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Skeletal muscle as an endocrine organ:Role of[Na+]i/[K+]i-mediated excitation-transcription coupling

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Genes & Diseases 2015年第4期2卷 328-336页

作者： Leonid V.Kapilevich Tatyana A.Kironenko Anna N.Zaharova Yuri V.Kotelevtsev Nickolai O.Dulin Sergei N.Orlov National Research Tomsk State University TomskRussia Skolkovo Institute of Science and Technology Moscow RegionRussia University of Chicago ILUSA Siberian Medical University TomskRussia M.V.Lomonosov moscow State University MoscowRussia

During the last two decadesnumerous research teams demonstratedthat skeletalmuscles function as an exercise-dependent endocrine organ secreting dozens of *** of physiological and pathophysiological implications of skeletalmusclemyokines secretion has been described;however,upstream signals and sensing mechanisms underlying this phenomenon remain poorly *** is well documented that in skeletal muscles intensive exercise triggers dissipation of transmembrane gradient of monovalent cations caused by permanent activation of voltage-gated Nat and Kt ***,we demonstrated that sustained elevation of the[Nat]i/[Kt]i ratio triggers expression of dozens ubiquitous genes including several canonical myokines,such as interleukin-6 and cyclooxygenase 2,in the presence of intra-and extracellular Ca2t *** data allowed us to suggest a novel[Nat]i/[Kt]i-sensitive,Ca2t i-independent mechanism of excitation-transcription coupling which triggers myokine *** pathway exists in parallel with canonical signaling mediated by Ca2t i,AMP-activated protein kinase and hypoxia-inducible factor 1a(HIF-1a).In ourmini-reviewwe briefly summarize data supporting this hypothesis as well as unresolved issues aiming to forthcoming studies.

关键词： Myokines Secretion Skeletal muscle Transcription Translation

Nuclear Physics with Magnetic Charges

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Journal of Modern Physics 2018年第2期9卷 145-171页

作者： Robert A. Sizov Solid State Physics Institute Moscow Region Russia

The magnetic spinor particles (magnetic charges) are the real structural components all varieties of the Mass, for example, atoms, nucleons, positrons and neutrinos. Atomic-shaped device of Mass is the natural and the only possible organization of electric and magnetic charges which can create a gravitational field. At level of a popular language one can define nucleons as “small atoms”, and positron and neutrino as “very small atoms”. The electric and magnetic fundamental particles in neutron and proton shells which by tradition should be called quarks have charges of smaller magnitude than the charges of particles in atomic shells. Positron which participates in the gravitational interaction and, consequently, has an atomic-shaped device is the most likely candidate for the role of the proton nucleus. The most likely candidate particles on the participation in nuclei of proton and neutron as well as in nuclei of the positron and neutrino are presented in the article. So-called abnormal magnetic moment of neutron is formed by the quark magnetic dipoles which are like to unpaired electrons in the so-called magnetic atoms rotate on the outer orbitals of the neutron shell. The participation of the “magnetic electron” (magneton) in the neutrino core assumes the existence of the so-called anomalous magnetic moment and in the neutrino shell. The existence of real magnetic charges in the structures of the Mass draws our attention on such important problem as interaction between charges in the framework of electromagnetic dipoles such as and in which manifest the weak attraction. Weak interaction by its nature is electromagnetic. So-called electromagnetic interaction, manifested in pairs of homogeneous charges of opposite signs, is either electric or magnetic, but not electromagnetic. The explanation of the weak interaction in the marked pairs of charges is based on the author’s concept of the World Physical Triad and “Dark Energy”. Forces responsible for the interaction o

关键词： Magnetic and Electric Charges Antielectrons Magnetons Antimagnetons Bispinor Physical Mass Vortex Electromagnetic (Gravitational) Field Quarks Protons Neutrons Positrons Neutrino Mesons Weak and Strong Interactions “Dark Energy”

Dirac’s “Holes” Are the True Antielectrons and Real Particles of Antimatter

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Journal of Modern Physics 2015年第15期6卷 2280-2289页

作者： Robert A. Sizov Solid State Physics Institute Moscow Region Russia

Experimental and theoretical studies performed by the author showed that electric and magnetic spinor particles as spinors, i.e. particles of Matter so and Antispinors, particles of Antimatter, are structural components of atoms and substance. Together with electric spinors, for example, electrons in the structures of atoms and substances in same quantities, there are real electric anti-spinors, i.e. the true antielectrons, which are not to be confused with electronic vacancies or positrons. Atomic-shaped electromagnetic structures, consisting of electric and magnetic spinor particles, such as nucleons and atoms, represent a Physical Mass. A characteristic property of all varieties of Physical Mass is the ability to emit a gravitational field which is a vortex electromagnetic field. Sources of the gravitational field are joint orbital currents of electric and magnetic charges in the compositions of atomic or nucleon shells. The main reason that the real antielectrons turned out in the Physical sciences under the guise of Dirac’s “holes” or vacancies of electrons, is the Physics of the confinement of these particles in atoms and a substance that is fundamentally different from the confinement of electrons. So, namely Physics confinement of the magnetic spinor particles and electric antispinors in atoms is the main “culprit” creating a fallacious concept of purely electronic atomic shells. The main contributions to the formation of the above-mentioned misconceptions did as J. C. Maxwell with its primitive-surface electromagnetic concept so and P. Dirac, with his erroneous theory of electronic vacancies or “holes”.

