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肩软骨形态学、T1ρ及T2的MR定量评估

国际医学放射学杂志 2017年第1期 117-118页

作者： L.Nardo J.Carballido-Gamio S.Tang A.Lai R.Krug 屈瑾 musculoskeletal quantitative imaging research group Department of Radiology and Biomedical Imaging University of California

摘要目的本研究旨在评价在临床可行的扫描时间内,比较不同脉冲序列对软骨形态学及弛豫定量的可行性,评价其在3 T下的可重复性。方法比较3种脉冲序列(SPGR、

关键词：脉冲序列 MR T2 弛豫可重复性形态学软骨运动器官

以髋关节镜检查为标准验证髋关节炎MRI评分(SHOMRI)的准确性

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国际医学放射学杂志 2019年第2期42卷 249-250页

作者： J.Neumann A.L.Zhang B.J.Schwaiger M.A.Samaan R.Souza S.C.Foreman 宋燕燕(译) 赵世华(校) musculoskeletal quantitative imaging research group Department of Radiology&Biomedical ImagingUniversity of California San Francisco185 Berry StSuite 350San FranciscoCA 94107USA 不详

目的基于髋关节镜对髋关节异常的评估来验证术前髋关节MRI检查进行髋关节炎MRI评分(SHOMRI)分级的准确性。方法2名放射科医师回顾性分析了39例股骨髋臼撞击综合征病人[平均年龄(34.7±9.0)岁。

关键词：髋关节炎髋关节镜 SHOMRI

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Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome

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World Journal of Gastroenterology 2007年第27期13卷 3699-3704页

作者： Clive H Wilder-Smith Joan Robert-Yap Brain-Gut research group Gastroenterology Group Practice Berne Switzerland Supported by the Brain-Gut Research Group Berne Switzerland

AIM： To investigate the role of endogenous pain modulatory mechanisms in the central sensitization implicated by the visceral hypersensitivity demonstrated in patients with irritable bowel syndrome （IBS）. Dysfunction of modulatory mechanisms would be expected to also result in changes of somatic sensory function. METHODS： Endogenous pain modulatory mechanisms were assessed using heterotopic stimulation and somatic and visceral sensory testing in IBS. Pain intensities （visual analogue scale, VAS 0-100） during suprathreshold rectal distension with a barostat, cold pressor stimulation of the foot and during both stimuli simultaneously （heterotopic stimulation） were recorded in 40 female patients with IBS and 20 female healthy controls. RESULTS： Rectal hypersensitivity （defined by 95% Cl of controls） was seen in 21 （53%）, somatic hypersensitivity in 22 （55%） and both rectal and somatic hypersensitivity in 14 of these IBS patients. Heterotopic stimulation decreased rectal pain intensity by 6 （-11 to -1） in controls, but increased rectal pain by 2 （-3 to ＋6） in all IBS patients （P 〈 0.05） and by 8 （-2 to ＋19） in IBS patients with somatic and visceral hypersensitivity （P 〈 0.02）. CONCLUSION： A majority of IBS patients had abnormal endogenous pain modulation and somatic hypersensitivity as evidence of central sensitization.

关键词： Diffuse noxious inhibitory controls Endogenous pain modulation Hypersensitivity Irritable Bowel Syndrome quantitative sensory testing Visceral pain Sensitization

A novel technique for sacropelvic fixation using image-guided sacroiliac screws:a case series and biomechanical study

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The Journal of Biomedical research 2019年第3期33卷 208-216页

作者： Kee D.Kim Huy Duong Aditya Muzumdar Mir Hussain Mark Moldavsky Bandon Bucklen Department of Neurological Surgery University of California Davis Department of Neurosurgery Kaiser Permanente Medical group musculoskeletal Education and research Center(MERC) Globus Medical Inc

In this study, we sought to assess the safety and accuracy of sacropelvic fixation performed with image-guided sacroiliac screw placement using postoperative computed tomography and X-rays. The sacroiliac screws were placed with navigation in five patients. Intact specimens were mounted onto a six-degrees-of-freedom spine motion simulator. Long lumbosacral constructs using bilateral sacroiliac screws and bilateral S1 pedicle and iliac screws were tested in seven cadaveric spines. Nine sacroiliac screws were well-placed under an image guidance system(IGS);one was placed poorly without IGS with no symptoms. Both fixation techniques significantly reduced range of motion(Presearch concluded that rigid lumbosacral fixation can be achieved with sacroiliac screws,and image guidance improves its safety and accuracy. This new technique of image-guided sacroiliac screw insertion should prove useful in many types of fusion to the sacrum, particularly for patients with poor bone quality,complicated anatomy, infection, previous failed fusion and iliac harvesting.

