检索结果-南通市图书馆

New era of drug innovation in China

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2019年第5期9卷 1084-1085页

作者： Xuan Ye Qingli Wang Haixue Wang office of Pharmacology and Toxicology Center for Drug evaluation National Medical Products Administration

In 2018, the China National Medical Products Administration(NMPA) approved new drug applications (NDAs) of 48 new drugs, which was the highest annual approval rate by the Chinese regulatory agency in the past 20 years. Nine of the 48 new drugs,including fruquintinib, anlotinib, toripalimab and sintilimab, are global new molecular entities (NME) that were developed by Chinese pharmaceutical companies.

关键词： New era drug innovation China

Construction of lake bathymetry from MODIS satellite data and GIS from 2003 to 2011

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Oceanology and Limnology 2014年第3期32卷 720-731页

作者：严翼肖飞杜耘 University of Chinese Academy of Sciences Institute of Geodesy and Geophysics Chinese Academy of SciencesKey Laboratory for Environment and Disaster Monitoring and Evaluation

In recent years, sedimentation conditions in Dongting Lake have varied greatly because of signifi cant changes in runoff and sediment load in the Changjiang(Yangtze) River following the construction of Three Gorges Dam. The topography of the lake bottom has changed rapidly because of the intense exchange of water and sediment between the lake and the Changjiang River. However, time series information on lake-bottom topographic change is lacking. In this study, we introduced a method that combines remote sensing data and in situ water level data to extract a record of Dongting Lake bottom topography from 2003 to 2011. Multi-temporal lake land/water boundaries were extracted from MODIS images using the linear spectral mixture model method. The elevation of water/land boundary points were calculated using water level data and spatial interpolation techniques. Digital elevation models of Dongting Lake bottom topography in different periods were then constructed with the multiple heighted waterlines. The mean root-mean-square error of the linear spectral mixture model was 0.036, and the mean predicted error for elevation interpolation was-0.19 m. Compared with fi eld measurement data and sediment load data, the method has proven to be most applicable. The results show that the topography of the bottom of Dongting Lake has exhibited uneven erosion and deposition in terms of time and space over the last nine years. Moreover, lake-bottom topography has undergone a slight erosion trend within this period, with 58.2% and 41.8% of the lake-bottom area being eroded and deposited, respectively.

关键词： Dongting Lake geomorphy time-series maps remote sensing MODIS data water level

Clinical review considerations of class I PI3K inhibitors in hematolymphatic malignancies by Center for Drug evaluation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2022年第4期34卷 415-421页

作者： Limin Zou Yueli Qi Ling Tang Yu Du Meiyi Xiang Xiaoming Chen Jun Ma Zhimin Yang office of Clinical evaluation 1 Center for Drug EvaluationNational Medical Products AdministrationBeijing 100022China office of Management and Communication Center for Drug EvaluationNational Medical Products AdministrationBeijing 100022China Harbin Institute of Hematology and Oncology Harbin 150010China

Several phosphoinositide 3-kinase(PI3 K) inhibitors are currently approved to treat hematolymphatic malignant diseases worldwide, and many drugs that have the same target are in the clinical research stage. In March 2022,duvelisib became the first PI3 K inhibitor approved in China indicated for the treatment of hematolymphatic malignant diseases. Meanwhile, linperlisib and copanlisib have almost completed the technical review of the clinical specialty. The Center for Drug evaluation(CDE) of the China National Medical Products Administration(NMPA) found that class I PI3 K inhibitors can cause various degrees of immune-related adverse events, which are associated with action mechanisms, affecting the benefit-risk assessment of the drugs. On April 21, 2021, the United States Food and Drug Administration(FDA) convened the Oncologic Drugs Advisory Committee(ODAC)meeting to discuss the safety of PI3 K inhibitors indicated for hematolymphatic malignancies and their related risk of death. The hematological tumor group of CDE of the China NMPA summarized and combined the data on PI3 K inhibitors listed or under technical review for marketing authorization applications and found that such products may have unique efficacy and safety characteristics in Chinese patients with malignant lymphoma.

