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Recent Developments in Metallic Degradable Micromotors for Biomedical and Environmental Remediation Applications

Nano-Micro Letters 2024年第3期16卷 1-35页

作者： Sourav Dutta Seungmin Noh Roger Sanchis Gual Xiangzhong Chen Salvador Pané Bradley J.Nelson Hongsoo Choi Department of robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea DGIST‑ETH Microrobotics Research center DGISTDaegu 42988Republic of Korea multi‑scale robotics Lab Institute of Robotics and Intelligent SystemsETH Zurich8092 ZurichSwitzerland Institute of Optoelectronics State Key Laboratory of Photovoltaic Science and TechnologyShanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionFudan UniversityShanghai 200433People’s Republic of China

Synthetic micromotor has gained substantial attention in biomedicine and environmental ***-based degradable micromotor composed of magnesium(Mg),zinc(Zn),and iron(Fe)have promise due to their nontoxic fuel-free propulsion,favorable biocompatibility,and safe excretion of degradation products Recent advances in degradable metallic micromotor have shown their fast movement in complex biological media,efficient cargo delivery and favorable biocompatibility.A noteworthy number of degradable metal-based micromotors employ bubble propulsion,utilizing water as fuel to generate hydrogen *** novel feature has projected degradable metallic micromotors for active in vivo drug delivery *** addition,understanding the degradation mechanism of these micromotors is also a key parameter for their design and *** propulsion efficiency and life span govern the overall performance of a degradable metallic *** we review the design and recent advancements of metallic degradable ***,we describe the controlled degradation,efficient in vivo drug delivery,and built-in acid neutralization capabilities of degradable micromotors with versatile biomedical ***,we discuss micromotors’efficacy in detecting and destroying environmental ***,we address the limitations and future research directions of degradable metallic micromotors.

关键词： Magnesium Zinc Iron Biodegradable microrobot Biomedical Environmental

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Light-based 3D printing of stimulus-responsive hydrogels for miniature devices:recent progress and perspective

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Bio-Design and Manufacturing 2024年第05期 721-746页

作者： Chen Xin Neng Xia Li Zhang Department of Mechanical and Automation Engineering The Chinese University of Hong Kong multi-scale medical robotics center Hong Kong Science Park Chow Yuk Ho Technology center for Innovative Medicine The Chinese University of Hong Kong Department of Surgery The Chinese University of Hong Kong CUHK T Stone robotics Institute The Chinese University of Hong Kong

Miniature devices comprising stimulus-responsive hydrogels with high environmental adaptability are now considered competitive candidates in the fields of biomedicine, precise sensors, and tunable optics. Reliable and advanced fabrication methods are critical for maximizing the application capabilities of miniature devices. Light-based three-dimensional(3D) printing technology offers the advantages of a wide range of applicable materials, high processing accuracy, and strong 3D fabrication capability, which is suitable for the development of miniature devices with various functions. This paper summarizes and highlights the recent advances in light-based 3D-printed miniaturized devices, with a focus on the latest breakthroughs in light-based fabrication technologies, smart stimulus-responsive hydrogels, and tunable miniature devices for the fields of miniature cargo manipulation, targeted drug and cell delivery, active scaffolds, environmental sensing, and optical imaging. Finally,the challenges in the transition of tunable miniaturized devices from the laboratory to practical engineering applications are presented. Future opportunities that will promote the development of tunable microdevices are elaborated, contributing to their improved understanding of these miniature devices and further realizing their practical applications in various fields.