关键词： lumbosacral fixation sacropelvic fixation sacroiliac screw computer-assisted surgery image-guided surgery

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On the use of horizontal acoustic Doppler profilers for continuous bed shear stress monitoring

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International Journal of Sediment research 2013年第2期28卷 260-268页

作者： B.VERMEULEN AJF HOITINK MG SASSI Hydrologyand quantitative Water Management group Department of Environmental SciencesWageningen UniversityPO Box 476700AA Wageningenthe Netherlands Ph.D.Candidate Institute for Marine and Atmospheric research Department of Physical Geography Utrecht UniversityPO Box 80.0053508TA Utrechtthe Netherlands Assoc.Prof. Hydrologyand quantitative Water Management group Department of Environmental SciencesWageningen UniversityPO Box 476700AA Wageningenthe Netherlands Hydrologyand quantitative Water Management group Department of Environmental SciencesWageningen UniversityPO Box 476700AA Wageningenthe Netherlands Dr.

Continuous monitoring of bed shear stress in large river systems may serve to better estimate alluvial sediment transport to the coastal *** we explore the possibility of using a horizontally deployed acoustic Doppler current profiler(ADCP) to monitor bed shear stress,applying a prescribed boundary layer model,previously used for discharge *** model parameters include the local roughness length and a dip correction factor to account for sidewall *** these parameters depend on river stage and on the position in the cross-section, and were estimated from shipborne ADCP *** applied the calibrated boundary layer model to obtain bed shear stress estimates over the measuring range of the *** validate the results,co-located coupled ADCPs were used to infer bed shear stress,both from Reynolds stress profiles and from mean velocity profiles. From HADCP data collected over a period of 1.5 years,a time series of width profiles of bed shear stress was obtained for a tidal reach of the Mahakam River,East Kalimantan,Indonesia.A smaller dataset covering 25 hours was used for comparison with results from the coupled *** bed shear stress estimates derived from Reynolds stress profiles appeared to be strongly affected by local effects causing upflow and downflow,which are not included in the boundary layer model used to derive bed shear stress with the horizontal *** shear stresses from the coupled ADCP are representative of a much more localized flow,while those derived with the horizontal ADCP resemble the net effect of the flow over larger *** shear stresses obtained from mean velocity profiles from the coupled ADCPs show a good agreement between the two methods,and highlight the robustness of the method to uncertainty in the estimates of the roughness length.

关键词： Bed-shear stress Horizontal ADCP Coupled ADCP Mahakam river Reynolds stress profiles

Comparison of Ontario’s roundwood and recycled fibre pulp and paper mills’performance using data Envelopment analysis

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Journal of Management Analytics 2021年第2期8卷 222-251页

作者： Shashi K.Shahi Mohamed Dia Supply Chain and Operations Management research group in Operations Analytics and Decision SciencesDepartment of Finance and OperationsFaculty of ManagementLaurentian UniversitySudburyONP3E 2C6Canada quantitative Methods and Operations Management Research Group in OperationsAnalytics and Decision SciencesDepartment of Finance and OperationsFaculty of ManagementLaurentian UniversitySudburyONCanada

The pulp and paper industry converts roundwood and recycled fibre,collected from wastepaper into printing and writing papers,and other specialty grades of *** pulp and paper mills in Ontario have been facing extreme competitive pressures,which have affected their performance leading to several mill *** purpose of this study is to evaluate and compare the relative performance of three types of Ontario’s pulp and paper mills(using all fibre,only roundwood fibre,and only recycled fibre).This study uses bootstrap data envelopment analysis in analyzing and comparing the operational efficiency of the Ontario’s pulp and paper mills,with 224 sample data observations over a period of 17 *** results indicate low levels of overall technical and managerial efficiencies in the pulp and paper mills using recycled *** results of the study highlight that the pulp and paper industry needs to divert their attention to streamlining the manufacturing processes,reducing costs,improving raw material usage,and making capital investments in the new and improved technology,in order to improve the operational efficiency and competitiveness of the Ontario’s pulp and paper *** pulp and paper mills using recycled fibre require huge capital investments,especially for installing the latest de-inking *** results of this study provide policy makers with detailed performance analysis so that future input resources can be reallocated to improve the performance of the pulp and paper mills in Ontario.

