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接受药物注射者治疗过程中的急性乙肝暴发,其中暴发性肝衰竭的相关因素

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 49-50页

作者： Garfein R.S. Bower W.A. Loney C.M. 沈才飞 ctr. for dis. Contr. an d prevention Mailstop G37 1600 Clifton Road Atlanta GA 30017 United States

Death related to acute hepatitis B occurs in approximately 1%of patients. We investigated an outbreak of hepatitis B virus (HBV) infections among injection d rug users (IDUs) resulting in several deaths. We conducted a case-control study of fulminant (case patients) and nonfulminant (control patients) HBV infections . We directly sequenced the entire HBV genome from fulminant and nonfulminant ca ses. From October 1998 to July 2000,21 acute HBV infections, including 10 fulminant hepatitis B cases, were identified. The med ian age was 30 (range, 18-49) years, 12 (57%) were female, 20 (95%) were Amer ican Indians, and 20 (95%) reported injecting illicit drugs. All patients with fulminant hepatitis B died (case-fatality rate = 47.6%). Case patients (n = 5) and control patients (n = 9) were similar with respect to age, sex, race, and h epatitis C virus serostatus. All case patients used acetaminophen during their i llness compared with 44%of control patients (P = .08). Compared with control pa tients, case patients lost more weight in the 6 months before illness (P = .04); during their illness, they used more alcohol (P = .03) and methamphetamine (P = .04). All 9 isolates sequenced were genotype D, shared 99.7%homology, and incl uded mutations previously described in association with fulminant hepatitis B. I n conclusion, a high prevalence of exposure to factors potentiating hepatic dama ge with acute hepatitis B contributed to the outbreak’s high mortality rate; mu tations present in the outbreak strain might also have been a factor. Improved v accination coverage among IDUs has the potential to prevent similar outbreaks in the future.

关键词：急性乙肝暴发性肝衰竭注射者急性乙型肝炎肝损害印地安人病例对照研究乙酰氨基酚发病期间同源性

抗酵母菌属抗体阳性与克罗恩病早期手术危险性增高相关

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 42-43页

作者： Forcione D.G. Rosen M.J. Kisiel J.B. Sands B.E. 马卉 Gastrointestinal Unit Ctr. Stud. Inflammatory Bowel Dis. Massachusetts General Hospital 55 Fruit StBostonMA02114United States

Background: Anti-Saccharomyces cerevisiae antibodies(ASCA) are a specific but only moderately sensitive diagnostic marker for Crohn s disease. We sought to explore the role of ASCA as a prognostic marker for aggressive disease phenotype in Crohn s disease. Aims: To determine the role of ASCA status as a risk factor for early surgery in Crohn s disease. Subjects:We performed a case control study in a cohort of patients, newly diagnosed with Crohn s disease, between 1991 and 1999. All patients were followed for at least three years. Case subjects(n=35) included those who had major surgery for Crohn s disease within three years of diagnosis. controls (n=35) included patients matched to cases for age, sex, disease location,and smoking status, and who did not undergo major surgery for Crohn s disease within three years of diagnosis. Methods:Blinded assays were performed on serum for ASCA (immunoglobulin(Ig)A and IgG). A paired analysis of cases-controls was performed to test for the association between ASCA status and risk of early surgery. Results: ASCA IgA was strongly associated with early surgery (odds ratio (OR) 8.5 (95% confidence interval (CI) 2.0-75.9); p = 0.0013). ASCA IgG+ and ASCA IgG+/IgA+ patients were also at increased risk for early surgery (OR 5.5 (95% CI 1.2-51.1), p = 0.0265; and OR 5.0(95% CI 1.1-46.9), p = 0.0433, respectively). The association between ASCA and early surgery was evident in patients requiring surgery for ileal or ileocolonic disease. Conclusions:Patients with Crohn s disease who are positive for ASCA IgA,IgG, or both, may define a subset of patients with Crohn s disease at increased risk for early surgery.

关键词：手术危险性克罗恩病结肠疾病干预组侵袭性种特异性吸烟状况 IgG 病例对照研究盲法

Parallel distance: A New Paradigm of Measurement for Parallel Driving

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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 1169-1178页

作者： Teng Liu Hong Wang Bin Tian Yunfeng Ai Long Chen the Vehicle Intelligence Pioneers Inc. Qingdao 266109 the Department of Automotive Engineering Chongqing UniversityChongqing 400044China the Mechanical and Mechatronics Engineering Department Waterloo UniversityN2L 3G1Canada the State Key Laboratory of Management and control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China the School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China the School of Data and Computer Science Sun Yat-sen UniversityGuangzhou 510006China

In this paper, a new paradigm named parallel distance is presented to measure the data information in parallel driving system. As an example, the core variables in the parallel driving system are measured and evaluated in the parallel distance framework. First, the parallel driving 3.0 system included control and management platform, intelligent vehicle platform and remote-control platform is introduced. Then,Markov chain(MC) is utilized to model the transition probability matrix of control commands in these systems. Furthermore, to distinguish the control variables in artificial and physical driving conditions, different distance calculation methods are enumerated to specify the differences between the virtual and real signals. By doing this, the real system can be guided and the virtual system can be im-proved. Finally, simulation results exhibit the merits and multiple applications of the proposed parallel distance framework.

关键词： Artificial and physical system parallel distance parallel driving 3.0 parallel system rotational and accelerator signal

Experimental study on the effect of Kang-Lai-Te induced apoptosis of human hepatoma carcinoma cell HepG2

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Hepatobiliary & Pancreatic diseases International 2009年第3期8卷 267-272页

作者： Lu, Yun Wu, Li-Qun Dong, Qian Li, Chang-Sheng Qingdao Univ Dept Hepatobiliary Surg Affiliated Hosp Coll Med Qingdao 266003 Peoples R China Qingdao Univ Dept Pediat Surg Affiliated Hosp Coll Med Qingdao 266003 Peoples R China Qingdao Univ Ctr Cell & Mol Pathol Affiliated Hosp Coll Med Qingdao 266003 Peoples R China

BACKGROUND: Kang-Lai-Te (KLT) is extracted from the traditional Chinese herbal medicine Semen Coicis, which has been used in China as an effective clinical drug for over a thousand years. It contains numerous ingredients with anti-tumor effects. In our previous studies on transplanted hepatomas in rats, KLT could stop the cells in the G2+M stage of cell cycle and then reduce the number of cells entering the stage G0 and G1, but the mechanism of the anti-proliferative effect was unknown. In this experiment, we examined whether KLT inhibits HepG2 cell growth, if so, tried to explore its mechanism. METHODS: KLT at different concentrations was used for the treatment of hepatocellular carcinoma cells in vitro, respectively. The proliferation inhibitory rate was evaluated by MTT assay, induction of cell apoptosis rate and the protein levels of Fas and Fas ligand (FasL) were determined by flow cytometry (FCM), and the expression of Fas and FasL mRNA was detected by real-time fluorescent quantitative RT-PCR. RESULTS: KLT produced an obvious time and dose-dependent inhibitory effect on HepG2 cells, and marked apoptosis was detected by FCM The protein of Fas increased by 11.01%, 18.71%, 28.71% and 37.15%; the protein of FasL increased by 1.49%, 1.91%, 3.27% and 3.38% in comparison with the control (Pdis Int 2009; 8: 267-272)

关键词： Kang-Lai-Te drugs, Chinese herbal hepatocellular carcinoma HepG2 Fas/FasL