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Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease

Neural Regeneration Research 2013年第12期8卷 1061-1070页

作者： Guang-Biao Huang Tong Zhao Sushma Shrestha Muna Hong-Mei Jin Jong-Il Park Kyu-Sik Jo Bo-Hee Lee Soo-Wan Chae Sun-Young Kim Soo-Hyun Park Eun-Ock Park Eun-Kyung Choi Young-Chul Chung Department of Psychiatry Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea muju chunma native local industrial center Muju 568-844 Republic of Korea Clinical Trial center for Functional Foods Chonbuk National University HospitalJeonju 561-756 Republic of Korea Department of Pharmacology Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea

Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide （Ap）-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer＇s disease, we established a rat model of AIzheimer＇s disease by injecting A325-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg Gastrodia elata Blume per day for 52 consecutive days. Morris water maze tests showed that Gastrodia elata Blume treatment significantly improved the spatial memory of Alzheimer＇s disease rats. Congo red staining revealed that Gastrodia elata Blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of Gastrodia elata Blume, while EIIman method showed significant decrease in the activity of acetylcholinesterase in all three regions （prefrontal cortex, medial septum and hippocampus）. These findings suggest that long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer＇s disease.

关键词： neural regeneration neuroprotective effect Traditional Chinese medicine Gastrodia elata Blume Alzheimer's disease Morris water maze test choline acetyltransferase acetylcholinesterase grants-supported paper neuroregeneration

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Evaluating soil erosion and runoff dynamics in a humid subtropic, low stream order, southern plains watershed from cultivation and solar farm development

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International Soil and Water Conservation Research 2024年第2期12卷 432-445页

作者： Luis Mier-Valderrama Julianna Leal Humberto L.Perotto-Baldivieso Brent Hedquist Hector M.Menendez Ambrose Anoruo Benjamin L.Turner Department of Agriculture Agribusinessand Environmental ScienceTexas A&M University-KingsvilleKingsvilleTXUSA Department of Rangeland and Wildlife Sciences And Caesar Kleberg Wildlife Research InstituteTexas A&M University-KingsvilleKingsvilleTXUSA Department of Physics and Geosciences Texas A&M University-KingsvilleKingsvilleTXUSA South Dakota State University West River Ag CenterRapid CitySDUSA

Much work has been done to understand and improve soil and water conservation where agriculture has driven land use *** is known about soil-and water-related impacts from intensification driven by solar farming,especially at *** we employed Hydrologic Engineering center's Hydrologic Modeling System(HEC-HMS)to model Pond Creek,a rural watershed in Texas,*** use is primarily crop cultivation and secondarily pasture for cattle ***,several industrial-scale projects are planned to convert≈15–30%of Pond Creek from agriculture to solar *** model was parameterized using public data sources and information from local stakeholders,then calibrated to several historical precipitation *** were conducted by varying precipitation depth,duration,and land uses:native vegetation pre-cultivation(control),cultivation(current),current conditions with 15%solar farm conversion(solar),and current conditions with 30%solar farm conversion(solar x2).Shifting to solar farming led to significant increases in cumulative sediment load(+12%–30%),with no significant differences in peak discharge rate changes(+0.38%–4%).Comparison to soil loss tolerance values showed current and solar treatment erosion rates exceeded tolerance values between 0.17 and 2.29 tons per hectare and all treatments were significantly different than the native *** discuss high leverage strategies applicable to solar farm development sites as well as watersheds where they *** demand for land for renewable energy such as solar farming warrants greater attention from the soil and water conservation community to anticipate and mitigate impacts across landscapes.

关键词： Erosion Sediment loading Runoff Watershed management Solar energy HEC-HMS

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Developing an effective industrial cluster from strawberry farms： A case of Dahu Township in Taiwan

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Chinese Business Review 2010年第11期9卷 34-39页

作者： Yu-Ning Hu Jerome Chih-Lung Chou Chia-Liang Hung Global Hakka Research center National United University Miaoli 360 Taiwan Department of Information Management Hwa-Hsia Institute of Technology Taipei 235 Taiwan Department of Information Management National Chi-Nan University Puli 545 Taiwan

Dahu, a small township in northern Taiwan, is famous for its produce of strawberries. Near Dahu, there are some attractions, such as hot springs, native Taiwan Residents tribes and a national park named Shei-pa. In order to better support more small businesses in this area, the local government is eager to promote an industrial cluster of agriculture and tourism based on the well-developed strawberry farms. In this research, the authors investigated 200 strawberry farmers to examine forming factors of the cluster, and effects of cluster on organizational performance. The findings are firstly, capital resource is regarded as the most effective forming factor of the cluster. Secondly, institutionalization, interaction mechanism and knowledge flow positively intermediate the clustering effects on organizational performance. These findings have important implications for the local government and the businesses as well.

关键词： industrial cluster organizational behavior organizational performance

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