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Antibacterial HA-coatings on bioresorbable Mg alloy

Journal of Magnesium and Alloys 2024年第5期12卷 1965-1985页

作者： K.v.Nadaraia D.v.Mashtalyar M.A.Piatkova A.I.Pleshkova I.M.Imshinetskiy M.S.Gerasimenko E.A.Belov v.v.Kumeiko D.N.Kozyrev K.A.Fomenko v.v.Mostovaya B.R.Torpanov A.R.Biktimirov I.S.Osmushko S.L.Sinebryukhov S.v.Gnedenkov Institute of Chemistry FEB RAS 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far Eastern Federal University 10 Ajax BayRussky IslandVladivostok 690922Russia A.v.Zhirmunsky National Scientific Center of Marine Biology FEB RAS 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical Dermatovenerological Dispensary 18 V St.GamarnikaVladivostok 690033Russia NMIC“Treatment and Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this study,a calcium-phosphate coating was formed on a Mg-Mn-Ce alloy by the plasma electrolytic oxidation(PEO).The antibiotic vancomycin,widely used in the treatment of infections caused by Staphylococcus aureus(***),was impregnated into the *** with vancomycin showed high bactericidal activity against *** mechanical and electrochemical properties of the formed coatings were studied,as well as in vitro cytotoxicity tests and in vivo tests on mature male rats were *** to SEM,EDS,XRD and XPS data,coatings had a developed morphology and contained hydroxyapatite,which indicates high *** analysis of roughness of coatings without and with vancomycin did not reveal any differences,confirming the high roughness of the *** electrochemical tests,an increase in corrosion resistance by more than two times after the application of PEO coatings was *** to the results of an in vivo study,after 28 days of the implantation of samples with calcium phosphate PEO coating and vancomycin,no signs of inflammation were observed,while an inflammatory reaction developed in the area of implantation of bare alloy,followed by *** release tests from the coatings show a sharp decrease in the concentration of the released antibiotic on day 7 and then a gradual decrease until day *** the experiment,no significant deviations in the condition and behavior of the animals were observed;clinical tests did not reveal a systemic toxic reaction.

关键词： Bioactive coatings Biocompatibility Mg alloy Plasma electrolytic oxidation Hydroxyapatite vancomycin

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One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide(NIPAM) in Water

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Chinese Journal of Polymer Science 2024年第1期42卷 1-6,I0004页

作者： Zi-Shan Li Jing Lyu Bei Qiu Ying-Hao Li Ruth Foley Ri-Jian Song Melissa Johnson Qiang Geng Wen-Xin Wang Institute of Precision Medicine(AUST-IPM) Anhui University of Science and TechnologyHuainan 232001China Charles Institute of Dermatology School of MedicineUniversity College DublinDublin D04 V1W8Ireland

Copper(0)-mediated reversible-deactivation radical polymerization(Cu(0)-mediated RDRP) of the water-soluble monomer Nisopropylacrylamide(NIPAM) has been challenging with the problems of high dispersity, poor control over the molecular weights(MWs) or complex or multi reaction steps, etc. In this work, we report the well-controlled polymerization of NIPAM in water via a facile one-pot and one-step Cu(0)-mediated RDRP. The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient Cu~I at the very beginning, and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process. For NIPAM, which has a high propagation rate constant, the deactivation control can be effectively enhanced by extra adding deactivator(i.e., Cu~II) to the system. Moreover, a low reaction temperature(4 ℃) is necessary in the controlled synthesis of higher MW poly(Nisopropylacrylamide)(PNIPAM) to avoid the compromise in control caused by the phase transition from its lower critical solution temperature(LCST). Through this new kinetically controlled strategy, PNIPAMs with well-defined structure, narrow molecular weight distributions(MWDs) and varied MWs were successfully achieved.

关键词： Cu(0)-mediated RDRP N-isopropylacrylamide Propagation Deactivation Reaction parameters

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A hybrid data-mining framework for train rescheduling strategy pattern discovery

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Transportation Safety and Environment 2024年第1期6卷 56-67页

作者： Ruirui Chen Xuekai Ge Ping Huang Chao Wen School of Transportation&Logistics Southwest Jiaotong UniversityChengdu 611756China Department of IT Operational Technology CN RailWaterloo N2V2R1Canada

This study presents a hybrid data-mining framework based on feature selection algorithms and clustering methods to perform the pattern discovery of high-speed railway train rescheduling strategies(RSs).The proposed model is composed of two *** the first state,decision tree,random forest,gradient boosting decision tree(GBDT)and extreme gradient boosting(XGBoost)models are used to investigate the importance of *** features that have a high influence on RSs are first *** the second state,a K-means clustering method is used to uncover the interdependences between RSs and the influencing features,based on the results in the first *** proposed method can determine the quantitative relationships between RSs and influencing *** results clearly show the influences of the factors on RSs,the possibilities of different train operation RSs under different situations,as well as some key time periods and key trains that the controllers should pay more attention *** research in this paper can help train traffic controllers better understand the train operation patterns and provides direction for optimizing rail traffic RSs.

