration showed significant overactivation of nuclear factor kappa B. These results suggested that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following stroke. Further, the effects were reversed by inhibition of DNA demethylation. Our findings suggest that DNA methylation regulates the inflammatory response in stroke

关键词： DNA demethylation DNA methylation DNMT3A functional outcome hyperinflammatory state interleukin neuroinflammation stroke TET2

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Spatiotemporal variation of rainy season span and precipitation recorded by lacustrine laminated pollen in the Tibetan Plateau during the past two millennia

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Science China Earth Sciences 2024年第3期67卷 789-801页

作者： Anning CUI Houyuan LU Juzhi HOU Xingqi LIU Deke XU Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China group of Alpine Paleoecology and Human Adaptation State Key Laboratory of Tibetan Plateau Earth SystemResources and EnvironmentInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Capital Normal University College of Resource Environment and Tourism Beijing 100048China

The quantitative reconstruction of the length of the rainy season and precipitation on the Tibetan Plateau(TP) is crucial for revealing the spatiotemporal evolution of the Westerlies and Asian summer monsoon, as well as its ecological and environmental effects. Accurately determining the start and end times of the rainy season on the Plateau remains *** study determined the start and end times of the rainy season in different locations on the Plateau by identifying precipitation inflection points. We calculated the duration and precipitation amount of the rainy season and established a transfer function between the modern pollen assemblages and them. Then, we reconstructed the rainy season variations in Kusai Lake(northern TP) and Jiang Co(central TP) during the past two millennia. The results showed that, the rainy season precipitation in Kusai Lake recorded five periods of high precipitation: AD 580–680, 1000–1100, 1200–1450, 1550–1780, and 1920–present, corresponding to the stages with long rainy season. The rainy season precipitation sequence in Jiang Co recorded four periods of high precipitation: AD 80–500, 800–950, 1250–1450, and 1780–present, which is consistent with the long rainy season before AD 1000 but unclear afterward. Spatially, rainy season precipitation on the Plateau exhibited four patterns: “wet in both north and south” may be related to abnormally strong summer monsoons;“dry in both north and south” likely associated with weak Westerly wind and weak summer monsoon;“wet in the south and dry in the north” linked to strong summer monsoon and weak Westerly wind;and “dry in the south and wet in the north” connected to weak summer monsoon and strong Westerly wind. This study revealed the spatiotemporal evolution pattern of the rainy season onset and end, duration, and precipitation amount on the Plateau over the past two millennia. It provides natural background support for further understanding the coupling between Westerly wind and Asia

关键词： Tibetan Plateau Past two millennia Rainy season length Rainy season precipitation quantitative reconstruction

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Preoperative prediction of lymphovascular and perineural invasion in gastric cancer using spectral computed tomography imaging and machine learning

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World Journal of Gastroenterology 2024年第6期30卷 542-555页

作者： Hui-Ting Ge Jian-Wu Chen Li-Li Wang Tian-Xiu Zou Bin Zheng Yuan-Fen Liu Yun-Jing Xue Wei-Wen Lin Department of Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Fujian Key Laboratory of Intelligent imaging and Precision Radiotherapy for Tumors Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Digestive Hematological and Breast MalignanciesClinical Research Center for Radiology and Radiotherapy of Fujian ProvinceFuzhou 350001Fujian ProvinceChina Department of Radiation Oncology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Department of Diagnostic Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina School of Electrical and Computer Engineering University of OklahomaOklahomaOK 73019United States

BACKGROUND Lymphovascular invasion(LVI)and perineural invasion(PNI)are important prognostic factors for gastric cancer(GC)that indicate an increased risk of metastasis and poor *** preoperative prediction of LVI/PNI status could help clinicians identify high-risk patients and guide treatment ***,prior models using conventional computed tomography(CT)images to predict LVI or PNI separately have had limited *** CT provides quantitative enhancement parameters that may better capture tumor *** hypothesized that a predictive model combining clinical and spectral CT parameters would accurately preoperatively predict LVI/PNI status in GC *** To develop and test a machine learning model that fuses spectral CT parameters and clinical indicators to predict LVI/PNI status *** This study used a retrospective dataset involving 257 GC patients(training cohort,n=172;validation cohort,n=85).First,several clinical indicators,including serum tumor markers,CT-TN stages and CT-detected extramural vein invasion(CT-EMVI),were extracted,as were quantitative spectral CT parameters from the delineated tumor ***,a two-step feature selection approach using correlation-based methods and information gain ranking inside a 10-fold cross-validation loop was utilized to select informative clinical and spectral CT parameters.A logistic regression(LR)-based nomogram model was subsequently constructed to predict LVI/PNI status,and its performance was evaluated using the area under the receiver operating characteristic curve(AUC).RESULTS In both the training and validation cohorts,CT T3-4 stage,CT-N positive status,and CT-EMVI positive status are more prevalent in the LVI/PNI-positive group and these differences are statistically significant(Pgroup showed preoperative CT-T stage,CT-EMVI,single-energy CT values of 70 keV of venous phase(VP-70 keV),and the ratio of standardized iodine co

关键词： Spectral computed tomography Gastric cancer Lymphovascular invasion Perineural invasion

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