关键词： Magnetic and Electric Spinorial Particles (Spinors and Antispinors) Antielectrons Magnetons Antimagnetons Bispinor Physical Mass Vortical Electromagnetic (Gravitational) Field Energo-Medium Dark Energy

Magnetic and Electric Charges in Physics and Technology of Electromagnetic and Magnetoelectric Induction

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Journal of Modern Physics 2017年第6期8卷 964-981页

作者： Robert A. Sizov Solid State Physics Institute Moscow Region Russia

Experimental and theoretical researches performed by the author (period: 1969-present) showed that magnetic spinor particles (magnetic charges) are real structural components of atoms and substance and immediate sources of all magnetic fields and magnetic manifestations in Nature. Magnetic charges, that constitute together with electrical charges atomic shells got of title: magnetons and antimagnetons (respectively with charges g−and g+ under fundamental condition: g = e). Furthermore, in addition to participating in structures of atomic shells, the magnetic charges exist in potential and even in real zones conduction of solids. The magnetic and electric spinor particles in atoms and substance exist in form such of the spinor associations as the magnetic and electric bispinors. Under influence of external magnetic field in conductor being implemented polarization of magnetic bispinors with formation of magnetic dipoles. Internal fields magnetic dipoles is directed against an external magnetic field and is a simple explanation of such a physical manifestation as diamagnetism. During the rotation of these dipoles in the conductor are formed of the vortex magnetic dipole fields, which and create an electromotive force, i.e. are responsible for the electromagnetic induction. Author proposed new magneto-electric technology called the magnetoelectric induction, as the result of which the permanent current of magnetic charges is created. However, such currents may be implemented solely in the superconductors. In the article presented the main reasons which more hundred year old hinder recognition and technical use of the real magnetic charges and their currents what considerably slow down the global scientific and technological progress.

关键词： Magnetic Spinor Particles (Spinors and Antispinors) Magnetons and Antimagnetons Bispinors Vortex Spinor Fields Electromagnetic and Magnetoelectric Induction

“Electrical” and “Magnetic” Worlds in Universe

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Journal of Modern Physics 2017年第7期8卷 1072-1086页

作者： Robert A. Sizov Solid State Physics Institute Moscow Region Russia

Magnetic spinor particles (magnetic charges), which are the direct sources of all magnetic fields and magnetic manifestations in Nature, were experimentally discovered by the author in the structures of atoms and substance. The main reasons that the real magnetic charges were “buried alive” in modern theoretical concepts are the Physics their of confinement in the structures of substance, which is cardinally different from the confinement of electrons, as well as electromagnetic concept of Maxwell, in which magnetic field was erroneously deprived of its own source, i.е. of magnetic pole or magnetic charge. Magnetic and electric charges form atomic shells, which are electromagnetic, and not electronic, as is commonly assumed in the existing physical theory. Namely, the magnetic and electric charges in the joint physical processes form all the varieties of the physical mass, i.е. atoms, nucleons, substance and others. The main feature of physical mass is its ability to radiate gravitational field, which in reality is of the vortex electromagnetic field. The immediate sources of gravitational field are joint orbital currents of electric and magnetic charges in compositions of atomic shells. In 2008 the author for the first time introduced the concepts of “electric” and “magnetic” worlds. So, in the “magnetic” world the processes of condensing all elementary varieties of physical mass: atoms, nucleons and others are initiated not by electric charges as in our “electric” world, but by means of magnetic charges. Electric and magnetic charges in the compositions of physical mass, in differently charged worlds are changing their functional roles and, for example, detect electrons in the “magnetic” world also difficult as the magnetic charges in our of “electric” world. According to conceptions of the author and in our Universe existence of both “electric” so and “magnetic” masses, including charged differently of biological masses is quite possible. It is impossible to excl

关键词： Magnetic and Electric Spinor Particles (Spinors and Antispinors) Antielectrons Magnetons Antimagnetons Bispinors Physical Mass Vortex Electromagnetic (Gravitational) Field “Electric” and “Magnetic” Worlds

Real Magnetic Charges in the Substance, Ferrogravitation and Technical Levitation

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Journal of Modern Physics 2015年第11期6卷 1591-1561页