关键词： Class I PI3K inhibitors efficacy hematolymphatic malignancies safety

A Review of CDER's Novel Drug Approvals for 2016

在线全文

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2017年第2期26卷 161-162页

作者： John Jenkins office of New Drugs in FDA’s Center for Drug evaluation and Research

This past year was another successful year for the new drugs program in FDA＇s Center for Drug evaluation and Research （CDER）. CDER reviewed and approved 22 novel drugs, most of which have the potential to add signi... 详细信息

关键词：期刊编辑工作中国药学会议信息

Adsorptive removal of tetracycline from water using Fe(Ⅲ)-functionalized carbonized humic acid

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2020年第10期28卷 2689-2698页

作者： Dairui Xie Hongcheng Zhang Meng Jiang Hao Huang Heng Zhang Yang Liao Shilin Zhao College of Chemistry and Material Science Sichuan Normal UniversityChengdu 610068China Key Laboratory of Land Resources evaluation and monitoring in Southwest Ministry of Education of ChinaChengdu 610068China

Humic acid(HA)was carbonized at 300,400 and 500℃ and then functionalized with 1 wt%–12 wt%Fe(Ⅲ)respectively[CHA300/400/500-Fe(Ⅲ)].Adsorption of such Fe(III)-functionalized carbonized HA as adsorbents to aqueous tetracycline(TC:25 mg·L^-1)was *** adsorption equilibrium time for CHA400-Fe(Ⅲ)to TC was 6 h faster and the adsorption removal efficiency(Re)was two times higher than that of HA/*** adsorption Reof CHA400-Fe(Ⅲ)loaded 10%iron[CHA400-(10%)Fe(Ⅲ)]to TC could reach 99.8%at 8 h and still kept80.6%after 8 *** adsorption kinetics were well fitted to the pseudo-second-order equation and the adsorption isotherms could be well delineated via Langmuir equations(R^2N 0.99),indicating that the homogeneous chemical adsorption of TC occurred on the *** main adsorption mechanisms of TC were complexation Fe(III)and hydrophobic *** and electronegative repulsion between TC and CHA400-(10%)Fe(Ⅲ)at lowly p H(2)and highly p H(8–10)respectively,leaded to the relatively low adsorption capacity and more notable influence of ion *** the p H was between 4 and 8,TC mainly existed in neutral molecules(TCH2),so the influence of ion concentration was not *** dynamic adsorption results showed that the CHA400-(10%)Fe(Ⅲ)could continuously treat about 2.4 L TC(27 mg·L^-1)wastewater with the effluent concentration as low as 0.068 mg·L^-*** study suggested a broad application prospect of a new,effective,lowcost and environment-friendly adsorbent CHA400-(10%)Fe(Ⅲ)for treatment of low-concentration TC polluted wastewater.

关键词： Fe(Ⅲ)-functionalized carbonized humic acid Composites Adsorption Low-concentration tetracycline Waste water

Reaction mechanism of fluoride conversion into BF^(4-) during sulphuric acid leaching of roasted bastnaesite

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2021年第2期39卷 186-193页

作者： Hongcheng Zhang Dairui Xie Heng Zhang Meng Jiang Hao Huang Yu Wan Yang Liao Shilin Zhao College of Chemistry and Material Science Sichuan Normal UniversityChengdu 610068China Key Laboratory of Land Resources evaluation and monitoring in Southwest Ministry of Education of ChinaChengdu 610068China

The bastnaesite used in hydrometallurgy usually contains 7%-11% fluorine,and the conversion of fluorine into high-value products is the key to achieving green production of rare earths and improving the comprehensive utilization of *** order to recover fluorine from bastnaesite in the form of KBF4,the mechanism of F^(-)conversion to BF^(4-)in sulphuric acid leaching solution of roasted bastnaesite was studied by using Eh-pH diagram and simulation *** shows that the formation of BF^(4-)is affected by pH in the absence of rare ***^(4-)is hydrolyzed to BF3 OH-and F-when the pH is greater than 3.9,and part of F-exists as HF^(2-)when pH is lower than *** the presence of La^(3+),the formation of BF^(4-)is mainly affected by LaF_(3) when pH is greater than 0,and in the case that the pH is lower than 2,it is mainly affected by HF^(2-).When Ce4+is present in solution,CeF_(2)^(2+) can exist stably in sulphuric acid *** down the pH can reduce the stability of CeF_(2)^(2+) and increase the BF^(4-)conversion *** on these results,KBF4 was prepared in the alkaline solution of bastnaesite,and the conversion of BF^(4-)is 84.31%.This provides a theoretical basis for the recovery of fluorine from bastnaesite in the form of KBF_(4).

