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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric research institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/Ps1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

Breaking solvation Dominance Effect Enabled by Ion-Dipole Interaction Toward Long-spanlife silicon Oxide Anodes in Lithium-Ion Batteries

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Nano-Micro Letters 2025年第4期17卷 367-380页

作者： shengwei Dong Lingfeng shi shenglu Geng Yanbin Ning Cong Kang Yan Zhang Ziwei Liu Jiaming Zhu Zhuomin Qiang Lin Zhou Geping Yin Dalong Li Tiansheng Mu shuaifeng Lou state Key Laboratory of space Power-sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China school of Marine science and Technology Harbin Institute of Technology at WeihaiWeihai 264200People’s Republic of China Chongqing research institute of HIT Chongqing 401135People’s Republic of China

Micrometer-sized silicon oxide(siO)anodes encounter challenges in large-scale applications due to significant volume expansion during the alloy/de-alloy ***,an innovative deep eutectic electrolyte derived from succinonitrile is introduced to enhance the cycling stability of siO *** functional theory calculations validate a robust ion-dipole interaction between lithium ions(Li^(+))and succinonitrile(sN).The cosolvent fluoroethylene carbonate(FEC)optimizes the Li^(+)solvation structure in the sN-based electrolyte with its weakly solvating *** dynamics simulations investigate the regulating mechanism of ion-dipole and cation-anion *** unique Li^(+)solvation structure,enriched with FEC and TFsI^(-),facilitates the formation of an inorganic-organic composite solid electrolyte interphase on siO ***-CT further detects the inhibiting effect on the siO volume *** a result,the siO|LiCoO_(2) full cells exhibit excellent electrochemical performance in deep eutectic-based *** work presents an effective strategy for extending the cycle life of siO anodes by designing a new sN-based deep eutectic electrolyte.

关键词： Lithium-ion batteries Micrometer-sized silicon oxide Ion-dipole interaction Long-term cycling

Antidepressive and anxiolytic effects of a combination of saffron and Chamomile in rats and their relationship with serotonin using in vivo methods

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Journal of Traditional Chinese Medicine 2025年第1期45卷 49-56页

作者： Faiq Amin saara Ahmad Muhammad Wasim Asra Khan Fazal Manzoor Arain Zehra Batool saiqa Tabassum saima Khaliq Noreen samad saida Haider Department of Biological and Biomedical sciences the Aga Khan University Maternal and children's Health research institute Shunde Women and Children's HospitalGuangdong Medical University Dr.Panjwani Center for Molecular Medicine and Drug research International Center for Chemical and Biological SciencesUniversity of Karachi Department of Biosciences Shaheed Zulfikar Ali Bhutto Institute of Science and Technology Department of Biochemistry Federal Urdu University of ScienceArts and Technology Department of Biochemistry Bahauddin Zakariya University Department of Biochemistry University of Karachi

OBJECTIVE: To explore the potential of combining natural herbs like chamomile and saffron for the management of anxiety and depression. METHODs: A rodent model of Major Depressive Disorder(MDD) and anxiety, secondary to streptozotocin-induced diabetes mellitus was made. A total of 6 rat groups were chosen; healthy and diseased controls; and diseased test groups of fluoxetine, saffron, chamomile, and combined saffron and chamomile treated(n = 6/group). Activity by forced swim test(FsT), elevated plus maze test(EPMT), and correlations with biochemical markers like serum glucose, tryptophan, C-reactive protein(CRP), brain derived neurotrophic factor(BDNF) and 5-hydroxytryptamine 2C receptor(5HT2CR) expression, were assessed at the end of the 3rd week of the treatment. A one-way analysis of variance with a post-hoc Tukey's test was applied. REsULTs: The combined herbal treatment group showed significantly better(P s in terms of anti-hyperglycemic effect. All treatments improved the CRP levels; however, the combination group was also significantly better than fluoxetine and the individual herb groups. Only the herb groups showed efficacy in the FsT with added benefits of the combination group over the healthy controls and similar trends in the EPMT. However, expression of 5HT2CR was repressed while BDNF was elevated through treatment. CONCLUsION: This study shows that in comparison to treatment with a ssRI, and individual herbs, the combination of chamomile and saffron showed overall improved outcomes.

