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discovery and structure-activity relationship studies of novel tetrahydro-β-carboline derivatives as apoptosis initiators for treating bacterial infections

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Journal of Integrative Agriculture 2024年第4期23卷 1259-1273页

作者： Shanshan Su Hongwu Liu Junrong Zhang Puying Qi Yue ding Ling Zhang Linli Yang Liwei Liu Xiang Zhou Song Yang National Key Laboratory of Green Pesticide/Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education/Center for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China

developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food *** this paper,to discover the new bactericide candidates,we designed,prepared a new type of1,2,3,4-tetrahydro-β-carboline(THC)derivatives and evaluated the in vitro and in vivo bioactivities against the Xanthomonas oryzae ***(Xoo),Xanthomonas axonopodis ***(Xac),and Pseudomonas syringae ***(Psa).The in vitro bioassay results exhibited that most title molecules possessed good activity toward the three plant pathogenic bacteria,the compound A17 showed the most active against Xoo and Xac with EC50 values of 7.27 and 4.89 mg mL^(-1)respectively,and compound A8 exhibited the best inhibitory activity against Psa with EC50value of 4.87 mg mL^(-1).Pot experiments showed that compound A17 exhibited excellent in vivo antibacterial activities to manage rice bacterial leaf blight and citrus bacterial canker,with protective efficiencies of 52.67 and 79.79%at 200 mgmL^(-1),***,compound A8 showed good control efficiency(84.31%)against kiwifruit bacterial canker at 200 mg mL^(-1).Antibacterial mechanism suggested that these compounds could interfere with the balance of the redox system,damage the cell membrane,and induce the apoptosis of Xoo *** together,our study revealed that tetrahydro-β-carboline derivatives could be a promising candidate model for novel broadspectrum bactericides.

关键词： tetrahydro-β-carboline derivatives antibacterial activity rOS cell apoptosis

Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants

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Science China(Life Sciences) 2024年第2期67卷 391-402页

作者： Awei Zhang Haizhen Zhang ronghua Wang Hongfu He Baoan Song runjiang Song National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang 550025China

The prevention and control of rice bacterial leaf blight(BLB)disease has not yet been achieved due to the lack of effective agrochemicals and available ***,we develop a series of novel bissulfones and a novel target with a unique mechanism to address this *** developed bissulfones can control Xanthomonas oryzae ***(Xoo),and 2-(bis(methylsulfonyl)methylene)-N-(4-chlorophenyl)hydrazine-1-carboxamide(B_(7))is more effective than the commercial drugs thiodiazole copper(TC)and bismerthiazol(BT).Pyruvate kinase(PYK)in Xoo has been identified for the first time as the target protein of our bissulfone B_(7).PYK modulates bacterial virulence via a CrP-like protein(Clp)/two-component system regulatory protein(reg r)*** elucidation of this pathway facilitates the use of B_(7)to reduce PYK expression at the transcriptional level,block PYK activity at the protein level,and impair the interaction within the PYK-Clp-reg r complex via competitive inhibition,thereby attenuating bacterial biology and *** study offers insights into the molecular and mechanistic aspects underlying anti-Xoo strategies that target *** believe that these valuable discoveries will be used for bacterial disease control in the future.

关键词： 2-bissulfone-N-phenylhydrazine-1-carboxamide derivatives Xoo antibacterial activities pyruvate kinase regulatory mechanism

Efficient dIPA-CrISPr-mediated knockout of an eye pigment gene in the white-backed planthopper,Sogatella furcifera

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Insect Science 2024年第4期31卷 1015-1025页

作者： Meng-Qi Zhang Lang-Lang Gong Ya-Qin Zhao Yun-Feng Ma Gui-Jun Long Huan Guo Xuan-Zheng Liu J.Joe Hull Youssef dewer Chao Yang Ning-Ning Zhang Ming He Peng He National Key Laboratory of Green Pesticides Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyangChina Pest Management and Biocontrol research Unit US Arid Land Agricultural Research CenterUSDA Agricultural Research ServicesMaricopaArizonaUSA Phytotoxicity research department Central Agricultural Pesticide LaboratoryAgricultural Research CenterDokkiGizaEgypt guizhou Jifeng Seed Industry Limited Liability Company XingyiGuizhou ProvinceChina Shandong Facility Horticulture Bioengineering research center Weifang University of Science and TechnologyWeifangShandong ProvinceChina