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Efficient Dynamic Locomotion of Quadruped Robot via Adaptive Diagonal Gait

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Journal of Bionic Engineering 2024年第1期21卷 126-136页

作者： Jian Bi Teng Chen Xuewen Rong Guoteng Zhang Guanglin Lu Jingxuan Cao Han Jiang Yibin Li The center for robotics School of Control Science and EngineeringShandong UniversityJi Nan 250000China

Quadruped animals in the nature realize high energy efficiency locomotion by automatically changing their gait at different *** by this character,an efficient adaptive diagonal gait locomotion controller is designed for quadruped robot.A unique gait planning method is proposed in this *** the speed of robot varies,the gait cycle time and the proportion of stance and swing phase of each leg are adjusted to form a variety of *** optimal joint torque is calculated by the controller combined with Virtual Model Control(VMC)and Whole-Body Control(WBC)to realize the desired *** gait and step frequency of the robot can automatically adapt to the change of *** experiments are done with a quadruped robot made by our laboratory to verify that the gait can change automatically from slow-trotting to flying-trot during the period when speed is from 0 to 4 m/*** ratio of swing phase is from less than 0.5 to more than 0.5 to realize the running motion with four feet off the *** have shown that the controller can indeed consume less energy when robot runs at a wide range of speeds comparing to the basic controller.

关键词： Quadruped robot Gait transition Adaptive gait Energy efficiency

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蚯蚓直线运动的三轴地面反作用力:测量、分析和对机器人建模的影响

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Acta Mechanica Sinica 2024年第2期40卷 1-14页

作者：方虹斌师瑞徐鉴 Institute of AI and robotics State Key Laboratory of Medical NeurobiologyMOE Engineering Research Center of AI&RoboticsFudan UniversityShanghai200433China

蚯蚓在狭窄受限环境中具有良好的移动性,但其在运动过程中与地面的三轴反作用力还未被深入研究.本文探讨了蚯蚓在直线运动过程中的三轴地反力特征及其对机器人建模的影响.具体地,本研究设计了一个基于应变片的三轴微型测力板来测量蚯蚓(... 详细信息

蚯蚓在狭窄受限环境中具有良好的移动性,但其在运动过程中与地面的三轴反作用力还未被深入研究.本文探讨了蚯蚓在直线运动过程中的三轴地反力特征及其对机器人建模的影响.具体地,本研究设计了一个基于应变片的三轴微型测力板来测量蚯蚓(***)在直线运动时的三轴地反力.通过建立地反力的时间历程与运动视频的对应关系,将蚯蚓的周期性运动划分为三个阶段,并从蚯蚓身体变形的角度解析了地反力在三个阶段的力学特征.本研究还对蚯蚓的地反力特征进行了统计分析,并建立了蚯蚓直线运动过程的阻力系数模型.以此为基础,本文还提出了与机器人节段/单元变形相关的阻力系数模型,为离散型和连续型仿蚯蚓机器人的动力学建模提供基础.本研究首次对蚯蚓运动过程中的mN级三轴地反力进行了测量、分析和建模,研究结果对蚯蚓运动生物力学、仿蚯蚓移动机器人设计和机器人-环境接触界面调控等具有重要的指导意义.

关键词：移动机器人直线运动运动视频运动生物力学应变片周期性运动环境接触界面调控

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Micro/nanosystems for controllable drug delivery to the brain

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The Innovation 2024年第1期5卷 139-157页

作者： Mingzhen Tian Zhichao Ma Guang-Zhong Yang Institute of medical robotics School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Drug delivery to the brain is crucial in the treatment for central nervous system *** significant progress has been made in recent years,there are still major challenges in achieving controllable drug delivery to the *** clinical needs arise from various factors,including controlled drug transport,handling large drug doses,methods for crossing biological barriers,the use of imaging guidance,and effective models for analyzing drug *** advances in micro/nanosystems have shown promise in addressing some of these *** include the utilization of microfluidic platforms to test and validate the drug delivery process in a controlled and biomimetic setting,the development of novel micro/nanocarriers for large drug loads across the blood-brain barrier,and the implementation of micro-intervention systems for delivering drugs through intraparenchymal or peripheral *** this article,we present a review of the latest developments in micro/nanosystems for controllable drug delivery to the *** also delve into the relevant diseases,biological barriers,and conventional *** addition,we discuss future prospects and the development of emerging robotic micro/nanosystems equipped with directed transportation,real-time image guidance,and closed-loop control.