关键词： chamomile crocus depression diabetes mellitus

Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

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Neural Regeneration research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry Timothy Barrett sovan sarkar I-sTEM CECSCorbeil-EssonnesFrance UniversitéParis-saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance institute of Cancer and Genomic sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

Atomically Precise Cu Nanoclusters:Recent Advances,Challenges,and Perspectives in synthesis and Catalytic Applications

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Nano-Micro Letters 2025年第4期17卷 130-165页

作者： Mengyao Chen Chengyu Guo Lubing Qin Lei Wang Liang Qiao Kebin Chi Zhenghua Tang New Energy research institute School of Environment and EnergySouth China University of TechnologyGuangzhou Higher Education Mega CentreGuangzhou 510006People’s Republic of China Petrochemical research institute PetroChina Company LimitedBeijing 102206People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry(Heilongjiang University) Ministry of EducationHarbin 150001People’s Republic of China

Atomically precise metal nanoclusters are an emerging type of nanomaterial which has diverse interfacial metal-ligand coordination motifs that can significantly affect their physicochemical properties and *** that,Cu nanoclusters have been gaining continuous increasing research attentions,thanks to the low cost,diversified structures,and superior catalytic performance for various *** this review,we first summarize the recent progress regarding the synthetic methods of atomically precise Cu nanoclusters and the coordination modes between Cu and several typical ligands and then discuss the catalytic applications of these Cu nanoclusters with some explicit examples to explain the atomical-level structure-performance ***,the current challenges and future research perspectives with some critical thoughts are *** hope this review can not only provide a whole picture of the current advances regarding the synthesis and catalytic applications of atomically precise Cu nanoclusters,but also points out some future research visions in this rapidly booming field.

关键词： Atomically precise Cu nanoclusters Controllable synthesis Catalytic applications structure-performance relationship Challenges and perspectives

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration research 2025年第11期20卷 3217-3218页

作者： Laura Huggon Emma L.Clayton UK Dementia research institute at King’s College London LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALs)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALs affecting upper and lower motor neurons),these two diseases are complexly *** and ALs exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci

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Chinese Journal of Cancer research 2025年第01期 1-13页

作者： Wenli Zhang Jinhong Zhu Mengzhen Zhang Jiaming Chang Jiabin Liu Liping Chen Xinxin Zhang Haiyan Wu Chunlei Zhou Jing He Department of Pediatric surgery Guangzhou Institute of Pediatrics Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease Guangzhou Women and Children's Medical Center Guangzhou Medical University Department of Clinical Laboratory Biobank Harbin Medical University Cancer Hospital Department of Pathology Children's Hospital of Nanjing Medical University

Objective: Neuroblastoma is the most common extracranial solid tumor in children and has complex genetic underpinnings. Previous genome-wide association studies(GWAss) have identified many loci associated with neuroblastoma susceptibility; however, their application in risk prediction for Chinese children has not been systematically explored. This study seeks to enhance neuroblastoma risk prediction by validating these loci and evaluating their performance in polygenic risk ***: We validated 35 GWAs-identified neuroblastoma susceptibility loci in a cohort of Chinese children,consisting of 402 neuroblastoma patients and 473 healthy controls. Genotyping these polymorphisms was conducted via the TaqMan method. Univariable and multivariable logistic regression analyses revealed the genetic loci significantly associated with neuroblastoma risk. We constructed polygenic risk models by combining these loci and assessed their predictive performance via area under the curve(AUC) analysis. We also established a polygenic risk scoring(PRs) model for risk prediction by adopting the PLINK ***: Fourteen loci, including ten protective polymorphisms from CAsC15, BARD1, LMO1, HsD17B12, and HACE1, and four risk variants from BARD1, RsRC1, CPZ and MMP20 were significantly associated with neuroblastoma risk. Compared with single-gene model, the 8-gene model(AUC=0.72) and 13-gene model(AUC=0.73) demonstrated superior predictive performance. Additionally, a PRs incorporating six significant loci achieved an AUC of 0.66, effectively stratifying individuals into distinct risk categories regarding neuroblastoma susceptibility. A higher PRs was significantly associated with advanced International Neuroblastoma staging system(INss) stages, suggesting its potential for clinical risk ***: Our findings validate multiple loci as neuroblastoma risk factors in Chinese children and demonstrate the utility of polygenic risk models, particularly the PRs, in

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A dry-electrode enabled ECG-on-Chip with arrhythmia-aware data transmission

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science China(Information sciences) 2025年第2期68卷 338-353页