Although CrISPr/Cas9 has been widely used in insect gene editing,the need for the microinjection of preblastoderm embryos can preclude the technique being used in insect species with eggs that are small,have hard shells,and/or are difficult to collect and maintain outside of their normal *** is the case with Sogatella furcifera,the white-backed planthopper(WBPH),a significant pest of Oryza sativa(rice)that oviposits inside rice *** extraction from the stem runs the risk of mechanical damage and hatching is heavily influenced by the micro-environment of the rice *** bypass these issues,we targeted embryos prior to oviposition via direct parental(dIPA)-CrISPr,in which Cas9 and single-guide rNAs(sgrNAs)for the WBPH eye pigment gene tryptophan 2,3-dioxygenase were injected into the hemocoel of adult *** at varying numbers of days posteclosion were evaluated to determine at what stage their oocyte might be most capable of taking up the gene-editing *** evaluation of the offspring indicated that the highest G0 gene-edited efficacy(56.7%)occurred in females injected 2 d posteclosion,and that those mutations were heritably transmitted to the G1 *** study demonstrates the potential utility of dIPA-CrISPr for future gene-editing studies in non-model insect species and can facilitate the development of novel pest management applications.

关键词： CrISPr/Cas9 dIPA-CrISPr gene editing tryptophan 2,3-dioxygenase WBPH

Modified electronic structure and enhanced hydroxyl adsorption make quaternary Pt-based nanosheets efficient anode electrocatalysts for formic acid-/alcohol-air fuel cells

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Journal of Energy Chemistry 2024年第5期92卷 142-150页

作者： Fengling Zhao Qiang Yuan Siyang Nie Liang Wu Xun Wang State-Local Joint Laboratory for Comprehensive Utilization of Biomass Center for R&D of Fine ChemicalsCollege of Chemistry and Chemical EngineeringGuizhou UniversityGuiyang 550025GuizhouChina Key Lab of Organic Optoelectronics&Molecular Engineering Tsinghua UniversityBeijing 100084China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Surface/interface engineering of a multimetallic nanostructure with diverse electrocatalytic properties for direct liquid fuel cells is desirable yet ***,using visible light,a class of quaternary Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)ultrathin nanosheets is fabricated and used as high-performance anode electrocatalysts for formic acid-/alcohol-air fuel *** modified electronic structure of Pt,enhanced hydroxyl adsorption,and abundant exterior defects afford Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C high intrinsic anodic electrocatalytic activity to boost the power densities of direct formic acid-/methanol-/ethanol-/ethylene glycol-/glycerol-air fuel cells,and the corresponding peak power density of Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C is respectively 129.7,142.3,105.4,124.3,and 128.0 mW cm^(-2),considerably outperforming Pt/*** in situ Fourier transform infrared reflection spectroscopy reveals that formic acid oxidation on Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C occurs via a CO_(2)-free direct *** functional theory calculations show that the presence of Ag,Bi,and Te in Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)suppresses CO^(*)formation while optimizing dehydrogenation steps and synergistic effect and modified Pt effectively enhance H_(2)O dissociation to improve electrocatalytic *** synthesis strategy can be extended to 43 other types of ultrathin multimetallic nanosheets(from ternary to octonary nanosheets),and efficiently capture precious metals(i.e.,Pd,Pt,rh,ru,Au,and Ag)from different water sources.

关键词： Pt-based nanosheets Modifiedelectronic structure Enhanced hydroxyl adsorption Formicacidand alcohol oxidation direct liquid fuel cells

Applying Hybrid Clustering in Pulsar Candidate Sifting with Multi-modality for FAST Survey

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research in Astronomy and Astrophysics 2024年第3期24卷 283-296页

作者： Zi-Yi You Yun-rong Pan Zhi Ma Li Zhang Shuo Xiao dan-dan Zhang Shi-Jun dang ru-Shuang Zhao Pei Wang Ai-Jun dong Jia-Tao Jiang Ji-Bing Leng Wei-An Li Si-Yao Li School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China guizhou Provincial Key Laboratory of radio Astronomy and data Processing Guizhou Normal UniversityGuiyang 550025China College of Big data and Information Engineering Guizhou UniversityGuiyang 550025China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Key Laboratory of Information and Computing guizhou province Guizhou Normal UniversityGuiyang 550001China School of Big data and Computer Science Guizhou Normal UniversityGuiyang 550025China guizhou Software Engineering research center Guiyang 550000China

Pulsar search is always the basis of pulsar navigation,gravitational wave detection and other research ***,the volume of pulsar candidates collected by the Five-hundred-meter Aperture Spherical radio Telescope(FAST)shows an explosive growth rate that has brought challenges for its pulsar candidate filtering ***,the multi-view heterogeneous data and class imbalance between true pulsars and non-pulsar candidates have negative effects on traditional single-modal supervised classification *** this study,a multi-modal and semi-supervised learning based on a pulsar candidate sifting algorithm is presented,which adopts a hybrid ensemble clustering scheme of density-based and partition-based methods combined with a feature-level fusion strategy for input data and a data partition strategy for *** on both High Time resolution Universe SurveyⅡ(HTrU2)and actual FAST observation data demonstrate that the proposed algorithm could excellently identify pulsars:On HTrU2,the precision and recall rates of its parallel mode reach0.981 and 0.988 *** FAST data,those of its parallel mode reach 0.891 and 0.961,meanwhile,the running time also significantly decreases with the increment of parallel nodes within ***,we can conclude that our algorithm could be a feasible idea for large scale pulsar candidate sifting for FAST drift scan observation.