关键词： high-speed railway rescheduling strategy pattern discovery feature identification clustering algorithm

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Relative(n,k)-Weak Cotorsion Modules

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Algebra Colloquium 2024年第3期31卷 481-498页

作者： Mostafa Amini Houda Amzil Driss Bennis Department of Mathematics Faculty of SciencesPayame Noor UniversityTehranIran Department of Mathematics Faculty of Sciences EI Jadida Chouaib Doukkali UniversityMorocco Department of Mathematics Faculty of Sciences Mohammed V University in RabatMorocco

Let R be a ring and n,k be two non-negative *** an extension of several known notions,we introduce and study(n,k)-weak cotorsion modules using the class of right R-modules with n-weak fat dimensions at most *** exampl... 详细信息

关键词： (n,k)-weak cotorsion module n-weak injective module n-weak fat module n-super finitely presented module

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Toward sustainable waste management in small islands developing states: integrated waste-to-energy solutions in Maldives context

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 133-148页

作者： Yao Wang Alejandro Ruiz-Acevedo Eemaan Rameez vijaya Raghavan Abid Hussain Xunchang Fei School of Civil and Environmental Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore United Nations Office for Project Services(UNOPS) United Nations BuildingBuruzu MaguMale’20184Maldives Department of Bioresource Engineering McGill UniversitySte-Anne-De-BellevueQuebec H9X 3V9Canada Department of Civil and Environmental Engineering Carleton UniversityOttawaOntario K1S 5B6H9X 3V9Canada

Effective waste management is a major challenge for Small Island Developing States (SIDS) like Maldives due to limited land availability. Maldives exemplifies these issues as one of the most geographically dispersed countries, with a population unevenly distributed across numerous islands varying greatly in size and population density. This study provides an in-depth analysis of the unique waste management practices across different regions of Maldives in relation to its natural and socioeconomic context. Data shows Maldives has one of the highest population density and per capita waste generation among SIDS, despite its small land area and medium GDP per capita. Large disparities exist between the densely populated capital Male’ with only 5.8 km2 area generating 63% of waste and the ~194 scattered outer islands with ad hoc waste management practices. Given Male’s dense population and high calorific waste, incineration could generate up to ~30 GW/a energy and even increase Maldives’ renewable energy supply by 200%. In contrast, decentralized anaerobic digestion presents an optimal solution for outer islands to reduce waste volume while providing over 40%–100% energy supply for daily cooking in local families. This timely study delivers valuable insights into designing context-specific waste-to-energy systems and integrated waste policies tailored to Maldives’ distinct regions. The framework presented can also guide other SIDS facing similar challenges as Maldives in establishing sustainable, ecologically sound waste management strategies.

关键词： Anaerobic digestion Waste incineration Waste management Maldives Small Island Developing States Waste-to-energy

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Surgical Management of a Collision Tumor: The Association of Intracranial Meningioma and Macroadenoma

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Open Journal of Modern Neurosurgery 2024年第1期14卷 48-56页

作者： Salma Abbas Yao Christian Hugues Dokponou Thameen Jaradat Mahjouba Boutarbouch Nadia Cherradi Hafsa El Ouazzani Abdessamad El Ouahabi Department of Neurosurgery Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco Department of Pathology Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco

Background: The simultaneous presence of a pituitary adenoma and a meningioma is a rare and underreported condition. The randomly encountered cases need to be reported to further allow our understanding of this collision tumors that are still not understood nor fully described. Patients and Method: We report a case of coexisting nonfunctioning pituitary adenoma and a left temporal lobe meningioma revealed by a 1-year history of progressive vision loss and occasional headaches in a 56-year-old woman. Her clinical condition worsened in the last 5 months with ptosis, cavernous sinus syndrome, and ophthalmoplegia of the right eye without papilledema. There was an improvement in the visual symptoms after subtotal resection of both lesions through a right frontotemporal craniotomy. Histology confirmed a collision tumor. The patient was referred for adjuvant treatment with gamma knife radiosurgery. He was doing well and back to his usual duties 6 months later. Conclusion: A gross total or subtotal resection with adjuvant therapy is the gold standard for the surgical management of collision tumors for a favorable patient outcome.

关键词： Collision Tumors Meningioma Pituitary Adenoma

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Immunomodulatory activity of polycaprolactone nanoparticles with calcium phosphate salts against Leishmania infantum infection

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 359-368页

作者： Kübra Kelleci Adil Allahverdiyev Melahat Bağırova Murat Ihlamur EmrahŞefik Abamor Department of Bioengineering Yildiz Technical UniversityIstanbulTurkey v.Akhundov National Scientific Research Medical Prophylactic Institute BakuAzerbaijan Department of Electronics and Automation Biruni UniversityIstanbulTurkey