关键词： equipped doses barriers

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Hemispherical resonator with low subsurface damage machined by small ball-end fine diamond grinding wheel:A novel grinding technique

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Chinese Journal of Aeronautics 2024年第5期37卷 570-585页

作者： Biao QIN Henan LIU Jian CHENG Jinchuan TIAN Jiangang SUN Zihan ZHOU Chuanzhen MA Mingjun CHEN State Key Laboratory of robotics and System Harbin Institute of TechnologyHarbin 150001China center for Precision Engineering Harbin Institute of TechnologyHarbin 150001China

As for the ultra-precision grinding of the hemispherical fused silica resonator,due to the hard and brittle nature of fused silica,subsurface damage(SSD)is easily generated,which enormously influences the performance of such ***,ultra-precision grinding experiments are carried out to investigate the surface/subsurface quality of the hemispherical resonator machined by the small ball-end fine diamond grinding *** influence of grinding parameters on the surface roughness(SR)and SSD depth of fused silica samples is then *** experimental results indicate that the SR and SSD depth decreased with the increase of grinding speed and the decrease of feed rate and grinding *** addition,based on the material strain rate and the maximum undeformed chip thickness,the effect of grinding parameters on the subsurface damage mechanism of fused silica samples is ***,a multi-step ultra-precision grinding technique of the hemispherical resonator is proposed based on the interaction influence between grinding depth and feed ***,the hemispherical resonator is processed by the proposed grinding technique,and the SR is improved from 454.328 nm to 110.449 nm while the SSD depth is reduced by 94%from 40μm to 2.379μ*** multi-step grinding technique proposed in this paper can guide the fabrication of the hemispherical resonator.

关键词： Fused silica Ultra-precision grinding Hemispherical resonator Subsurface damage Grinding technique

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Establishment of Constraint Relation of Robot Dynamics Equation Based on Kinematic Influence Coefficients Method

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Journal of Shanghai Jiaotong university(Science) 2024年第3期29卷 450-456页

作者：徐亚茹李克鸿商新娜金晓明刘荣张建成 Beijing Engineering Research center of Smart Mechanical Innovation Design Service Beijing Union UniversityBeijing 100027China College of robotics Beijing Union UniversityBeijing 100020China robotics Institute Beihang UniversityBeijing 100191China

Due to the diversity of work requirements and environment,the number of degrees of freedom(DOFs)and the complexity of structure of industrial robots are constantly *** is difficult to establish the accurate dynamical model of industrial robots,which greatly hinders the realization of a stable,fast and accurate trajectory tracking ***,the general expression of the constraint relation in the explicit dynamic equation of the multi-DOF industrial robot is derived on the basis of solving the Jacobian matrix and Hessian matrix by using the kinematic influence coefficients ***,an explicit dynamic equation with general constraint relation expression is established based on the Udwadia-Kalaba *** problem of increasing the time of establishing constraint relationship when the multi-DOF industrial robots complete complex task constraints is *** the SCARA robot as the research object,the simulation results show that the proposed method can provide a new idea for industrial robot system modeling with complex constraints.

关键词： industrial robot constraint relationship kinematic influence coefficients method Jacobian matrix Hessian matrix

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Game theory based finite-time formation control using artificial potentials for tethered space net robot

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Chinese Journal of Aeronautics 2024年第8期37卷 358-372页

作者： Yifeng MA Yizhai ZHANG Panfeng HUANG Ya LIU Fan ZHANG The Research center for Intelligent robotics School of AstronauticsNorthwestern Polytechnical UniversityXi’an 710072China School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The Tethered Space Net Robot(TSNR)is an innovative solution for active space debris capture and *** large envelope and simple capture method make it an attractive option for this ***,capturing maneuverable debris with the flexible and elastic underactuated net poses significant *** address this,a novel formation control method for the TSNR is proposed through the integration of differential game theory and robust adaptive control in this ***,the trajectory of the TSNR is obtained through the solution of a real-time feedback pursuit-evasion game with a dynamic target,where the primary condition is to ensure the stability of the ***,to minimize tracking errors and maintain a specific configuration,a robust adaptive formation control scheme with Artificial Potential Field(APF)based on a Finite-Time Convergent Extended State Observer(FTCESO)is *** proposed control method has a key advantage in suppressing complex oscillations by a new adaptive law,thus precisely maintaining the ***,numerical simulations are performed to demonstrate the effectiveness of the proposed scheme.