关键词： methods data analysis-surveys-methods numerical

revealing the intrinsic mechanisms for accelerating nitrogen removal efficiency in the Anammox reactor by adding Fe(Ⅱ)at low temperature

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Chinese Chemical Letters 2024年第8期35卷 341-348页

作者： Linjing Li Wenlai Xu Jianyong Ning Yaping Zhong Chuyue Zhang Jiane Zuo Zhicheng Pan State Key Laboratory of geohazard prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China National Postdoctoral research Station Haitian Water GroupChengdu 610213China National Enterprise Technology center Haitian Water GroupChengdu 610213China Water Safety and Water Pollution Control Engineering Technology research center in Sichuan province Chengdu 610213China Laboratory of Municipal Wastewater Treatment Technology in Sichuan province Chengdu 610213China Institute of Environment and Ecology Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Fe(Ⅱ)is an essential trace element for anaerobic ammonium oxidation bacteria(AAOB)metabolism,and can improve the nitrogen removal efficiency of anaerobic ammonia oxidation(Anammox).Here we oper-ated two identical expanded granular sludge bed(EGSB)reactors at low temperature(15±3℃)for 154 *** 1(r_(1))received additional Fe(Ⅱ)(0.12 mmol/L)during the late startup phase,while reactor 0(r_(0))served as the control and did not receive extra Fe(Ⅱ).Nitrogen removal in r_(1)became stable at 55 d of operation,ten days earlier than r_(0).The nitrogen removal rate(Nrr)of r_(1) was 1.64 kg N m^(−3)d^(−1)and its TN removal rate was as high as 89%,while r_(0)only reached 75%.The addition of Fe(Ⅱ)was fur-ther beneficial to aggregation and stability of the granular sludge,and the used sludge of both reactors showed enrichment for AAOB populations compared to the inoculum,for instance,increased abundance of Candidatus-Kuenenia and in particular of Candidatus-Brocadia(from 0.17%to 10.10%in r_(0)and 7.79%in r_(1)).diverse microbial species and complex microbial network structure in r_(1)compared to r_(0)promoted the coupled denitrogenation by Anammox,dissimilatory nitrate reduction to ammonium(dNrA),nitrate-dependent Fe oxidation(NdFO),and ferric ammonium oxidation(Feammox).In addition,the microbial community in r_(1)was more resistant to short-term low temperature(2-7℃)starvation,illustrating a further positive effect of adding Fe(Ⅱ)during the startup phase of an Anammox reactor.

关键词： Ambient low temperature Anammox Fe(Ⅱ) Extracellular polymeric substances Microbial community Microbial network analysis

Acetyl coenzyme A carboxylase modulates lipogenesis and sugar homeostasis in Blattella germanica

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Insect Science 2024年第2期31卷 387-404页

作者： Xiaojin Pei Tiantian Bai Yuan Luo Zhanfeng Zhang Sheng Li Yongliang Fan Tong-Xian Liu Guangdong Provincial Key Laboratory of Insect developmental Biology and Applied Technology and Institute of Insect Science and Technology School of Life SciencesSouth China Normal UniversityGuangzhouChina State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau Ministry of AgricultureNorthwest A&F UniversityYanglingShaanxiChina Guangmeiyuan r&d center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina Institute of Entomology Guizhou UniversityGuiyangChina