作者： Robert A. Sizov Solid State Physics Institute Moscow Region Russia

Experimental and theoretical investigations by author of the present article (period: 1968-2013) have shown that the magnetic spinor particles (magnetic charges) are real structural components of atoms and substance and are immediate sources of all magnetic fields in Nature. Joint orbital currents of electric and magnetic charges within atomic shells are the natural sources of gravitational field which is a vortex electromagnetic field. The vector character of the elementary gravitational field is similar to the vortex magnetic field that allows entering in the submission of such fundamental states of the gravitational field, as a paragravitation and ferrogravitation. Physical masses (atoms, nucleons, substance, etc.), which emit ferrogravitational field are repelled off from sources paragravitational field, for example, from Earth. It is a manifestation of the effect of levitation, which was discovered by the author of this article. Technical forces levitation, that induced by technical ferrogravitational fields, could be used in transport, lifting and space technology, power engineering and many other areas of human activity. The main reasons that real magnetic charges are “buried alive” in modern theoretical notions are as physics their of confinement in the structures of atoms and substance which are radically different from the confinement of electrons so and fallacious electromagnetic concept Maxwell in which the magnetic field is by mistake deprived of its own source of the magnetic pole or of the magnetic charge.

关键词： Magnetic Spinor Particles (Spinors and Antispinors) Magneton and Antimagneton Bispinor Physical Mass Vortical Electromagnetic (Gravitational) Field Paragravitation and Ferrogravitation Levitation Effect

Formation of Neutron Fields from Radionuclide Neutron Sources for Metrological Support of Dosimetric Quantities Measurements

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Journal of Applied Mathematics and Physics 2015年第8期3卷 937-941页

作者： S. G. Fedorov P. F. Maslyaev FSUE “VNIIFTRI” Moscow region Russian Federation

The problems of formation of neutron fields are using the radionuclide neutron sources. Theoretical estimates of the contribution to the values of the neutron flux density, kerma and ambient dose equivalent scattered neutron radiation under various conditions of use of neutron sources. The coefficients for calculating the values of different variables at different distances from the source are using the measured values at certain distances from the source. The values of the average energies for neutron spectra are obtained using the radionuclide neutron sources.

关键词： Neutron Dosimetry Neutron Spectrometry Absorbed Dose Dose Equivalent Ambient Dose Equivalent Personal Dose Equivalent the Energy Dependence of Sensitivity

A comprehensive approach to the delayed treatment of post-burn facial scars

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中国整形与重建外科(英文) 2023年第3期5卷 159-162页

作者： Victoria Ivanovna Polshina Maria Cervatiuc Igor Vladimirovich Reshetov Alim Arsenovich Nebejev Eldor Jonnazarov Department of Oncology Radiotherapy and Plastic SurgeryI.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia Department of Oncology and Plastic Surgery Academy of Postgraduate Education of the FSBI FSCC Federal Medico-Biological Agency of RussiaMoscow 119435Russia Department of Ophthalmology I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia

Background:Damage to the skin and underlying tissues due to thermal burns is *** the success of modern medicine,repairing thermal damage to the skin is a difficult task in reconstructive plastic surgery because of the nature of the damage and the regenerative *** post-burn changes are associated with different depths of damage when areas of deep damage are combined with more superficial ***:We described a clinical case of the staged surgical treatment of a cicatricial deformity of the buccalperiorbital-perioral region resulting from a childhood burn injury from a hot *** 44-year-old patient complained of an aesthetic and functional deformity of the buccal-periorbital-perioral region and had previously undergone repeated nonsurgical ***:A comprehensive approach to the surgical treatment of a patient with post-burn deformities using a diplene adhesive membrane directly affected the stage of the surgical treatment and contributed to improved functional and aesthetic ***:The positive treatment results with preserved contraction and relaxation processes of the facial muscles as well as satisfactory aesthetic results allow us to recommend the use of a biodegradable diplene film during facial reconstructive operations.

关键词： Thermal burn Facial scarring Diplene film Buccal-periorbital-perioral region Adhesive membrane Deformation

Biocompatibility of biphasic α,β-tricalcium phosphate ceramics in vitro

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Bioactive Materials 2020年第2期5卷 423-427页

作者： T.V.Safronova I.I.Selezneva S.A.Tikhonova A.S.Kiselev G.A.Davydova T.B.Shatalova D.S.Larionov J.V.Rau Lomonosov moscow State University Leninskie Gory1Moscow119991Russia Institute of Theoretical and Experimental Biophysics Russian Academy of SciencesPushchino142292Moscow RegionRussia Istituto di Struttura Della Materia Consiglio Nazionale Delle Ricerche(ISM-CNR)Via Del Fosso Del Cavaliere 10000133RomeItaly

The biocompatibility of biphasicα,β-tricalcium phosphate ceramics,obtained by annealing a compact preform based onβ-tricalcium phosphate powder,was studied in *** was found that within 10–30 days the adhesion of primary dental pulp stem cells located on the surface of biphasicα,β-tricalcium phosphate ceramics is *** of the cell number on the surface of biphasicα,β-tricalcium phosphate ceramics,most likely,can be associated with both the pH level(acidic)as a result of hydrolysis of the more soluble phase ofα-tricalcium phosphate and with the nature of surface that changes as a result of the formation and growth of hydroxyapatite crystals.

关键词： Tricalcium phosphate Ceramics Phase composition Dental pulp stem cells Biocompatibility