Objective:To prepare and characterize polycaprolactone(PCL)nanoparticles loaded with sonicator fragmented(SLA)and freeze-thaw Leishmania antigens(FTLA)and to investigate the in vitro immunogenicity of antigen-encapsulated nanoparticles with calcium phosphate ***:The water/oil/water binary emulsion solvent evaporation method was used to synthesize antigen-loaded PCL *** were characterized by scanning electron microscopy and zeta potential *** cytotoxicity in J774 macrophages in vitro was determined by MTT *** addition,the amount of nitric oxide and the level of cytokines produced by macrophages were determined by Griess reaction and ELISA method,*** protective effect of the developed formulations was evaluated by determining the infection index percentage in macrophages infected with Leishmania ***:Compared to the control group,SLA PCL and FTLA PCL nanoparticles with calcium phosphate adjuvant induced a 6-and 7-fold increase in nitric oxide,***,the vaccine formulations promoted the production of IFN-γand *** PCL and FTLA PCL nanoparticles combined with calcium phosphate adjuvant caused an approximately 13-and 11-fold reduction in infection index,respectively,compared to the control ***:The encapsulation of antigens obtained by both sonication and freeze-thawing into PCL nanoparticles and the formulations with calcium phosphate adjuvant show strong in vitro immune stimulating ***,PCL-based antigen delivery systems and calcium phosphate adjuvant are recommended as a potential vaccine candidate against leishmaniasis.

关键词： Leishmaniasis Calcium phosphate Polycaprolactone Nanoparticle Antigen delivery system Adjuvant vaccine design

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Radiation protection knowledge and practices among Moroccan dentists:A cross-sectional study

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Radiation Medicine and Protection 2024年第2期5卷 131-138页

作者： Naoual Elmorabit Majdouline Obtel Mohamed Azougagh Oumkeltoum Ennibi Laboratory of Research on Oral Biology and Biotechnology Faculty of Dental MedicineMohammed V UniversityRabatMorocco Department of Public Health Faculty of Medicine and PharmacyMohammed V UniversityRabatMorocco National Graduate of Arts and Crafts(ENSAM) Mohammed V UniversityRabatMorocco

Objective:To analyze the current status of knowledge and practices among the Moroccan dentists in the region of Rabat-Sale-Kenitra,towards radiation ***:This is a cross-sectional study based on a questionnaire related to knowledge and practice regarding radiation protection of patients and dental staff from April to June *** study sample included 325 dentists practicing in the Rabat-Sale-Kenitra *** target population consisted of all dentists working in public,semipublic and private ***:96.6%of dentists were aware of radiation ***,nearly 35%were aware of ALARA(as low as reasonably achievable)principle and 73.9%thought that dental X-rays are harmful.63.6%of subjects used digital image *** 16.7%of them used a film holder and more than 60%didn't follow the position and distance *** median knowledge score was 7[5,9],and there was a statistically significant difference according to dentist qualification(P=0.007),dental radiation protection continuous training(Pve relationship between knowledge score and practice score(r=0.24,Pving dentists'knowledge of radiation protection measures and tools as well as dose reduction techniques could increase their safe practices in dental radiology.

关键词： Dentists Radiation protection Awareness Dental radiography

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Correlation between mechano-electronic features and scattering rates using deformation potential theory

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Communications in Theoretical Physics 2024年第2期76卷 166-181页

作者： Meryem Ziati Sanaa Lahlali Hamid Ez-Zahraouy Laboratory of Condensed Matter and Interdisciplinary Sciences `Unitéde recherche labellisée CNRST'Faculty of SciencesMohammed V UniversityRabatMorocco Mohammed vI Polytechnic University(UM6P) BenGuerir 43150Morocco

This research paper provides valuable insight into the electronic,mechanical and transport properties of the Sr_(2)RuO_(2)F_(2)*** study shows that the Sr_(2)RuO_(4)compound exhibits a metallic ground state and that the energy gap widens with oxygen substitution with *** concept of absolute deformation potential and its correlation with band energies and strains is explained using deformation potential *** paper also examines the mechanical features of Sr_(2)RuO_(2)F_(2)using the voigt-Reuss-Hill approximation method and analyzes its elastic constants,bulk modulus and shear modulus,indicating flexibility and suitability for optoelectronic *** role of acoustic phonons in scattering rates and carrier mobility in Sr_(2)RuO_(2)F_(2)and its potential for phonon-mediated superconductivity is *** intrinsic resistivity of electrons and holes under strain and its potential impact on superconductivity and electrical resistivity are also *** insight provided by this study contributes to the current understanding of Sr_(2)RuO_(2)F_(2),and its potential applications.

关键词： density functional theory deformation potential theory scattering rates carrier mobility intrinsic resistivity

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Considerations for exerkine research focusing on the response to exercise training

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Journal of Sport and Health Science 2024年第2期13卷 130-132页

作者： Ian A.J.Darragh Brendan Egan School of Health and Human Performance Dublin City UniversityGlasnevinDublin D09 V209Ireland Florida Institute for Human and Machine Cognition PensacolaFL 32502USA

García-Hermoso and colleagues1 recently published a systematic literature review and meta-analysis on exercise training-induced changes in exerkine concentrations in type 2diabetes mellitus patients,providing a contemporary view on how exerkines respond to exercise *** review prompted us to highlight 2 additional considerations that should be taken into account when studying the response of exerkines to exercise ***,whether exerkines can exhibit discordant responses to acute exercise compared to exercise training,and secondly,the need to consider the residual effects of the most recent exercise bout.

关键词： acute exercise prompt

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