关键词： bootstrapping data envelopment analysis forest industry recycled fibre roundwood fibre technical efficiency Ontario Canada

Prognostic values of tumor endothelial markers in patients with colorectal cancer

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World Journal of Gastroenterology 2005年第9期11卷 1283-1286页

作者： KA Rmali MCA Puntis WG Jiang Metastasis and Angiogenesis research group University Department of Surgery

AIM: Tumor endothelial markers (TEMs) are a newly discovered family of endothelial markers associated with tumor specificangiogenesis. This study sought to examine the levels of expression (qualitatively and quantitatively)for TEMs in human colon ***: Human colorectal cancer tissues (n = 48)and normal background tissues (n = 31) were obtained after surgery. RNA was extracted from frozen sections for gene amplification. The expression of TEMs (TEM-1to TEM-8) was assessed using RT-PCR and their transcript levels were determined using real-time-quantitative PCR(Q-RT-PCR).RESULTS: TEM-1 (P = 0.01), TEM-7 (P = 0.04), TEM-7R(P= 0.03), TEM-8 (P = 0.001) significantly raised in colon cancer tissues compared with the levels detected in normal background tissues. The expressions of TEM-2 and TEM-6were found to be not significantly different between tumor tissues and normal tissues (P＞0.05). Patients who had cancer penetrating into and through the muscularis propria of the bowel wall and developed nodal involvement(Dukes C) exhibited significantly higher levels of TEM -8compared to patients who were node negative (P＜0.05).TEM-7 and TEM-7R showed high level of transcripts in Dukes C, but they were not statistically ***: The level of the expression of TEM-1,TEM-7, TEM-7R and TEM-8 (but not TEM-2 and TEM-6)were associated with both nodal involvement and disease progression, and may therefore, have a prognostic value in colorectal cancer.

关键词： Colon cancer Angiogenesis Tumor endothelial markers Dukes stages

Adiponectin signalling in bone homeostasis,with age and in disease

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Bone research 2021年第1期9卷 15-25页

作者： Jonathan W.Lewis James R.Edwards Amy J.Naylor Helen M.McGettrick Rheumatology research group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&Regeneration research group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and *** studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,human studies often demonstrate an inverse relationship between adiponectin concentration and bone ***,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional *** such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease.

关键词： homeostasis metabolism consequences

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应用MRI化学位移水/脂肪分离技术对绝经后妇女的腓肠肌脂肪浸润进行定量评估并与临床半定量评估进行对比的研究

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国际医学放射学杂志 2012年第5期 500-501页

作者： H.Alizai L.Nardo D.C.Karampinos G.B.Joseph S.P.Yap T.Baum 吴垠垠 musculoskeletal and quantitative imaging research group Department of Radiology and Biomedical ImagingUniversity of CaliforniaSan Francisco185 Berry StreetSuite 350San FranciscoCA 94107USA

摘要目的比较评价肌肉脂肪浸润的半定量Goutallier分级方法和定量的MRI化学位移水/脂肪分离技术的一致性。方法62例女性[年龄(61±6)岁],其中27例患糖尿病,在3T MRI上进行腓肠肌的T1快速自旋回波序列和梯度回波序列扫描。用IDEAL算法计... 详细信息

摘要目的比较评价肌肉脂肪浸润的半定量Goutallier分级方法和定量的MRI化学位移水/脂肪分离技术的一致性。方法62例女性[年龄(61±6)岁],其中27例患糖尿病,在3T MRI上进行腓肠肌的T1快速自旋回波序列和梯度回波序列扫描。用IDEAL算法计算水/脂肪图像和脂肪分数图,并通过T2*修正和多峰模型重建脂肪谱图。

关键词：骨骼肌 MRI 脂肪组织新陈代谢综合征神经肌疾病肌肉衰减症