关键词： Game theory Formation control Artificial potential field Relative distance constraint Tethered space net robot(TSNR)

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Dynamic adaptive spatio-temporal graph network for COVID-19 forecasting

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 769-786页

作者： Xiaojun Pu Jiaqi Zhu Yunkun Wu Chang Leng Zitong Bo Hongan Wang Institute of Software Chinese Academy of Sciences BeijingChina Ecovacs robotics Co. Ltd.SuzhouJiangsuChina Automotive Software Innovation center ChongqingChina

Appropriately characterising the mixed space-time relations of the contagion process caused by hybrid space and time factors remains the primary challenge in COVID-19 ***,in previous deep learning models for epidemic forecasting,spatial and temporal variations are captured separately.A unified model is developed to cover all spatio-temporal ***,this measure is insufficient for modelling the complex spatio-temporal relations of infectious disease transmission.A dynamic adaptive spatio-temporal graph network(DASTGN)is proposed based on attention mechanisms to improve prediction *** DASTGN,complex spatio-temporal relations are depicted by adaptively fusing the mixed space-time effects and dynamic space-time dependency *** dual-scale model considers the time-specific,space-specific,and direct effects of the propagation process at the fine-grained ***,the model characterises impacts from various space-time neighbour blocks under time-varying interventions at the coarse-grained *** performance comparisons on the three COVID-19 datasets reveal that DASTGN achieves state-of-the-art results with a maximum improvement of 17.092%in the root mean-square error and 11.563%in the mean absolute *** results indicate that the mechanisms of designing DASTGN can effectively detect some spreading characteristics of *** spatio-temporal weight matrices learned in each proposed module reveal diffusion patterns in various *** conclusion,DASTGN has successfully captured the dynamic spatio-temporal variations of COVID-19,and considering multiple dynamic space-time relationships is essential in epidemic forecasting.

关键词： adaptive COVID-19 forecasting dynamic intervention spatio-temporal graph neural networks

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Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing

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Nano Research 2024年第2期17卷 778-787页

作者： Jun Zhang Xingmei Chen Jingseng Lin Pei Zhang Iek Man Lei Yue Tao Jiajun Zhang Tian Luo Ji Liu Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China Research and Innovation center SKG Health TechnologyShenzhen 518000China SAFE(Shenzhen)medical Technology Company Limited Shenzhen 518000China Shenzhen Key Laboratory of Biomimetic robotics and Intelligent Systems Department of Mechanical and Energy EngineeringSouthern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation robotics in Universities Southern University of Science and TechnologyShenzhen 518055China

Repairing Achilles tendon has emerged as a long-standing challenge in the orthopaedic *** suture is the gold standard for re-attaching and repairing the fractured Achilles tendons in clinical surgeries,it is still subjected to numerous adverse side-effects,including chronic inflammatory,tendon tissue re-rupture,scar formation,and post-surgical peritendinous *** this work,we develop a class of hydrogel bioadhesives with tailored nanoscale phase separation for Achilles tendon *** address the existing limitations of sutures,our hydrogel bioadhesives encompass three core functionalities:(i)instant and tough adhesion to Achilles tendon tissues,(ii)extraordinary long-term adhesion robustness under wet and dynamic in vivo conditions,and(iii)anti-postsurgical peritendinous *** our hydrogel bioadhesives with sutures,such kind of integrated approach enables a conformable yet robust biointerface with the tendon tissues,and prevents the fibroblast migration and formation of connective tissues,thus facilitating the tendon *** hydrogel bioadhesives reported here open up new opportunities for the repairing of fractured Achilles tendons in diverse and complicated clinical scenarios.

关键词： hydrogels phase separation bioadhesion robustness tendon repairing

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