Lipid and sugar homeostasis is critical for insect development and *** this study,we characterized an acetyl coenzyme A carboxylase gene in Blattella germanica(BgACC)that is involved in both lipogenesis and sugar *** found that BgACC was dominantly expressed in the fat body and integument,and was significantly upregulated after *** of BgACC in 5th-instar nymphs did not affect their normal molting to the next nymphal stage,but it caused a lethal phenotype during adult ***-rNA interference(rNAi)significantly downregulated total free fatty acid(FFA)and triacylglycerol(TAG)levels,and also caused a significant decrease of cuticular hydrocarbons(CHCs).repression of BgACC in adult females affected the development of oocytes and resulted in sterile females,but BgACC-rNAi did not affect the reproductive ability of ***,knockdown of BgACC also changed the expression of insulin-like peptide genes(BglLPs),which mimicked a physiological state of high sugar *** addition,BgACC was upregulated when *** were fed on a high sucrose diet,and repression of BgACC upregulated the expression of the glycogen synthase gene(BgGlyS).Moreover,BgACC-rNAi increased the circulating sugar levels and glycogen storage,and a longevity assay suggested that BgACC was important for the survival of *** under conditions of high sucrose *** results confirm that BgACC is involved in multiple lipid biogenesis and sugar homeostasis processes,which further modulates insect reproduction and sugar *** study benefits our understanding of the crosstalk between lipid and sugar metabolism.

关键词： acetyl-CoA carboxylase German cockroach lipid biosynthesis sugar tolerance

Bond-Slip Behavior of Steel Bar and recycled Steel Fibre-reinforced Concrete

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Journal of renewable Materials 2024年第1期12卷 167-186页

作者： Ismail Shah Jing Li Nauman Khan Hamad r.Almujibah Muhammad Mudassar rehman Ali raza Yun Peng School of Architecture and Civil Engineering Yunnan Agricultural UniversityKunming650000China Institute of mountain Hazards and Environment Chinese Academy of SciencesChengdu610041China Yunnan International Joint r&d center of Smart Agriculture and Water Security Yunnan Agricultural UniversityKunming650201China School of Water Conservancy Yunnan Agricultural UniversityKunming650201China School of Civil Engineering Guizhou UniversityGuiyang550025China department of Civil Engineering College of EngineeringTaif UniversityP.O.Box 11099Taif City21974Saudi Arabia School of Civil Engineering Zhengzhou UniversityZhengzhou450001China

recycled steel fiber reinforced concrete is an innovative construction material that offers exceptional mechanical properties and *** is considered a sustainable material due to its low carbon footprint and environmental friendly *** study examines the key influencing factors that affect the behavior of this material,such as the steel fiber volume ratio,recycled aggregate replacement rate,concrete strength grade,anchorage length,and stirrup *** study investigates the bond failure morphology,bond-slip,and bond strength constitutive relationship of steel fiber recycled *** results show that the addition of steel fibers at 0.5%,1.0%,and 1.5%volume ratios can improve the ultimate bond strength of pull-out specimens by 9.05%,6.94%,and 5.52%,*** replacement rate of recycled aggregate has minimal effect on the typical bond strength of pull-out ***,the ultimate bond strengths of pull-out specimens with concrete strength grades C45 and C60 have improved compared to those with C30 *** specimens with longer anchorage lengths exhibit lower ultimate bond strength,with a reduction of 33.19%and 46.37%for anchorage lengths of 5d and 7d,respectively,compared to those without *** restraint of 1φ8 and 2φ8 improves the ultimate bond strength by 5.29%and 6.90%,*** fibers have a significant effect on the behavior of concrete after it cracks,especially during the stable expansion stage,crack instability expansion stage,and failure stage.

关键词： recycled coarse aggregates(rCA) steel fiber bonding performance bond-slip environmental challenges

design Strategy of diagonal Compressors in Compressed Air Energy Storage System

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Journal of Thermal Science 2024年第3期33卷 872-887页

作者： ZHANG Yuxin ZUO Zhitao GUO Wenbin LIANG Qi CHEN Haisheng Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China National Energy Large Scale Physical Energy Storage Technologies r&d center of Bijie Bijie551700China Nanjing Institute of Future Energy System IETCASNanjing211135China

As a kind of large-scale physical energy storage,compressed air energy storage(CAES)plays an important role in the construction of more efficient energy system based on renewable energy in the *** with traditional industrial compressors,the compressor of CAES has higher off-design performance *** the perspective of design,it needs to pay attention not only to the performance of the design point,but also to the performance of all the stable working ***,from the previous literature,no diagonal compressor was used in CAES which can meet the requirements,which also reflects the design program can be further ***,this paper studies the design strategy of high efficient diagonal compressor for large-scale CAES,and gives the complete strategy algorithms used for different program *** pressure ratio,isentropic efficiency and stable working range are comprehensively *** the design process,the criteria for the key parameters of the diagonal flow angle of the diagonal compressor are given for the first *** results show that the isentropic efficiency at the design point is 92.7%,the total pressure ratio is1.97,and the stable working range exceeds 20%,which meets the design requirements of the compressor for CAES and exceeds the overall performance of the previous compressors in the entire working range.

关键词： compressed air energy storage design strategy diagonal compressor optimal selection design procedure