检索结果-南通市图书馆

HBV genotype C is independently associated with cirrhosis in community-based population

World Journal of Gastroenterology 2010年第3期16卷 379-383页

作者： Yin, Jian-Hua Zhao, Jun Zhang, Hong-Wei Xie, Jia-Xin Li, Wei-Ping Xu, Guo-Zhang Shen, Jie Dong, Hong-Jun Zhang, Jun Wang, Lin Han, Jian-Kang Wang, Hong-Yang Cao, Guang-Wen Second Mil Med Univ Dept Epidemiol Shanghai 200433 Peoples R China Second Mil Med Univ Affiliated Hosp 3 Dept Hepatobiliary Surg Shanghai 200438 Peoples R China Second Mil Med Univ Dept Ultrasonog Affiliated Hosp 1 Shanghai 200433 Peoples R China municipal ctr dis control & prevent Ningbo Ningbo 315010 Zhejiang Peoples R China municipal ctr dis control & prevent Soochow Suzhou 215007 Jiangsu Peoples R China dist ctr dis control & prevent Yangpu Shanghai 200090 Peoples R China municipal ctr dis control & prevent huzhou Huzhou 313000 Zhejiang Peoples R China Second Mil Med Univ Lab Signal Transduct Affiliated Hosp 3 Shanghai 200438 Peoples R China

AIM:To determine the association of hepatitis B virus (HBV) genotypes with probable cirrhosis and fatty liver in community-based ***: A multi-stage cluster probability sampling method was applied to recruit 10 167 subjects aged between 6 and 72 years from our epidemiological bases in Eastern China. After excluding the subjects co-infected with hepatitis C or hepatitis D viruses, the hepatitis B surface antigen (HBsAg)-positive subjects were examined for HBV genotype, serum viral load, alanine aminotransferase (ALT), hepatitis B e antigen (HBeAg) status, and ultrasonographic changes. Logistic regression models were used to determine the factors associated with probable cirrhosis and fatty ***: Of 634 HBsAg-positive subjects with HBV genotype determined, 82 had probable cirrhosis (ultrasonographic score ≥5), 42 had ultrasonographic fatty liver. Probable cirrhosis was only found in the HBeAg-negative subjects, and more frequently found in the subjects with genotype C than in those with genotype B (14.8% vs 8.0%, P=0.018). In HBeAg-negative subjects, high viral load was frequently asso-ciated with abnormal ALT level, while ALT abnormality was more frequent in those with probable cirrhosis than those without (19.5% vs 7.8%, P=0.001). Univariate analysis showed that age, sex, HBV genotypes, and viral load were not significantly associated with ultrasonographic fatty liver, whereas ALT abnormality was significantly related to ultrasonographic fatty liver (OR=4.54,95% CI:2.11-9.75, P<0.001). Multivariate analysis demonstrated that HBV genotype C, age (≥45 years), male sex, and ALT abnormality were independently associated with probable cirrhosis (AOR=2.30,95% CI:1.26-4.19; AOR =1.81,95% CI:1.10-2.99;AOR=1.74,95% CI:1.03-2.95; AOR=2.98,95% CI:1.48-5.99, respectively).CONCLUSION: A crude prevalence of probable cirrhosis is 12.9% in the community-based HBV-infected subjects. HBV genotype C is independently associated with probable cirrhosis in the HBe

关键词： Hepatitis B virus Genotype Viral load Alanine aminotransferase Probable cirrhosis Ultrasonography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis

引用

World Journal of Gastroenterology 2010年第7期16卷 886-896页

作者： Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai 200127 Peoples R China Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Shanghai 200011 Peoples R China Indiana Univ Sch Med Dept Cellular & Integrat Physiol Indianapolis IN 46202 USA Shanghai Inst Digest dis Shanghai 200001 Peoples R China Fudan Univ Huashan Hosp Dept Gastroenterol Shanghai 200040 Peoples R China Shanghai Hlth Dev Res ctr Shanghai 200040 Peoples R China

AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(***)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of controlled Trials,Premedline and *** ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention ***:Fifteen observational studies and 5 RCTs were identified and used for *** pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all ***:This meta-analysis on observational studies suggests an association between *** and *** RCTs,eradication of *** can improve HB and SF levels but not significantly.

关键词： Helicobacter pylori Iron-deficiency anemia Meta-analysis Hemoglobins Odds ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：