作者： Xinzi XU Yanxing sUO Yang ZHAO Peiyi ZHOU Xiao HAN Qiao CAI Min WANG Jiajun YUAN Liebin ZHAO Yongfu LI Guoxing WANG Yong LIAN Department of Micro-Nano Electronics and MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong University Pediatric AI Clinical Application and research Center Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP)Child Health Advocacy InstituteShanghai Children's Medical CenterSchool of MedicineShanghai Jiao Tong University shanghai Engineering research Center of Intelligence Pediatrics (sERCIP) Xin Hua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine

Early detection and treatment of cardiovascular diseases(CVDs) can be significantly enhanced through the use of flexible wearable electrocardiogram(ECG) sensors, potentially reducing CVD-related mortality. This paper introduces an ECG-on-Chip(EoC) solution tailored for flexible ECG sensors, incorporating novel features to address common challenges in wearable ECG technology. The EoC integrates a chopper-stabilized capacitively-coupled instrumentation amplifier(Cs-CCIA),ensuring a high common-mode rejection ratio(CMRR) and low noise performance. Performance is further boosted via a positive feedback loop(PFL) and a programmable gain amplifier(PGA) with shared on-chip calibration logic, which enhances input impedance and minimizes gain variability to ensure consistent algorithm performance. Additionally, a secondary chopping technique is employed to further reduce noise, achieving an input-referred noise level of 454 nVrms. The embedded algorithm within the EoC is designed to extract clinically meaningful features, facilitating robust real-time arrhythmia analysis. Fabricated using a 0.18 μm CMOs process, the EoC consumes 14.9 μW with a supply voltage of 1.2 V. The algorithm's efficacy has been validated over 0.4 million heartbeats, demonstrating a sensitivity of over 99.7% for R-peak detection and 98.3% for arrhythmia analysis. To demonstrate practical application, the EoC has been integrated with a commercial Bluetooth low energy(BLE)transceiver, forming a wireless arrhythmia monitoring sensor equipped with dry electrodes. This system consumes 292.04 μW in arrhythmia-aware transmission mode, supporting 13 days of operation with a 30 mAh thin-film battery.

关键词： ECG flexible dry electrodes analog front-end abnormality detection AsIC wireless transmission

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Ammonium sensing Patch with Ultrawide Linear Range and Eliminated Interference for Universal Body Fluids Analysis

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Nano-Micro Letters 2025年第4期17卷 332-346页

作者： Mingli Huang Xiaohao Ma Zongze Wu Jirong Li Yuqing shi Teng Yang Jiarun Xu shuhan Wang Kongpeng Lv Yuanjing Lin school of Microelectronics Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Interventional Radiology Shenzhen People’s HospitalShenzhen 518020People’s Republic of China College of Mechanical and Energy Engineering Shaoyang UniversityShaoyang 422000HunanPeople’s Republic of China shenzhen Hainwise Medical Technology Co. LTDShenzhen 518118People’s Republic of China shenzhen institute for Drug Control(shenzhen Testing Center of Medical Devices) Shenzhen 518000People’s Republic of China institute of Innovative Materials Guangming Advanced Research InstituteSouthern University of Science and TechnologyShenzhen 518055People’s Republic of China

Ammonium level in body fluids serves as one of the critical biomarkers for healthcare,especially those relative to liver *** continuous and real-time monitoring in both invasive and noninvasive manners is highly desired,while the ammonium concentrations vary largely in different body ***,the sensing reliability based on ion-selective biosensors can be significantly interfered by potassium *** tackle these challenges,a flexible and biocompatible sensing patch for wireless ammonium level sensing was reported with an ultrawide linear range for universal body fluids including blood,tears,saliva,sweat and *** as-prepared biocompatible sensors deliver a reliable sensitivity of 58.7 mV decade-1 in the range of 1-100 mM and a desirable selectivity coefficient of 0.11 in the interference of potassium ions,attributed to the cross-calibration within the sensors *** sensor’s biocompatibility was validated by the cell growth on the sensor surface(>80%),hemolysis rates(sponses and weight changes of the mice with implanted *** biocompatible sensors with ultrawide linear range and desirable selectivity open up new possibility of highly compatible biomarker analysis via different body fluids in versatile approaches.

关键词： Biocompatible sensors Implantable bioelectronics Ammonium sensing Cross-calibration Ultrawide linear range