检索结果-南通市图书馆

Nietzsche＇s Naturalistic Metaethics： In Defense of Privilege＊

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Philosophy Study 2012年第2期2卷 92-102页

作者： Timothy McWhirter montgomery college

In his essay ＂Nietzsche＇s Metaethics： Against the Privilege Readings,＂ Brian Leiter critically examines Richard Schacht＇s naturalistic interpretation of Nietzsche. Leiter focuses on the metaethical question：＂What status--metaphysical, epistemological^o the values used to undertake [Nietzsche＇s] revaluation [of value] （the ＇assessing values＇） enjoy？＂（2000, 277）. Are these values true or better justified？ Leiter describes Schacht＇s position as a ＂privilege reading＂ that holds that the perspective from which Nietzsche revaluates values is privileged on the basis of＂normative facts＂ which are constituted by certain ＂natural facts＂（2000, 279）. Leiter attempts to outline and even enhance the argument he sees Schacht making for this position, which Leiter calls a naturalistic realism. Leiter however finds that the arguments for ＂privilege readings＂ are insufficient. He concludes that the perspective from which Nietzsche revaluates values is not privileged at all. It is simply the idiosyncratic perspective from which Nietzsche revaluates values. In this paper I argue that a version of Schacht＇s privilege reading can be supported using two fundamental components of Leiter＇s interpretation of Nietzsche： his methodological and substantive naturalism. When we use scientific methods and view social systems like other natural systems, we find that in contemporary science a privilege is given to the maximum power principle. This concept was initially conceived by the chemist and mathematician Alfred Lotka and further developed by the ecologist Howard Odum and it has a fundamental similarity to the will to power. This principle provides an empirical foundation for the will to power and Schacht＇s privilege reading of Nietzsche＇s metaethics. It provides further evidence that human life is ultimately part of a vast natural process and the growth of all natural systems is made possible by an increase in power.

关键词： Nietzsche naturalism metaethics

Liver transplantation in alcoholic liver disease current status and controversies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第36期19卷 5953-5963页

作者： Ashwani K Singal Khushdeep S Chaha Khalid Rasheed Bhupinderjit S Anand Division of Gastroenterology and Hepatology Department of Medicine University of Alabama at Birmingham Department of Medicine UAB Huntsville Program Huntsville Department of Medicine UAB Montgomery Program Montgomery Department of Gastroenterology and Hepatology Michael DeBakey VA Center Baylor College of Medicine Houston

Alcoholic cirrhosis remains the second most common indication for liver transplantation.A comprehensive medical and psychosocial evaluation is needed when making a decision to place such patients on the transplant *** transplant centers worldwide need a minimum of 6 mo of alcohol abstinence for listing these *** with alcohol dependence are at high risk for relapse to alcohol use after transplantation(recidivism).These patients need to be identified and require alcohol rehabilitation treatment before *** to the level of harmful drinking is reported in about 15%-20%***,recurrent cirrhosis and graft loss from recidivism is rare,occurring in less than 5%of all alcoholic cirrhosis-related transplants,harmful drinking in the post-transplant pe-riod does impact the long-term *** development of metabolic syndrome with cardiovascular events and de novo malignancy are important contributors to non liver-related mortality amongst transplants for alcoholic liver *** protocols for earlier detection of de novo malignancy are needed to improve the long-term *** need for a minimum of 6 mo of abstinence before listing makes transplant a nonviable option for patients with severe alcoholic hepatitis who do not respond to *** data from retrospective and prospective studies has challenged the 6 mo rule,and beneficial effects of liver transplantation have been reported in select patients with a first episode of severe alcoholic hepatitis who are unresponsive to steroids.

关键词： Alcoholic liver disease Liver transplantation Transplant evaluation Recidivism Six months rule Alcoholic hepatitis

Oscillatory Behavior of a Network Epidemic SIS Model with Nonlinear Infectivity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics 2014年第1期5卷 203-211页

作者： Chunhua Feng Carl S. Pettis college of Science Mathematics and Technology Alabama State University Montgomery USA

In this paper, an epidemic SIS model with nonlinear infectivity on heterogeneous networks and time delays is investigated. The oscillatory behavior of the solutions is studied. Two sufficient conditions are provided t... 详细信息

关键词： Sepidemic SIS Network Model Delay Oscillation

Time Delay Induced Oscillation: An Example on a Class of <i>n</i>Coupled Van Der Pol Oscillators Model with Delays

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics 2012年第6期3卷 571-576页

作者： Chunhua Feng Carl S. Pettis college of Science Mathematics and Technology Alabama State University Montgomery USA

In this paper, a class of n coupled van der Pol oscillator model with delays is considered. By employing an analysis approach, some sufficient conditions to guarantee the existence of stability and oscillations for th... 详细信息

关键词： n Coupled Van Der Pol Oscillator Model Characteristic Equation Delay Oscillation

Studies on Enzyme Kinetics by Microchip and Related Techniques

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高等学校化学学报 2004年第Z1期25卷 165-166页

作者： James J. Bao WANG Huai-Feng ZHOU Da-Wei Ken R. Wehmeyer college of Pharmaceuticals Tianjin University Tianjin 300072 China College of Pharmaceuticals Tianjin University Tianjin 300072 China College of Pharmaceuticals Tianjin University Tianjin 300072 China Procter & Gamble Pharmaceuticals 8700 Mason-Montgomery Road Mason OH 45040 USA

Both conventional and microchip-based capillary electrophoresis(CE) technologies have been used for the analysis of enzymes. Practical procedures of using CE to determine the Km and Vmax values of an enzyme have been developed. By studying the inhibition to the enzyme, it is possible to select a suitable drug candidate. When compared with the conventional CE method, single lane microchip-based method can improve the speed for the assay three times. By using multiple lane-based microchip, the speed can be further increased.