关键词： BF^(4-) Bastnaesite E_(h)-pH diagram Sulphuric acid leaching Rare earths

Diagnosis of dynamic process over rainband of landfall typhoon

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2010年第7期19卷 611-623页

作者：冉令坤杨文霞楚艳丽 Institute of Atmospheric Physics Chinese Academy of Sciences Hebei Weather Modification office Hebei Laboratory of Ecological and Enviromental monitoring Institute of Urban Meteorology CMA

This paper introduces a new physical parameter -- thermodynamic shear advection parameter combining the perturbation vertical component of convective vorticity vector with the coupling of horizontal divergence perturbation and vertical gradient of general potential temperature perturbation. For a heavy-rainfall event resulting from the landfall typhoon ＇Wipha＇, the parameter is calculated by using National Centres for Enviromental Prediction/National Centre for Atmospheric Research global final analysis data. The results showed that the parameter corresponds to the observed 6 h accumulative rainband since it is capable of catching hold of the dynamic and thermodynamic disturbance in the lower troposphere over the observed rainband. Before the typhoon landed, the advection of the parameter by basic-state flow and the coupling of general potential temperature perturbation with curl of Coriolis force perturbation are the primary dynamic processes which are responsible for the local change of the parameter. After the typhoon landed, the disturbance is mainly driven by the combination of five primary dynamic processes. The advection of the parameter by basic-state flow was weakened after the typhoon landed.

关键词： thermodynamic shear advection parameter convective vorticity vector horizontal divergence general potential temperature

Preparation of Pt/γ-Al2O3-C Heterogeneous Catalyst for Highly Selective Hydrogenation of Cinnamaldehyde Towards Cinnamyl Alcohol

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2017年第4期33卷 660-665页

作者： MA Jun Sichuan Province Institutions of Higher Education and Key Laboratory of Land Resources evaluation and monitoring in Southwest Ministry of Education Chengdu 610068 P. R. China

A Pt/γ-Al2O3-C heterogeneous catalyst with improved catalytic performance was successfully prepared. Bayberry talmin（BT）, an abundant natural plant polyphenol, was utilized to modifiy the surface of the Pt/γ-Al2O3 matrix and then stabilize Pt nanoparticles（NPs）. The catalyst was systematically and specifically characterized by a collec- tion of analytic tools including XRD, XPS, FTIR, TEM, and TG. It was found that the Pt NPs were envenly dispered on the γ-Al2O3-C matrix. Meanwhile, when the catalyst was applied for selective hydrogenation of cilmamalde- hyde（CMA） in the presence of KOH promoter in solvent, excellent catalytic performance was obtained. The selecti- vity to cinnamyl alcohol（CMO） reached 97.88% with 88.45% CMA conversion within 30 min in the presence of 0.037 mol/L KOH, without significant loss of catalytic activity even under cyclic measurements for 5 times. The excelleut catalytic performances should be ascribed predominantly to the uniform and stable dispersion ofPt NPs on the γ-Al2O3-C matrix and the excellent heat stability of BT.

关键词： Heterogeneous catalyst Pt/γ-Al2O3-C Barberry tannin Selective hydrogenation Ciunamaldehyde

Mixing state of individual carbonaceous particles during a severe haze episode in January 2013,Nanjing,China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2015年第3期13卷 16-23页

作者： Honglei Wang Bin Zhu Zefeng Zhang Junlin An Lijuan Shen Collaborative Innovation Center on Forecast and evaluation of Meteorological Disasters Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological AdministrationNanjing University of Information Science and Technology Jiaxing Environmental monitoring Station

Chemical composition, hourly counts, and sizes of atmospheric carbonaceous particles were measured to investigate their mixing state on clear and hazy days. 823,122 carbonaceous particles with sizes 0.2-2.0μm was analyzed using a single-particle aerosol mass spectrometer from 1st to 17th January 2013. Particle types included biomass/biofuel burning particles （biomass）, element carbon （EC-dominant） particles that were also mixed with biomass/biofuel burning species （EC-biomass） or secondary species （EC-secondary）, organic carbon （OC）, internally mixed OC and EC （OCEC）, ammonium-containing （ammo- nium） and sodium-containing （sodium） particles. On clear days the top ranked carbonaceous particle types were biomass （48.2%）, EC-biomass （15.7%）, OCEC （11.1%）, and sodium （9.6%）, while on hazy days they were biomass （37.3%）, EC-biomass （17,6%）, EC-secondary （16.6%）, and sodium （12.7%）. The fractions of EC-secondary, ammonium （10%）, and sodium particle types were elevated on hazy days. Numbers of EC-secondary particles were more than four times those on clear days （4.1%）. Thus, carbonaceous particles mixed with ammonium, nitrate and sulfate during aging and transport, enhancing their light extinction effects and hygroscopic growth under high relative humidity on hazy days, further reducing visibility. Our real-time single-particle data showed that changes to mixing state had a significant impact on light extinction during haze events in Nanjing.

关键词： HazeSingle particleMixing stateSPAMSCarbonaceous particleSecondary aerosols