关键词： Enzyme Enzyme kinetics Inhibition Enzyme activity

Modeling the Structure of Yeast MAT<i>α</i>1: An HMG-Box Motif with a C-Terminal Helical Extension

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Biophysics 2013年第1期3卷 1-12页

作者： Doba Jackson Tarnisha Lawson Robert Villafane Lisa Gary Department of Chemistry and Biochemistry Huntingdon College Montgomery USA Department of Microbiology Alabama State University Montgomery USA School of Public Health University of Alabama Birmingham Birmingham USA

The yeast MATα1 is required for the activation of α-specific genes in Saccharomyces cerevisiae and thus confers the α-cell identity of the yeast. MATα1 contains a domain called the α-domain which has significant sequence identity to the HMG-box family of proteins. A multiple sequence alignment of several α-domains and various structurally determined HMG-box domains has revealed that both domains possess very similar structural and functional residues. We found that the basic amino acids of the N-terminal loop, the intercalating hydrophobic residues of the first helix, and the hydrophobic residues required for interactions within the core of the protein are remarkably conserved in α-domains and HMG-box proteins. Our generated molecular models suggest that the first and third helix will be shorter and that the HMG-box core is not an isolated domain. The region beyond the conserved HMG-box motif contains an extended helical region for about 20 - 30 amino acids. Structural models generated by comparative modeling and ab initio modeling reveal that this region will add two or more additional α-helices and will make significant contacts to helix III, II and I of the HMG-box core. We were able to illustrate how the extended α-domain would bind to DNA by merging of the α-domain and the LEF-1/DNA complex. The models we are reporting will be helpful in understanding how MATα1 binds to DNA with its partner MCM1 and activates transcription of α-specific genes. These models will also aid in future biophysical studies of MATα1 including the crystallization and structure determination.

关键词： MATα1 MATα2 Gene Regulation Mating-Type Yeast α-Domain Combinatorial Control of Transcription

Expanding plant genome-editing scope by an engineered iSpyMacCas9 system that targets A-rich PAM sequences

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2021年第2期2卷 78-88页

作者： Simon Sretenovic Desuo Yin Adam Levav Jeremy D.Selengut Stephen M.Mount Yiping Qi Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA Hubei Academy of Agricultural Sciences Wuhan 430064China montgomery Blair High School Silver SpringMD 20901USA Center for Bioinformatics and Computational Biology University of MarylandCollege ParkMD 20742USA Department of Cell Biology and Molecular Genetics University of MarylandCollege ParkMD 20742USA Institute for Bioscience and Biotechnology Research University of MarylandRockvilleMD 20850USA

The most popular CRISPR-SpCas9 systemrecognizes canonical NGG protospacer adjacent motifs(PAMs).Previously engineered SpCas9 variants,such as Cas9-NG,favor G-rich PAMs in genome *** this manuscript,we describe a new plant genome-editing system based on a hybrid iSpyMacCas9 platform that allows for targeted mutagenesis,C to T base editing,and A to G base editing at A-rich *** study fills amajor technology gap in the CRISPR-Cas9 system for editing NAAR PAMs in plants,which greatly expands the targeting scope of ***,our vector systems are fully compatible with Gateway cloning and will work with all existing single-guide RNA expression systems,facilitating easy adoption of the systems by *** anticipate that more tools,such as prime editing,homology-directed repair,CRISPR interference,and CRISPR activation,will be further developed based on our promising iSpyMac-Cas9 platform.

关键词： plant genome editing iSpyMacCas9 PAM cytosine base editing adenine base editing

Case study approach to modeling historical disinfection by-product exposure in Iowa drinking waters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2017年第8期29卷 183-190页

作者： Stuart W.Krasner Kenneth P.Cantor Peter J.Weyer Mariana Hildesheim Gary Amy Metropolitan Water District of Southern California Water Quality La Verne CA 91750 USA National Cancer Institute National Institutes of Health Bethesda MD 20892 USA Center for Health Effects of Environmental Contamination(CHEEC) University of Iowa Coralville IA 52242 USA Medical Research Solutions LLC Montgomery Village MD 20886 USA college of Engineering Computing and Applied SciencesClemson University Clemson SC 29631 USA

In the 1980 s, a case–control epidemiologic study was conducted in Iowa（USA） to analyze the association between exposure to disinfection by-products（DBPs） and bladder cancer risk. Trihalomethanes（THMs）, the most commonly measured and dominant class of DBPs in drinking water, served as a primary metric and surrogate for the full DBP *** THM exposure was calculated, based on rough estimates of past levels in Iowa. To reduce misclassification, a follow-up study was undertaken to improve estimates of past THM levels and to re-evaluate their association with cancer risk. In addition, the risk associated with haloacetic acids, another class of DBPs, was examined. In the original analysis, surface water treatment plants were assigned one of two possible THM levels depending on the point of chlorination. The re-assessment considered each utility treating surface or groundwater on a case-by-case basis. Multiple treatment/disinfection scenarios and water quality parameters were considered with actual DBP measurements to develop estimates of past levels. The highest annual average THM level in the re-analysis was156 μg/L compared to 74 μg/L for the original analysis. This allowed the analysis of subjects exposed at higher levels（〉 96 μg/L）. The re-analysis established a new approach, based on case studies and an understanding of the water quality and operational parameters that impact DBP formation, for determining historical exposure.

关键词： Disinfection by-products Trihalomethanes Haloacetic acids Exposure assessment Epidemiology Bladder cancer

Studies on Enzyme Kinetics by Microchip and Related Techniques

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Studies on Enzyme Kinetics by Microchip and Related Techniqu...